Adam10 (ADAM metallopeptidase domain 10) - Rat Genome Database

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Gene: Adam10 (ADAM metallopeptidase domain 10) Rattus norvegicus
Symbol: Adam10
Name: ADAM metallopeptidase domain 10
RGD ID: 2032
Description: Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including postsynaptic membrane; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of several diseases, including Alzheimer's disease; cataract; status epilepticus; thoracic aortic aneurysm; and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; ADAM 10; disintegrin and metalloproteinase domain-containing protein 10; kuzbanian; kuzbanian protein homolog; LOC501019; MADM; mammalian disintegrin-metalloprotease; RGD1566370; RGD1566370
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8880,226,862 - 80,358,728 (+)NCBIGRCr8
mRatBN7.2871,346,008 - 71,477,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,345,837 - 71,477,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,880,624 - 77,005,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,153,639 - 75,278,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,991,371 - 73,115,716 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,107,355 - 77,237,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,107,536 - 77,237,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,842,118 - 75,974,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,200,657 - 75,289,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,307,687 - 75,310,191 (+)NCBI
Celera870,259,195 - 70,383,316 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
calcium dichloride  (EXP)
casticin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enzalutamide  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
fulvestrant  (ISO)
ginsenoside Rg1  (EXP)
indometacin  (EXP)
isoflavones  (ISO)
ivermectin  (ISO)
lovastatin  (EXP,ISO)
melittin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phorbol 12,13-dibutanoate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IEA,ISO)
amyloid precursor protein catabolic process  (IEA,ISO)
amyloid-beta formation  (IMP)
cochlea development  (IEA,ISO)
constitutive protein ectodomain proteolysis  (IEA,ISO)
epidermal growth factor receptor ligand maturation  (IEA,ISO)
in utero embryonic development  (IEA,ISO,ISS)
membrane protein ectodomain proteolysis  (IBA,ISO,ISS)
monocyte activation  (IEA,ISO)
negative regulation of cell adhesion  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
Notch signaling pathway  (IBA,IEA,ISO,ISS)
pore complex assembly  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of T cell chemotaxis  (IEA,ISO)
postsynapse organization  (IEA,ISO)
protein catabolic process at postsynapse  (IEA,ISO)
protein processing  (ISO)
proteolysis  (IEA)
regulation of cellular component organization  (IEA)
regulation of dendritic spine morphogenesis  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
regulation of Notch signaling pathway  (IEA,ISO)
regulation of osteoclast differentiation  (NAS)
regulation of postsynapse organization  (IEA,ISO)
regulation of vasculature development  (IEA,ISO)
response to antineoplastic agent  (IEP)
response to tumor necrosis factor  (IEA,ISO)
signaling receptor ligand precursor processing  (ISO)
spermatogenesis  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8.
3. Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aß-related metabolism. Chen L, etal., Neurosci Lett. 2017 May 22;650:146-152. doi: 10.1016/j.neulet.2017.04.047. Epub 2017 Apr 25.
4. Localization of ADAM10 and Notch receptors in bone. Dallas DJ, etal., Bone 1999 Jul;25(1):9-15.
5. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
6. The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway. Gardoni F, etal., J Cell Sci. 2012 Mar 15;125(Pt 6):1401-6. doi: 10.1242/jcs.097576. Epub 2012 Feb 10.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hartmann D, etal., Hum Mol Genet 2002 Oct 1;11(21):2615-24.
11. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Howard L, etal., Biochem J 1996 Jul 1;317 ( Pt 1):45-50.
12. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Huang YJ, etal., Toxicol Lett. 2013 Mar 13;217(3):184-91. doi: 10.1016/j.toxlet.2012.12.023. Epub 2013 Jan 4.
13. Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CX3 CL1 in rheumatoid arthritis. Jones BA, etal., Arthritis Rheum. 2013 Nov;65(11):2814-25. doi: 10.1002/art.38095.
14. Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy. Lim SC, Biomol Ther (Seoul). 2013 Sep 30;21(5):371-80. doi: 10.4062/biomolther.2013.034.
15. Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis. Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795.
16. ADAM10 and BACE1 are localized to synaptic vesicles. Lundgren JL, etal., J Neurochem. 2015 Nov;135(3):606-15. doi: 10.1111/jnc.13287. Epub 2015 Sep 17.
17. Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. Marcello E, etal., J Neurosci. 2007 Feb 14;27(7):1682-91.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Excessive hydrogen peroxide enhances the attachment of amyloid ß1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts. Nagai N and Ito Y, Toxicology. 2014 Jan 6;315:55-64. doi: 10.1016/j.tox.2013.08.003. Epub 2013 Aug 11.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus. Ortiz RM, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):272-5. Epub 2005 Apr 20.
23. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. Pasternak SH, etal., J Biol Chem 2003 Jul 18;278(29):26687-94.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation. Saraceno C, etal., Cell Death Dis. 2014 Nov 27;5:e1547. doi: 10.1038/cddis.2014.492.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation. Urriola-Muñoz P, etal., Biol Res. 2014 Jul 4;47:31. doi: 10.1186/0717-6287-47-31.
33. Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results. Walkiewicz K, etal., Dis Markers. 2019 Sep 2;2019:5035234. doi: 10.1155/2019/5035234. eCollection 2019.
34. Effects of aluminium on ß-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. Wang L, etal., Neurochem Res. 2014 Jul;39(7):1338-45. doi: 10.1007/s11064-014-1317-z. Epub 2014 May 3.
35. MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury. Warren KM, etal., J Neurotrauma. 2012 Jul 1;29(10):1922-40. doi: 10.1089/neu.2012.2383. Epub 2012 May 14.
Additional References at PubMed
PMID:11831872   PMID:12176995   PMID:12475894   PMID:12535668   PMID:12714508   PMID:12794186   PMID:14733940   PMID:14761956   PMID:17245433   PMID:17557115   PMID:17965014   PMID:18355445  
PMID:18355449   PMID:18373975   PMID:18419754   PMID:18676862   PMID:19114711   PMID:19455579   PMID:19946888   PMID:20383322   PMID:20458337   PMID:20501653   PMID:20624979   PMID:20711474  
PMID:21123580   PMID:21423176   PMID:23035126   PMID:23091066   PMID:23676497   PMID:24006456   PMID:24990881   PMID:28164773   PMID:28169407   PMID:28729535   PMID:28855301   PMID:29176823  
PMID:29180109   PMID:29325091   PMID:29397483   PMID:29430990   PMID:30117015   PMID:30446855   PMID:30463011   PMID:30639848   PMID:30989630   PMID:34647720  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8880,226,862 - 80,358,728 (+)NCBIGRCr8
mRatBN7.2871,346,008 - 71,477,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,345,837 - 71,477,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,880,624 - 77,005,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,153,639 - 75,278,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,991,371 - 73,115,716 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,107,355 - 77,237,483 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,107,536 - 77,237,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,842,118 - 75,974,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,200,657 - 75,289,572 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,307,687 - 75,310,191 (+)NCBI
Celera870,259,195 - 70,383,316 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381558,588,809 - 58,749,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1558,588,809 - 58,749,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371558,881,008 - 59,041,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,675,802 - 56,829,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 341556,676,368 - 56,829,469NCBI
Celera1535,776,749 - 35,930,110 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,711,409 - 35,864,717 (-)NCBIHuRef
CHM1_11559,006,506 - 59,160,121 (-)NCBICHM1_1
T2T-CHM13v2.01556,390,788 - 56,551,686 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39970,586,133 - 70,687,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl970,586,279 - 70,687,511 (+)EnsemblGRCm39 Ensembl
GRCm38970,678,944 - 70,780,229 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl970,678,997 - 70,780,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv37970,526,808 - 70,628,036 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36970,478,343 - 70,577,515 (+)NCBIMGSCv36mm8
Celera967,896,038 - 67,997,081 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.53NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545015,853,366 - 15,928,200 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,853,372 - 15,927,966 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21647,857,920 - 48,011,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11552,040,227 - 52,194,225 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01537,562,930 - 37,717,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,873,796 - 56,027,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,873,606 - 56,027,188 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13023,605,724 - 23,732,038 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,606,517 - 23,731,823 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,577,513 - 23,704,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,770,904 - 23,899,036 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,770,904 - 23,899,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,696,156 - 23,822,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,781,555 - 23,908,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,923,628 - 24,051,939 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640101,911,860 - 102,063,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,758,118 - 19,911,759 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,760,709 - 19,911,759 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1113,289,209 - 113,412,798 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,289,480 - 113,407,940 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,476,146 - 125,527,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12624,768,827 - 24,921,169 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2624,768,915 - 24,919,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048116,399,555 - 116,551,303 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478113,195,755 - 13,321,823 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,195,390 - 13,321,823 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adam10
361 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:73
Interacting mature miRNAs:84
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0875,844,197 - 75,844,372UniSTSRnor5.0
Celera870,260,105 - 70,260,280UniSTS
Cytogenetic Map8q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 42 52 36 19 36 6 6 74 35 38 11 6
Low 1 5 5 5 2 5 3 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000083255   ⟹   ENSRNOP00000073306
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,346,008 - 71,477,889 (+)Ensembl
Rnor_6.0 Ensembl877,107,536 - 77,237,483 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106931   ⟹   ENSRNOP00000085911
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,345,837 - 71,477,889 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109936   ⟹   ENSRNOP00000080617
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl871,346,008 - 71,475,537 (+)Ensembl
RefSeq Acc Id: NM_019254   ⟹   NP_062127
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8880,226,862 - 80,358,728 (+)NCBI
mRatBN7.2871,346,008 - 71,477,889 (+)NCBI
Rnor_6.0877,107,536 - 77,237,483 (+)NCBI
Rnor_5.0875,842,118 - 75,974,564 (-)NCBI
Celera870,259,195 - 70,383,316 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062127 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA88359 (Get FASTA)   NCBI Sequence Viewer  
  EDL84174 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073306
GenBank Protein Q10743 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062127   ⟸   NM_019254
- Peptide Label: precursor
- UniProtKB: Q10743 (UniProtKB/Swiss-Prot),   A0A0G2K562 (UniProtKB/TrEMBL),   A0A8I5ZQN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073306   ⟸   ENSRNOT00000083255
RefSeq Acc Id: ENSRNOP00000085911   ⟸   ENSRNOT00000106931
RefSeq Acc Id: ENSRNOP00000080617   ⟸   ENSRNOT00000109936
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10743-F1-model_v2 AlphaFold Q10743 1-749 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696108
Promoter ID:EPDNEW_R6633
Type:initiation region
Description:ADAM metallopeptidase domain 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0877,107,504 - 77,107,564EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2032 AgrOrtholog
BioCyc Gene G2FUF-29908 BioCyc
Ensembl Genes ENSRNOG00000054257 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006672 UniProtKB/Swiss-Prot
  ENSRNOG00060018682 UniProtKB/Swiss-Prot
  ENSRNOG00065016421 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083255 ENTREZGENE
  ENSRNOT00000083255.2 UniProtKB/Swiss-Prot
  ENSRNOT00000106931.1 UniProtKB/TrEMBL
  ENSRNOT00000109936.1 UniProtKB/TrEMBL
  ENSRNOT00055010887 UniProtKB/Swiss-Prot
  ENSRNOT00060032187 UniProtKB/Swiss-Prot
  ENSRNOT00065027331 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM10_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29650 UniProtKB/Swiss-Prot
  PTHR45702:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM10_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam10 PhenoGen
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054257 RatGTEx
  ENSRNOG00055006672 RatGTEx
  ENSRNOG00060018682 RatGTEx
  ENSRNOG00065016421 RatGTEx
SMART DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231107
  A0A8I6A091_RAT UniProtKB/TrEMBL
  ADA10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K562 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Adam10  ADAM metallopeptidase domain 10  RGD1566370  RGD1566370  Data merged from RGD:1566370 737654 PROVISIONAL
2008-09-18 Adam10  ADAM metallopeptidase domain 10  Adam10  a disintegrin and metallopeptidase domain 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566370  RGD1566370   RGD1566370_predicted  RGD1566370 (predicted)  'predicted' is removed 2292626 APPROVED
2008-02-14 Adam10  a disintegrin and metallopeptidase domain 10  Adam10  a disintegrin and metalloprotease domain 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566370_predicted  RGD1566370 (predicted)  LOC501019  LOC501019  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501019  LOC501019      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat brain 69738
gene_expression expressed in neonatal cartilage and bone 631800
gene_product member of the reprolysin family 69738