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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methdilazine
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Accession:CHEBI:6823 term browser browse the term
Definition:A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.
Synonyms:exact_synonym: 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
 related_synonym: 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine;   Dilosyn;   Formula=C18H20N2S;   InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3;   InChIKey=HTMIBDQKFHUPSX-UHFFFAOYSA-N;   MJ 5022;   SMILES=C1=CC=C2C(=C1)SC=3C(N2CC4CN(CC4)C)=CC=CC3;   Tacaryl;   Tacazyl;   metdilazina;   methdilazinum
 xref: CAS:1982-37-2;   DrugBank:DB00902;   Drug_Central:1742;   HMDB:HMDB0015038;   KEGG:C07175;   KEGG:D04979
 xref_mesh: MESH:C044642
 xref: PMID:14080889;   PMID:14403486;   PMID:15782943;   PMID:19696152;   PMID:19790517;   PMID:2905130;   PMID:4381504;   PMID:8103345;   PMID:8975609;   PMID:9700532;   Reaxys:31266;   Wikipedia:Methdilazine


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methdilazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO methdilazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        pharmacological role 18830
          antagonist 16283
            histamine antagonist 4617
              methdilazine 1
                methdilazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    main group molecular entity 19658
                      s-block molecular entity 19423
                        hydrogen molecular entity 19416
                          hydrides 18755
                            inorganic hydride 17460
                              pnictogen hydride 17435
                                nitrogen hydride 17281
                                  azane 17017
                                    ammonia 17016
                                      organic amino compound 17015
                                        tertiary amino compound 8654
                                          N-alkylpyrrolidine 1170
                                            methdilazine 1
                                              methdilazine hydrochloride 0
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