Glrx5 (glutaredoxin 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Glrx5 (glutaredoxin 5) Rattus norvegicus
Analyze
Symbol: Glrx5
Name: glutaredoxin 5
RGD ID: 1308383
Description: Predicted to be involved in [2Fe-2S] cluster assembly; protein maturation by [2Fe-2S] cluster transfer; and protein maturation by [4Fe-4S] cluster transfer. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutaredoxin 5 homolog; glutaredoxin 5 homolog (S. cerevisiae) ; glutaredoxin-related protein 5, mitochondrial; LOC362776; RGD1308383; similar to 2900070E19Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,752,902 - 129,763,278 (+)NCBIGRCr8
mRatBN7.26123,988,461 - 123,998,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,118,169 - 124,128,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,413,421 - 124,423,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,785,337 - 123,795,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,750,503 - 128,760,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,947,583 - 137,957,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,233,209 - 129,243,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,236,842 - 129,245,795 (+)NCBI
Celera6121,459,083 - 121,469,162 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14651853   PMID:18614015   PMID:20364084   PMID:24334290  


Genomics

Comparative Map Data
Glrx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86129,752,902 - 129,763,278 (+)NCBIGRCr8
mRatBN7.26123,988,461 - 123,998,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,118,169 - 124,128,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,413,421 - 124,423,489 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06123,785,337 - 123,795,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06128,750,503 - 128,760,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,947,583 - 137,957,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,233,209 - 129,243,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,236,842 - 129,245,795 (+)NCBI
Celera6121,459,083 - 121,469,162 (+)NCBICelera
Cytogenetic Map6q32NCBI
GLRX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381495,535,050 - 95,544,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,533,503 - 95,544,724 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,001,387 - 96,011,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,071,076 - 95,080,808 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,071,075 - 95,080,808NCBI
Celera1476,057,010 - 76,066,743 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1476,186,979 - 76,196,711 (+)NCBIHuRef
CHM1_11495,939,246 - 95,948,981 (+)NCBICHM1_1
T2T-CHM13v2.01489,765,742 - 89,775,402 (+)NCBIT2T-CHM13v2.0
Glrx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,998,877 - 105,007,170 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,998,947 - 105,009,165 (+)EnsemblGRCm39 Ensembl
GRCm3812105,032,618 - 105,040,911 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,032,688 - 105,042,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,270,899 - 106,279,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,433,739 - 105,441,960 (+)NCBIMGSCv36mm8
Celera12106,265,134 - 106,273,355 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.04NCBI
Glrx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,066,955 - 17,075,789 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,067,017 - 17,076,162 (-)NCBIChiLan1.0ChiLan1.0
GLRX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21596,688,753 - 96,698,490 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11495,905,267 - 95,914,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,162,541 - 76,172,291 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11495,486,818 - 95,496,438 (+)NCBIpanpan1.1PanPan1.1panPan2
GLRX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,383,203 - 64,392,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,383,227 - 64,383,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,961,948 - 63,972,042 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0864,651,949 - 64,662,047 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,652,309 - 64,662,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,326,648 - 64,336,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,385,664 - 64,395,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,710,831 - 64,720,934 (+)NCBIUU_Cfam_GSD_1.0
GLRX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7116,787,432 - 116,800,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17116,787,346 - 116,797,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27124,001,745 - 124,011,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12473,387,941 - 73,398,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2473,387,641 - 73,398,233 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605360,564,346 - 60,574,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glrx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,987,116 - 7,995,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,986,999 - 7,995,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glrx5
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:147
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000005781
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

Markers in Region
RH128046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,996,866 - 123,997,076 (+)MAPPERmRatBN7.2
Rnor_6.06128,759,202 - 128,759,411NCBIRnor6.0
Rnor_5.06137,956,282 - 137,956,491UniSTSRnor5.0
RGSC_v3.46129,241,615 - 129,241,824UniSTSRGSC3.4
Celera6121,467,484 - 121,467,693UniSTS
RH 3.4 Map6820.0UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000005781   ⟹   ENSRNOP00000005781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,988,134 - 123,998,545 (+)Ensembl
Rnor_6.0 Ensembl6128,750,795 - 128,760,880 (+)Ensembl
RefSeq Acc Id: NM_001108722   ⟹   NP_001102192
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,753,194 - 129,763,278 (+)NCBI
mRatBN7.26123,988,461 - 123,998,545 (+)NCBI
Rnor_6.06128,750,795 - 128,760,880 (+)NCBI
Rnor_5.06137,947,583 - 137,957,960 (+)NCBI
RGSC_v3.46129,233,209 - 129,243,293 (+)RGD
Celera6121,459,083 - 121,469,162 (+)RGD
Sequence:
RefSeq Acc Id: XM_063262127   ⟹   XP_063118197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86129,752,902 - 129,762,033 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102192 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81815 (Get FASTA)   NCBI Sequence Viewer  
  EDL81816 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005781.5
RefSeq Acc Id: NP_001102192   ⟸   NM_001108722
- UniProtKB: A6JES1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005781   ⟸   ENSRNOT00000005781
RefSeq Acc Id: XP_063118197   ⟸   XM_063262127
- Peptide Label: isoform X1
Protein Domains
Glutaredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADD7-F1-model_v2 AlphaFold D4ADD7 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694809
Promoter ID:EPDNEW_R5334
Type:multiple initiation site
Name:Glrx5_1
Description:glutaredoxin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06128,750,802 - 128,750,862EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308383 AgrOrtholog
BioCyc Gene G2FUF-36351 BioCyc
Ensembl Genes ENSRNOG00000004206 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005781.6 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutaredoxin UniProtKB/TrEMBL
  GRX_PICOT_like UniProtKB/TrEMBL
  Monothiol_GRX_rel UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:362776 UniProtKB/TrEMBL
NCBI Gene 362776 ENTREZGENE
PANTHER GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL UniProtKB/TrEMBL
  Glutredox-rel UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
PhenoGen Glrx5 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004206 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A6JES1 ENTREZGENE, UniProtKB/TrEMBL
  D4ADD7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-16 Glrx5  glutaredoxin 5  Glrx5  glutaredoxin 5 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Glrx5  glutaredoxin 5 homolog (S. cerevisiae)   Glrx5_predicted  glutaredoxin 5 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Glrx5_predicted  glutaredoxin 5 homolog (S. cerevisiae) (predicted)  RGD1308383_predicted  similar to 2900070E19Rik protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308383_predicted  similar to 2900070E19Rik protein (predicted)  LOC362776_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362776_predicted  similar to 2900070E19Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL