Rapgef2 (Rap guanine nucleotide exchange factor 2) - Rat Genome Database

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Gene: Rapgef2 (Rap guanine nucleotide exchange factor 2) Rattus norvegicus
Analyze
Symbol: Rapgef2
Name: Rap guanine nucleotide exchange factor 2
RGD ID: 1306434
Description: Enables protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of neuron projection development. Located in several cellular components, including neuron projection; neuronal cell body; and synapse. Part of protein-containing complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2); PARTICIPATES IN adenosine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: PROVISIONAL
Previously known as: CNrasGEF; cyclic nucleotide ras GEF; LOC102553473; LOC310533; neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Rap guanine nucleotide exchange factor (GEF) 2; rap guanine nucleotide exchange factor 6-like; ras/Rap1-associating GEF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Celera2158,305,258 - 158,419,241 (-)NCBICelera
Cytogenetic Map2q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
allethrin  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
caffeine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dibutyl phthalate  (EXP)
Enterolactone  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
hemin  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
permethrin  (EXP)
potassium chromate  (ISO)
propiconazole  (EXP,ISO)
pyrethrins  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triacsin C  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO,ISS)
blood vessel development  (ISO,ISS)
brain-derived neurotrophic factor receptor signaling pathway  (IMP)
cAMP-mediated signaling  (ISO,ISS)
cellular response to cAMP  (ISO,ISS)
cellular response to cGMP  (ISO,ISS)
cellular response to nerve growth factor stimulus  (IDA)
establishment of endothelial barrier  (ISO,ISS)
establishment of endothelial intestinal barrier  (ISO)
forebrain neuron development  (ISO,ISS)
G protein-coupled receptor signaling pathway  (ISO,ISS)
microvillus assembly  (ISO)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of dendrite morphogenesis  (ISO,ISS)
negative regulation of melanin biosynthetic process  (ISO,ISS)
nerve growth factor signaling pathway  (IDA)
neuron migration  (ISO,ISS)
neuron projection development  (ISO,ISS)
neuropeptide signaling pathway  (ISO,ISS)
positive regulation of dendritic cell apoptotic process  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO,ISS)
positive regulation of neuron migration  (ISO,ISS)
positive regulation of neuron projection development  (IMP)
positive regulation of vasculogenesis  (ISO,ISS)
protein localization to plasma membrane  (ISO)
Rap protein signal transduction  (ISO,ISS)
Ras protein signal transduction  (IBA)
regulation of cell junction assembly  (ISO,ISS)
regulation of modification of postsynaptic structure  (ISO)
regulation of synaptic plasticity  (IDA)
ventricular system development  (ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
4. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
5. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Ohtsuka T, etal., Biochem Biophys Res Commun. 1999 Nov;265(1):38-44.
6. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Pak Y, etal., Mol Cell Biol. 2002 Nov;22(22):7942-52.
7. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Pham N, etal., Curr Biol. 2000 May 4;10(9):555-8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10608844   PMID:10608883   PMID:10873669   PMID:10934204   PMID:11168587   PMID:11359771   PMID:11598133   PMID:16272156   PMID:17826737   PMID:19453629   PMID:19635461   PMID:21840392  
PMID:21864586   PMID:22797597   PMID:23800469   PMID:23885123   PMID:24567337   PMID:29476059   PMID:30053369   PMID:32885411  


Genomics

Comparative Map Data
Rapgef2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82166,505,868 - 166,728,139 (-)NCBIGRCr8
mRatBN7.22164,207,513 - 164,322,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2171,425,256 - 171,539,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02169,440,712 - 169,555,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02164,049,532 - 164,164,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02177,836,191 - 178,057,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2177,836,202 - 178,057,157 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02197,171,946 - 197,285,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42170,472,420 - 170,587,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12170,422,533 - 170,512,880 (-)NCBI
Celera2158,305,258 - 158,419,241 (-)NCBICelera
Cytogenetic Map2q33NCBI
RAPGEF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384159,103,079 - 159,360,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4159,103,013 - 159,360,174 (+)EnsemblGRCh38hg38GRCh38
GRCh374160,024,231 - 160,281,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364160,408,448 - 160,500,752 (+)NCBINCBI36Build 36hg18NCBI36
Celera4157,529,482 - 157,621,655 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4155,939,342 - 156,031,440 (+)NCBIHuRef
CHM1_14160,165,501 - 160,257,796 (+)NCBICHM1_1
T2T-CHM13v2.04162,453,893 - 162,710,940 (+)NCBIT2T-CHM13v2.0
Rapgef2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39378,969,818 - 79,194,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl378,969,823 - 79,193,824 (-)EnsemblGRCm39 Ensembl
GRCm38379,062,511 - 79,286,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl379,062,516 - 79,286,517 (-)EnsemblGRCm38mm10GRCm38
MGSCv37378,866,450 - 78,949,797 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36379,148,443 - 79,372,981 (-)NCBIMGSCv36mm8
MGSCv36379,728,293 - 79,956,813 (-)NCBIMGSCv36mm8
Celera379,094,490 - 79,178,178 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map334.91NCBI
Rapgef2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547112,670,764 - 12,815,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547112,670,837 - 12,838,910 (+)NCBIChiLan1.0ChiLan1.0
RAPGEF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23156,967,271 - 157,228,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14157,322,566 - 157,584,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04151,419,402 - 151,680,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14163,316,387 - 163,489,514 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4163,316,396 - 163,487,495 (+)Ensemblpanpan1.1panPan2
RAPGEF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11556,133,094 - 56,353,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1556,174,578 - 56,352,569 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1556,473,491 - 56,715,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01556,855,560 - 57,097,663 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1556,855,619 - 57,097,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11556,092,734 - 56,334,363 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01556,190,343 - 56,432,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01556,504,459 - 56,746,362 (+)NCBIUU_Cfam_GSD_1.0
Rapgef2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530133,800,312 - 33,963,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365765,583,805 - 5,746,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365765,583,847 - 5,746,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl848,021,604 - 48,277,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1848,183,518 - 48,277,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2850,390,322 - 50,684,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17105,672,583 - 105,883,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7105,624,608 - 105,884,366 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603785,337,825 - 85,597,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248483,968,362 - 4,182,885 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248483,968,845 - 4,184,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rapgef2
1220 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:293
Interacting mature miRNAs:392
Transcripts:ENSRNOT00000012792, ENSRNOT00000029340
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 25 9 19 9 8 8 74 28 34 11 8
Low 3 2 32 32 32 3 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000012792   ⟹   ENSRNOP00000012792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2164,207,513 - 164,244,247 (-)Ensembl
Rnor_6.0 Ensembl2177,836,202 - 177,950,517 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000029340   ⟹   ENSRNOP00000037119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2177,838,210 - 177,924,970 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091135   ⟹   ENSRNOP00000068918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2177,837,270 - 178,057,157 (-)Ensembl
RefSeq Acc Id: NM_001107684   ⟹   NP_001101154
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,868 - 166,620,371 (-)NCBI
mRatBN7.22164,207,513 - 164,322,157 (-)NCBI
Rnor_6.02177,836,202 - 177,950,517 (-)NCBI
Rnor_5.02197,171,946 - 197,285,983 (-)NCBI
RGSC_v3.42170,472,420 - 170,587,987 (-)RGD
Celera2158,305,258 - 158,419,241 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281806   ⟹   XP_063137876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281807   ⟹   XP_063137877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281808   ⟹   XP_063137878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,728,139 (-)NCBI
RefSeq Acc Id: XM_063281809   ⟹   XP_063137879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,701,616 (-)NCBI
RefSeq Acc Id: XM_063281810   ⟹   XP_063137880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,620,625 (-)NCBI
RefSeq Acc Id: XM_063281811   ⟹   XP_063137881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,628,728 (-)NCBI
RefSeq Acc Id: XM_063281812   ⟹   XP_063137882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,632,879 (-)NCBI
RefSeq Acc Id: XM_063281813   ⟹   XP_063137883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,620,735 (-)NCBI
RefSeq Acc Id: XM_063281814   ⟹   XP_063137884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,595,783 (-)NCBI
RefSeq Acc Id: XM_063281815   ⟹   XP_063137885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82166,505,876 - 166,604,460 (-)NCBI
RefSeq Acc Id: NP_001101154   ⟸   NM_001107684
- UniProtKB: D3ZD17 (UniProtKB/Swiss-Prot),   F1M386 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068918   ⟸   ENSRNOT00000091135
RefSeq Acc Id: ENSRNOP00000037119   ⟸   ENSRNOT00000029340
RefSeq Acc Id: ENSRNOP00000012792   ⟸   ENSRNOT00000012792
RefSeq Acc Id: XP_063137877   ⟸   XM_063281807
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137878   ⟸   XM_063281808
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137876   ⟸   XM_063281806
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137879   ⟸   XM_063281809
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137882   ⟸   XM_063281812
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137881   ⟸   XM_063281811
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063137883   ⟸   XM_063281813
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063137880   ⟸   XM_063281810
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063137885   ⟸   XM_063281815
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063137884   ⟸   XM_063281814
- Peptide Label: isoform X8
Protein Domains
N-terminal Ras-GEF   PDZ   Ras-associating   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M386-F1-model_v2 AlphaFold F1M386 1-1496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691400
Promoter ID:EPDNEW_R1908
Type:single initiation site
Name:Rapgef2_1
Description:Rap guanine nucleotide exchange factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02178,057,104 - 178,057,164EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306434 AgrOrtholog
BioCyc Gene G2FUF-52736 BioCyc
Ensembl Genes ENSRNOG00000021581 Ensembl
  ENSRNOG00055001378 UniProtKB/Swiss-Prot
  ENSRNOG00065031294 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055002294 UniProtKB/Swiss-Prot
  ENSRNOT00065054234 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  RA_dom UniProtKB/Swiss-Prot
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot
  RASGEF_cat_dom UniProtKB/Swiss-Prot
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:310533 UniProtKB/Swiss-Prot
NCBI Gene 310533 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE RAS GEF UniProtKB/Swiss-Prot
  CYTOSKELETON-ASSOCIATED PROTEIN 4 UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
  PF00788 UniProtKB/Swiss-Prot
  RasGEF UniProtKB/Swiss-Prot
  RasGEF_N UniProtKB/Swiss-Prot
PhenoGen Rapgef2 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PS50200 UniProtKB/Swiss-Prot
  RASGEF_CAT UniProtKB/Swiss-Prot
  RASGEF_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021581 RatGTEx
  ENSRNOG00055001378 RatGTEx
  ENSRNOG00065031294 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  RasGEF UniProtKB/Swiss-Prot
  RasGEFN UniProtKB/Swiss-Prot
  SM00314 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48366 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF51206 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt D3ZD17 ENTREZGENE
  F1M386 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3ZD17 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef2  Rap guanine nucleotide exchange factor 2  Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2  LOC102553473  rap guanine nucleotide exchange factor 6-like  Data merged from RGD:7554452 737654 PROVISIONAL
2013-12-17 LOC102553473  rap guanine nucleotide exchange factor 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Rapgef2  Rap guanine nucleotide exchange factor (GEF) 2   Rapgef2_predicted  Rap guanine nucleotide exchange factor (GEF) 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rapgef2_predicted  Rap guanine nucleotide exchange factor (GEF) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED