NRK (Nik related kinase) - Rat Genome Database

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Gene: NRK (Nik related kinase) Chlorocebus sabaeus
Analyze
Symbol: NRK
Name: Nik related kinase
RGD ID: 18467915
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); parturition (ortholog); positive regulation of JNK cascade (ortholog); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nik-related protein kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X93,688,895 - 93,822,776 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX93,689,023 - 93,825,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606518,696,953 - 18,832,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X93,688,895 - 93,822,776 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX93,689,023 - 93,825,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606518,696,953 - 18,832,336 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X105,821,786 - 105,958,610 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX105,822,539 - 105,958,610 (+)EnsemblGRCh38hg38GRCh38
GRCh37X105,066,532 - 105,202,602 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X104,953,192 - 105,089,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X104,872,680 - 105,008,744NCBI
CeleraX105,541,018 - 105,677,081 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX94,691,867 - 94,829,421 (+)NCBIHuRef
CHM1_1X104,977,838 - 105,113,888 (+)NCBICHM1_1
T2T-CHM13v2.0X104,253,759 - 104,390,422 (+)NCBIT2T-CHM13v2.0
Nrk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X137,814,980 - 137,911,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX137,815,179 - 137,911,281 (+)EnsemblGRCm39 Ensembl
GRCm38X138,914,231 - 139,010,532 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX138,914,430 - 139,010,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X135,448,969 - 135,543,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X134,260,869 - 134,354,417 (+)NCBIMGSCv36mm8
CeleraX122,184,305 - 122,278,072 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.15NCBI
Nrk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X107,159,154 - 107,256,417 (+)NCBIGRCr8
mRatBN7.2X102,365,765 - 102,462,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX102,365,765 - 102,459,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX104,503,462 - 104,597,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X108,002,202 - 108,095,770 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X105,571,175 - 105,664,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X110,065,199 - 110,089,124 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0X109,940,439 - 110,036,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX109,940,350 - 110,033,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X109,798,013 - 109,890,635 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X109,913,500 - 109,944,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X126,448,334 - 126,541,575 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX103,155,670 - 103,249,235 (+)NCBICelera
Cytogenetic MapXq32NCBI
Nrk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555482,675,645 - 2,797,548 (+)NCBIChiLan1.0ChiLan1.0
NRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X105,340,811 - 105,477,642 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X105,344,411 - 105,481,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X94,957,923 - 95,094,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X105,337,040 - 105,473,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX105,337,327 - 105,470,331 (+)Ensemblpanpan1.1panPan2
NRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X79,341,449 - 79,488,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX79,341,412 - 79,485,661 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX65,486,392 - 65,633,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X80,973,839 - 81,118,252 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX80,973,793 - 81,117,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X78,456,281 - 78,603,092 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X80,152,102 - 80,292,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X79,935,837 - 80,082,696 (+)NCBIUU_Cfam_GSD_1.0
Nrk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X78,909,811 - 79,031,463 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364998,629,563 - 8,747,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX86,534,488 - 86,663,337 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X86,534,467 - 86,663,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X100,896,640 - 101,021,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nrk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480310,719,694 - 10,861,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 19 4
Low 17 9 16
Below cutoff 9 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007370   ⟹   ENSCSAP00000005553
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 EnsemblX93,689,023 - 93,825,346 (+)Ensembl
RefSeq Acc Id: XM_007992456   ⟹   XP_007990647
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X93,688,895 - 93,822,776 (+)NCBI
Vero_WHO_p1.0NW_02366606518,696,954 - 18,832,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007992458   ⟹   XP_007990649
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X93,689,084 - 93,822,776 (+)NCBI
Vero_WHO_p1.0NW_02366606518,696,956 - 18,832,336 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037988986   ⟹   XP_037844914
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606518,696,956 - 18,830,528 (+)NCBI
RefSeq Acc Id: XM_037988987   ⟹   XP_037844915
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606518,696,955 - 18,830,528 (+)NCBI
RefSeq Acc Id: XM_037988988   ⟹   XP_037844916
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606518,696,953 - 18,820,747 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007990647   ⟸   XM_007992456
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007990649   ⟸   XM_007992458
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000005553   ⟸   ENSCSAT00000007370
RefSeq Acc Id: XP_037844916   ⟸   XM_037988988
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037844915   ⟸   XM_037988987
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037844914   ⟸   XM_037988986
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RAB4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007370.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CNH_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene NRK ENTREZGENE
PANTHER MISSHAPEN LIKE KINASE 1 UniProtKB/TrEMBL
  NIK-RELATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam CNH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CNH UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART CNH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RAB4 ENTREZGENE, UniProtKB/TrEMBL