NRK (Nik related kinase) - Rat Genome Database

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Gene: NRK (Nik related kinase) Canis lupus familiaris
Analyze
Symbol: NRK
Name: Nik related kinase
RGD ID: 12155352
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); parturition (ortholog); positive regulation of JNK cascade (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nik-related protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X79,341,449 - 79,488,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX79,341,412 - 79,485,661 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX80,973,793 - 81,117,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X79,341,449 - 79,488,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX79,341,412 - 79,485,661 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX80,973,793 - 81,117,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBIUU_Cfam_GSD_1.0
NRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X105,821,786 - 105,958,610 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX105,822,539 - 105,958,610 (+)EnsemblGRCh38hg38GRCh38
GRCh37X105,066,532 - 105,202,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X104,953,192 - 105,089,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X104,872,680 - 105,008,744NCBI
CeleraX105,541,018 - 105,677,081 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX94,691,867 - 94,829,421 (+)NCBIHuRef
CHM1_1X104,977,838 - 105,113,888 (+)NCBICHM1_1
T2T-CHM13v2.0X104,253,759 - 104,390,422 (+)NCBIT2T-CHM13v2.0
Nrk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X137,814,980 - 137,911,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX137,815,179 - 137,911,281 (+)EnsemblGRCm39 Ensembl
GRCm38X138,914,231 - 139,010,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX138,914,430 - 139,010,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X135,448,969 - 135,543,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X134,260,869 - 134,354,417 (+)NCBIMGSCv36mm8
CeleraX122,184,305 - 122,278,072 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.15NCBI
Nrk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X107,159,154 - 107,256,417 (+)NCBIGRCr8
mRatBN7.2X102,365,765 - 102,462,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,365,765 - 102,459,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,503,462 - 104,597,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X108,002,202 - 108,095,770 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X105,571,175 - 105,664,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X110,065,199 - 110,089,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0X109,940,439 - 110,036,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX109,940,350 - 110,033,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X109,798,013 - 109,890,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X109,913,500 - 109,944,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,448,334 - 126,541,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX103,155,670 - 103,249,235 (+)NCBICelera
Cytogenetic MapXq32NCBI
Nrk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555482,675,645 - 2,797,548 (+)NCBIChiLan1.0ChiLan1.0
NRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X105,340,811 - 105,477,642 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X105,344,411 - 105,481,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X94,957,923 - 95,094,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X105,337,040 - 105,473,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX105,337,327 - 105,470,331 (+)Ensemblpanpan1.1panPan2
Nrk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X78,909,811 - 79,031,463 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364998,629,563 - 8,747,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX86,534,488 - 86,663,337 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X86,534,467 - 86,663,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X100,896,640 - 101,021,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X93,688,895 - 93,822,776 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX93,689,023 - 93,825,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606518,696,953 - 18,832,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480310,719,694 - 10,861,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NRK
915 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 1
Below cutoff 5 5 21 6 6 6 6 6 11 8 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022415989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022415993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038450546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038450547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038464947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038464948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038523997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038523998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038587977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038587978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038652494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038652495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000028377   ⟹   ENSCAFP00000026391
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX79,341,412 - 79,485,661 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046014   ⟹   ENSCAFP00000039932
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX79,477,960 - 79,485,661 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080994   ⟹   ENSCAFP00000047287
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX79,341,412 - 79,424,893 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845028858   ⟹   ENSCAFP00845022707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX80,973,793 - 81,117,892 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029004   ⟹   ENSCAFP00845022815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX81,110,178 - 81,117,892 (+)Ensembl
RefSeq Acc Id: XM_038450546   ⟹   XP_038306474
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBI
RefSeq Acc Id: XM_038450547   ⟹   XP_038306475
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBI
RefSeq Acc Id: XM_038464947   ⟹   XP_038320875
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBI
RefSeq Acc Id: XM_038464948   ⟹   XP_038320876
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBI
RefSeq Acc Id: XM_038523997   ⟹   XP_038379925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBI
RefSeq Acc Id: XM_038523998   ⟹   XP_038379926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBI
RefSeq Acc Id: XM_038587977   ⟹   XP_038443905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBI
RefSeq Acc Id: XM_038587978   ⟹   XP_038443906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBI
RefSeq Acc Id: XM_038652494   ⟹   XP_038508422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBI
RefSeq Acc Id: XM_038652495   ⟹   XP_038508423
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000026391   ⟸   ENSCAFT00000028377
RefSeq Acc Id: ENSCAFP00000047287   ⟸   ENSCAFT00000080994
RefSeq Acc Id: ENSCAFP00000039932   ⟸   ENSCAFT00000046014
RefSeq Acc Id: XP_038379925   ⟸   XM_038523997
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038379926   ⟸   XM_038523998
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038508422   ⟸   XM_038652494
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038508423   ⟸   XM_038652495
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038306474   ⟸   XM_038450546
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038306475   ⟸   XM_038450547
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TES9 (UniProtKB/TrEMBL),   A0A8I3NZN7 (UniProtKB/TrEMBL),   A0A8C0NE37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038320875   ⟸   XM_038464947
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038320876   ⟸   XM_038464948
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TES9 (UniProtKB/TrEMBL),   A0A8I3NZN7 (UniProtKB/TrEMBL),   A0A8C0NE37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443905   ⟸   XM_038587977
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE37 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443906   ⟸   XM_038587978
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NE37 (UniProtKB/TrEMBL),   A0A8C0TES9 (UniProtKB/TrEMBL),   A0A8I3NZN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022815   ⟸   ENSCAFT00845029004
RefSeq Acc Id: ENSCAFP00845022707   ⟸   ENSCAFT00845028858
Protein Domains
CNH   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017883 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013058 UniProtKB/TrEMBL
  ENSCAFG00040021601 UniProtKB/TrEMBL
  ENSCAFG00845016215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000028377.6 UniProtKB/TrEMBL
  ENSCAFT00000046014.3 UniProtKB/TrEMBL
  ENSCAFT00000080994.2 UniProtKB/TrEMBL
  ENSCAFT00030024356.1 UniProtKB/TrEMBL
  ENSCAFT00040040137.1 UniProtKB/TrEMBL
  ENSCAFT00040040275.1 UniProtKB/TrEMBL
  ENSCAFT00040040298.1 UniProtKB/TrEMBL
  ENSCAFT00845028858 ENTREZGENE
  ENSCAFT00845028858.1 UniProtKB/TrEMBL
  ENSCAFT00845029004.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene NRK ENTREZGENE
PANTHER MISSHAPEN LIKE KINASE 1 UniProtKB/TrEMBL
  NIK-RELATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0NE37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TCL6_CANLF UniProtKB/TrEMBL
  A0A8C0TES9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TFP7_CANLF UniProtKB/TrEMBL
  A0A8I3NZN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P4H4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0T079 UniProtKB/TrEMBL
VGNC ID VGNC:43971 ENTREZGENE