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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methdilazine
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Accession:CHEBI:6823 term browser browse the term
Definition:A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.
Synonyms:exact_synonym: 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
 related_synonym: 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine;   Dilosyn;   Formula=C18H20N2S;   InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3;   InChIKey=HTMIBDQKFHUPSX-UHFFFAOYSA-N;   MJ 5022;   SMILES=C1=CC=C2C(=C1)SC=3C(N2CC4CN(CC4)C)=CC=CC3;   Tacaryl;   Tacazyl;   metdilazina;   methdilazinum
 xref: CAS:1982-37-2;   DrugBank:DB00902;   Drug_Central:1742;   HMDB:HMDB0015038;   KEGG:C07175;   KEGG:D04979
 xref_mesh: MESH:C044642
 xref: PMID:14080889;   PMID:14403486;   PMID:15782943;   PMID:19696152;   PMID:19790517;   PMID:2905130;   PMID:4381504;   PMID:8103345;   PMID:8975609;   PMID:9700532;   Reaxys:31266;   Wikipedia:Methdilazine



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methdilazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO methdilazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          antagonist 16322
            histamine antagonist 4619
              methdilazine 1
                methdilazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        tertiary amino compound 8697
                                          N-alkylpyrrolidine 1183
                                            methdilazine 1
                                              methdilazine hydrochloride 0
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