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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anthra[1,9-cd]pyrazol-6(2H)-one
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Accession:CHEBI:90695 term browser browse the term
Definition:A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Synonyms:related_synonym: 1,9-Pyrazoloanthrone;   2H-dibenzo[cd,g]indazol-6-one;   C.I. 70300;   Formula=C14H8N2O;   InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16);   InChIKey=ACPOUJIDANTYHO-UHFFFAOYSA-N;   Pyrazolanthrone;   Pyrazoleanthrone;   SMILES=N1N=C2C3=C1C=CC=C3C(C4=C2C=CC=C4)=O;   SP 600125
 xref: CAS:129-56-6;   LINCS:LSM-1163
 xref_mesh: MESH:C432165
 xref: PMID:25866226;   PMID:26465378;   PMID:26704630;   PMID:27005940;   Reaxys:746890;   Wikipedia:1\,9-Pyrazoloanthrone


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anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA]; pyrazolanthrone inhibits the reaction [Oxygen deficiency results in increased expression of ABCB1 mRNA]
pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
CTD PMID:15604272 PMID:18474546 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP pyrazolanthrone inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:20600246 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]] CTD PMID:31447676 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA] CTD PMID:18577375 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO pyrazolanthrone binds to and results in increased activity of AHR protein CTD PMID:17959153 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [arsenic trioxide affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of AIFM1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
CTD PMID:18412143 PMID:20423716 PMID:24577723 PMID:25043952 PMID:29289695 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions EXP pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [diallyl trisulfide results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]
pyrazolanthrone results in decreased expression of AKT1 protein
CTD PMID:16046226 PMID:17341418 PMID:20534739 PMID:22020565 PMID:22696236 PMID:25939952 PMID:28087840 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO pyrazolanthrone results in decreased expression of ALOX5 protein CTD PMID:23539630 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of AMPD3 mRNA] CTD PMID:17460151 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apod apolipoprotein D multiple interactions ISO pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein] CTD PMID:21688324 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:16648635 PMID:28004443 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of AQP1 protein] CTD PMID:21647617 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Ar androgen receptor multiple interactions ISO pyrazolanthrone affects the reaction [Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]] CTD PMID:20148354 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ATF2 protein]
pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]
CTD PMID:12393500 PMID:12663670 PMID:22003962 PMID:23591579 PMID:23836369 PMID:24469321 PMID:24525298 PMID:28975372 PMID:30768131 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]
pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF3 protein]
CTD PMID:22003962 PMID:25531190 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA] CTD PMID:20920558 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in increased expression of BAD protein] CTD PMID:19747539 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein] CTD PMID:22020323 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [docetaxel results in increased activity of BAK1 protein] CTD PMID:17317842 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased activity of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]
pyrazolanthrone inhibits the reaction [bakuchiol affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein]
CTD PMID:14514659 PMID:15034932 PMID:16046226 PMID:16972261 PMID:17292878 PMID:17317842 PMID:19428505 PMID:19540902 PMID:19954742 PMID:20423716 PMID:21420390 PMID:24036456 PMID:24577723 PMID:25043952 PMID:29289695 PMID:30653946 PMID:31044527 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 protein] CTD PMID:30472098 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of BCAS2 mRNA] CTD PMID:17460151 NCBI chr 2:205,662,633...205,670,514
Ensembl chr 2:205,662,588...205,670,511
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases phosphorylation
ISO
EXP
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [fosbretabulin results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of BCL2 protein]
pyrazolanthrone results in decreased phosphorylation of BCL2 protein
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 mRNA]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2 protein modified form]; pyrazolanthrone inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; pyrazolanthrone results in increased phosphorylation of and results in decreased activity of BCL2 protein
pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
CTD PMID:14724571 PMID:17317842 PMID:17786558 PMID:18412143 PMID:19428505 PMID:19540902 PMID:19747539 PMID:19954742 PMID:20166895 PMID:20920558 PMID:21420390 PMID:23212307 PMID:23423712 PMID:24036456 PMID:24321340 PMID:24577723 PMID:24833599 PMID:25043952 PMID:25446857 PMID:30472098 PMID:30653946 PMID:30871965 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO
EXP
[pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2L1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2L1 protein modified form]
CTD PMID:18281123 PMID:19540902 PMID:19747539 PMID:20166895 PMID:31044527 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 protein]
pyrazolanthrone inhibits the reaction [docetaxel results in increased degradation of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA]; pyrazolanthrone inhibits the reaction [temozolomide results in increased expression of BCL2L11 mRNA]
CTD PMID:16166651 PMID:17317842 PMID:18766339 PMID:26418950 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein] CTD PMID:22261313 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
pyrazolanthrone promotes the reaction [polyphyllin I results in increased expression of BECN1 protein]
CTD PMID:26588882 PMID:28842171 PMID:31421117 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein] CTD PMID:26136938 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO pyrazolanthrone promotes the reaction [arsenic trioxide results in increased cleavage of BID protein] CTD PMID:16972261 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA] CTD PMID:12832416 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 protein] CTD PMID:16328441 PMID:19747539 PMID:21594580 PMID:22706169 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of BNIP3 protein] CTD PMID:24824807 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:21933187 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Capn1 calpain 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein] CTD PMID:29289695 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp1 caspase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [irinotecan results in increased cleavage of CASP1 protein]
pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]
CTD PMID:26431797 PMID:28004443 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions EXP pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein] CTD PMID:24140863 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp2 caspase 2 decreases activity ISO pyrazolanthrone results in decreased activity of CASP2 protein CTD PMID:17317842 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Phytochemicals results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]
pyrazolanthrone results in increased expression of CASP3 protein modified form
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [satratoxin H results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; Taurine promotes the reaction [pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]
pyrazolanthrone results in decreased activity of CASP3 protein
pyrazolanthrone results in increased activity of CASP3 protein
CTD PMID:12393500 PMID:15034932 PMID:15095415 PMID:15254339 PMID:15501958 PMID:15767555 PMID:15831436 PMID:15850772 PMID:16061660 PMID:16310883 PMID:16322078 PMID:16357177 PMID:16712891 PMID:16787641 PMID:16843435 PMID:17292878 PMID:17341418 PMID:18281123 PMID:18703135 PMID:18767140 PMID:19193634 PMID:19361540 PMID:19631732 PMID:20632440 PMID:20830294 PMID:20920558 PMID:21165570 PMID:21295052 PMID:21600974 PMID:21843585 PMID:21843586 PMID:22654482 PMID:22863859 PMID:23082001 PMID:23212307 PMID:23405080 PMID:23416140 PMID:23578390 PMID:23836369 PMID:24036456 PMID:24111524 PMID:24157283 PMID:24577723 PMID:25043952 PMID:25078063 PMID:25305377 PMID:25446857 PMID:25882087 PMID:26588882 PMID:26630137 PMID:27539140 PMID:28383207 PMID:28391263 PMID:28474156 PMID:29289695 PMID:29968959 PMID:30259999 PMID:30871965 PMID:30928397 PMID:31044527 PMID:31421117 PMID:31447676 PMID:32574669 PMID:32652169 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP4 protein] CTD PMID:16357177 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP6 protein]
pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP6 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]
CTD PMID:15501958 PMID:16310883 PMID:17341418 PMID:19954742 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased activity of CASP7 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP7 protein]
CTD PMID:20920558 PMID:21843585 PMID:21843586 PMID:23405080 PMID:24157283 PMID:25078063 PMID:25882087 PMID:27539140 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP8 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of CASP8 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15501958 PMID:15767555 PMID:16061660 PMID:16972261 PMID:17145888 PMID:21138480 PMID:21165570 PMID:23212307 PMID:29968959 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP9 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pyrazolanthrone results in increased activity of CASP9 protein
CTD PMID:15034932 PMID:15501958 PMID:15831436 PMID:16310883 PMID:16322078 PMID:17341418 PMID:17786558 PMID:20920558 PMID:21138480 PMID:21165570 PMID:21420390 PMID:21843586 PMID:23212307 PMID:27539140 PMID:29968959 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO pyrazolanthrone promotes the reaction [Pyrogallol results in decreased expression of CAT protein] CTD PMID:20191265 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitates results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of CCL2 mRNA]
pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CCL2 protein]
CTD PMID:17460151 PMID:18303122 PMID:20354174 PMID:20712904 PMID:23958496 PMID:26641773 PMID:28087833 PMID:28505368 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein] CTD PMID:31044527 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CCNB1 protein] CTD PMID:23212307 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO pyrazolanthrone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 mRNA]; pyrazolanthrone inhibits the reaction [kahweol results in decreased expression of CCND1 protein]; pyrazolanthrone inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein]
pyrazolanthrone results in decreased expression of CCND1 protein
CTD PMID:18593901 PMID:19801633 PMID:27424123 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein] CTD PMID:26163174
G Cd14 CD14 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CD14 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:14729647 PMID:18180316 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd207 CD207 molecule multiple interactions
decreases expression
ISO pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]
pyrazolanthrone results in decreased expression of CD207 protein
CTD PMID:15588916 NCBI chr 4:115,333,124...115,355,034
Ensembl chr 4:115,348,491...115,354,795
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CD36 mRNA] CTD PMID:21873422 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD80 protein] CTD PMID:28235615 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD86 protein] CTD PMID:28235615 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein] CTD PMID:16179969 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO pyrazolanthrone results in decreased expression of CDH1 protein
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]
CTD PMID:15588916 PMID:31447676 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Varenicline results in decreased expression of CDH5] CTD PMID:28842382 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein]
pyrazolanthrone results in decreased expression of CDK1 protein
CTD PMID:18593901 PMID:23212307 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
ISO pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of CDK2 protein]
pyrazolanthrone results in decreased activity of CDK2 protein
CTD PMID:12534346 PMID:19747539 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]; pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein] CTD PMID:24481447 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA] CTD PMID:21736731 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA]
pyrazolanthrone promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A protein]
pyrazolanthrone results in increased expression of CDKN1A protein
CTD PMID:15961274 PMID:16061660 PMID:16283431 PMID:19418558 PMID:31734849 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPA protein] CTD PMID:24376792 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]; pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPB protein] CTD PMID:14729647 PMID:24376792 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPD protein] CTD PMID:24376792 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Ces3a carboxylesterase 3a multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of CES3 mRNA] CTD PMID:17460151 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of CHUK protein] CTD PMID:19616567 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cldn4 claudin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CPEB1 mRNA] CTD PMID:21620800 NCBI chr 1:143,171,457...143,278,485
Ensembl chr 1:143,171,264...143,278,485
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of CPT1B mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CPT1B mRNA]
CTD PMID:21873422 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO
EXP
pyrazolanthrone results in decreased phosphorylation of CREB1 protein
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]
CTD PMID:25605016 PMID:28087833 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO pyrazolanthrone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA] CTD PMID:28189027 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein] CTD PMID:19460412 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csnk1d casein kinase 1, delta decreases activity ISO pyrazolanthrone results in decreased activity of CSNK1D protein CTD PMID:12534346 NCBI chr10:110,147,786...110,182,413
Ensembl chr10:110,148,600...110,182,408
JBrowse link
G Cst3 cystatin C multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of CST3 protein]] CTD PMID:31447676 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein] CTD PMID:28087833 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA] CTD PMID:12832416 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:22245600 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide affects the localization of CYCS protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD PMID:16322078 PMID:16972261 PMID:19954742 PMID:30653946 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cygb cytoglobin multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]
CTD PMID:26209791 PMID:28697429 PMID:29567110 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
pyrazolanthrone results in increased expression of CYP17A1 mRNA
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]
pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]
CTD PMID:16269825 PMID:29567110 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:20096755 PMID:20678559 PMID:28571770 PMID:28697429 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A1 mRNA]
pyrazolanthrone results in decreased expression of CYP1A1 mRNA
pyrazolanthrone inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]
CTD PMID:17959153 PMID:18078826 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of CYP1A2 mRNA
pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A2 mRNA]
CTD PMID:17959153 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]; pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 protein] CTD PMID:30709899 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]
CTD PMID:17049495 PMID:17341418 PMID:19139269 PMID:20920558 PMID:24612139 PMID:26203587 PMID:28988120 PMID:30508555 PMID:31348969 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Doc2b double C2 domain beta multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of DOC2B mRNA] CTD PMID:17460151 NCBI chr10:63,921,255...63,952,944
Ensembl chr10:63,928,064...63,952,726
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO pyrazolanthrone results in decreased activity of DYRK1A protein CTD PMID:12534346 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:24376792 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Smoke analog results in increased expression of EDNRB protein] CTD PMID:20561571 PMID:20716444 PMID:26496744 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egf epidermal growth factor multiple interactions ISO pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA] CTD PMID:15961274 PMID:21613822 PMID:22766066 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO
EXP
pyrazolanthrone results in decreased expression of EGFR mRNA; pyrazolanthrone results in decreased expression of EGFR protein CTD PMID:15923621 PMID:18332871 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of EGR1 mRNA]
CTD PMID:15688020 PMID:18316600 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein] CTD PMID:12660819 PMID:18316600 PMID:21642427 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Endog endonuclease G multiple interactions EXP pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of ENDOG protein] CTD PMID:24577723 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] CTD PMID:20189893 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of ERN1 protein] CTD PMID:19139269 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ETFA protein] CTD PMID:24394546 NCBI chr 8:60,028,786...60,086,352
Ensembl chr 8:60,028,789...60,086,403
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G F2 coagulation factor II multiple interactions ISO pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein] CTD PMID:19944065 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA] CTD PMID:16009787 PMID:19944065 PMID:20118172 PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fadd Fas associated via death domain multiple interactions
decreases phosphorylation
ISO pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]
pyrazolanthrone results in decreased phosphorylation of FADD protein
CTD PMID:16450001 PMID:21138480 PMID:23285096 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases activity
increases expression
ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein]
pyrazolanthrone results in increased activity of FAS protein
pyrazolanthrone results in increased expression of FAS protein
CTD PMID:16061660 PMID:16162944 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO pyrazolanthrone affects the reaction [temozolomide results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [[sorafenib co-treated with Vitamin K 1] results in increased expression of FASLG protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of FASLG protein] CTD PMID:20301194 PMID:21165570 PMID:26418950 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO pyrazolanthrone inhibits the reaction [Indican results in increased expression of FBXO32 protein] CTD PMID:30849338 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fem1b fem-1 homolog B multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of FEM1B mRNA] CTD PMID:17460151 NCBI chr 8:67,695,041...67,708,313
Ensembl chr 8:67,694,904...67,708,304
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA] CTD PMID:15121739 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]
pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]
CTD PMID:12832416 PMID:19176594 PMID:25290095 PMID:26800359 PMID:28087833 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein] CTD PMID:15677771 PMID:16162944 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein] CTD PMID:31447676 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of FOS protein]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]
CTD PMID:22020770 PMID:24469321 PMID:24967690 PMID:28087833 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA] CTD PMID:14565943 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein] CTD PMID:26385185 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein] CTD PMID:26470730 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:22067323 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of GABPA protein] CTD PMID:16308312 NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GADD45A protein]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A mRNA]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A protein]
pyrazolanthrone inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
CTD PMID:15064713 PMID:20955365 PMID:25469469 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B mRNA]; pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B protein] CTD PMID:21062976 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of GALNT3 mRNA] CTD PMID:24614234 NCBI chr 3:52,174,469...52,212,395
Ensembl chr 3:52,175,547...52,212,412
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein] CTD PMID:23940812 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA] CTD PMID:12832416 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC protein]
pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA]; pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA]
CTD PMID:17460151 PMID:19328227 PMID:21469739 PMID:25881548 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
decreases activity
ISO pyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]
pyrazolanthrone results in decreased activity of GCLM protein
CTD PMID:16972261 PMID:25881548 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO pyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein] CTD PMID:24440808 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein] CTD PMID:26141394 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Amphetamine results in increased expression of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA]
pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of GJA1 protein]
CTD PMID:15194466 PMID:24449132 PMID:32045570 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]; pyrazolanthrone promotes the reaction [SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]]; SB 203580 promotes the reaction [pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]] CTD PMID:31734849 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein] CTD PMID:20523355 NCBI chr10:57,260,680...57,263,546
Ensembl chr10:57,260,680...57,263,546
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:20166895 PMID:26218279 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein] CTD PMID:25619392 PMID:28993908 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of H3-4 protein] CTD PMID:16179969 NCBI chr10:45,304,696...45,305,106 JBrowse link
G Hat1 histone acetyltransferase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Quercetin results in increased activity of HAT1 protein] CTD PMID:21165570 NCBI chr 3:58,022,395...58,070,067
Ensembl chr 3:58,022,238...58,070,068
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:19193634 PMID:26800359 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein] CTD PMID:20152896 PMID:28651835 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [iron protoporphyrin IX results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 mRNA
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone promotes the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 protein
CTD PMID:12637567 PMID:16171798 PMID:16439612 PMID:16631525 PMID:18078826 PMID:18289802 PMID:18332044 PMID:18404528 PMID:18636201 PMID:21469739 PMID:22056766 PMID:23318726 PMID:23535287 PMID:23845594 PMID:24140437 PMID:24423726 PMID:25449124 PMID:25881548 PMID:26291278 PMID:26385185 PMID:26404762 PMID:26542248 PMID:27393035 PMID:27777014 PMID:28087833 PMID:29426002 PMID:31790703 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of HNF4A mRNA
pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]
CTD PMID:19883121 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hpx hemopexin multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA] CTD PMID:17460151 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA] CTD PMID:29567110 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA] CTD PMID:20920558 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HSPA1A protein] CTD PMID:28087833 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]
pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]
CTD PMID:17341418 PMID:20920558 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form] CTD PMID:22706169 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]; pyrazolanthrone inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723 PMID:24140437 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of HSPB8 mRNA] CTD PMID:17460151 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of IBSP protein] CTD PMID:31051157 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] CTD PMID:12832416 PMID:22166487 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [Eosine I Bluish results in increased expression of IFNG mRNA]
[pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
CTD PMID:16307444 PMID:16488514 PMID:21295052 PMID:22440610 PMID:23831309 PMID:26609140 PMID:29385629 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein] CTD PMID:17458902 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein] CTD PMID:19616567 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL10 protein] CTD PMID:28235615 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]
pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:15778123 PMID:19101624 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions EXP pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein] CTD PMID:29385629 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]
pyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]
CTD PMID:20381601 PMID:26431797 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1A mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased secretion of CXCL8 protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CCL8 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CXCL3 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of SAA1 mRNA]
pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1A protein]
CTD PMID:12832416 PMID:19782127 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [IL1B results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1B protein]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]; pyrazolanthrone affects the reaction [Fungal Polysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of IL1B mRNA]
CTD PMID:12832416 PMID:15019843 PMID:15677771 PMID:16359550 PMID:16365456 PMID:16614379 PMID:17641275 PMID:18982426 PMID:19626664 PMID:19782127 PMID:19812349 PMID:20712904 PMID:21295052 PMID:21430222 PMID:21447443 PMID:22547200 PMID:22687552 PMID:22727857 PMID:22728154 PMID:23535185 PMID:24781252 PMID:26218279 PMID:26431797 PMID:27174766 PMID:27556861 PMID:28004443 PMID:31199065 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein] CTD PMID:26003274 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [cadmium acetate results in increased secretion of IL6 protein]
[pyrazolanthrone co-treated with Acrylamide] results in decreased expression of IL6 mRNA; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL6 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of IL6 mRNA]
CTD PMID:12832416 PMID:17460151 PMID:18515973 PMID:19074641 PMID:19101624 PMID:19782127 PMID:20712904 PMID:21548952 PMID:22488045 PMID:22727857 PMID:22728154 PMID:23535185 PMID:24631921 PMID:25047101 PMID:25677194 PMID:27427241 PMID:28087833 PMID:28235615 PMID:28474156 PMID:29385629 PMID:29426002 PMID:29906494 PMID:30078834 PMID:30259999 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [GW8510 results in increased expression of INS2 mRNA]
pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased uptake of Glucose]]
CTD PMID:17728140 PMID:22242153 PMID:24349194 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]
pyrazolanthrone inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]
CTD PMID:19345745 PMID:24349194 PMID:29793316 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
CTD PMID:17728140 PMID:29793316 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM mRNA]; pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM protein] CTD PMID:18778786 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jag1 jagged canonical Notch ligand 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA] CTD PMID:21843347 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases activity
decreases phosphorylation
increases degradation
decreases expression
ISO
EXP
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]; [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein]; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Estradiol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Leflunomide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Methyl Methanesulfonate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Quercetin affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]
pyrazolanthrone results in decreased activity of JUN protein
pyrazolanthrone results in increased degradation of JUN protein
pyrazolanthrone results in decreased expression of JUN protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Amphetamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Indolinone A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [tripterine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]
pyrazolanthrone inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [monobutyl phthalate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12169099 PMID:12393500 PMID:12663670 PMID:12774022 PMID:12832416 PMID:15019843 PMID:15028728 PMID:15034932 PMID:15194466 PMID:15196213 PMID:15252869 PMID:15322261 PMID:15342272 PMID:15677771 PMID:15838870 PMID:15850772 PMID:15923621 PMID:15930183 PMID:16041517 PMID:16061660 PMID:16166651 PMID:16322078 PMID:16337876 PMID:16357177 PMID:16407847 PMID:16872482 PMID:16932349 PMID:17125918 PMID:17460151 PMID:17950587 PMID:18021293 PMID:18593901 PMID:18633430 PMID:18982426 PMID:19002563 PMID:19225867 PMID:19292871 PMID:19418558 PMID:19768117 PMID:19812349 PMID:20148354 PMID:20301194 PMID:20338993 PMID:20632440 PMID:21062976 PMID:21165570 PMID:21911303 PMID:22003962 PMID:22020770 PMID:22166487 PMID:22288910 PMID:23082001 PMID:23103562 PMID:23219847 PMID:23836369 PMID:24111524 PMID:24469321 PMID:24967690 PMID:25200491 PMID:26209791 PMID:26514923 PMID:26630137 PMID:28087833 PMID:28474156 PMID:28697429 PMID:28988120 PMID:30133131 PMID:30709899 PMID:30768131 PMID:31306638 PMID:32738922 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein] CTD PMID:24830941 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of KCNE4 mRNA] CTD PMID:17460151 NCBI chr 9:84,688,873...84,693,066
Ensembl chr 9:84,689,150...84,690,338
JBrowse link
G Klf5 Kruppel-like factor 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA] CTD PMID:17460151 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Klhl2 kelch-like family member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLHL2 mRNA] CTD PMID:17460151 NCBI chr16:26,755,246...26,852,134
Ensembl chr16:26,739,389...26,852,179
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR protein] CTD PMID:22388943 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin multiple interactions ISO pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor affects response to substance ISO LEPR protein affects the susceptibility to pyrazolanthrone CTD PMID:22933112 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of LPL mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA]
CTD PMID:21873422 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA] CTD PMID:15604272 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MAP3K6 mRNA] CTD PMID:17460151 NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:15342272 PMID:17458902 PMID:19135517 PMID:21933187 PMID:22727857 PMID:24349194 PMID:26136938 PMID:26359795 PMID:26609140 PMID:28087833 PMID:30317802 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK14 protein
pyrazolanthrone results in increased expression of MAPK14 protein
CTD PMID:15964311 PMID:16046226 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:15342272 PMID:17458902 PMID:19135517 PMID:21933187 PMID:22727857 PMID:24349194 PMID:26136938 PMID:26359795 PMID:26609140 PMID:28087833 PMID:30317802 PMID:30580027 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression
decreases phosphorylation
decreases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of MAPK8 protein]; pyrazolanthrone inhibits the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [dracorhodin analog results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK8 protein modified form]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK8 protein]
pyrazolanthrone results in increased expression of MAPK8 protein
pyrazolanthrone results in decreased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paroxetine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of MAPK8 protein]; pyrazolanthrone results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
pyrazolanthrone results in decreased activity of MAPK8 protein
CTD PMID:12534346 PMID:14610070 PMID:15322261 PMID:15767555 PMID:15831436 PMID:15964311 PMID:16041517 PMID:16046226 PMID:16151469 PMID:16374168 PMID:16442704 PMID:16648635 PMID:16687388 PMID:16777994 PMID:16864444 PMID:17185352 PMID:17651887 PMID:17728140 PMID:18347188 PMID:18412143 PMID:18495191 PMID:18506790 PMID:18728404 PMID:18840457 PMID:19038359 PMID:19135517 PMID:19436114 PMID:20206247 PMID:20534739 PMID:20632440 PMID:20678559 PMID:21112663 PMID:21219922 PMID:21626648 PMID:21843586 PMID:21933187 PMID:22085843 PMID:22696236 PMID:24833599 PMID:25531190 PMID:26385185 PMID:27174766 PMID:28474156 PMID:29906494 PMID:30259999 PMID:30768131 PMID:31176653 PMID:31348969 PMID:31421117 PMID:31447676 PMID:31587482 PMID:31734849 PMID:32574669 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases phosphorylation
decreases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK9 protein modified form]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK9 protein
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein]
pyrazolanthrone results in decreased activity of MAPK9 protein
CTD PMID:12534346 PMID:15322261 PMID:15831436 PMID:16151469 PMID:16687388 PMID:16777994 PMID:17651887 PMID:18347188 PMID:18412143 PMID:18728404 PMID:18840457 PMID:19038359 PMID:19135517 PMID:20206247 PMID:20678559 PMID:21843586 PMID:22085843 PMID:22696236 PMID:25531190 PMID:26385185 PMID:27174766 PMID:28474156 PMID:29906494 PMID:31348969 PMID:31421117 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 decreases activity EXP pyrazolanthrone results in decreased activity of MAPKAPK2 protein CTD PMID:15196213 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:23082001 PMID:25078063 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [trichostatin A results in decreased expression of MCM2 protein] CTD PMID:23770000 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir21 microRNA 21 affects expression
multiple interactions
ISO pyrazolanthrone affects the expression of MIR21 mRNA
pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]
CTD PMID:24434654 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir328 microRNA 328 increases expression ISO pyrazolanthrone results in increased expression of MIR328 mRNA CTD PMID:25605016 NCBI chr19:37,263,199...37,263,282
Ensembl chr19:37,263,199...37,263,282
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 protein] CTD PMID:12832416 PMID:20004183 PMID:24469321 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]; pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein] CTD PMID:16948116 PMID:20004183 PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO pyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP2]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone promotes the reaction [Resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]
pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
CTD PMID:16213474 PMID:20599481 PMID:24841706 PMID:25605016 PMID:27060453 PMID:28722351 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein] CTD PMID:12832416 PMID:16778083 PMID:19361540 PMID:20004183 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
ISO
EXP
[kahweol acetate co-treated with pyrazolanthrone] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP9]; pyrazolanthrone inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]
pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone promotes the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
pyrazolanthrone results in decreased activity of MMP9 protein
CTD PMID:16213474 PMID:19447859 PMID:20152819 PMID:21354279 PMID:22033475 PMID:22705379 PMID:22926441 PMID:23774252 PMID:24841706 PMID:25200491 PMID:26514923 PMID:26807887 PMID:27060453 PMID:28722351 PMID:30133131 PMID:30590137 PMID:30766661 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:17460151 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]; pyrazolanthrone promotes the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] CTD PMID:21544845 PMID:22766066 PMID:25177032 PMID:30935901 PMID:31944254 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO
EXP
pyrazolanthrone results in increased expression of MYC protein
pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]
MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of MYC protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]
CTD PMID:15034932 PMID:19418558 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh2 myosin heavy chain 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MYH2 mRNA] CTD PMID:17460151 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH6 mRNA] CTD PMID:21873422 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH7 mRNA] CTD PMID:21873422 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Glucose results in increased expression of NCF1 protein] CTD PMID:22245600 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of NFE2L2 protein]
pyrazolanthrone results in decreased expression of NFE2L2 protein
CTD PMID:16631525 PMID:17640564 PMID:23535287 PMID:25449124 PMID:25649257 PMID:28087833 PMID:29426002 PMID:30928397 PMID:31790703 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of NFKB1 protein]
CTD PMID:18507870 PMID:22547200 PMID:29528074 PMID:30259999 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
pyrazolanthrone inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18507870 PMID:22245600 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]
pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein]
CTD PMID:17651887 PMID:19954754 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions EXP pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]
CTD PMID:28004443 PMID:30259999 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]
CTD PMID:16417967 PMID:16488514 PMID:17570326 PMID:18507870 PMID:19376148 PMID:19497418 PMID:20004183 PMID:20423716 PMID:20712904 PMID:21818760 PMID:22227475 PMID:22547200 PMID:23268108 PMID:23500011 PMID:23727179 PMID:23735482 PMID:24239652 PMID:26218279 PMID:30259999 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB mRNA] CTD PMID:21873422 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]
CTD PMID:18752316 PMID:29426002 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO pyrazolanthrone results in increased expression of NR1H3 mRNA CTD PMID:19883121 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]] CTD PMID:28505368 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]] CTD PMID:15249158 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of NR4A1 mRNA] CTD PMID:17460151 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Optn optineurin multiple interactions EXP pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein] CTD PMID:28776281 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Osm oncostatin M multiple interactions ISO pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:21548952 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] CTD PMID:30580027 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Pappa1 pappalysin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA] CTD PMID:24781252 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of PARP1 protein]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [3-dinitrobenzene results in increased cleavage of PARP1 protein]
CTD PMID:14724571 PMID:15501958 PMID:16151469 PMID:16328441 PMID:16407847 PMID:17292878 PMID:18281123 PMID:19477251 PMID:19777565 PMID:20403343 PMID:21165570 PMID:21843586 PMID:23082001 PMID:23405080 PMID:24036456 PMID:24577723 PMID:25043952 PMID:25446857 PMID:25939952 PMID:27539140 PMID:28087840 PMID:28283887 PMID:29968959 PMID:30871965 PMID:31421117 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP
ISO
pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
pyrazolanthrone results in decreased expression of PCNA protein
CTD PMID:18593901 PMID:19418558 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression EXP pyrazolanthrone results in decreased expression of PDGFRB mRNA; pyrazolanthrone results in decreased expression of PDGFRB protein CTD PMID:18332871 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PDK4 mRNA] CTD PMID:17460151 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP pyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein] CTD PMID:23378038 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone promotes the reaction [resveratrol results in decreased expression of PLAU protein] CTD PMID:19874453 PMID:23437203 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] CTD PMID:22261521 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA] CTD PMID:19225867 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] CTD PMID:19225867 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA] CTD PMID:19225867 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA] CTD PMID:20628022 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Plxna2 plexin A2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PLXNA2 mRNA] CTD PMID:17460151 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO pyrazolanthrone results in decreased expression of PON2 protein CTD PMID:15544923 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]
pyrazolanthrone results in increased expression of PPARA mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARA mRNA]
CTD PMID:19883121 PMID:21873422 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein] CTD PMID:17341418 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of PPARG mRNA; pyrazolanthrone results in increased expression of PPARG protein
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]
CTD PMID:17372590 PMID:28283887 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of PPARGC1A mRNA
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]
CTD PMID:21873422 PMID:31447676 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prf1 perforin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein] CTD PMID:20082299 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Procr protein C receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased cleavage of PROCR protein] CTD PMID:24632454 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Psat1 phosphoserine aminotransferase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PSAT1 mRNA] CTD PMID:17460151 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of PTEN protein] CTD PMID:20534739 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgds prostaglandin D2 synthase multiple interactions ISO pyrazolanthrone affects the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGDS mRNA] CTD PMID:20382172 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Sodium Fluoride results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]]
pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:12832416 PMID:17084486 PMID:18481333 PMID:18507870 PMID:18596194 PMID:18840457 PMID:19376214 PMID:19808956 PMID:20004183 PMID:21262218 PMID:21818760 PMID:21911040 PMID:22288910 PMID:22547200 PMID:22728154 PMID:22767315 PMID:23268108 PMID:23376440 PMID:23416140 PMID:23500011 PMID:23727179 PMID:23735482 PMID:24239652 PMID:24967690 PMID:25199686 PMID:25888188 PMID:26218279 PMID:27818125 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA] CTD PMID:12832416 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA] CTD PMID:22579953 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA] CTD PMID:17460151 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 protein] CTD PMID:14729647 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of REG3G mRNA] CTD PMID:17460151 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of RELA protein]; pyrazolanthrone inhibits the reaction [Acids results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]
pyrazolanthrone results in decreased expression of RELA protein
pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of RELA protein]; pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cyclosporine affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of RELA protein]
CTD PMID:18507870 PMID:19074641 PMID:19616567 PMID:20534739 PMID:21295052 PMID:22547200 PMID:22706169 PMID:23103562 PMID:23774252 PMID:23958496 PMID:25540590 PMID:25677194 PMID:25888188 PMID:28474156 PMID:29426002 PMID:29528074 PMID:30133131 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Robo1 roundabout guidance receptor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein] CTD PMID:25030704 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases activity
ISO pyrazolanthrone inhibits the reaction [arsenite results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6KB1 protein]
pyrazolanthrone results in decreased activity of RPS6KB1 protein
CTD PMID:12534346 PMID:20589738 PMID:31051157 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP
ISO
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of RUNX2 mRNA]
pyrazolanthrone inhibits the reaction [Ethanol results in increased activity of RUNX2 protein]
pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]
CTD PMID:26136938 PMID:31306638 PMID:32198086 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of RXRA protein]
CTD PMID:16038797 PMID:16184197 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein] CTD PMID:16948116 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein] CTD PMID:16162944 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina7 serpin family A member 7 multiple interactions EXP pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein] CTD PMID:29385629 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA] CTD PMID:12832416 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]
pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]
CTD PMID:17379280 PMID:23378038 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO pyrazolanthrone results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein] CTD PMID:21616139 PMID:22020565 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]
pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein]
CTD PMID:22669716 PMID:31082419 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein] CTD PMID:25496994 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC27A1 mRNA]
pyrazolanthrone results in increased expression of SLC27A1 mRNA
CTD PMID:21873422 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of SMAD3 protein]
CTD PMID:19418558 PMID:31447676 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein] CTD PMID:27060453 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:12832416 PMID:22261313 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SOX2 protein] CTD PMID:23219847 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO pyrazolanthrone promotes the reaction [resveratrol results in increased expression of SOX9] CTD PMID:24841706 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions ISO pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of SP7 protein] CTD PMID:31306638 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]
pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein]
CTD PMID:15121739 PMID:31051157 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [methylmercuric chloride results in increased expression of SQSTM1 protein]
pyrazolanthrone results in decreased expression of SQSTM1 protein
pyrazolanthrone results in increased expression of SQSTM1 protein
CTD PMID:24833599 PMID:25881548 PMID:27393035 PMID:27667695 PMID:28842171 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein] CTD PMID:16162944 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein] CTD PMID:22388943 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Srrt serrate, RNA effector molecule multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:23219847 NCBI chr12:22,457,898...22,471,090 JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tretinoin results in increased expression of ST8SIA3 mRNA] CTD PMID:17069899 NCBI chr18:59,748,766...59,755,257
Ensembl chr18:59,748,444...59,755,226
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]
CTD PMID:29567110 PMID:32199951 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] CTD PMID:26609140 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of STAT3 protein]
CTD PMID:19429262 PMID:22696236 PMID:24349194 PMID:27174766 PMID:30871965 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 protein] CTD PMID:16308312 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Syt11 synaptotagmin 11 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ozone results in increased expression of SYT11 mRNA] CTD PMID:17460151 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP pyrazolanthrone promotes the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Taldo1 transaldolase 1 multiple interactions ISO pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]] CTD PMID:19436114 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO pyrazolanthrone promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form] CTD PMID:22879928 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] CTD PMID:15744361 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA] CTD PMID:23382840 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]
CTD PMID:16365456 PMID:21613822 PMID:25358858 PMID:31447676 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thpo thrombopoietin multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Thra thyroid hormone receptor alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of THRA mRNA alternative form
[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]
CTD PMID:17641275 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein] CTD PMID:27060453 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein] CTD PMID:27060453 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA]; pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Acetaminophen]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; pyrazolanthrone inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12774022 PMID:14644621 PMID:15302094 PMID:15322261 PMID:16271621 PMID:16488514 PMID:17185352 PMID:17460151 PMID:17464197 PMID:18577375 PMID:19812349 PMID:19874453 PMID:19883121 PMID:20118172 PMID:20166895 PMID:20371967 PMID:20712904 PMID:20932985 PMID:21447443 PMID:22705379 PMID:22728154 PMID:22926441 PMID:23103562 PMID:23268108 PMID:23535185 PMID:23774252 PMID:23831309 PMID:24525298 PMID:25047101 PMID:25677194 PMID:26691871 PMID:28087840 PMID:28474156 PMID:28483571 PMID:28776281 PMID:29426002 PMID:29673704 PMID:29906494 PMID:30078834 PMID:30259999 PMID:31199065 PMID:31447676 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO pyrazolanthrone inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 PMID:24813642 PMID:25234201 PMID:25290095 PMID:25677506 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of TNFSF10 mRNA]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein] CTD PMID:17545621 PMID:20403343 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnni2 troponin I2, fast skeletal type multiple interactions ISO pyrazolanthrone promotes the reaction [Ozone results in increased expression of TNNI2 mRNA] CTD PMID:17460151 NCBI chr 1:215,609,110...215,611,652
Ensembl chr 1:215,609,036...215,611,658
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein] CTD PMID:15923621 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO
EXP
[sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Capsaicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased stability of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Pyrogallol results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of TP53 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein]
pyrazolanthrone results in increased phosphorylation of TP53 protein
pyrazolanthrone promotes the reaction [TRP53 gene mutant form results in decreased susceptibility to sodium arsenite]
pyrazolanthrone results in increased expression of TP53 protein; pyrazolanthrone results in increased expression of TP53 protein modified form
pyrazolanthrone results in decreased expression of TP53 protein
CTD PMID:15034932 PMID:16046226 PMID:16061660 PMID:16166651 PMID:16450001 PMID:17292493 PMID:20191265 PMID:22706169 PMID:25305377 PMID:25939952 PMID:26630137 PMID:28842171 PMID:31734849 PMID:32238696 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TRHR protein] CTD PMID:22889935 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO pyrazolanthrone results in decreased expression of UBA7 protein CTD PMID:25649257 NCBI chr 8:116,754,178...116,766,765
Ensembl chr 8:116,754,178...116,764,126
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA] CTD PMID:17256720 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16271621 PMID:19609071 PMID:28483571 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein] CTD PMID:18596194 PMID:19176594 PMID:23968725 PMID:28651835 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein] CTD PMID:27060453 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA] CTD PMID:23103562 NCBI chr10:58,860,647...58,872,782
Ensembl chr10:58,860,940...58,873,674
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein] CTD PMID:23423712 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A multiple interactions EXP pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein] CTD PMID:26865670 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      group 19722
        inorganic group 19180
          oxo group 18427
            organic oxo compound 18427
              carbonyl compound 18427
                ketone 16171
                  cyclic ketone 13874
                    anthra[1,9-cd]pyrazol-6(2H)-one 328
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      ketone 16171
                                        cyclic ketone 13874
                                          anthra[1,9-cd]pyrazol-6(2H)-one 328
paths to the root