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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sevoflurane
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Accession:CHEBI:9130 term browser browse the term
Definition:An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Synonyms:related_synonym: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane;   Formula=C4H3F7O;   InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2;   InChIKey=DFEYYRMXOJXZRJ-UHFFFAOYSA-N;   SMILES=FCOC(C(F)(F)F)C(F)(F)F;   Sevofluran;   Sevoflurano;   Sevofluranum
 xref: Beilstein:2041023;   CAS:28523-86-6;   DrugBank:DB01236;   Drug_Central:2439;   KEGG:C07520;   KEGG:D00547
 xref_mesh: MESH:C009250
 xref: Patent:DE1954268;   Patent:US3689571;   Wikipedia:Sevoflurane


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sevoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase affects expression EXP sevoflurane affects the expression of AASS mRNA CTD PMID:15967596 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328
JBrowse link
G Aatf apoptosis antagonizing transcription factor affects expression EXP sevoflurane affects the expression of AATF mRNA CTD PMID:15967596 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP sevoflurane affects the expression of ABCB1A mRNA CTD PMID:15967596 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression EXP sevoflurane affects the expression of ABCC2 mRNA CTD PMID:15967596 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Aco2 aconitase 2 affects expression EXP sevoflurane affects the expression of ACO2 mRNA CTD PMID:15967596 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 affects expression EXP sevoflurane affects the expression of ADAMTS1 mRNA CTD PMID:15967596 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP sevoflurane results in increased phosphorylation of AKT1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]
CTD PMID:19881297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 affects expression EXP sevoflurane affects the expression of ALAS1 mRNA CTD PMID:15967596 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 affects expression EXP sevoflurane affects the expression of AMD1 mRNA CTD PMID:15967596 NCBI chr20:45,384,000...45,399,694
Ensembl chr20:45,384,000...45,399,694
JBrowse link
G App amyloid beta precursor protein affects cleavage
increases expression
multiple interactions
ISO sevoflurane affects the cleavage of APP protein
sevoflurane results in increased expression of APP protein modified form
sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane affects the cleavage of APP protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased expression of APP protein modified form]
CTD PMID:19433662 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) affects expression EXP sevoflurane affects the expression of AQP3 mRNA CTD PMID:15967596 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP sevoflurane affects the expression of ARC mRNA CTD PMID:15967596 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like affects expression EXP sevoflurane affects the expression of ARNTL mRNA CTD PMID:15967596 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Asl argininosuccinate lyase affects expression EXP sevoflurane affects the expression of ASL mRNA CTD PMID:15967596 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO sevoflurane results in increased phosphorylation of ATF2 protein CTD PMID:18349187 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Avpr1a arginine vasopressin receptor 1A affects expression EXP sevoflurane affects the expression of AVPR1A mRNA CTD PMID:15967596 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase affects expression EXP sevoflurane affects the expression of BAAT mRNA CTD PMID:15967596 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Bace1 beta-secretase 1 increases expression ISO sevoflurane results in increased expression of BACE1 protein CTD PMID:19433662 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 affects expression EXP sevoflurane affects the expression of BHLHE41 mRNA CTD PMID:15967596 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO sevoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO
EXP
sevoflurane results in increased activity of CASP3 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; Roscovitine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]
Sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]; Sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
sevoflurane results in increased cleavage of CASP3 protein
sevoflurane results in increased expression of CASP3 mRNA
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; L 685458 inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:15915027 PMID:16678324 PMID:18349187 PMID:18852026 PMID:19212262 PMID:19433662 PMID:19572936 PMID:33548343 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO sevoflurane results in increased activity of CASP7 protein CTD PMID:16678324 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cckbr cholecystokinin B receptor affects expression EXP sevoflurane affects the expression of CCKBR mRNA CTD PMID:15967596 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP sevoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 affects expression EXP sevoflurane affects the expression of CCND1 mRNA CTD PMID:15967596 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh17 cadherin 17 affects expression EXP sevoflurane affects the expression of CDH17 mRNA CTD PMID:15967596 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP Roscovitine inhibits the reaction [Sevoflurane results in increased expression of CDKN1A protein] CTD PMID:33548343 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects expression EXP sevoflurane affects the expression of CEBPB mRNA CTD PMID:15967596 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces2c carboxylesterase 2C affects expression EXP sevoflurane affects the expression of CES2C mRNA CTD PMID:15967596 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Cgrrf1 cell growth regulator with ring finger domain 1 affects expression EXP sevoflurane affects the expression of CGRRF1 mRNA CTD PMID:15967596 NCBI chr15:23,619,176...23,639,622
Ensembl chr15:23,619,123...23,639,628
JBrowse link
G Chka choline kinase alpha affects expression EXP sevoflurane affects the expression of CHKA mRNA CTD PMID:15967596 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 affects expression EXP sevoflurane affects the expression of CNGA4 mRNA CTD PMID:15967596 NCBI chr 1:170,238,959...170,246,858
Ensembl chr 1:170,242,846...170,246,858
JBrowse link
G Cntn2 contactin 2 affects expression EXP sevoflurane affects the expression of CNTN2 mRNA CTD PMID:15967596 NCBI chr13:49,280,913...49,314,061
Ensembl chr13:49,285,310...49,313,940
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression EXP sevoflurane affects the expression of CPT1A mRNA CTD PMID:15967596 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
multiple interactions
EXP Sevoflurane results in decreased expression of CREB1 mRNA
Sevoflurane results in decreased phosphorylation of CREB1 protein
Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of CREB1 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased phosphorylation of CREB1 protein]
CTD PMID:30842370 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP sevoflurane affects the expression of CREM mRNA CTD PMID:15967596 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression EXP sevoflurane affects the expression of CRY2 mRNA CTD PMID:15967596 NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
JBrowse link
G Ctsl cathepsin L affects expression EXP sevoflurane affects the expression of CTSL mRNA CTD PMID:15967596 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP sevoflurane results in decreased expression of CXCL1 mRNA
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP sevoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
EXP sevoflurane results in increased expression of CXCL2 mRNA
sevoflurane results in decreased expression of CXCL2 mRNA
CTD PMID:10422944 PMID:15564938 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 affects expression EXP sevoflurane affects the expression of CYP2B12 mRNA CTD PMID:15967596 NCBI chr 1:83,511,167...83,522,965
Ensembl chr 1:83,511,167...83,584,589
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression EXP sevoflurane affects the expression of CYP2B2 mRNA CTD PMID:15967596 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 affects expression EXP sevoflurane affects the expression of CYP2B21 mRNA CTD PMID:15967596 NCBI chr 1:83,389,783...83,418,613
Ensembl chr 1:83,389,788...83,418,777
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP sevoflurane affects the expression of CYP2C mRNA; sevoflurane affects the expression of CYP2C11 mRNA CTD PMID:15967596 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of sevoflurane CTD PMID:7879937 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression EXP sevoflurane affects the expression of CYP2F4 mRNA CTD PMID:15967596 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 affects expression EXP sevoflurane affects the expression of CYP7A1 mRNA CTD PMID:15967596 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Dbn1 drebrin 1 decreases expression
multiple interactions
EXP Sevoflurane results in decreased expression of DBN1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]
CTD PMID:33548343 NCBI chr17:9,679,511...9,693,878
Ensembl chr17:9,679,628...9,693,820
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor affects expression EXP sevoflurane affects the expression of DBP mRNA CTD PMID:15967596 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Dhx30 DExH-box helicase 30 affects expression EXP sevoflurane affects the expression of DHX30 mRNA CTD PMID:15967596 NCBI chr 8:118,160,315...118,194,674
Ensembl chr 8:118,160,299...118,187,791
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
EXP Sevoflurane results in decreased expression of DLG4 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]
CTD PMID:33548343 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dnase2b deoxyribonuclease 2 beta affects expression EXP sevoflurane affects the expression of DNASE2B mRNA CTD PMID:15967596 NCBI chr 2:252,436,363...252,475,506
Ensembl chr 2:252,436,332...252,451,999
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in increased expression of DNM1L protein] CTD PMID:27684054 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
increases phosphorylation
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein] CTD PMID:33548343 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dusp16 dual specificity phosphatase 16 affects expression EXP sevoflurane affects the expression of DUSP16 mRNA CTD PMID:15967596 NCBI chr 4:168,470,141...168,551,346
Ensembl chr 4:168,472,412...168,517,177
JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP sevoflurane affects the expression of DUSP6 mRNA CTD PMID:15967596 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dynll1 dynein light chain LC8-type 1 affects expression EXP sevoflurane affects the expression of DYNLL1 mRNA CTD PMID:15967596 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Edn1 endothelin 1 affects expression EXP sevoflurane affects the expression of EDN1 mRNA CTD PMID:15967596 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Efna1 ephrin A1 affects expression EXP sevoflurane affects the expression of EFNA1 mRNA CTD PMID:15967596 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egr1 early growth response 1 affects expression EXP sevoflurane affects the expression of EGR1 mRNA CTD PMID:15967596 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 affects expression EXP sevoflurane affects the expression of EGR2 mRNA CTD PMID:15967596 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP sevoflurane affects the expression of EPHX1 mRNA CTD PMID:15967596 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fads2 fatty acid desaturase 2 affects expression EXP sevoflurane affects the expression of FADS2 mRNA CTD PMID:15967596 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 affects expression EXP sevoflurane affects the expression of FMO2 mRNA CTD PMID:15967596 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Foxa3 forkhead box A3 affects expression EXP sevoflurane affects the expression of FOXA3 mRNA CTD PMID:15967596 NCBI chr 1:79,921,292...79,930,219
Ensembl chr 1:79,920,752...79,930,263
JBrowse link
G Fst follistatin affects expression EXP sevoflurane affects the expression of FST mRNA CTD PMID:15967596 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO sevoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects expression EXP sevoflurane affects the expression of GABRG2 mRNA CTD PMID:15967596 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Sevoflurane results in increased expression of GAD2 mRNA; Sevoflurane results in increased expression of GAD2 protein CTD PMID:30502404 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP sevoflurane affects the expression of GADD45A mRNA CTD PMID:15967596 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gch1 GTP cyclohydrolase 1 affects expression EXP sevoflurane affects the expression of GCH1 mRNA CTD PMID:15967596 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gck glucokinase affects expression EXP sevoflurane affects the expression of GCK mRNA CTD PMID:15967596 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gja4 gap junction protein, alpha 4 affects expression EXP sevoflurane affects the expression of GJA4 mRNA CTD PMID:15967596 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO sevoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Gmfb glia maturation factor, beta affects expression EXP sevoflurane affects the expression of GMFB mRNA CTD PMID:15967596 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gnb5 G protein subunit beta 5 affects expression EXP sevoflurane affects the expression of GNB5 mRNA CTD PMID:15967596 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184
JBrowse link
G Gnl3 G protein nucleolar 3 affects expression EXP sevoflurane affects the expression of GNL3 mRNA CTD PMID:15967596 NCBI chr16:7,097,580...7,103,518
Ensembl chr16:7,097,507...7,103,604
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression EXP sevoflurane affects the expression of GOT1 mRNA CTD PMID:15967596 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial affects expression EXP sevoflurane affects the expression of GPAM mRNA CTD PMID:15967596 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gphn gephyrin increases expression ISO Sevoflurane results in increased expression of GPHN mRNA; Sevoflurane results in increased expression of GPHN protein CTD PMID:30502404 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B affects expression EXP sevoflurane affects the expression of GPRC5B mRNA CTD PMID:15967596 NCBI chr 1:188,688,743...188,713,724
Ensembl chr 1:188,688,743...188,713,280
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression ISO Sevoflurane results in increased expression of GRIA1 protein CTD PMID:30502404 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression ISO Sevoflurane results in increased expression of GRIA2 protein CTD PMID:30502404 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane] CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression
EXP Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B protein]
Sevoflurane results in decreased expression of GRIN2B mRNA; Sevoflurane results in decreased expression of GRIN2B protein
CTD PMID:30842370 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein] CTD PMID:20807582 PMID:33548343 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression EXP Sevoflurane affects the expression of GSTA3 mRNA CTD PMID:15967596 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gys2 glycogen synthase 2 affects expression EXP sevoflurane affects the expression of GYS2 mRNA CTD PMID:15967596 NCBI chr 4:176,638,632...176,679,805
Ensembl chr 4:176,638,629...176,679,815
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression
EXP Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 protein]
Sevoflurane results in increased expression of HDAC2 mRNA; Sevoflurane results in increased expression of HDAC2 protein
CTD PMID:30842370 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hhex hematopoietically expressed homeobox affects expression EXP sevoflurane affects the expression of HHEX mRNA CTD PMID:15967596 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression EXP sevoflurane affects the expression of HNRNPD mRNA CTD PMID:15967596 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hoxa4 homeo box A4 affects expression EXP sevoflurane affects the expression of HOXA4 mRNA CTD PMID:15967596 NCBI chr 4:82,158,234...82,160,317
Ensembl chr 4:82,158,892...82,160,240
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects expression EXP sevoflurane affects the expression of HSD17B2 mRNA CTD PMID:15967596 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects expression EXP sevoflurane affects the expression of HSPA8 mRNA CTD PMID:15967596 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Htt huntingtin multiple interactions ISO sevoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP sevoflurane results in decreased expression of ICAM1 mRNA; sevoflurane results in decreased expression of ICAM1 protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 affects expression EXP sevoflurane affects the expression of ID2 mRNA CTD PMID:15967596 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 affects expression EXP sevoflurane affects the expression of IFRD1 mRNA CTD PMID:15967596 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Il1b interleukin 1 beta increases expression EXP sevoflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inhba inhibin subunit beta A affects expression EXP sevoflurane affects the expression of INHBA mRNA CTD PMID:15967596 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Klf15 Kruppel-like factor 15 affects expression EXP sevoflurane affects the expression of KLF15 mRNA CTD PMID:15967596 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Klf9 Kruppel-like factor 9 affects expression EXP sevoflurane affects the expression of KLF9 mRNA CTD PMID:15967596 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Limk2 LIM domain kinase 2 affects expression EXP sevoflurane affects the expression of LIMK2 mRNA CTD PMID:15967596 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892
JBrowse link
G Lox lysyl oxidase affects expression EXP sevoflurane affects the expression of LOX mRNA CTD PMID:15967596 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mafb MAF bZIP transcription factor B affects expression EXP sevoflurane affects the expression of MAFB mRNA CTD PMID:15967596 NCBI chr 3:156,338,993...156,340,913
Ensembl chr 3:156,339,004...156,340,913
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K3 protein CTD PMID:18349187 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K6 protein CTD PMID:18349187 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP3K5 protein CTD PMID:18349187 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Map7 microtubule-associated protein 7 affects expression EXP sevoflurane affects the expression of MAP7 mRNA CTD PMID:15967596 NCBI chr 1:15,620,665...15,748,203
Ensembl chr 1:15,620,653...15,748,203
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein] CTD PMID:19881297 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein] CTD PMID:19881297 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP sevoflurane affects the expression of MAT1A mRNA CTD PMID:15967596 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency inhibits the reaction [Glucose results in increased expression of MFN2 protein]]; sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein] CTD PMID:27684054 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A affects expression EXP sevoflurane affects the expression of MFSD2A mRNA CTD PMID:15967596 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Mir34a microRNA 34a multiple interactions
increases response to substance
EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]
MIR34A mRNA results in increased susceptibility to Sevoflurane
CTD PMID:32147387 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]] CTD PMID:32147387 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions
EXP sevoflurane results in decreased activity of MPO protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 affects expression EXP sevoflurane affects the expression of NAT8F3 mRNA CTD PMID:15967596 NCBI chr 4:117,488,089...117,492,315
Ensembl chr 4:117,490,035...117,490,721
JBrowse link
G Neu1 neuraminidase 1 affects expression EXP sevoflurane affects the expression of NEU1 mRNA CTD PMID:15967596 NCBI chr20:4,610,995...4,615,258
Ensembl chr20:4,610,995...4,615,247
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression EXP sevoflurane affects the expression of NFIL3 mRNA CTD PMID:15967596 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Ngfr nerve growth factor receptor affects expression EXP sevoflurane affects the expression of NGFR mRNA CTD PMID:15967596 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Noct nocturnin affects expression EXP sevoflurane affects the expression of NOCT mRNA CTD PMID:15967596 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:32147387 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nostrin nitric oxide synthase trafficking affects expression EXP sevoflurane affects the expression of NOSTRIN mRNA CTD PMID:15967596 NCBI chr 3:55,369,282...55,433,840
Ensembl chr 3:55,369,214...55,433,843
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 affects expression EXP sevoflurane affects the expression of NR1D1 mRNA CTD PMID:15967596 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression EXP sevoflurane affects the expression of NR1I2 mRNA CTD PMID:15967596 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects expression EXP sevoflurane affects the expression of NR4A1 mRNA CTD PMID:15967596 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Omd osteomodulin affects expression EXP sevoflurane affects the expression of OMD mRNA CTD PMID:15967596 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of OPA1 protein] CTD PMID:27684054 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 affects expression EXP sevoflurane affects the expression of OSGIN1 mRNA CTD PMID:15967596 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G P2rx7 purinergic receptor P2X 7 affects expression EXP sevoflurane affects the expression of P2RX7 mRNA CTD PMID:15967596 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Pde3b phosphodiesterase 3B affects expression EXP sevoflurane affects the expression of PDE3B mRNA CTD PMID:15967596 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pde4b phosphodiesterase 4B affects expression EXP sevoflurane affects the expression of PDE4B mRNA CTD PMID:15967596 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pdgfd platelet derived growth factor D affects expression EXP sevoflurane affects the expression of PDGFD mRNA CTD PMID:15967596 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression EXP sevoflurane affects the expression of PDK4 mRNA CTD PMID:15967596 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 affects expression EXP sevoflurane affects the expression of PDP2 mRNA CTD PMID:15967596 NCBI chr19:597,427...601,556
Ensembl chr19:597,427...601,469
JBrowse link
G Per2 period circadian regulator 2 affects expression EXP sevoflurane affects the expression of PER2 mRNA CTD PMID:15967596 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pex14 peroxisomal biogenesis factor 14 affects expression EXP sevoflurane affects the expression of PEX14 mRNA CTD PMID:15967596 NCBI chr 5:165,782,895...165,918,445
Ensembl chr 5:165,782,895...165,918,445
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 affects expression EXP sevoflurane affects the expression of PFKFB3 mRNA CTD PMID:15967596 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha affects expression EXP sevoflurane affects the expression of PKIA mRNA CTD PMID:15967596 NCBI chr 2:96,593,185...96,668,222
Ensembl chr 2:96,595,088...96,668,222
JBrowse link
G Plk3 polo-like kinase 3 affects expression EXP sevoflurane affects the expression of PLK3 mRNA CTD PMID:15967596 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 affects expression EXP sevoflurane affects the expression of PNPLA7 mRNA CTD PMID:15967596 NCBI chr 3:2,182,191...2,261,890
Ensembl chr 3:2,182,957...2,261,878
Ensembl chr 3:2,182,957...2,261,878
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP sevoflurane affects the expression of POR mRNA CTD PMID:15967596 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP sevoflurane affects the expression of PPARA mRNA CTD PMID:15967596 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B affects expression EXP sevoflurane affects the expression of PPP1R3B mRNA CTD PMID:15967596 NCBI chr16:60,415,192...60,427,498
Ensembl chr16:60,415,229...60,427,474
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:32147387 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 affects expression EXP sevoflurane affects the expression of PTP4A1 mRNA CTD PMID:15967596 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R affects expression EXP sevoflurane affects the expression of PTPRR mRNA CTD PMID:15967596 NCBI chr 7:59,039,717...59,325,925
Ensembl chr 7:59,039,720...59,325,947
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 affects expression EXP sevoflurane affects the expression of PXMP4 mRNA CTD PMID:15967596 NCBI chr 3:150,091,646...150,108,893
Ensembl chr 3:150,091,630...150,108,898
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects expression EXP sevoflurane affects the expression of RAF1 mRNA CTD PMID:15967596 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 affects expression EXP sevoflurane affects the expression of RAPGEF4 mRNA CTD PMID:15967596 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rbm3 RNA binding motif protein 3 affects expression EXP sevoflurane affects the expression of RBM3 mRNA CTD PMID:15967596 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340
JBrowse link
G Rgcc regulator of cell cycle affects expression EXP sevoflurane affects the expression of RGCC mRNA CTD PMID:15967596 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein] CTD PMID:12960549 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein] CTD PMID:12960549 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G S100a9 S100 calcium binding protein A9 affects expression EXP sevoflurane affects the expression of S100A9 mRNA CTD PMID:15967596 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 affects expression EXP sevoflurane affects the expression of S1PR1 mRNA CTD PMID:15967596 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 affects expression EXP sevoflurane affects the expression of SCN2B mRNA CTD PMID:15967596 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha affects expression EXP sevoflurane affects the expression of SCNN1A mRNA CTD PMID:15967596 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Sdc4 syndecan 4 affects expression EXP sevoflurane affects the expression of SDC4 mRNA CTD PMID:15967596 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 affects expression EXP sevoflurane affects the expression of SDR42E1 mRNA CTD PMID:15967596 NCBI chr19:50,207,960...50,220,455
Ensembl chr19:50,207,980...50,220,455
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP sevoflurane affects the expression of SGK1 mRNA CTD PMID:15967596 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sik1 salt-inducible kinase 1 affects expression EXP sevoflurane affects the expression of SIK1 mRNA CTD PMID:15967596 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP sevoflurane affects the expression of SLC13A2 mRNA CTD PMID:15967596 NCBI chr10:65,664,665...65,692,046
Ensembl chr10:65,664,667...65,692,023
JBrowse link
G Slc17a6 solute carrier family 17 member 6 affects expression EXP sevoflurane affects the expression of SLC17A6 mRNA CTD PMID:15967596 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704
JBrowse link
G Slc20a1 solute carrier family 20 member 1 affects expression EXP sevoflurane affects the expression of SLC20A1 mRNA CTD PMID:15967596 NCBI chr 3:121,725,204...121,739,160
Ensembl chr 3:121,725,859...121,739,173
JBrowse link
G Slc25a25 solute carrier family 25 member 25 affects expression EXP sevoflurane affects the expression of SLC25A25 mRNA CTD PMID:15967596 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529
JBrowse link
G Slc25a32 solute carrier family 25 member 32 affects expression EXP sevoflurane affects the expression of SLC25A32 mRNA CTD PMID:15967596 NCBI chr 7:77,983,885...78,005,058
Ensembl chr 7:77,987,212...78,004,975
JBrowse link
G Slc28a2 solute carrier family 28 member 2 affects expression EXP sevoflurane affects the expression of SLC28A2 mRNA CTD PMID:15967596 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382
JBrowse link
G Slc38a2 solute carrier family 38, member 2 affects expression EXP sevoflurane affects the expression of SLC38A2 mRNA CTD PMID:15967596 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression EXP sevoflurane affects the expression of SLC3A2 mRNA CTD PMID:15967596 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc6a9 solute carrier family 6 member 9 affects expression EXP sevoflurane affects the expression of SLC6A9 mRNA CTD PMID:15967596 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Slc7a10 solute carrier family 7 member 10 affects expression EXP sevoflurane affects the expression of SLC7A10 mRNA CTD PMID:15967596 NCBI chr 1:91,432,952...91,448,566
Ensembl chr 1:91,433,030...91,448,564
JBrowse link
G Slc7a2 solute carrier family 7 member 2 affects expression EXP sevoflurane affects the expression of SLC7A2 mRNA CTD PMID:15967596 NCBI chr16:54,459,409...54,513,349
Ensembl chr16:54,460,067...54,513,349
JBrowse link
G Smad3 SMAD family member 3 affects response to substance
multiple interactions
ISO SMAD3 protein affects the susceptibility to sevoflurane
TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]
CTD PMID:18434384 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 decreases activity ISO sevoflurane results in decreased activity of SMPD1 protein CTD PMID:19572936 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Sqle squalene epoxidase affects expression EXP sevoflurane affects the expression of SQLE mRNA CTD PMID:15967596 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases response to substance
EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
STAT1 results in decreased susceptibility to Sevoflurane
CTD PMID:32147387 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects expression EXP sevoflurane affects the expression of SULT1A1 mRNA CTD PMID:15967596 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Susd3 sushi domain containing 3 affects expression EXP sevoflurane affects the expression of SUSD3 mRNA CTD PMID:15967596 NCBI chr17:15,814,132...15,830,328
Ensembl chr17:15,814,132...15,830,328
JBrowse link
G Syp synaptophysin decreases expression
multiple interactions
EXP Sevoflurane results in decreased expression of SYP protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
CTD PMID:33548343 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression EXP sevoflurane affects the expression of TDO2 mRNA CTD PMID:15967596 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member affects expression EXP sevoflurane affects the expression of TEF mRNA CTD PMID:15967596 NCBI chr 7:123,033,971...123,058,606
Ensembl chr 7:123,043,503...123,058,604
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
affects response to substance
ISO TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]
TGFB1 protein affects the susceptibility to sevoflurane
CTD PMID:18434384 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP sevoflurane results in decreased expression of TNF mRNA CTD PMID:15564938 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO sevoflurane results in increased expression of TP53 mRNA CTD PMID:19572936 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 affects expression EXP sevoflurane affects the expression of TRIB3 mRNA CTD PMID:15967596 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tuba1a tubulin, alpha 1A affects expression EXP sevoflurane affects the expression of TUBA1A mRNA CTD PMID:15967596 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tuba1b tubulin, alpha 1B affects expression EXP sevoflurane affects the expression of TUBA1B mRNA CTD PMID:15967596 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Tuba3b tubulin, alpha 3B affects expression EXP sevoflurane affects the expression of TUBA3B mRNA CTD PMID:15967596 NCBI chr 4:179,905,154...179,910,703
Ensembl chr 4:179,905,116...179,910,704
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP sevoflurane affects the expression of UGT1A1 mRNA CTD PMID:15967596 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects expression EXP sevoflurane affects the expression of UGT1A2 mRNA; sevoflurane affects the expression of UGT1A3 mRNA CTD PMID:15967596 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 affects expression EXP sevoflurane affects the expression of UGT1A5 mRNA CTD PMID:15967596 NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects expression EXP sevoflurane affects the expression of UGT1A6 mRNA CTD PMID:15967596 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 affects expression EXP sevoflurane affects the expression of UGT1A8 mRNA CTD PMID:15967596 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP sevoflurane affects the expression of UGT1A9 mRNA CTD PMID:15967596 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Usp2 ubiquitin specific peptidase 2 affects expression EXP sevoflurane affects the expression of USP2 mRNA CTD PMID:15967596 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Zfp354a zinc finger protein 354A affects expression EXP sevoflurane affects the expression of ZFP354A mRNA CTD PMID:15967596 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link

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  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            central nervous system drug 16483
              central nervous system depressant 16022
                sevoflurane 201
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  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            heteroorganic entity 19207
                              organochalcogen compound 18958
                                organooxygen compound 18886
                                  ether 16892
                                    2-methoxypropane 201
                                      sevoflurane 201
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