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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sevoflurane
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Accession:CHEBI:9130 term browser browse the term
Definition:An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Synonyms:related_synonym: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane;   Formula=C4H3F7O;   InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2;   InChIKey=DFEYYRMXOJXZRJ-UHFFFAOYSA-N;   SMILES=FCOC(C(F)(F)F)C(F)(F)F;   Sevofluran;   Sevoflurano;   Sevofluranum
 xref: Beilstein:2041023;   CAS:28523-86-6;   DrugBank:DB01236;   Drug_Central:2439;   KEGG:C07520;   KEGG:D00547
 xref_mesh: MESH:C009250
 xref: Patent:DE1954268;   Patent:US3689571;   Wikipedia:Sevoflurane


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sevoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase affects expression EXP sevoflurane affects the expression of AASS mRNA CTD PMID:15967596 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136 		JBrowse link
G Aatf apoptosis antagonizing transcription factor affects expression EXP sevoflurane affects the expression of AATF mRNA CTD PMID:15967596 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP sevoflurane affects the expression of ABCB1A mRNA CTD PMID:15967596 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression EXP sevoflurane affects the expression of ABCC2 mRNA CTD PMID:15967596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Aco2 aconitase 2 affects expression EXP sevoflurane affects the expression of ACO2 mRNA CTD PMID:15967596 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases methylation ISO Sevoflurane results in increased methylation of ACSL6 mRNA CTD PMID:35249202 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 affects expression EXP sevoflurane affects the expression of ADAMTS1 mRNA CTD PMID:15967596 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 decreases methylation ISO Sevoflurane results in decreased methylation of ADAMTS15 mRNA CTD PMID:35249202 NCBI chr 8:29,307,864...29,331,249
Ensembl chr 8:29,307,865...29,331,249 		JBrowse link
G Agmo alkylglycerol monooxygenase decreases methylation ISO Sevoflurane results in decreased methylation of AGMO mRNA CTD PMID:35249202 NCBI chr 6:53,986,236...54,317,838
Ensembl chr 6:53,986,292...54,317,623 		JBrowse link
G Agt angiotensinogen decreases methylation ISO Sevoflurane results in decreased methylation of AGT mRNA CTD PMID:35249202 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahcyl2 adenosylhomocysteinase-like 2 increases expression ISO Sevoflurane results in increased expression of AHCYL2 protein CTD PMID:35249202 NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP sevoflurane results in increased phosphorylation of AKT1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]		 CTD PMID:19881297 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 affects expression EXP sevoflurane affects the expression of ALAS1 mRNA CTD PMID:15967596 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase increases expression ISO Sevoflurane results in increased expression of ALKBH5 protein CTD PMID:35249202 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 affects expression EXP sevoflurane affects the expression of AMD1 mRNA CTD PMID:15967596 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476 		JBrowse link
G Aopep aminopeptidase O increases methylation ISO Sevoflurane results in increased methylation of AOPEP mRNA CTD PMID:35249202 NCBI chr17:1,811,922...2,127,316
Ensembl chr17:1,811,980...2,127,331 		JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression		 ISO APOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of MAP2 protein]; APOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of PHF1 protein]; APOE protein alternative form inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPT protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL1B protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL6 protein]; Sevoflurane affects the reaction [APOE protein affects the expression of TNF protein]; Sevoflurane results in increased expression of and results in increased degradation of APOE protein
Sevoflurane results in increased expression of APOE mRNA; Sevoflurane results in increased expression of APOE mRNA alternative form		 CTD PMID:35575159 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein affects cleavage
multiple interactions
increases expression		 ISO
EXP		 sevoflurane affects the cleavage of APP protein
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane affects the cleavage of APP protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased expression of APP protein modified form]
sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of APP protein]		 CTD PMID:19433662 PMID:35174938 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) affects expression EXP sevoflurane affects the expression of AQP3 mRNA CTD PMID:15967596 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP sevoflurane affects the expression of ARC mRNA CTD PMID:15967596 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 decreases expression ISO Sevoflurane results in decreased expression of ARFGEF1 protein CTD PMID:35249202 NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326 		JBrowse link
G Arg1 arginase 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of ARG1 mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of ARG1 mRNA] CTD PMID:35430185 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Asl argininosuccinate lyase affects expression EXP sevoflurane affects the expression of ASL mRNA CTD PMID:15967596 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO sevoflurane results in increased phosphorylation of ATF2 protein CTD PMID:18349187 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Sevoflurane results in increased expression of ATG5 protein CTD PMID:35472370 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A affects expression EXP sevoflurane affects the expression of AVPR1A mRNA CTD PMID:15967596 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase affects expression EXP sevoflurane affects the expression of BAAT mRNA CTD PMID:15967596 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Bace1 beta-secretase 1 increases expression
multiple interactions		 ISO
EXP		 sevoflurane results in increased expression of BACE1 protein
Sevoflurane results in increased expression of BACE1 protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of BACE1 protein]		 CTD PMID:19433662 PMID:35174938 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases methylation ISO Sevoflurane results in decreased methylation of BACH1 mRNA CTD PMID:35249202 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD protein]
Sevoflurane results in increased expression of BAD mRNA; Sevoflurane results in increased expression of BAD protein		 CTD PMID:35350913 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 Dietary Fats promotes the reaction [Sevoflurane results in increased expression of BAX protein]; Nimodipine inhibits the reaction [Sevoflurane results in increased expression of BAX protein] CTD PMID:33171207 PMID:33928466 PMID:35110470 PMID:35174938 PMID:35249202 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcdin3d BCDIN3 domain containing RNA methyltransferase decreases methylation ISO Sevoflurane results in decreased methylation of BCDIN3D mRNA CTD PMID:35249202 NCBI chr 7:130,605,540...130,610,134
Ensembl chr 7:130,605,541...130,610,115 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Dietary Fats promotes the reaction [Sevoflurane results in decreased expression of BCL2 protein]; Nimodipine inhibits the reaction [Sevoflurane results in decreased expression of BCL2 protein] CTD PMID:33171207 PMID:35110470 PMID:35174938 PMID:35472370 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of BCL2L1 mRNA; Sevoflurane results in decreased expression of BCL2L1 protein
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 protein]		 CTD PMID:35350913 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BDNF protein] CTD PMID:35350913 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 affects expression EXP sevoflurane affects the expression of BHLHE41 mRNA CTD PMID:15967596 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Bles03 basophilic leukemia expressed protein BLES03 decreases expression ISO Sevoflurane results in decreased expression of C11ORF68 protein CTD PMID:35249202 NCBI chr 1:202,734,555...202,736,809
Ensembl chr 1:202,734,555...202,736,804 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 affects expression EXP Sevoflurane affects the expression of BMAL1 mRNA CTD PMID:15967596 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Btla B and T lymphocyte associated increases methylation ISO Sevoflurane results in increased methylation of BTLA mRNA CTD PMID:35249202 NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO sevoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calhm5 calcium homeostasis modulator family member 5 increases methylation ISO Sevoflurane results in increased methylation of CALHM5 mRNA CTD PMID:35249202 NCBI chr20:26,066,270...26,072,348
Ensembl chr20:26,066,242...26,072,272 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta increases methylation ISO Sevoflurane results in increased methylation of CAPZB mRNA CTD PMID:35249202 NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409 		JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions		 EXP Sevoflurane results in increased cleavage of CASP1 protein
PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of and results in increased cleavage of CASP1 protein]; Sevoflurane results in increased expression of and results in increased cleavage of CASP1 protein		 CTD PMID:36047109 PMID:36155068 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 ISO
EXP		 sevoflurane results in increased activity of CASP3 protein
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; L 685458 inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
sevoflurane results in increased expression of CASP3 mRNA
Sevoflurane results in increased cleavage of CASP3 protein
alpha-solamargine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of CASP3 mRNA]; Sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]; Sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; Dietary Fats promotes the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP3 protein modified form]; Roscovitine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of CASP3 protein]]		 CTD PMID:15915027 PMID:16678324 PMID:18349187 PMID:18852026 PMID:19212262 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO sevoflurane results in increased activity of CASP7 protein CTD PMID:16678324 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP9 protein modified form] CTD PMID:33171207 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP WDR48 protein affects the reaction [Sevoflurane results in decreased activity of CAT protein] CTD PMID:36047109 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc166 coiled-coil domain containing 166 decreases methylation ISO Sevoflurane results in decreased methylation of CCDC166 mRNA CTD PMID:35249202 NCBI chr 7:107,693,572...107,695,375
Ensembl chr 7:107,693,574...107,695,375 		JBrowse link
G Ccdc8 coiled-coil domain containing 8 decreases methylation ISO Sevoflurane results in decreased methylation of CCDC8 mRNA CTD PMID:35249202 NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090 		JBrowse link
G Cckbr cholecystokinin B receptor affects expression EXP sevoflurane affects the expression of CCKBR mRNA CTD PMID:15967596 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP sevoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 affects expression EXP sevoflurane affects the expression of CCND1 mRNA CTD PMID:15967596 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CCR2 mRNA] CTD PMID:35953652 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases methylation ISO Sevoflurane results in decreased methylation of CCR5 mRNA CTD PMID:35249202 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd274 CD274 molecule decreases expression ISO Sevoflurane results in decreased expression of CD274 mRNA; Sevoflurane results in decreased expression of CD274 protein CTD PMID:34018092 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd68 Cd68 molecule multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Sevoflurane results in increased expression of CD68 mRNA] CTD PMID:35953652 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression		 ISO dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of CD86 mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of CD86 mRNA] CTD PMID:35430185 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdadc1 cytidine and dCMP deaminase domain containing 1 decreases methylation ISO Sevoflurane results in decreased methylation of CDADC1 mRNA CTD PMID:35249202 NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576 		JBrowse link
G Cdc42bpa CDC42 binding protein kinase alpha decreases expression ISO Sevoflurane results in decreased expression of CDC42BPA protein CTD PMID:35249202 NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 ISO Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CDH1 mRNA]
Sevoflurane results in decreased expression of CDH1 protein		 CTD PMID:35953652 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of CDH11 mRNA] CTD PMID:35953652 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272 		JBrowse link
G Cdh17 cadherin 17 affects expression EXP sevoflurane affects the expression of CDH17 mRNA CTD PMID:15967596 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP Roscovitine inhibits the reaction [Sevoflurane results in increased expression of CDKN1A protein] CTD PMID:33548343 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects expression EXP sevoflurane affects the expression of CEBPB mRNA CTD PMID:15967596 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces2c carboxylesterase 2C affects expression EXP sevoflurane affects the expression of CES2C mRNA CTD PMID:15967596 NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790 		JBrowse link
G Cgnl1 cingulin-like 1 decreases methylation ISO Sevoflurane results in decreased methylation of CGNL1 mRNA CTD PMID:35249202 NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917 		JBrowse link
G Cgrrf1 cell growth regulator with ring finger domain 1 affects expression EXP sevoflurane affects the expression of CGRRF1 mRNA CTD PMID:15967596 NCBI chr15:20,088,564...20,109,042
Ensembl chr15:20,088,571...20,109,037 		JBrowse link
G Chka choline kinase alpha affects expression EXP sevoflurane affects the expression of CHKA mRNA CTD PMID:15967596 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO Sevoflurane results in decreased expression of CKAP5 protein CTD PMID:35249202 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 affects expression EXP sevoflurane affects the expression of CNGA4 mRNA CTD PMID:15967596 NCBI chr 1:159,752,357...159,756,369
Ensembl chr 1:159,752,357...159,756,375 		JBrowse link
G Cnnm3 cyclin and CBS domain divalent metal cation transport mediator 3 decreases methylation ISO Sevoflurane results in decreased methylation of CNNM3 mRNA CTD PMID:35249202 NCBI chr 9:38,755,374...38,770,740
Ensembl chr 9:38,755,390...38,770,740 		JBrowse link
G Cntn2 contactin 2 affects expression
decreases methylation		 EXP
ISO		 sevoflurane affects the expression of CNTN2 mRNA
Sevoflurane results in decreased methylation of CNTN2 mRNA		 CTD PMID:15967596 PMID:35249202 NCBI chr13:43,942,868...43,975,973
Ensembl chr13:43,947,265...43,975,887 		JBrowse link
G Cntnap5b contactin associated protein family member 5B decreases methylation ISO Sevoflurane results in decreased methylation of CNTNAP5 mRNA CTD PMID:35249202 NCBI chr13:17,863,367...18,766,983
Ensembl chr13:18,093,420...18,761,014 		JBrowse link
G Cort cortistatin increases methylation ISO Sevoflurane results in increased methylation of CORT mRNA CTD PMID:35249202 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression EXP sevoflurane affects the expression of CPT1A mRNA CTD PMID:15967596 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crb2 crumbs cell polarity complex component 2 decreases methylation ISO Sevoflurane results in decreased methylation of CRB2 mRNA CTD PMID:35249202 NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
multiple interactions
decreases phosphorylation		 EXP
ISO		 Sevoflurane results in decreased expression of CREB1 mRNA
Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of CREB1 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased phosphorylation of CREB1 protein]
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein]		 CTD PMID:30842370 PMID:35350913 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator affects expression EXP sevoflurane affects the expression of CREM mRNA CTD PMID:15967596 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression EXP sevoflurane affects the expression of CRY2 mRNA CTD PMID:15967596 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965 		JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 decreases expression ISO Sevoflurane results in decreased expression of CSPG4 protein CTD PMID:35249202 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010 		JBrowse link
G Ctsl cathepsin L affects expression EXP sevoflurane affects the expression of CTSL mRNA CTD PMID:15967596 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions		 EXP sevoflurane results in decreased expression of CXCL1 mRNA
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]		 CTD PMID:15564938 PMID:32147387 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP sevoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Sevoflurane results in increased expression of CXCL12 protein CTD PMID:36207479 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression		 EXP sevoflurane results in increased expression of CXCL2 mRNA
sevoflurane results in decreased expression of CXCL2 mRNA		 CTD PMID:10422944 PMID:15564938 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Sevoflurane results in increased expression of CXCR4 protein CTD PMID:36207479 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression		 EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CYCS protein] CTD PMID:33171207 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 affects expression EXP sevoflurane affects the expression of CYP2B12 mRNA CTD PMID:15967596 NCBI chr 1:82,007,609...82,019,409
Ensembl chr 1:82,007,609...82,080,480 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression EXP sevoflurane affects the expression of CYP2B2 mRNA CTD PMID:15967596 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 affects expression EXP sevoflurane affects the expression of CYP2B21 mRNA CTD PMID:15967596 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP sevoflurane affects the expression of CYP2C mRNA; sevoflurane affects the expression of CYP2C11 mRNA CTD PMID:15967596 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of sevoflurane CTD PMID:7879937 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression EXP sevoflurane affects the expression of CYP2F4 mRNA CTD PMID:15967596 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Sevoflurane CTD PMID:7879937 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 affects expression EXP sevoflurane affects the expression of CYP7A1 mRNA CTD PMID:15967596 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dbn1 drebrin 1 decreases expression
multiple interactions		 EXP Sevoflurane results in decreased expression of DBN1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]		 CTD PMID:33548343 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor affects expression EXP sevoflurane affects the expression of DBP mRNA CTD PMID:15967596 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Dcakd dephospho-CoA kinase domain containing increases expression ISO Sevoflurane results in increased expression of DCAKD protein CTD PMID:35249202 NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054 		JBrowse link
G Dhx30 DExH-box helicase 30 affects expression EXP sevoflurane affects the expression of DHX30 mRNA CTD PMID:15967596 NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381 		JBrowse link
G Dhx38 DEAH-box helicase 38 increases methylation ISO Sevoflurane results in increased methylation of DHX38 mRNA CTD PMID:35249202 NCBI chr19:37,512,891...37,530,140
Ensembl chr19:37,512,891...37,530,140 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions		 EXP
ISO		 Sevoflurane results in decreased expression of DLG4 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]		 CTD PMID:33548343 PMID:35350913 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta affects expression EXP sevoflurane affects the expression of DNASE2B mRNA CTD PMID:15967596 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in increased expression of DNM1L protein] CTD PMID:27684054 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dock3 dedicator of cyto-kinesis 3 increases expression ISO Sevoflurane results in increased expression of DOCK3 protein CTD PMID:35249202 NCBI chr 8:107,552,462...107,903,527
Ensembl chr 8:107,552,463...107,903,514 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
increases phosphorylation		 EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein] CTD PMID:33548343 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dsel dermatan sulfate epimerase-like decreases methylation ISO Sevoflurane results in decreased methylation of DSEL mRNA CTD PMID:35249202 NCBI chr13:186,413...192,592
Ensembl chr13:175,805...192,647 		JBrowse link
G Dusp10 dual specificity phosphatase 10 decreases methylation ISO Sevoflurane results in decreased methylation of DUSP10 mRNA CTD PMID:35249202 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp16 dual specificity phosphatase 16 affects expression EXP sevoflurane affects the expression of DUSP16 mRNA CTD PMID:15967596 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP sevoflurane affects the expression of DUSP6 mRNA CTD PMID:15967596 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 affects expression EXP sevoflurane affects the expression of DYNLL1 mRNA CTD PMID:15967596 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Dynll2 dynein light chain LC8-type 2 decreases expression ISO Sevoflurane results in decreased expression of DYNLL2 protein CTD PMID:35249202 NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805 		JBrowse link
G Edn1 endothelin 1 affects expression EXP sevoflurane affects the expression of EDN1 mRNA CTD PMID:15967596 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases methylation ISO Sevoflurane results in decreased methylation of EEF1E1 mRNA CTD PMID:35249202 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Efna1 ephrin A1 affects expression EXP sevoflurane affects the expression of EFNA1 mRNA CTD PMID:15967596 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Egr1 early growth response 1 affects expression EXP sevoflurane affects the expression of EGR1 mRNA CTD PMID:15967596 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 affects expression EXP sevoflurane affects the expression of EGR2 mRNA CTD PMID:15967596 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G decreases expression ISO Sevoflurane results in decreased expression of EIF3G protein CTD PMID:35249202 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases methylation ISO Sevoflurane results in decreased methylation of ELAVL1 mRNA CTD PMID:35249202 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Elmod1 ELMO domain containing 1 increases expression ISO Sevoflurane results in increased expression of ELMOD1 protein CTD PMID:35249202 NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140 		JBrowse link
G Emc8 ER membrane protein complex subunit 8 increases expression ISO Sevoflurane results in increased expression of EMC8 protein CTD PMID:35249202 NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543 		JBrowse link
G Ephb2 Eph receptor B2 increases expression ISO Sevoflurane results in increased expression of EPHB2 mRNA CTD PMID:35953652 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP sevoflurane affects the expression of EPHX1 mRNA CTD PMID:15967596 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ewsr1 EWS RNA-binding protein 1 increases expression ISO Sevoflurane results in increased expression of EWSR1 mRNA CTD PMID:35953652 NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544 		JBrowse link
G Fads2 fatty acid desaturase 2 affects expression EXP sevoflurane affects the expression of FADS2 mRNA CTD PMID:15967596 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO Sevoflurane results in decreased expression of FAF2 protein CTD PMID:35249202 NCBI chr17:9,947,216...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Fam135b family with sequence similarity 135, member B decreases methylation ISO Sevoflurane results in decreased methylation of FAM135B mRNA CTD PMID:35249202 NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708 		JBrowse link
G Fam13c family with sequence similarity 13, member C increases methylation ISO Sevoflurane results in increased methylation of FAM13C mRNA CTD PMID:35249202 NCBI chr20:18,065,625...18,187,653
Ensembl chr20:18,065,628...18,187,592 		JBrowse link
G Fat1 FAT atypical cadherin 1 decreases methylation ISO Sevoflurane results in decreased methylation of FAT1 mRNA CTD PMID:35249202 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fat4 FAT atypical cadherin 4 decreases methylation ISO Sevoflurane results in decreased methylation of FAT4 mRNA CTD PMID:35249202 NCBI chr 2:121,928,188...122,056,711
Ensembl chr 2:121,927,942...122,056,707 		JBrowse link
G Fcgr3a Fc gamma receptor 3A increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of FCGR3A protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of FCGR3A protein]		 CTD PMID:35174938 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 affects expression EXP sevoflurane affects the expression of FMO2 mRNA CTD PMID:15967596 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Sevoflurane results in increased expression of FN1 mRNA CTD PMID:35953652 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Foxa3 forkhead box A3 affects expression EXP sevoflurane affects the expression of FOXA3 mRNA CTD PMID:15967596 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155 		JBrowse link
G Foxc1 forkhead box C1 decreases methylation ISO Sevoflurane results in decreased methylation of FOXC1 mRNA CTD PMID:35249202 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation
multiple interactions		 ISO Sevoflurane results in decreased phosphorylation of FOXO3 protein
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein]; Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein		 CTD PMID:35350913 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Fst follistatin affects expression EXP sevoflurane affects the expression of FST mRNA CTD PMID:15967596 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO Sevoflurane results in decreased expression of FTO protein CTD PMID:35249202 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Fxyd5 FXYD domain-containing ion transport regulator 5 increases expression ISO Sevoflurane results in increased expression of FXYD5 mRNA CTD PMID:35953652 NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519 		JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Sevoflurane results in decreased methylation of FZD8 mRNA CTD PMID:35249202 NCBI chr17:57,312,924...57,320,551
Ensembl chr17:57,314,450...57,320,650 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO sevoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects expression EXP sevoflurane affects the expression of GABRG2 mRNA CTD PMID:15967596 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Sevoflurane results in increased expression of GAD2 mRNA; Sevoflurane results in increased expression of GAD2 protein CTD PMID:30502404 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP sevoflurane affects the expression of GADD45A mRNA CTD PMID:15967596 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gch1 GTP cyclohydrolase 1 affects expression EXP sevoflurane affects the expression of GCH1 mRNA CTD PMID:15967596 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gck glucokinase affects expression EXP sevoflurane affects the expression of GCK mRNA CTD PMID:15967596 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
decreases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of GCLM mRNA
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLM mRNA]		 CTD PMID:35350913 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf11 growth differentiation factor 11 decreases methylation ISO Sevoflurane results in decreased methylation of GDF11 mRNA CTD PMID:35249202 NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 increases expression ISO Sevoflurane results in increased expression of GDPD1 protein CTD PMID:35249202 NCBI chr10:71,840,497...71,883,936
Ensembl chr10:71,840,497...71,883,850 		JBrowse link
G Gja4 gap junction protein, alpha 4 affects expression EXP sevoflurane affects the expression of GJA4 mRNA CTD PMID:15967596 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO sevoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Glrx5 glutaredoxin 5 decreases expression ISO Sevoflurane results in decreased expression of GLRX5 protein CTD PMID:35249202 NCBI chr 6:123,988,169...123,998,545
Ensembl chr 6:123,988,134...123,998,545 		JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression ISO Sevoflurane results in increased expression of GLUD1 protein CTD PMID:36207479 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Gmfb glia maturation factor, beta affects expression EXP sevoflurane affects the expression of GMFB mRNA CTD PMID:15967596 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331 		JBrowse link
G Gnb5 G protein subunit beta 5 affects expression EXP sevoflurane affects the expression of GNB5 mRNA CTD PMID:15967596 NCBI chr 8:76,076,227...76,104,151
Ensembl chr 8:76,073,306...76,105,069 		JBrowse link
G Gnl3 G protein nucleolar 3 affects expression EXP sevoflurane affects the expression of GNL3 mRNA CTD PMID:15967596 NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression ISO Sevoflurane results in increased expression of GNRH1 mRNA CTD PMID:35953652 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression EXP sevoflurane affects the expression of GOT1 mRNA CTD PMID:15967596 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial affects expression EXP sevoflurane affects the expression of GPAM mRNA CTD PMID:15967596 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gphn gephyrin increases expression ISO Sevoflurane results in increased expression of GPHN mRNA; Sevoflurane results in increased expression of GPHN protein CTD PMID:30502404 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612 		JBrowse link
G Gpr161 G protein-coupled receptor 161 increases methylation ISO Sevoflurane results in increased methylation of GPR161 mRNA CTD PMID:35249202 NCBI chr13:77,578,257...77,623,661
Ensembl chr13:77,577,739...77,619,613 		JBrowse link
G Gpr17 G protein-coupled receptor 17 decreases expression ISO Sevoflurane results in decreased expression of GPR17 protein CTD PMID:35249202 NCBI chr18:23,576,212...23,583,177
Ensembl chr18:23,577,242...23,582,966 		JBrowse link
G Gpr63 G protein-coupled receptor 63 increases methylation ISO Sevoflurane results in increased methylation of GPR63 mRNA CTD PMID:35249202 NCBI chr 5:38,672,548...38,727,224
Ensembl chr 5:38,635,472...38,727,677 		JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B affects expression EXP sevoflurane affects the expression of GPRC5B mRNA CTD PMID:15967596 NCBI chr 1:173,316,398...173,340,951
Ensembl chr 1:173,316,907...173,340,932 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression ISO Sevoflurane results in increased expression of GRIA1 protein CTD PMID:30502404 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression ISO Sevoflurane results in increased expression of GRIA2 protein CTD PMID:30502404 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
decreases expression		 ISO GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]
Sevoflurane results in decreased expression of GRIN2A mRNA		 CTD PMID:15731593 PMID:33928466 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression		 EXP Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B protein]
Sevoflurane results in decreased expression of GRIN2B mRNA; Sevoflurane results in decreased expression of GRIN2B protein		 CTD PMID:30842370 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 decreases methylation ISO Sevoflurane results in decreased methylation of GRK2 mRNA CTD PMID:35249202 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Gsdmd gasdermin D increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of GSDMD protein modified form
PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of GSDMD protein modified form]		 CTD PMID:36155068 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation		 EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein] CTD PMID:20807582 PMID:33548343 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression EXP Sevoflurane affects the expression of GSTA3 mRNA CTD PMID:15967596 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gys2 glycogen synthase 2 affects expression EXP sevoflurane affects the expression of GYS2 mRNA CTD PMID:15967596 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228 		JBrowse link
G Habp4 hyaluronan binding protein 4 increases expression ISO Sevoflurane results in increased expression of HABP4 protein CTD PMID:35249202 NCBI chr17:934,931...957,604
Ensembl chr17:935,654...957,565 		JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression		 EXP Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 protein]
Sevoflurane results in increased expression of HDAC2 mRNA; Sevoflurane results in increased expression of HDAC2 protein		 CTD PMID:30842370 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO Sevoflurane results in increased expression of HEXB protein CTD PMID:35249202 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like decreases methylation ISO Sevoflurane results in decreased methylation of HEYL mRNA CTD PMID:35249202 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Sevoflurane results in increased expression of HGF mRNA]
Sevoflurane results in increased expression of HGF mRNA; Sevoflurane results in increased expression of HGF protein		 CTD PMID:35953652 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hhex hematopoietically expressed homeobox affects expression EXP sevoflurane affects the expression of HHEX mRNA CTD PMID:15967596 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Sevoflurane results in increased expression of HIF1A protein CTD PMID:35953652 PMID:36207479 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of HMOX1 mRNA; Sevoflurane results in decreased expression of HMOX1 protein
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein]		 CTD PMID:35350913 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression EXP sevoflurane affects the expression of HNRNPD mRNA CTD PMID:15967596 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hoxa4 homeo box A4 affects expression EXP sevoflurane affects the expression of HOXA4 mRNA CTD PMID:15967596 NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685 		JBrowse link
G Hpse heparanase increases expression ISO Sevoflurane results in increased expression of HPSE mRNA CTD PMID:35953652 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Sevoflurane results in increased expression of HRAS mRNA CTD PMID:35953652 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects expression EXP sevoflurane affects the expression of HSD17B2 mRNA CTD PMID:15967596 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects expression EXP sevoflurane affects the expression of HSPA8 mRNA CTD PMID:15967596 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions		 EXP Sevoflurane results in decreased expression of HSPD1 mRNA; Sevoflurane results in decreased expression of HSPD1 protein
Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 mRNA]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 protein]		 CTD PMID:34590382 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO Sevoflurane results in increased expression of HTATIP2 mRNA CTD PMID:35953652 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629 		JBrowse link
G Htt huntingtin multiple interactions ISO sevoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 EXP sevoflurane results in decreased expression of ICAM1 mRNA; sevoflurane results in decreased expression of ICAM1 protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]		 CTD PMID:15564938 PMID:32147387 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 affects expression EXP sevoflurane affects the expression of ID2 mRNA CTD PMID:15967596 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ids iduronate 2-sulfatase decreases methylation ISO Sevoflurane results in decreased methylation of IDS mRNA CTD PMID:35249202 NCBI chr  X:149,025,977...149,046,639
Ensembl chr  X:149,025,976...149,046,663 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of IFNG mRNA
dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of IFNG mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of IFNG mRNA]		 CTD PMID:35430185 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 affects expression EXP sevoflurane affects the expression of IFRD1 mRNA CTD PMID:15967596 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Sevoflurane results in increased expression of IGF1 mRNA CTD PMID:35953652 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 decreases secretion
multiple interactions		 ISO Sevoflurane results in decreased secretion of IL10 protein
dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased secretion of IL10 protein]]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased secretion of IL10 protein]		 CTD PMID:35430185 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 decreases methylation ISO Sevoflurane results in decreased methylation of IL12RB1 mRNA CTD PMID:35249202 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 EXP
ISO		 Sevoflurane results in increased expression of IL18 mRNA; Sevoflurane results in increased expression of IL18 protein
PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of IL18 protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL18 mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL18 protein]		 CTD PMID:35953652 PMID:36047109 PMID:36155068 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 EXP
ISO		 Sevoflurane results in increased expression of IL1B mRNA; Sevoflurane results in increased expression of IL1B protein
Sevoflurane results in increased secretion of IL1B protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Sevoflurane results in increased expression of IL1B protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of IL1B protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL1B mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL1B protein]
alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of IL1B mRNA]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL1B protein]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL1B protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL1B protein]		 CTD PMID:10422944 PMID:35110470 PMID:35174938 PMID:35350913 PMID:35430185 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions		 EXP
ISO		 Sevoflurane results in increased secretion of IL6 protein
Sevoflurane results in increased expression of IL6 mRNA; Sevoflurane results in increased expression of IL6 protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Sevoflurane results in increased expression of IL6 protein]
dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL6 protein]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL6 protein]; Sevoflurane affects the reaction [APOE protein affects the expression of IL6 protein]		 CTD PMID:35110470 PMID:35174938 PMID:35430185 PMID:35575159 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A affects expression EXP sevoflurane affects the expression of INHBA mRNA CTD PMID:15967596 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Ino80 INO80 complex ATPase subunit increases methylation ISO Sevoflurane results in increased methylation of INO80 mRNA CTD PMID:35249202 NCBI chr 3:106,368,455...106,465,716
Ensembl chr 3:106,368,455...106,467,911 		JBrowse link
G Itga7 integrin subunit alpha 7 decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of ITGA7 mRNA
Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of ITGA7 mRNA]		 CTD PMID:35953652 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression		 EXP Dietary Fats promotes the reaction [Sevoflurane results in increased expression of ITGAM protein] CTD PMID:35174938 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Sevoflurane results in decreased expression of ITGB3 mRNA CTD PMID:35953652 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Kbtbd8 kelch repeat and BTB domain containing 8 decreases methylation ISO Sevoflurane results in decreased methylation of KBTBD8 mRNA CTD PMID:35249202 NCBI chr 4:127,675,967...127,688,785
Ensembl chr 4:127,676,141...127,687,697 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 increases methylation ISO Sevoflurane results in increased methylation of KCNJ6 mRNA CTD PMID:35249202 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor decreases expression ISO Sevoflurane results in decreased expression of KISS1 mRNA CTD PMID:35953652 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612 		JBrowse link
G Kiss1r KISS1 receptor decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of KISS1R mRNA
Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of KISS1R mRNA]		 CTD PMID:35953652 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793 		JBrowse link
G Klf15 KLF transcription factor 15 affects expression EXP sevoflurane affects the expression of KLF15 mRNA CTD PMID:15967596 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374 		JBrowse link
G Klf9 KLF transcription factor 9 affects expression EXP sevoflurane affects the expression of KLF9 mRNA CTD PMID:15967596 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression ISO Sevoflurane results in decreased expression of KRAS mRNA CTD PMID:35953652 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 decreases methylation ISO Sevoflurane results in decreased methylation of LAMTOR3 mRNA CTD PMID:35249202 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607 		JBrowse link
G Lcn2 lipocalin 2 increases secretion ISO Sevoflurane results in increased secretion of LCN2 protein CTD PMID:30538007 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lifr LIF receptor subunit alpha decreases methylation ISO Sevoflurane results in decreased methylation of LIFR mRNA CTD PMID:35249202 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Limk2 LIM domain kinase 2 affects expression EXP sevoflurane affects the expression of LIMK2 mRNA CTD PMID:15967596 NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007 		JBrowse link
G LOC688765 hypothetical protein LOC688765 increases methylation ISO Sevoflurane results in increased methylation of C8ORF48 mRNA CTD PMID:35249202 NCBI chr16:55,244,744...55,246,642
Ensembl chr16:55,236,322...55,246,650 		JBrowse link
G Lox lysyl oxidase affects expression EXP sevoflurane affects the expression of LOX mRNA CTD PMID:15967596 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 increases methylation ISO Sevoflurane results in increased methylation of LRCH4 mRNA CTD PMID:35249202 NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577 		JBrowse link
G Lrrc47 leucine rich repeat containing 47 increases expression ISO Sevoflurane results in increased expression of LRRC47 protein CTD PMID:35249202 NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174 		JBrowse link
G Lrrtm2 leucine rich repeat transmembrane neuronal 2 increases methylation ISO Sevoflurane results in increased methylation of LRRTM2 mRNA CTD PMID:35249202 NCBI chr18:26,817,816...26,822,864
Ensembl chr18:26,817,816...26,822,864 		JBrowse link
G Lyrm9 LYR motif containing 9 decreases methylation ISO Sevoflurane results in decreased methylation of LYRM9 mRNA CTD PMID:35249202 NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772 		JBrowse link
G Maf1 MAF1 homolog, negative regulator of RNA polymerase III multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of ARG1 mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of MRC1 mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of TGFB1 mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased secretion of IL10 protein]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of CD86 mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of IFNG mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of NOS2 mRNA]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL1B protein]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL6 protein]]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of TNF protein]]; MAF1 protein affects the reaction [Sevoflurane affects the localization of NFE2L2 protein]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of ARG1 mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of MRC1 mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of TGFB1 mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased secretion of IL10 protein]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of CD86 mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of IFNG mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of NOS2 mRNA]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL1B protein]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL6 protein]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of TNF protein]
Sevoflurane results in decreased expression of MAF1 mRNA; Sevoflurane results in decreased expression of MAF1 protein		 CTD PMID:35430185 NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249 		JBrowse link
G Mafb MAF bZIP transcription factor B affects expression EXP sevoflurane affects the expression of MAFB mRNA CTD PMID:15967596 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 increases methylation ISO Sevoflurane results in increased methylation of MAN2A1 mRNA CTD PMID:35249202 NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression
decreases lipidation
multiple interactions
increases lipidation		 ISO
EXP		 Sevoflurane results in decreased expression of MAP1LC3B protein
Sevoflurane results in decreased lipidation of MAP1LC3B protein
Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased lipidation of MAP1LC3B protein]; MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein]; Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein]]
3-methyladenine inhibits the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]		 CTD PMID:34590382 PMID:35249202 PMID:35472370 PMID:36177783 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression		 ISO APOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of MAP2 protein] CTD PMID:35575159 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K3 protein CTD PMID:18349187 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K6 protein CTD PMID:18349187 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP3K5 protein CTD PMID:18349187 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map7 microtubule-associated protein 7 affects expression EXP sevoflurane affects the expression of MAP7 mRNA CTD PMID:15967596 NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein]
Sevoflurane results in increased phosphorylation of MAPK1 protein		 CTD PMID:19881297 PMID:36207479 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein]
Sevoflurane results in increased phosphorylation of MAPK3 protein		 CTD PMID:19881297 PMID:36207479 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions		 ISO Sevoflurane results in increased phosphorylation of MAPT protein
APOE protein alternative form inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPT protein]		 CTD PMID:35575159 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Marcksl1 MARCKS-like 1 decreases expression ISO Sevoflurane results in decreased expression of MARCKSL1 protein CTD PMID:35249202 NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817 		JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP sevoflurane affects the expression of MAT1A mRNA CTD PMID:15967596 NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit increases expression ISO Sevoflurane results in increased expression of MAT2B protein CTD PMID:35249202 NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777 		JBrowse link
G Mcam melanoma cell adhesion molecule multiple interactions
decreases expression		 ISO Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of MCAM mRNA]
Sevoflurane results in decreased expression of MCAM mRNA		 CTD PMID:35953652 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein increases methylation ISO Sevoflurane results in increased methylation of MCM3AP mRNA CTD PMID:35249202 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of MET mRNA
Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of MET mRNA]		 CTD PMID:35953652 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression
increases expression		 ISO Sevoflurane results in decreased expression of METTL3 mRNA
Sevoflurane results in increased expression of METTL3 protein		 CTD PMID:33928466 PMID:35249202 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mettl4 methyltransferase 4, N6-adenosine increases expression ISO Sevoflurane results in increased expression of METTL4 protein CTD PMID:35249202 NCBI chr 9:111,440,976...111,523,871
Ensembl chr 9:111,441,027...111,464,749 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency inhibits the reaction [Glucose results in increased expression of MFN2 protein]]; sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein] CTD PMID:27684054 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid affects expression EXP sevoflurane affects the expression of MFSD2A mRNA CTD PMID:15967596 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of MGAT5 mRNA
Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of MGAT5 mRNA]		 CTD PMID:35953652 NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513 		JBrowse link
G Mir204 microRNA 204 increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of MIR204 mRNA
MIR204 mRNA affects the reaction [Sevoflurane results in decreased expression of SQSTM1 protein]; MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein]; MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in decreased expression of SQSTM1 protein]]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein]]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of CASP3 protein]]		 CTD PMID:36177783 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir330 microRNA 330 multiple interactions
increases expression		 EXP Dexmedetomidine inhibits the reaction [Sevoflurane results in increased expression of MIR330 mRNA] CTD PMID:34590382 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274 		JBrowse link
G Mir34a microRNA 34a multiple interactions
increases response to substance		 EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]
MIR34A mRNA results in increased susceptibility to Sevoflurane		 CTD PMID:32147387 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Sevoflurane results in increased expression of MKI67 protein CTD PMID:36207479 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of MMP13 mRNA]
Sevoflurane results in increased expression of MMP13 mRNA		 CTD PMID:35953652 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 EXP
ISO		 MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]
Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of MMP9 mRNA]
Sevoflurane results in increased expression of MMP9 mRNA		 CTD PMID:32147387 PMID:35953652 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mocs3 molybdenum cofactor synthesis 3 decreases expression ISO Sevoflurane results in decreased expression of MOCS3 protein CTD PMID:35249202 NCBI chr 3:156,939,763...156,941,723
Ensembl chr 3:156,939,809...156,941,890 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 increases expression ISO Sevoflurane results in increased expression of MPC1 protein CTD PMID:36207479 NCBI chr 1:52,437,745...52,449,369
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions		 EXP sevoflurane results in decreased activity of MPO protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]		 CTD PMID:15564938 PMID:32147387 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions
decreases expression		 ISO dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of MRC1 mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of MRC1 mRNA] CTD PMID:35430185 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Sevoflurane results in decreased expression of COX1 protein CTD PMID:35249202 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mta1 metastasis associated 1 multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of MTA1 mRNA] CTD PMID:35953652 NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO Sevoflurane promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [Sevoflurane results in decreased phosphorylation of MTOR protein] CTD PMID:35472370 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Sevoflurane results in increased expression of MYC mRNA CTD PMID:35953652 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G N6amt1 N-6 adenine-specific DNA methyltransferase 1 increases expression ISO Sevoflurane results in increased expression of N6AMT1 protein CTD PMID:35249202 NCBI chr11:26,584,750...26,597,790
Ensembl chr11:26,584,724...26,608,248 		JBrowse link
G Naa30 N(alpha)-acetyltransferase 30, NatC catalytic subunit decreases methylation ISO Sevoflurane results in decreased methylation of NAA30 mRNA CTD PMID:35249202 NCBI chr15:22,454,914...22,474,789
Ensembl chr15:22,455,662...22,474,789 		JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 decreases expression ISO Sevoflurane results in decreased expression of NAP1L1 protein CTD PMID:35249202 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593 		JBrowse link
G Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 affects expression EXP sevoflurane affects the expression of NAT8F3 mRNA CTD PMID:15967596 NCBI chr 4:118,241,792...118,246,010
Ensembl chr 4:118,239,304...118,285,500 		JBrowse link
G Ncln nicalin increases expression ISO Sevoflurane results in increased expression of NCLN protein CTD PMID:35249202 NCBI chr 7:8,211,978...8,221,938
Ensembl chr 7:8,211,996...8,221,934 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 increases expression ISO Sevoflurane results in increased expression of NDUFB3 protein CTD PMID:35249202 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446 		JBrowse link
G Neu1 neuraminidase 1 affects expression EXP sevoflurane affects the expression of NEU1 mRNA CTD PMID:15967596 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of NF2 mRNA
Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of NF2 mRNA]		 CTD PMID:35953652 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO Sevoflurane affects the localization of NFE2L2 protein
MAF1 protein affects the reaction [Sevoflurane affects the localization of NFE2L2 protein]		 CTD PMID:35430185 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression EXP sevoflurane affects the expression of NFIL3 mRNA CTD PMID:15967596 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation		 EXP WDR48 protein affects the reaction [Sevoflurane results in increased phosphorylation of NFKBIA protein] CTD PMID:36047109 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngfr nerve growth factor receptor affects expression EXP sevoflurane affects the expression of NGFR mRNA CTD PMID:15967596 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nlgn1 neuroligin 1 decreases expression ISO Sevoflurane results in decreased expression of NLGN1 mRNA CTD PMID:33928466 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of NLRP3 protein
PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of NLRP3 protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of NLRP3 protein]		 CTD PMID:36047109 PMID:36155068 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nmt2 N-myristoyltransferase 2 increases methylation ISO Sevoflurane results in increased methylation of NMT2 mRNA CTD PMID:35249202 NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080 		JBrowse link
G Noct nocturnin affects expression EXP sevoflurane affects the expression of NOCT mRNA CTD PMID:15967596 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Sevoflurane results in increased expression of NOS2 mRNA
dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of NOS2 mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased expression of NOS2 mRNA]		 CTD PMID:32147387 PMID:35430185 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nostrin nitric oxide synthase trafficking affects expression EXP sevoflurane affects the expression of NOSTRIN mRNA CTD PMID:15967596 NCBI chr 3:53,904,746...53,970,995
Ensembl chr 3:53,904,827...53,970,988 		JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression EXP Sevoflurane results in increased expression of NOVA1 mRNA; Sevoflurane results in increased expression of NOVA1 protein CTD PMID:35110470 NCBI chr 6:63,780,105...63,905,950
Ensembl chr 6:63,783,489...63,906,289 		JBrowse link
G Nox1 NADPH oxidase 1 increases expression EXP Sevoflurane results in increased expression of NOX1 protein CTD PMID:35110470 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression EXP Sevoflurane results in increased expression of NOX4 protein CTD PMID:35110470 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nptx1 neuronal pentraxin 1 decreases expression ISO Sevoflurane results in decreased expression of NPTX1 mRNA CTD PMID:33928466 NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367 		JBrowse link
G Npy neuropeptide Y decreases expression
multiple interactions		 EXP Sevoflurane results in decreased expression of NPY protein
PHLDA1 protein promotes the reaction [Sevoflurane results in decreased expression of NPY protein]		 CTD PMID:36155068 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 ISO Sevoflurane results in decreased expression of NQO1 mRNA; Sevoflurane results in decreased expression of NQO1 protein
alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 protein]		 CTD PMID:35350913 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 affects expression EXP sevoflurane affects the expression of NR1D1 mRNA CTD PMID:15967596 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression EXP sevoflurane affects the expression of NR1I2 mRNA CTD PMID:15967596 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects expression EXP sevoflurane affects the expression of NR4A1 mRNA CTD PMID:15967596 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nrk Nik related kinase increases methylation ISO Sevoflurane results in increased methylation of NRK mRNA CTD PMID:35249202 NCBI chr  X:102,365,747...102,462,957
Ensembl chr  X:102,365,765...102,459,657 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases phosphorylation		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nudt3 nudix hydrolase 3 decreases expression ISO Sevoflurane results in decreased expression of NUDT3 protein CTD PMID:35249202 NCBI chr20:5,634,345...5,686,950
Ensembl chr20:5,634,349...5,686,874 		JBrowse link
G Omd osteomodulin affects expression EXP sevoflurane affects the expression of OMD mRNA CTD PMID:15967596 NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of OPA1 protein] CTD PMID:27684054 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 affects expression EXP sevoflurane affects the expression of OSGIN1 mRNA CTD PMID:15967596 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G P2rx7 purinergic receptor P2X 7 affects expression EXP sevoflurane affects the expression of P2RX7 mRNA CTD PMID:15967596 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pcdhga9 protocadherin gamma subfamily A, 9 increases methylation ISO Sevoflurane results in increased methylation of PCDHGA9 mRNA CTD PMID:35249202 NCBI chr18:29,564,614...29,667,865 JBrowse link
G Pcp4l1 Purkinje cell protein 4-like 1 increases expression ISO Sevoflurane results in increased expression of PCP4L1 protein CTD PMID:35249202 NCBI chr13:83,588,992...83,612,631
Ensembl chr13:83,588,992...83,609,966 		JBrowse link
G Pdcd4 programmed cell death 4 decreases methylation ISO Sevoflurane results in decreased methylation of PDCD4 mRNA CTD PMID:35249202 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pde3b phosphodiesterase 3B affects expression EXP sevoflurane affects the expression of PDE3B mRNA CTD PMID:15967596 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4b phosphodiesterase 4B affects expression EXP sevoflurane affects the expression of PDE4B mRNA CTD PMID:15967596 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pdgfd platelet derived growth factor D affects expression EXP sevoflurane affects the expression of PDGFD mRNA CTD PMID:15967596 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression EXP sevoflurane affects the expression of PDK4 mRNA CTD PMID:15967596 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 affects expression EXP sevoflurane affects the expression of PDP2 mRNA CTD PMID:15967596 NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074 		JBrowse link
G Per2 period circadian regulator 2 affects expression EXP sevoflurane affects the expression of PER2 mRNA CTD PMID:15967596 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Pex14 peroxisomal biogenesis factor 14 affects expression EXP sevoflurane affects the expression of PEX14 mRNA CTD PMID:15967596 NCBI chr 5:159,399,776...159,536,260
Ensembl chr 5:159,399,776...159,536,272 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 affects expression EXP sevoflurane affects the expression of PFKFB3 mRNA CTD PMID:15967596 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pgls 6-phosphogluconolactonase decreases expression ISO Sevoflurane results in decreased expression of PGLS protein CTD PMID:35249202 NCBI chr16:18,300,317...18,305,803
Ensembl chr16:18,300,317...18,305,803 		JBrowse link
G Phf1 PHD finger protein 1 increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of PHF1 protein
APOE protein alternative form inhibits the reaction [Sevoflurane results in increased expression of PHF1 protein]		 CTD PMID:35575159 NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of PHLDA1 mRNA; Sevoflurane results in increased expression of PHLDA1 protein
PHLDA1 protein promotes the reaction [Sevoflurane results in decreased expression of NPY protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of and results in increased cleavage of CASP1 protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of and results in increased phosphorylation of RAC1 protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of GSDMD protein modified form]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of IL18 protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of IL1B protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of NLRP3 protein]; PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of TRAF6 protein]		 CTD PMID:36155068 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases methylation ISO Sevoflurane results in increased methylation of PHOSPHO1 mRNA CTD PMID:35249202 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342 		JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha affects expression EXP sevoflurane affects the expression of PKIA mRNA CTD PMID:15967596 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression		 ISO Lipopolysaccharides promotes the reaction [Sevoflurane results in increased expression of PLAUR mRNA] CTD PMID:35953652 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 decreases methylation ISO Sevoflurane results in decreased methylation of PLEKHM1 mRNA CTD PMID:35249202 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412 		JBrowse link
G Plk3 polo-like kinase 3 affects expression EXP sevoflurane affects the expression of PLK3 mRNA CTD PMID:15967596 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Pnn pinin, desmosome associated protein multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of PNN mRNA]
Sevoflurane results in increased expression of PNN mRNA		 CTD PMID:35953652 NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889 		JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 affects expression EXP sevoflurane affects the expression of PNPLA7 mRNA CTD PMID:15967596 NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497 		JBrowse link
G Poglut3 protein O-glucosyltransferase 3 decreases methylation ISO Sevoflurane results in decreased methylation of POGLUT3 mRNA CTD PMID:35249202 NCBI chr 8:53,777,614...53,795,404
Ensembl chr 8:53,777,785...53,795,399 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP sevoflurane affects the expression of POR mRNA CTD PMID:15967596 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP sevoflurane affects the expression of PPARA mRNA CTD PMID:15967596 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B affects expression EXP sevoflurane affects the expression of PPP1R3B mRNA CTD PMID:15967596 NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406 		JBrowse link
G Prpf8 pre-mRNA processing factor 8 increases expression ISO Sevoflurane results in increased expression of PRPF8 protein CTD PMID:35249202 NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606 		JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions
decreases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of PRRX1 protein] CTD PMID:35350913 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Ptafr platelet-activating factor receptor decreases methylation ISO Sevoflurane results in decreased methylation of PTAFR mRNA CTD PMID:35249202 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP Dietary Fats promotes the reaction [Sevoflurane results in increased expression of PTGS2 protein]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:32147387 PMID:35174938 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 affects expression EXP sevoflurane affects the expression of PTP4A1 mRNA CTD PMID:15967596 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Ptp4a2 protein tyrosine phosphatase 4A2 increases expression ISO Sevoflurane results in increased expression of PTP4A2 protein CTD PMID:35249202 NCBI chr 5:142,165,405...142,192,412
Ensembl chr 5:142,165,700...142,191,899 		JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R affects expression EXP sevoflurane affects the expression of PTPRR mRNA CTD PMID:15967596 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603 		JBrowse link
G Pxmp4 peroxisomal membrane protein 4 affects expression EXP sevoflurane affects the expression of PXMP4 mRNA CTD PMID:15967596 NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression
multiple interactions
increases phosphorylation		 ISO
EXP		 Sevoflurane results in decreased expression of RAC1 protein
PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of and results in increased phosphorylation of RAC1 protein]
Sevoflurane results in increased phosphorylation of RAC1 protein		 CTD PMID:35249202 PMID:36155068 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects expression EXP sevoflurane affects the expression of RAF1 mRNA CTD PMID:15967596 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Ranbp3 RAN binding protein 3 increases expression ISO Sevoflurane results in increased expression of RANBP3 protein CTD PMID:35249202 NCBI chr 9:1,507,233...1,544,460
Ensembl chr 9:1,507,361...1,544,460 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 decreases expression ISO Sevoflurane results in decreased expression of RAPGEF2 protein CTD PMID:35249202 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 affects expression EXP sevoflurane affects the expression of RAPGEF4 mRNA CTD PMID:15967596 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316 		JBrowse link
G Rasgrp2 RAS guanyl releasing protein 2 increases expression ISO Sevoflurane results in increased expression of RASGRP2 protein CTD PMID:35249202 NCBI chr 1:203,705,777...203,722,993
Ensembl chr 1:203,707,481...203,722,993 		JBrowse link
G Rbm3 RNA binding motif protein 3 affects expression EXP sevoflurane affects the expression of RBM3 mRNA CTD PMID:15967596 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions		 EXP Sevoflurane results in increased phosphorylation of RELA protein
WDR48 protein affects the reaction [Sevoflurane results in increased phosphorylation of RELA protein]		 CTD PMID:36047109 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgcc regulator of cell cycle affects expression EXP sevoflurane affects the expression of RGCC mRNA CTD PMID:15967596 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141 		JBrowse link
G RGD1306746 similar to Hypothetical protein MGC25529 decreases methylation ISO Sevoflurane results in decreased methylation of C2ORF42 mRNA CTD PMID:35249202 NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein] CTD PMID:12960549 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 increases expression ISO Sevoflurane results in increased expression of RMDN3 protein CTD PMID:35249202 NCBI chr 3:106,125,961...106,146,568
Ensembl chr 3:106,125,951...106,146,586 		JBrowse link
G Rnf34 ring finger protein 34 decreases methylation ISO Sevoflurane results in decreased methylation of RNF34 mRNA CTD PMID:35249202 NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein] CTD PMID:12960549 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rorb RAR-related orphan receptor B increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of RORB mRNA
Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of RORB mRNA]		 CTD PMID:35953652 NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390 		JBrowse link
G S100a16 S100 calcium binding protein A16 increases methylation ISO Sevoflurane results in increased methylation of S100A16 mRNA CTD PMID:35249202 NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117 		JBrowse link
G S100a9 S100 calcium binding protein A9 affects expression EXP sevoflurane affects the expression of S100A9 mRNA CTD PMID:15967596 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 affects expression EXP sevoflurane affects the expression of S1PR1 mRNA CTD PMID:15967596 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 affects expression EXP sevoflurane affects the expression of SCN2B mRNA CTD PMID:15967596 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha affects expression EXP sevoflurane affects the expression of SCNN1A mRNA CTD PMID:15967596 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Sdc4 syndecan 4 affects expression EXP sevoflurane affects the expression of SDC4 mRNA CTD PMID:15967596 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 affects expression EXP sevoflurane affects the expression of SDR42E1 mRNA CTD PMID:15967596 NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901 		JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Sevoflurane results in decreased expression of SERPINF1 protein CTD PMID:36207479 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sestd1 SEC14 and spectrin domain containing 1 decreases expression ISO Sevoflurane results in decreased expression of SESTD1 protein CTD PMID:35249202 NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546 		JBrowse link
G Set Set nuclear proto-oncogene increases expression
multiple interactions		 ISO Sevoflurane results in increased expression of SET mRNA
Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of SET mRNA]		 CTD PMID:35953652 NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP sevoflurane affects the expression of SGK1 mRNA CTD PMID:15967596 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sh3bgrl3 SH3 domain binding glutamate-rich protein like 3 decreases expression ISO Sevoflurane results in decreased expression of SH3BGRL3 protein CTD PMID:35249202 NCBI chr 5:146,354,152...146,355,525
Ensembl chr 5:146,354,152...146,355,331 		JBrowse link
G Shroom2 shroom family member 2 decreases expression ISO Sevoflurane results in decreased expression of SHROOM2 protein CTD PMID:35249202 NCBI chr  X:21,812,469...21,983,724
Ensembl chr  X:21,812,469...21,984,153 		JBrowse link
G Sik1 salt-inducible kinase 1 affects expression EXP sevoflurane affects the expression of SIK1 mRNA CTD PMID:15967596 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases methylation ISO Sevoflurane results in decreased methylation of SIPA1L2 mRNA CTD PMID:35249202 NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428 		JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP sevoflurane affects the expression of SLC13A2 mRNA CTD PMID:15967596 NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 affects expression EXP sevoflurane affects the expression of SLC17A6 mRNA CTD PMID:15967596 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Slc20a1 solute carrier family 20 member 1 affects expression EXP sevoflurane affects the expression of SLC20A1 mRNA CTD PMID:15967596 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 affects expression EXP sevoflurane affects the expression of SLC25A25 mRNA CTD PMID:15967596 NCBI chr 3:15,708,702...15,742,195
Ensembl chr 3:15,708,703...15,742,216 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 affects expression EXP sevoflurane affects the expression of SLC25A32 mRNA CTD PMID:15967596 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases expression ISO Sevoflurane results in decreased expression of SLC25A4 protein CTD PMID:35249202 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 decreases methylation ISO Sevoflurane results in decreased methylation of SLC26A6 mRNA CTD PMID:35249202 NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778 		JBrowse link
G Slc28a2 solute carrier family 28 member 2 affects expression EXP sevoflurane affects the expression of SLC28A2 mRNA CTD PMID:15967596 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
increases expression		 ISO Sevoflurane results in decreased expression of SLC2A1 protein
Sevoflurane results in increased expression of SLC2A1 protein		 CTD PMID:35249202 PMID:36207479 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc35d3 solute carrier family 35, member D3 increases methylation ISO Sevoflurane results in increased methylation of SLC35D3 mRNA CTD PMID:35249202 NCBI chr 1:14,565,482...14,573,581
Ensembl chr 1:14,569,687...14,573,159 		JBrowse link
G Slc36a1 solute carrier family 36 member 1 decreases methylation ISO Sevoflurane results in decreased methylation of SLC36A1 mRNA CTD PMID:35249202 NCBI chr10:39,319,062...39,357,374
Ensembl chr10:39,324,337...39,354,217 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 affects expression EXP sevoflurane affects the expression of SLC38A2 mRNA CTD PMID:15967596 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases methylation ISO Sevoflurane results in decreased methylation of SLC38A7 mRNA CTD PMID:35249202 NCBI chr19:9,209,203...9,225,472
Ensembl chr19:9,209,257...9,225,454 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression EXP sevoflurane affects the expression of SLC3A2 mRNA CTD PMID:15967596 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 affects expression EXP sevoflurane affects the expression of SLC6A9 mRNA CTD PMID:15967596 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Slc7a10 solute carrier family 7 member 10 affects expression EXP sevoflurane affects the expression of SLC7A10 mRNA CTD PMID:15967596 NCBI chr 1:87,829,084...87,845,073
Ensembl chr 1:87,829,175...87,845,071 		JBrowse link
G Slc7a2 solute carrier family 7 member 2 affects expression EXP sevoflurane affects the expression of SLC7A2 mRNA CTD PMID:15967596 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of SMAD2 mRNA]
Sevoflurane results in increased expression of SMAD2 mRNA		 CTD PMID:35953652 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 affects response to substance
multiple interactions		 ISO SMAD3 protein affects the susceptibility to sevoflurane
TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]		 CTD PMID:18434384 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 decreases activity ISO sevoflurane results in decreased activity of SMPD1 protein CTD PMID:19572936 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Snrnp25 small nuclear ribonucleoprotein U11/U12 subunit 25 increases methylation ISO Sevoflurane results in increased methylation of SNRNP25 mRNA CTD PMID:35249202 NCBI chr10:15,420,482...15,423,806
Ensembl chr10:15,420,486...15,423,804 		JBrowse link
G Spryd4 SPRY domain containing 4 increases methylation ISO Sevoflurane results in increased methylation of SPRYD4 mRNA CTD PMID:35249202 NCBI chr 7:633,400...637,564
Ensembl chr 7:633,394...637,557 		JBrowse link
G Sqle squalene epoxidase affects expression EXP sevoflurane affects the expression of SQLE mRNA CTD PMID:15967596 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 ISO
EXP		 Sevoflurane results in decreased expression of SQSTM1 protein
MIR204 mRNA affects the reaction [Sevoflurane results in decreased expression of SQSTM1 protein]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in decreased expression of SQSTM1 protein]]		 CTD PMID:35472370 PMID:36177783 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression ISO Sevoflurane results in increased expression of SRC mRNA CTD PMID:35953652 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srpk1 SRSF protein kinase 1 decreases methylation ISO Sevoflurane results in decreased methylation of SRPK1 mRNA CTD PMID:35249202 NCBI chr20:6,645,809...6,682,448
Ensembl chr20:6,645,809...6,682,134 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases response to substance		 EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
STAT1 results in decreased susceptibility to Sevoflurane		 CTD PMID:32147387 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects expression EXP sevoflurane affects the expression of SULT1A1 mRNA CTD PMID:15967596 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Susd3 sushi domain containing 3 affects expression EXP sevoflurane affects the expression of SUSD3 mRNA CTD PMID:15967596 NCBI chr17:15,400,845...15,417,851
Ensembl chr17:15,400,845...15,417,044 		JBrowse link
G Syp synaptophysin decreases expression
multiple interactions		 EXP
ISO		 Sevoflurane results in decreased expression of SYP protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
YTHDF1 protein inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]		 CTD PMID:33548343 PMID:33928466 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Sypl1 synaptophysin-like 1 multiple interactions
decreases expression		 ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL protein] CTD PMID:35350913 NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330 		JBrowse link
G Syt11 synaptotagmin 11 increases expression ISO Sevoflurane results in increased expression of SYT11 mRNA CTD PMID:33928466 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Taf11 TATA-box binding protein associated factor 11 decreases methylation ISO Sevoflurane results in decreased methylation of TAF11 mRNA CTD PMID:35249202 NCBI chr20:5,955,774...5,963,593
Ensembl chr20:5,955,777...5,961,905 		JBrowse link
G Tbc1d10b TBC1 domain family, member 10b increases expression ISO Sevoflurane results in increased expression of TBC1D10B protein CTD PMID:35249202 NCBI chr 1:181,814,972...181,826,628
Ensembl chr 1:181,814,972...181,826,628 		JBrowse link
G Tcap titin-cap increases methylation ISO Sevoflurane results in increased methylation of TCAP mRNA CTD PMID:35249202 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression EXP sevoflurane affects the expression of TDO2 mRNA CTD PMID:15967596 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 increases expression ISO Sevoflurane results in increased expression of TECPR1 protein CTD PMID:35249202 NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611 		JBrowse link
G Tef TEF transcription factor, PAR bZIP family member affects expression EXP sevoflurane affects the expression of TEF mRNA CTD PMID:15967596 NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
affects response to substance
decreases expression		 ISO dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of TGFB1 mRNA]]; MAF1 protein inhibits the reaction [Sevoflurane results in decreased expression of TGFB1 mRNA]; TGFB1 protein affects the reaction [Sevoflurane affects the localization of SMAD3 protein]
TGFB1 protein affects the susceptibility to sevoflurane		 CTD PMID:18434384 PMID:35430185 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 EXP Sevoflurane results in increased expression of TLR4 mRNA; Sevoflurane results in increased expression of TLR4 protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of TLR4 mRNA]; Dietary Fats promotes the reaction [Sevoflurane results in increased expression of TLR4 protein]		 CTD PMID:35174938 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem132b transmembrane protein 132B increases methylation ISO Sevoflurane results in increased methylation of TMEM132B mRNA CTD PMID:35249202 NCBI chr12:30,829,900...31,093,840
Ensembl chr12:30,832,605...31,093,896 		JBrowse link
G Tmem267 transmembrane protein 267 increases methylation ISO Sevoflurane results in increased methylation of TMEM267 mRNA CTD PMID:35249202 NCBI chr 2:51,580,210...51,588,937
Ensembl chr 2:51,581,252...51,587,636 		JBrowse link
G Tmprss12 transmembrane serine protease 12 increases methylation ISO Sevoflurane results in increased methylation of TMPRSS12 mRNA CTD PMID:35249202 NCBI chr 7:131,433,158...131,445,806
Ensembl chr 7:131,433,484...131,445,791 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases secretion
increases expression
multiple interactions		 EXP
ISO		 sevoflurane results in decreased expression of TNF mRNA
Sevoflurane results in increased secretion of TNF protein
Sevoflurane results in increased expression of TNF mRNA; Sevoflurane results in increased expression of TNF protein
Dietary Fats promotes the reaction [Sevoflurane results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Sevoflurane results in increased expression of TNF protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of TNF mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of TNF protein]
alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of TNF mRNA]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of TNF protein]]; MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of TNF protein]; Sevoflurane affects the reaction [APOE protein affects the expression of TNF protein]		 CTD PMID:15564938 PMID:35110470 PMID:35174938 PMID:35350913 PMID:35430185 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO sevoflurane results in increased expression of TP53 mRNA CTD PMID:19572936 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tppp tubulin polymerization promoting protein increases expression ISO Sevoflurane results in increased expression of TPPP protein CTD PMID:35249202 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions
increases expression		 EXP PHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of TRAF6 protein] CTD PMID:36155068 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trib3 tribbles pseudokinase 3 affects expression EXP sevoflurane affects the expression of TRIB3 mRNA CTD PMID:15967596 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Tuba1a tubulin, alpha 1A affects expression EXP sevoflurane affects the expression of TUBA1A mRNA CTD PMID:15967596 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba1b tubulin, alpha 1B affects expression EXP sevoflurane affects the expression of TUBA1B mRNA CTD PMID:15967596 NCBI chr 7:130,090,669...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba3b tubulin, alpha 3B affects expression EXP sevoflurane affects the expression of TUBA3B mRNA CTD PMID:15967596 NCBI chr 4:178,588,779...178,594,328
Ensembl chr 4:178,588,779...178,594,326 		JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 decreases methylation ISO Sevoflurane results in decreased methylation of UBA2 mRNA CTD PMID:35249202 NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682 		JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 increases methylation ISO Sevoflurane results in increased methylation of UBE2Q2 mRNA CTD PMID:35249202 NCBI chr 8:55,518,402...55,578,342
Ensembl chr 8:55,519,147...55,577,212 		JBrowse link
G Ubqln4 ubiquilin 4 increases methylation ISO Sevoflurane results in increased methylation of UBQLN4 mRNA CTD PMID:35249202 NCBI chr 2:174,012,726...174,028,062
Ensembl chr 2:174,012,777...174,028,059 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Sevoflurane affects the expression of UGT1A1 mRNA CTD PMID:15967596 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects expression EXP sevoflurane affects the expression of UGT1A2 mRNA; sevoflurane affects the expression of UGT1A3 mRNA CTD PMID:15967596 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 affects expression EXP sevoflurane affects the expression of UGT1A5 mRNA CTD PMID:15967596 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects expression EXP sevoflurane affects the expression of UGT1A6 mRNA CTD PMID:15967596 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 affects expression EXP Sevoflurane affects the expression of UGT1A8 mRNA CTD PMID:15967596 NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP sevoflurane affects the expression of UGT1A9 mRNA CTD PMID:15967596 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 decreases expression
multiple interactions		 EXP Sevoflurane results in decreased expression of ULK1 mRNA
Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of ULK1 mRNA]		 CTD PMID:34590382 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 affects expression EXP sevoflurane affects the expression of USP2 mRNA CTD PMID:15967596 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression
multiple interactions		 EXP Sevoflurane results in decreased expression of VCAM1 protein
VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in decreased expression of SQSTM1 protein]]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of and results in increased lipidation of MAP1LC3B protein]]; VCAM1 protein affects the reaction [MIR204 mRNA affects the reaction [Sevoflurane results in increased cleavage of CASP3 protein]]		 CTD PMID:36177783 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vps50 VPS50 subunit of EARP/GARPII complex decreases expression ISO Sevoflurane results in decreased expression of VPS50 protein CTD PMID:35249202 NCBI chr 4:31,484,424...31,585,617
Ensembl chr 4:31,484,463...31,585,617 		JBrowse link
G Vps52 VPS52 subunit of GARP complex increases expression ISO Sevoflurane results in increased expression of VPS52 protein CTD PMID:35249202 NCBI chr20:4,920,715...4,931,685
Ensembl chr20:4,860,843...4,931,665 		JBrowse link
G Wdr45b WD repeat domain 45B increases expression ISO Sevoflurane results in increased expression of WDR45B protein CTD PMID:35249202 NCBI chr10:106,597,558...106,629,488
Ensembl chr10:106,599,364...106,629,441 		JBrowse link
G Wdr47 WD repeat domain 47 decreases expression ISO Sevoflurane results in decreased expression of WDR47 protein CTD PMID:35249202 NCBI chr 2:196,226,757...196,287,739
Ensembl chr 2:196,205,238...196,287,739 		JBrowse link
G Wdr48 WD repeat domain 48 multiple interactions
increases expression		 EXP WDR48 protein affects the reaction [Sevoflurane results in decreased activity of CAT protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL18 mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL18 protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL1B mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of IL1B protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of NLRP3 protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of TNF mRNA]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of TNF protein]; WDR48 protein affects the reaction [Sevoflurane results in increased phosphorylation of NFKBIA protein]; WDR48 protein affects the reaction [Sevoflurane results in increased phosphorylation of RELA protein]
Sevoflurane results in increased expression of WDR48 mRNA; Sevoflurane results in increased expression of WDR48 protein		 CTD PMID:36047109 NCBI chr 8:119,622,053...119,655,264
Ensembl chr 8:119,622,048...119,655,264 		JBrowse link
G Ythdf1 YTH N6-methyladenosine RNA binding protein F1 multiple interactions
decreases expression		 ISO YTHDF1 protein inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
Sevoflurane results in decreased expression of YTHDF1 mRNA; Sevoflurane results in decreased expression of YTHDF1 protein		 CTD PMID:33928466 NCBI chr 3:168,024,660...168,040,172
Ensembl chr 3:168,024,663...168,040,172 		JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein F3 increases expression ISO Sevoflurane results in increased expression of YTHDF3 protein CTD PMID:35249202 NCBI chr 2:98,350,304...98,384,608
Ensembl chr 2:98,350,588...98,384,606 		JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases methylation ISO Sevoflurane results in decreased methylation of ZBTB20 mRNA CTD PMID:35249202 NCBI chr11:57,052,129...57,823,679
Ensembl chr11:57,072,880...57,510,210 		JBrowse link
G Zfp354a zinc finger protein 354A affects expression EXP sevoflurane affects the expression of ZFP354A mRNA CTD PMID:15967596 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068 		JBrowse link
G Zfp521 zinc finger protein 521 increases methylation ISO Sevoflurane results in increased methylation of ZNF521 mRNA CTD PMID:35249202 NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458 		JBrowse link
G Zfp646 zinc finger protein 646 decreases methylation ISO Sevoflurane results in decreased methylation of ZNF646 mRNA CTD PMID:35249202 NCBI chr 1:182,485,009...182,494,961
Ensembl chr 1:182,485,949...182,494,731 		JBrowse link
G Zfp709 zinc finger protein 709 increases methylation ISO Sevoflurane results in increased methylation of ZNF729 mRNA CTD PMID:35249202 NCBI chr16:17,907,599...17,920,047
Ensembl chr16:17,909,641...17,919,700 		JBrowse link
G Zranb2 zinc finger RANBP2-type containing 2 increases expression ISO Sevoflurane results in increased expression of ZRANB2 protein CTD PMID:35249202 NCBI chr 2:246,573,110...246,586,942
Ensembl chr 2:246,573,166...246,586,942 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      application 19615
        pharmaceutical 19493
          drug 19493
            central nervous system drug 16698
              central nervous system depressant 16171
                sevoflurane 436
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            heteroorganic entity 19450
                              organochalcogen compound 19236
                                organooxygen compound 19149
                                  ether 17173
                                    2-methoxypropane 436
                                      sevoflurane 436
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