Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDpyrazolanthrone results in increased expression of BAX proteinPMID:16046226 PMID:19428505
Baxmultiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [bakuchiol affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]PMID:14514659 PMID:17292878 PMID:24577723 PMID:25043952 PMID:29289695 PMID:35172196
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDpyrazolanthrone results in increased expression of BAX proteinPMID:15034932
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]PMID:20423716 PMID:33684387
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; pyrazolanthrone affects the reaction [Methylmercury Compounds affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased activity of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Methylmercury Compounds inhibits the reaction [BAX protein binds to YWHAZ protein]]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]PMID:15034932 PMID:16972261 PMID:17317842 PMID:19540902 PMID:19954742 PMID:21420390 PMID:24036456 PMID:30653946 PMID:31044527 PMID:33959992 PMID:34999165 PMID:35499276
Go Back to source page   Continue to Ontology report