Agmo (alkylglycerol monooxygenase) - Rat Genome Database

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Gene: Agmo (alkylglycerol monooxygenase) Rattus norvegicus
Analyze
Symbol: Agmo
Name: alkylglycerol monooxygenase
RGD ID: 1312038
Description: Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process; membrane lipid metabolic process; and triglyceride biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AGMO (alkylglycerol monooxygenase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362732; RGD1312038; similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884) ; Tmem195; transmembrane protein 195
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8659,713,495 - 60,044,851 (+)NCBIGRCr8
mRatBN7.2653,986,236 - 54,317,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl653,986,292 - 54,317,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx654,286,337 - 54,629,952 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0654,601,226 - 54,944,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0654,073,814 - 54,404,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0656,846,859 - 57,193,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl656,846,789 - 57,193,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0666,448,763 - 66,793,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4656,042,873 - 56,380,045 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1656,045,999 - 56,382,545 (+)NCBI
Celera653,118,342 - 53,442,669 (+)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:20643956  


Genomics

Comparative Map Data
Agmo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8659,713,495 - 60,044,851 (+)NCBIGRCr8
mRatBN7.2653,986,236 - 54,317,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl653,986,292 - 54,317,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx654,286,337 - 54,629,952 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0654,601,226 - 54,944,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0654,073,814 - 54,404,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0656,846,859 - 57,193,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl656,846,789 - 57,193,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0666,448,763 - 66,793,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4656,042,873 - 56,380,045 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1656,045,999 - 56,382,545 (+)NCBI
Celera653,118,342 - 53,442,669 (+)NCBICelera
Cytogenetic Map6q21NCBI
AGMO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38715,117,223 - 15,562,015 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl715,200,317 - 15,562,015 (-)EnsemblGRCh38hg38GRCh38
GRCh37715,239,942 - 15,601,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36715,206,468 - 15,568,165 (-)NCBINCBI36Build 36hg18NCBI36
Celera715,219,639 - 15,581,346 (-)NCBICelera
Cytogenetic Map7p21.2NCBI
HuRef715,123,252 - 15,486,473 (-)NCBIHuRef
CHM1_1715,239,321 - 15,601,040 (-)NCBICHM1_1
T2T-CHM13v2.0715,250,047 - 15,695,255 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2715,291,248 - 15,654,751 (-)NCBI
Agmo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,291,638 - 37,632,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,291,640 - 37,632,201 (+)EnsemblGRCm39 Ensembl
GRCm381237,241,639 - 37,581,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,241,641 - 37,582,202 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,968,226 - 38,308,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361237,752,045 - 37,914,494 (+)NCBIMGSCv36mm8
Celera1238,679,380 - 39,021,590 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.84NCBI
Agmo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541018,713,191 - 18,881,824 (-)NCBIChiLan1.0ChiLan1.0
AGMO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2620,032,513 - 20,444,733 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1768,357,236 - 68,769,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0715,863,957 - 16,219,070 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1715,194,384 - 15,549,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl715,180,426 - 15,549,016 (-)Ensemblpanpan1.1panPan2
AGMO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11429,863,011 - 30,208,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1429,864,318 - 30,324,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1429,386,911 - 29,730,252 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01429,779,813 - 30,123,841 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1429,778,469 - 30,123,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11429,875,816 - 30,219,301 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01429,602,388 - 29,946,221 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01429,912,164 - 30,256,735 (-)NCBIUU_Cfam_GSD_1.0
Agmo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511874,180,126 - 74,504,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365461,855,801 - 2,179,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365461,993,477 - 2,179,623 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGMO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl984,551,889 - 84,894,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1984,551,874 - 84,931,146 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2993,083,980 - 93,427,801 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGMO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12142,525,086 - 42,877,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2142,525,847 - 42,876,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604261,619,472 - 61,972,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agmo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473914,587,427 - 14,775,057 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agmo
2427 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:55
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000032108
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

Markers in Region
RH132346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2654,317,393 - 54,317,586 (+)MAPPERmRatBN7.2
Rnor_6.0657,193,682 - 57,193,874NCBIRnor6.0
Rnor_5.0666,792,930 - 66,793,122UniSTSRnor5.0
RGSC_v3.4656,379,809 - 56,380,001UniSTSRGSC3.4
Celera653,442,433 - 53,442,625UniSTS
RH 3.4 Map6383.5UniSTS
Cytogenetic Map6q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 23 2 23 8
Low 1 11 25 12 14 12 8 9 39 9 11 11 8
Below cutoff 10 6 6 3 6 2 15 20 16

Sequence


RefSeq Acc Id: ENSRNOT00000032108   ⟹   ENSRNOP00000029816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl653,986,292 - 54,317,623 (+)Ensembl
Rnor_6.0 Ensembl656,846,789 - 57,193,961 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107905   ⟹   ENSRNOP00000082715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl653,986,292 - 53,989,000 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108556   ⟹   ENSRNOP00000090360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl653,986,292 - 54,172,076 (+)Ensembl
RefSeq Acc Id: NM_001135899   ⟹   NP_001129371
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8659,713,589 - 60,044,851 (+)NCBI
mRatBN7.2653,986,348 - 54,317,630 (+)NCBI
Rnor_6.0656,846,859 - 57,193,918 (+)NCBI
Rnor_5.0666,448,763 - 66,793,166 (+)NCBI
RGSC_v3.4656,042,873 - 56,380,045 (+)RGD
Celera653,118,342 - 53,442,669 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112499   ⟹   XP_038968427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8659,713,495 - 60,044,524 (+)NCBI
mRatBN7.2653,986,236 - 54,317,838 (+)NCBI
RefSeq Acc Id: NP_001129371   ⟸   NM_001135899
- UniProtKB: A0JPQ8 (UniProtKB/Swiss-Prot),   A0A8I6GIU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029816   ⟸   ENSRNOT00000032108
RefSeq Acc Id: XP_038968427   ⟸   XM_039112499
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GIU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082715   ⟸   ENSRNOT00000107905
RefSeq Acc Id: ENSRNOP00000090360   ⟸   ENSRNOT00000108556
Protein Domains
Fatty acid hydroxylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0JPQ8-F1-model_v2 AlphaFold A0JPQ8 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694565
Promoter ID:EPDNEW_R5090
Type:initiation region
Name:Agmo_1
Description:alkylglycerol monooxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0656,846,841 - 56,846,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312038 AgrOrtholog
BioCyc Gene G2FUF-37780 BioCyc
Ensembl Genes ENSRNOG00000023116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032108 ENTREZGENE
  ENSRNOT00000032108.6 UniProtKB/Swiss-Prot
  ENSRNOT00000107905.1 UniProtKB/TrEMBL
  ENSRNOT00000108556.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321962 IMAGE-MGC_LOAD
InterPro Fatty_acid_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362732 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156828 IMAGE-MGC_LOAD
NCBI Gene 362732 ENTREZGENE
PANTHER ALKYLGLYCEROL MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROL DESATURASE-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Agmo PhenoGen
RatGTEx ENSRNOG00000023116 RatGTEx
UniProt A0A8I6G9U4_RAT UniProtKB/TrEMBL
  A0A8I6GIU1 ENTREZGENE, UniProtKB/TrEMBL
  A0JPQ8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Agmo  alkylglycerol monooxygenase  Tmem195  transmembrane protein 195  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-01 Tmem195  transmembrane protein 195  RGD1312038  similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1312038  similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884)   RGD1312038_predicted  similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1312038_predicted  similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884) (predicted)  LOC362732_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362732_predicted  similar to putative protein, with at least 6 transmembrane domains, of ancient origin (58.5 kD) (3N884) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL