Mettl4 (methyltransferase 4, N6-adenosine)

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Gene: Mettl4 (methyltransferase 4, N6-adenosine) Rattus norvegicus

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Symbol:

Mettl4

Name:

methyltransferase 4, N6-adenosine

RGD ID:

1306451

Description:

Predicted to enable RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Predicted to be involved in RNA modification; regulation of gene expression; and regulation of mitochondrial DNA replication. Predicted to be located in mitochondrial matrix. Predicted to be part of RNA N6-methyladenosine methyltransferase complex and oxidoreductase complex. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine); INTERACTS WITH amphetamine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC316731; methyltransferase like 4; methyltransferase-like protein 4; N(6)-adenine-specific methyltransferase METTL4; RGD1306451; similar to hypothetical protein FLJ23017

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,887,740 - 118,967,433 (+)	NCBI		GRCr8
mRatBN7.2	9	111,440,976 - 111,523,871 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	111,441,027 - 111,464,749 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	119,844,679 - 119,866,565 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,973,930 - 124,995,816 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	123,310,491 - 123,332,377 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,871,519 - 119,953,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,873,170 - 119,897,268 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	119,324,922 - 119,373,475 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,736,288 - 110,766,258 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,945,767 - 110,975,115 (+)	NCBI
Celera	9	108,569,553 - 108,589,384 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

aflatoxin B1 (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

butanal (ISO)

carbon nanotube (ISO)

cobalt atom (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

gentamycin (EXP)

lead diacetate (ISO)

leflunomide (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium chromate (ISO)

sevoflurane (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

testosterone enanthate (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

mRNA modification (IBA)

negative regulation of gene expression, epigenetic (ISO)

regulation of mitochondrial DNA replication (ISO)

regulation of mitochondrial transcription (ISO)

regulation of RNA splicing (ISO)

snRNA (adenine-N6)-methylation (ISO)

Cellular Component

cytosol (IBA,ISO)

mitochondrial matrix (ISO)

nucleus (IBA,ISO)

oxidoreductase complex (ISO)

RNA N6-methyladenosine methyltransferase complex (IBA,ISO)

Molecular Function

nucleic acid binding (IEA)

RNA methyltransferase activity (IBA,ISO)

site-specific DNA-methyltransferase (adenine-specific) activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:30982744	PMID:31913360	PMID:33992834

Genomics

Comparative Map Data

Mettl4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,887,740 - 118,967,433 (+)	NCBI		GRCr8
mRatBN7.2	9	111,440,976 - 111,523,871 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	111,441,027 - 111,464,749 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	119,844,679 - 119,866,565 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,973,930 - 124,995,816 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	123,310,491 - 123,332,377 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,871,519 - 119,953,248 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,873,170 - 119,897,268 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	119,324,922 - 119,373,475 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,736,288 - 110,766,258 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,945,767 - 110,975,115 (+)	NCBI
Celera	9	108,569,553 - 108,589,384 (+)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

METTL4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	2,537,530 - 2,571,505 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	2,537,525 - 2,571,509 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	2,537,529 - 2,571,504 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	2,527,524 - 2,561,489 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	2,527,529 - 2,561,470	NCBI
Celera	18	2,412,830 - 2,446,793 (-)	NCBI		Celera
Cytogenetic Map	18	p11.32	NCBI
HuRef	18	2,499,255 - 2,532,978 (-)	NCBI		HuRef
CHM1_1	18	2,536,901 - 2,570,862 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	2,693,282 - 2,727,252 (-)	NCBI		T2T-CHM13v2.0

Mettl4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	95,030,018 - 95,057,579 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	95,030,018 - 95,057,447 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	94,722,590 - 94,750,214 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	94,722,590 - 94,750,019 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	95,126,420 - 95,149,232 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	95,031,189 - 95,054,001 (-)	NCBI		MGSCv36	mm8
Celera	17	99,126,838 - 99,149,657 (-)	NCBI		Celera
Cytogenetic Map	17	E5	NCBI
cM Map	17	61.17	NCBI

Mettl4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	7,732,627 - 7,763,038 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	7,733,220 - 7,762,756 (+)	NCBI	ChiLan1.0	ChiLan1.0

METTL4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,874,434 - 35,908,314 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	21,567,026 - 21,600,906 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	11,711,502 - 11,745,222 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	14,018,279 - 14,051,974 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	14,018,279 - 14,051,974 (+)	Ensembl	panpan1.1		panPan2

METTL4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,229,717 - 69,268,223 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	69,191,223 - 69,267,683 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	68,665,874 - 68,723,331 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,272,450 - 69,330,069 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,291,648 - 69,329,591 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	68,955,089 - 69,012,718 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	68,975,650 - 69,032,839 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,272,402 - 69,330,056 (-)	NCBI		UU_Cfam_GSD_1.0

Mettl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	65,601,744 - 65,630,845 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,910,851 - 1,941,520 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936672	1,911,109 - 1,940,897 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	104,055,814 - 104,078,381 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	104,055,813 - 104,384,416 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

METTL4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	61,767,806 - 61,834,994 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	61,799,324 - 61,834,973 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	36,653,215 - 36,694,906 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mettl4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	12,905,100 - 12,938,189 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	12,905,138 - 12,937,859 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mettl4
457 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	245
Count of miRNA genes:	150
Interacting mature miRNAs:	171
Transcripts:	ENSRNOT00000037587
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat

Markers in Region

RH142477

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	111,452,853 - 111,453,144 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	119,883,389 - 119,883,678	NCBI	Rnor6.0
Rnor_5.0	9	119,336,803 - 119,337,092	UniSTS	Rnor5.0
RGSC_v3.4	9	110,746,136 - 110,746,425	UniSTS	RGSC3.4
Celera	9	108,579,401 - 108,579,690	UniSTS
RH 3.4 Map	9	867.0	UniSTS
Cytogenetic Map	9	q38	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001839664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010054608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010054609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037587 ⟹ ENSRNOP00000029385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	111,442,631 - 111,464,749 (+)	Ensembl
Rnor_6.0 Ensembl	9	119,873,170 - 119,897,268 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115048 ⟹ ENSRNOP00000092806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	111,441,027 - 111,464,749 (+)	Ensembl

RefSeq Acc Id:

NM_001191814 ⟹ NP_001178743

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,889,613 - 118,911,473 (+)	NCBI
mRatBN7.2	9	111,443,005 - 111,464,867 (+)	NCBI
Rnor_6.0	9	119,873,541 - 119,896,104 (+)	NCBI
Rnor_5.0	9	119,324,922 - 119,373,475 (+)	NCBI
Celera	9	108,569,553 - 108,589,384 (+)	NCBI

Sequence:

show sequence

ATGTCCGTGGTGCATCATTTGCCACCTGGATGGTTACTGGATCATCTTTCTTTCATTAACAAAG
TCAACTATCAACTTTGCCAGCATCAAGAGCCTTTTTGTAGCAAAAACAAGCCCACTTCTTCTGT
CTACTTGGATTCTCTTCAGCCAGATCCCGTGTCTCCTTTTGGAACTCCTGCTCCGTGCTTTGCT
CCTGACGCCACTACTGTGTTAGACAAGGAGGATGGTGGAAGTTGTGAAGTGATCACCCAAAAAT
ATGTTTTTCGGTCCGAACTATTTAATGTCACCAAACCTTACATAACTCCAGCCGTTCACAAAAA
GGACCAACAAAGTAAGAAAGATGAAAATCTAGTGACCGGTGAAAAACAAGAGGTCTCTGTTTCT
GTTGGGAAGAAACGTAAAAGATGCGTTGCTTTCAATCGAGGTGAATTGGATGCTATGGAATATC
ATACAAAGATCAGAGAGCTGATTTTGGATGGATCTTCTCAGTTAATCCAAGAAGGTCTCAGAAG
TGGTTTCCTTTTCCCACTTGTTGAAAAACATGATGGCAGTAGTGGACGCATCACTTTACCGCTT
GATGCCTGCAATTTGTCAGAGTTATGCGAGATGGCAAAGCATTTGCCTTCCTTGAATGACATGG
AGCTTCAAACGCTACAGTTGATGGGAGATGATGTGTTTGTTACAGAGCTGGACTTATCTTCACG
GATCATTGAAAACAACTCTAGCTTTTCCAAAATGATCACTTTAATGGGACAGAGATATCTGCTG
CCACCAAAAAGCAGCTTTCTTTTGTCTGACATTTCTTGTATGCAGCCACTTCTTAACTGTAATA
AGACATTCGATGTGATTGTGATTGATCCACCATGGGAGAACAAATCGGTTAAAAGAAGTAACAG
GTACAATAGTTTATCCCCACAGCAGATAAAGAGAATGCCTGTCCCTAAGCTGGCTGCTCCTGAC
TGTCTTGTCGTTACTTGGGTGACCAACAGGCAGAAGCATCTGTGCTTTGTGAAGGAGGAACTGT
ACCCTTCATGGTCTGTGGAAGTCATTGCAGAGTGGTACTGGGTAAAAATCACAAATTCAGGGGA
GTTTGTGTTCCCATTGGATTCTCTACACAAAAAGCCTTATGAATGTCTTGTTCTGGGGAGAGTT
AAAGAAAAAACTGCTTTAGCATTAAGGAATGAAGCTGTAAGAACGCCCCCGGTTCCAGATCAGA
GGTTGATCGTCAGTGTGCCCTGTGCTCTGCACTCACACAAGCCGCCTCTCGCCGAAGTTCTGAA
AGACTACATCAAGCCAGGTGGCCAGTGTTTGGAATTGTTTGCTCGAAATTTACAGCCAGGTTGG
ATGAGTTGGGGCAACGAAGTCCTCAAGTTTCAGCACATGGATTATTTCATTGCTCTGGAGTCTG
GACAGTGACTGAAAAGGTGTGCTGCCTTTACCCCAGCTCGTTTCTCTGAACTCATTTCCCCTTG
TACCAGGCAGTGTGTTAGACGTATGAACTTTTATAGCAATCAGTGTGCGTAGAAATGTATATAC
GTCCCCCACAGCCCTTTGCAGTGAGTCTCTCCCTTCGCTCCCTGATCTCTGGCAAACAGTGGTT
TGTTTTCTCACGTTAGTGTTAGTGTTTCCTGTTTAGAAACCTCTGGATGTGGAGCCATGTGGTG
CAGAAACCCTTGAGTCTGGCTCCTTCCACTTAGTATTCAGGAAAACCACTAGCACCATTTATAA
GCCGCTCCCTGCGTACTTAGGAGATGGTTAGACTGAAAGCACTTGGACAAGCTCACTTCACCTA
CTCACTTTTTCACCAGACATTAATTCTGAGGTTTGTTCATCTTTTGAGGGCGTAAGGCTAATGC
CTTTTATTATTACTTTAAACTGCCAGTTGAATACACGACTCATTGAATTATTAAGTATATTCCT
TTAAGCTTTCTATGGAGTTTTCCTGTCTAAATTTTTTTTGTTCGTTTGTTTCCGTGCACCGGAT
ATCCTGACCCACACCTGACTTTCTGCCTTAAAAATAAAACCAAGGCCACACCTCA

hide sequence

RefSeq Acc Id:

XM_006245658 ⟹ XP_006245720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,924,629 (+)	NCBI
mRatBN7.2	9	111,440,984 - 111,464,867 (+)	NCBI
Rnor_6.0	9	119,871,521 - 119,896,104 (+)	NCBI
Rnor_5.0	9	119,324,922 - 119,373,475 (+)	NCBI

Sequence:

show sequence

CGTCCGCGCTGTGACGCGCTCAGGACCCCGTGCGGGTCGTCCTCCGGGACCGTGACCGGAGGGG
AATCTTGCCCTTTTTGGGGAGCTGGCGTCTAGGACGAGTAGCGAGCGCCACGGGGCCGAGCGGC
CCGAGTCCTCCTGGAGTCGGGTTCCGTACAGCAATATGGCTGCGCCCTGGAACTAGGGAAGCAA
GGGTTTGCTTCCGAAAAGATGGCGGCCAGGACCAGTTTTATATGAGTGCTGTTTCCACGGGGCG
AGCCTAGGAGGCGGCGTGAGGTGTCCTAACGGACACTCACCTTTTAAGGAGTTAGTGACTTGAA
TACTTGGACGATGTGGACTAGTGCTTTGATTCAAGGACCAAAACAGGACCACAGAGGACCAAAG
AAAGGATCAAACTGAAACTCGTCTTTGGCTAAGTTGGCTGAAAATTTTTAATGACCAATTCTGA
AATTAAGTGACATTTAAAGTTCTTCATTTTTGCCCCTTAGGGGTGGCATGTATATTTAGATATA
AAACCTACTGTGGGCACAAAGCACATCATCGAGATACAGGACATTGAGAACGTAATTACAACAT
TGGGTATCAAACCCAGAACTCCCATACCGAGCACTCCCAGCCCTTGTTCTGATTCTTGATTATC
AGACCCCTCCCCCACCCAGAATGTCCGTGGTGCATCATTTGCCACCTGGATGGTTACTGGATCA
TCTTTCTTTCATTAACAAAGTCAACTATCAACTTTGCCAGCATCAAGAGCCTTTTTGTAGCAAA
AACAAGCCCACTTCTTCTGTCTACTTGGATTCTCTTCAGCCAGATCCCGTGTCTCCTTTTGGAA
CTCCTGCTCCGTGCTTTGCTCCTGACGCCACTACTGTGTTAGACAAGGAGGATGGTGGAAGTTG
TGAAGTGATCACCCAAAAATATGTTTTTCGGTCCGAACTATTTAATGTCACCAAACCTTACATA
ACTCCAGCCGTTCACAAAAAGGACCAACAAAGTAAGAAAGATGAAAATCTAGTGACCGGTGAAA
AACAAGAGGTCTCTGTTTCTGTTGGGAAGAAACGTAAAAGATGCGTTGCTTTCAATCGAGGTGA
ATTGGATGCTATGGAATATCATACAAAGATCAGAGAGCTGATTTTGGATGGATCTTCTCAGTTA
ATCCAAGAAGGTCTCAGAAGTGGTTTCCTTTTCCCACTTGTTGAAAAACATGATGGCAGTAGTG
GACGCATCACTTTACCGCTTGATGCCTGCAATTTGTCAGAGTTATGCGAGATGGCAAAGCATTT
GCCTTCCTTGAATGACATGGAGCTTCAAACGCTACAGTTGATGGGAGATGATGTGTTTGTTACA
GAGCTGGACTTATCTTCACGGATCATTGAAAACAACTCTAGCTTTTCCAAAATGATCACTTTAA
TGGGACAGAGATATCTGCTGCCACCAAAAAGCAGCTTTCTTTTGTCTGACATTTCTTGTATGCA
GCCACTTCTTAACTGTAGTAAGACATTCGATGTGATTGTGATTGATCCACCATGGGAGAACAAA
TCGGTTAAAAGAAGTAACAGGTACAATAGTTTATCCCCACAGCAGATAAAGAGAATGCCTGTCC
CTAAGCTGGCTGCTCCTGACTGTCTTGTCGTTACTTGGGTGACCAACAGGCAGAAGCATCTGTG
CTTTGTGAAGGAGGAACTGTACCCTTCATGGTCTGTGGAAGTCATTGCAGAGTGGTACTGGGTA
AAAATCACAAATTCAGGGGAGTTTGTGTTCCCATTGGATTCTCTACACAAAAAGCCTTATGAAT
GTCTTGTTCTGGGGAGAGTTAAAGAAAAAACTGCTTTAGCATTAAGGAATGAAGCTGTAAGAAC
GCCCCCGGTTCCAGATCAGAGGTTGATCGTCAGTGTGCCCTGTGCTCTGCACTCACACAAGCCG
CCTCTCGCCGAAGTTCTGAAAGACTACATCAAGCCAGGTGGCCAGTGTTTGGAATTGTTTGCTC
GAAATTTACAGCCAGGTTGGATGAGTTGGGGCAACGAAGTCCTCAAGTTTCAGCACATGGATTA
TTTCATTGCTCTGGAGTCTGGACAGTGACTGAAAAGGTGTGCTGCCTTTACCCCAGCTCGTTTC
TCTGAACTCATTTCCCCTTGTACCAGGCAGTGTGTTAGACGTATGAACTTTTATAGCAATCAGT
GTGCGTAGAAATGTATATACGTCCCCCACAGCCCTTTGCAGTGAGTCTCTCCCTTCGCTCCCTG
ATCTCTGGCAAACAGTGGTTTGTTTTCTCACGTTAGTGTTAGTGTTTCCTGTTTAGAAACCTCT
GGATGTGGAGCCATGTGGTGCAGAAACCCTTGAGTCTGGCTCCTTCCACTTAGTATTCAGGAAA
ACCACTAGCACCATTTATAAGCCGCTCCCTGCGTACTTAGGAGATGGTTAGACTGAAAGCACTT
GGACAAGCTCACTTCACCTACTCACTTTTTCACCAGACATTAATTCTGAGGTTTGTTCATCTTT
TGAGGGCGTAAGGCTAATGCCTTTTATTATTACTTTAAACTGCCAGTTGAATACACGACTCATT
GAATTATTAAGTATATTCCTTTAAGCTTTCTATGGAGTTTTCCTGTCTAAATTTTTTTTGTTCG
TTTGTTTCCGTGCACCGGATATCCTGACCCACACCTGACTTTCTGCCTTAAAAATAAAACCAAG
GCCACACCTCA

hide sequence

RefSeq Acc Id:

XM_039083791 ⟹ XP_038939719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,890,021 - 118,924,629 (+)	NCBI
mRatBN7.2	9	111,443,417 - 111,464,867 (+)	NCBI

RefSeq Acc Id:

XM_039083792 ⟹ XP_038939720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,741 - 118,924,629 (+)	NCBI
mRatBN7.2	9	111,440,984 - 111,464,867 (+)	NCBI

RefSeq Acc Id:

XM_063267334 ⟹ XP_063123404

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,935,006 (+)	NCBI

RefSeq Acc Id:

XM_063267335 ⟹ XP_063123405

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,967,433 (+)	NCBI

RefSeq Acc Id:

XM_063267336 ⟹ XP_063123406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,910,829 (+)	NCBI

RefSeq Acc Id:

XM_063267337 ⟹ XP_063123407

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,901,970 (+)	NCBI

RefSeq Acc Id:

XR_010054608

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,967,433 (+)	NCBI

RefSeq Acc Id:

XR_010054609

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	118,887,740 - 118,910,750 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001178743	(Get FASTA)	NCBI Sequence Viewer
	XP_006245720	(Get FASTA)	NCBI Sequence Viewer
	XP_038939719	(Get FASTA)	NCBI Sequence Viewer
	XP_038939720	(Get FASTA)	NCBI Sequence Viewer
	XP_063123404	(Get FASTA)	NCBI Sequence Viewer
	XP_063123405	(Get FASTA)	NCBI Sequence Viewer
	XP_063123406	(Get FASTA)	NCBI Sequence Viewer
	XP_063123407	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90960	(Get FASTA)	NCBI Sequence Viewer
	EDL90961	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029385.4
	ENSRNOP00000092806.1

RefSeq Acc Id:

NP_001178743 ⟸ NM_001191814

- Sequence:

show sequence

MSVVHHLPPGWLLDHLSFINKVNYQLCQHQEPFCSKNKPTSSVYLDSLQPDPVSPFGTPAPCFA
PDATTVLDKEDGGSCEVITQKYVFRSELFNVTKPYITPAVHKKDQQSKKDENLVTGEKQEVSVS
VGKKRKRCVAFNRGELDAMEYHTKIRELILDGSSQLIQEGLRSGFLFPLVEKHDGSSGRITLPL
DACNLSELCEMAKHLPSLNDMELQTLQLMGDDVFVTELDLSSRIIENNSSFSKMITLMGQRYLL
PPKSSFLLSDISCMQPLLNCNKTFDVIVIDPPWENKSVKRSNRYNSLSPQQIKRMPVPKLAAPD
CLVVTWVTNRQKHLCFVKEELYPSWSVEVIAEWYWVKITNSGEFVFPLDSLHKKPYECLVLGRV
KEKTALALRNEAVRTPPVPDQRLIVSVPCALHSHKPPLAEVLKDYIKPGGQCLELFARNLQPGW
MSWGNEVLKFQHMDYFIALESGQ

hide sequence

RefSeq Acc Id:	XP_006245720 ⟸ XM_006245658
- Peptide Label:	isoform X1
- UniProtKB:	D3ZD59 (UniProtKB/TrEMBL), A0A8I6AHA3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSVVHHLPPGWLLDHLSFINKVNYQLCQHQEPFCSKNKPTSSVYLDSLQPDPVSPFGTPAPCFA PDATTVLDKEDGGSCEVITQKYVFRSELFNVTKPYITPAVHKKDQQSKKDENLVTGEKQEVSVS VGKKRKRCVAFNRGELDAMEYHTKIRELILDGSSQLIQEGLRSGFLFPLVEKHDGSSGRITLPL DACNLSELCEMAKHLPSLNDMELQTLQLMGDDVFVTELDLSSRIIENNSSFSKMITLMGQRYLL PPKSSFLLSDISCMQPLLNCSKTFDVIVIDPPWENKSVKRSNRYNSLSPQQIKRMPVPKLAAPD CLVVTWVTNRQKHLCFVKEELYPSWSVEVIAEWYWVKITNSGEFVFPLDSLHKKPYECLVLGRV KEKTALALRNEAVRTPPVPDQRLIVSVPCALHSHKPPLAEVLKDYIKPGGQCLELFARNLQPGW MSWGNEVLKFQHMDYFIALESGQ hide sequence

Ensembl Acc Id:

ENSRNOP00000029385 ⟸ ENSRNOT00000037587

RefSeq Acc Id:	XP_038939720 ⟸ XM_039083792
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038939719 ⟸ XM_039083791
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000092806 ⟸ ENSRNOT00000115048

RefSeq Acc Id:	XP_063123405 ⟸ XM_063267335
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AHA3 (UniProtKB/TrEMBL), D3ZD59 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123404 ⟸ XM_063267334
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AHA3 (UniProtKB/TrEMBL), D3ZD59 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123406 ⟸ XM_063267336
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AHA3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123407 ⟸ XM_063267337
- Peptide Label:	isoform X3
- UniProtKB:	A6KFA8 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZD59-F1-model_v2	AlphaFold	D3ZD59	1-471	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306451	AgrOrtholog
BioCyc Gene	G2FUF-26324	BioCyc
Ensembl Genes	ENSRNOG00000026280	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037587.6	UniProtKB/TrEMBL
	ENSRNOT00000115048.1	UniProtKB/TrEMBL
InterPro	DNA_methylase_N6_adenine_CS	UniProtKB/TrEMBL
	MT-A70	UniProtKB/TrEMBL
	SAM-dependent_MTases-like	UniProtKB/TrEMBL
NCBI Gene	316731	ENTREZGENE
PANTHER	N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4	UniProtKB/TrEMBL
	N6-ADENOSINE-METHYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	MT-A70	UniProtKB/TrEMBL
PhenoGen	Mettl4	PhenoGen
PROSITE	MT_A70	UniProtKB/TrEMBL
	N6_MTASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026280	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A8I6AHA3	ENTREZGENE, UniProtKB/TrEMBL
	A6KFA8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZD59	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-17	Mettl4	methyltransferase 4, N6-adenosine	Mettl4	methyltransferase like 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Mettl4	methyltransferase like 4	RGD1306451_predicted	similar to hypothetical protein FLJ23017 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1306451_predicted	similar to hypothetical protein FLJ23017 (predicted)	LOC316731_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC316731_predicted	similar to hypothetical protein FLJ23017 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar