Nrk (Nik related kinase) - Rat Genome Database

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Gene: Nrk (Nik related kinase) Rattus norvegicus
Analyze
Symbol: Nrk
Name: Nik related kinase
RGD ID: 1566163
Description: Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of JNK cascade. Predicted to act upstream of or within negative regulation of cell population proliferation; parturition; and regulation of spongiotrophoblast cell proliferation. Predicted to be active in cytosol. Orthologous to human NRK (Nik related kinase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315907; nik-related protein kinase; RGD1566163; similar to Nck-interacting kinase-like embryo specific kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X102,365,765 - 102,462,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,365,765 - 102,459,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,503,462 - 104,597,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X108,002,202 - 108,095,770 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X105,571,175 - 105,664,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X110,065,199 - 110,089,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0X109,940,439 - 110,036,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX109,940,350 - 110,033,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X109,913,500 - 109,944,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X109,798,013 - 109,890,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,448,334 - 126,541,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX103,155,670 - 103,249,235 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10801798   PMID:21715335  


Genomics

Comparative Map Data
Nrk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X102,365,765 - 102,462,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,365,765 - 102,459,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,503,462 - 104,597,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X108,002,202 - 108,095,770 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X105,571,175 - 105,664,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X110,065,199 - 110,089,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0X109,940,439 - 110,036,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX109,940,350 - 110,033,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X109,913,500 - 109,944,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X109,798,013 - 109,890,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,448,334 - 126,541,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX103,155,670 - 103,249,235 (+)NCBICelera
Cytogenetic MapXq32NCBI
NRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X105,821,786 - 105,958,610 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX105,822,539 - 105,958,610 (+)EnsemblGRCh38hg38GRCh38
GRCh37X105,066,532 - 105,202,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X104,953,192 - 105,089,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X104,872,680 - 105,008,744NCBI
CeleraX105,541,018 - 105,677,081 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX94,691,867 - 94,829,421 (+)NCBIHuRef
CHM1_1X104,977,838 - 105,113,888 (+)NCBICHM1_1
T2T-CHM13v2.0X104,253,759 - 104,390,422 (+)NCBIT2T-CHM13v2.0
Nrk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X137,814,980 - 137,911,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX137,815,179 - 137,911,281 (+)EnsemblGRCm39 Ensembl
GRCm38X138,914,231 - 139,010,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX138,914,430 - 139,010,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X135,448,969 - 135,543,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X134,260,869 - 134,354,417 (+)NCBIMGSCv36mm8
CeleraX122,184,305 - 122,278,072 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.15NCBI
Nrk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555482,675,645 - 2,797,548 (+)NCBIChiLan1.0ChiLan1.0
NRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X105,344,411 - 105,481,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X94,957,923 - 95,094,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X105,337,040 - 105,473,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX105,337,327 - 105,470,331 (+)Ensemblpanpan1.1panPan2
NRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X79,341,449 - 79,488,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX79,341,412 - 79,485,661 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX80,973,793 - 81,117,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBIUU_Cfam_GSD_1.0
Nrk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X78,909,811 - 79,031,463 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364998,629,563 - 8,747,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX86,534,488 - 86,663,337 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X86,534,467 - 86,663,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X100,896,640 - 101,021,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X93,688,895 - 93,822,776 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX93,689,023 - 93,825,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606518,696,953 - 18,832,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480310,719,694 - 10,861,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrk
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000057049
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat

Markers in Region
AV168563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X102,461,333 - 102,461,413 (+)MAPPERmRatBN7.2
Rnor_6.0X110,087,501 - 110,087,580NCBIRnor6.0
Rnor_6.0X110,034,738 - 110,034,817NCBIRnor6.0
Rnor_5.0X109,892,312 - 109,892,391UniSTSRnor5.0
Rnor_5.0X109,942,456 - 109,942,535UniSTSRnor5.0
RGSC_v3.4X126,543,252 - 126,543,331UniSTSRGSC3.4
CeleraX103,250,912 - 103,250,991UniSTS
Cytogenetic MapXq35UniSTS
RH139627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X102,435,942 - 102,436,144 (+)MAPPERmRatBN7.2
mRatBN7.2X102,436,090 - 102,436,144 (+)MAPPERmRatBN7.2
Rnor_6.0X110,009,497 - 110,009,550NCBIRnor6.0
Rnor_6.0X110,009,349 - 110,009,550NCBIRnor6.0
Rnor_5.0X109,867,071 - 109,867,124UniSTSRnor5.0
Rnor_5.0X109,866,923 - 109,867,124UniSTSRnor5.0
RGSC_v3.4X126,517,861 - 126,518,062UniSTSRGSC3.4
RGSC_v3.4X126,518,009 - 126,518,062UniSTSRGSC3.4
CeleraX103,225,668 - 103,225,721UniSTS
CeleraX103,225,520 - 103,225,721UniSTS
RH 3.4 Map71128.32UniSTS
Cytogenetic MapXq35UniSTS
px-41g5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X102,459,848 - 102,459,950 (+)MAPPERmRatBN7.2
Rnor_6.0X110,086,016 - 110,086,117NCBIRnor6.0
Rnor_6.0X110,033,253 - 110,033,354NCBIRnor6.0
Rnor_5.0X109,890,827 - 109,890,928UniSTSRnor5.0
Rnor_5.0X109,940,971 - 109,941,072UniSTSRnor5.0
RGSC_v3.4X126,541,767 - 126,541,868UniSTSRGSC3.4
CeleraX103,249,427 - 103,249,528UniSTS
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 6 6 6 2 2 12 26 2
Low 19 24 16 5 16 4 4 49 12 10 5 4
Below cutoff 5 20 12 13 12 2 4 20 8 4 4 2

Sequence


RefSeq Acc Id: ENSRNOT00000057049   ⟹   ENSRNOP00000053882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX102,365,765 - 102,459,657 (+)Ensembl
Rnor_6.0 EnsemblX109,940,439 - 110,033,061 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093349   ⟹   ENSRNOP00000076290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX109,996,163 - 110,005,708 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093539   ⟹   ENSRNOP00000076224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX110,007,214 - 110,012,918 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093542   ⟹   ENSRNOP00000076095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX110,016,995 - 110,033,085 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093543   ⟹   ENSRNOP00000076291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX109,940,350 - 109,992,862 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093611   ⟹   ENSRNOP00000076116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX110,014,252 - 110,016,409 (+)Ensembl
RefSeq Acc Id: NM_001191797   ⟹   NP_001178726
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,366,085 - 102,459,657 (+)NCBI
Rnor_6.0X109,940,439 - 110,033,061 (+)NCBI
Rnor_5.0X109,798,013 - 109,890,635 (+)NCBI
CeleraX103,155,670 - 103,249,235 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411591   ⟹   NP_001398520
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X102,365,765 - 102,462,957 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178726 (Get FASTA)   NCBI Sequence Viewer  
  NP_001398520 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88010 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053882
  ENSRNOP00000053882.3
RefSeq Acc Id: NP_001178726   ⟸   NM_001191797
- Peptide Label: isoform 2
- UniProtKB: F1LZB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053882   ⟸   ENSRNOT00000057049
RefSeq Acc Id: ENSRNOP00000076116   ⟸   ENSRNOT00000093611
RefSeq Acc Id: ENSRNOP00000076095   ⟸   ENSRNOT00000093542
RefSeq Acc Id: ENSRNOP00000076291   ⟸   ENSRNOT00000093543
RefSeq Acc Id: ENSRNOP00000076224   ⟸   ENSRNOT00000093539
RefSeq Acc Id: ENSRNOP00000076290   ⟸   ENSRNOT00000093349
RefSeq Acc Id: NP_001398520   ⟸   NM_001411591
- Peptide Label: isoform 1
Protein Domains
CNH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZB6-F1-model_v2 AlphaFold F1LZB6 1-1454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701950
Promoter ID:EPDNEW_R12472
Type:single initiation site
Name:Nrk_1
Description:Nik related kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X109,940,360 - 109,940,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566163 AgrOrtholog
BioCyc Gene G2FUF-1572 BioCyc
Ensembl Genes ENSRNOG00000008880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057049 ENTREZGENE
  ENSRNOT00000057049.4 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Citron UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:315907 UniProtKB/TrEMBL
NCBI Gene 315907 ENTREZGENE
PANTHER MISSHAPEN LIKE KINASE 1 UniProtKB/TrEMBL
  NIK-RELATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Nrk PhenoGen
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008880 RatGTEx
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt F1LZB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Nrk  Nik related kinase   Nrk_predicted  Nik related kinase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Nrk_predicted  Nik related kinase (predicted)  RGD1566163_predicted  similar to Nck-interacting kinase-like embryo specific kinase (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1566163_predicted  similar to Nck-interacting kinase-like embryo specific kinase (predicted)  LOC315907  similar to Nck-interacting kinase-like embryo specific kinase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315907  similar to Nck-interacting kinase-like embryo specific kinase      Symbol and Name status set to provisional 70820 PROVISIONAL