Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methdilazine
go back to main search page
Accession:CHEBI:6823 term browser browse the term
Definition:A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties.
Synonyms:exact_synonym: 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
 related_synonym: 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine;   Dilosyn;   Formula=C18H20N2S;   InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3;   InChIKey=HTMIBDQKFHUPSX-UHFFFAOYSA-N;   MJ 5022;   SMILES=C1=CC=C2C(=C1)SC=3C(N2CC4CN(CC4)C)=CC=CC3;   Tacaryl;   Tacazyl;   metdilazina;   methdilazinum
 xref: CAS:1982-37-2;   DrugBank:DB00902;   Drug_Central:1742;   HMDB:HMDB0015038;   KEGG:C07175;   KEGG:D04979
 xref_mesh: MESH:C044642
 xref: PMID:14080889;   PMID:14403486;   PMID:15782943;   PMID:19696152;   PMID:19790517;   PMID:2905130;   PMID:4381504;   PMID:8103345;   PMID:8975609;   PMID:9700532;   Reaxys:31266;   Wikipedia:Methdilazine



show annotations for term's descendants           Sort by:
methdilazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO methdilazine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19747
    role 19720
      biological role 19718
        pharmacological role 18978
          antagonist 17005
            histamine antagonist 4863
              methdilazine 1
                methdilazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19747
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19547
                        hydrogen molecular entity 19540
                          hydrides 19024
                            inorganic hydride 17952
                              pnictogen hydride 17937
                                nitrogen hydride 17834
                                  azane 17617
                                    ammonia 17616
                                      organic amino compound 17616
                                        tertiary amino compound 9927
                                          N-alkylpyrrolidine 1209
                                            methdilazine 1
                                              methdilazine hydrochloride 0
paths to the root