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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionEXP 6480464CTDpyrazolanthrone results in decreased expression of AKT1 proteinPMID:16046226
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [diallyl trisulfide results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]PMID:17341418 PMID:20534739 PMID:22020565 PMID:22696236 PMID:25939952 PMID:28087840
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]PMID:33618463 PMID:33771252
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