Pdp2 (pyruvate dehydrogenase phosphatase catalytic subunit 2) - Rat Genome Database

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Gene: Pdp2 (pyruvate dehydrogenase phosphatase catalytic subunit 2) Rattus norvegicus
Analyze
Symbol: Pdp2
Name: pyruvate dehydrogenase phosphatase catalytic subunit 2
RGD ID: 628812
Description: Enables protein serine/threonine phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; PDP 2; PDPC 2; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehydrogenase phosphatase, catalytic subunit 2; pyruvate dehyrogenase phosphatase catalytic subunit 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.219386,408 - 394,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19386,406 - 394,074 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19378,153 - 382,197 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0191,144,960 - 1,149,004 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.019420,155 - 424,199 (-)NCBIRnor_WKY
Rnor_6.019597,427 - 601,556 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19597,427 - 601,469 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019591,892 - 596,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419307,961 - 312,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119306,317 - 312,004 (-)NCBI
Celera19386,151 - 390,194 (-)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1-benzylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
ketamine  (EXP)
leflunomide  (EXP,ISO)
methyl methanesulfonate  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Huang B, etal., Diabetes. 2003 Jun;52(6):1371-6.
3. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, etal., J Biol Chem 1998 Jul 10;273(28):17680-8.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Voss M, etal., Cell Signal. 2011 Jan;23(1):114-24. doi: 10.1016/j.cellsig.2010.08.010. Epub 2010 Aug 27.
Additional References at PubMed
PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Pdp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.219386,408 - 394,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19386,406 - 394,074 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19378,153 - 382,197 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0191,144,960 - 1,149,004 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.019420,155 - 424,199 (-)NCBIRnor_WKY
Rnor_6.019597,427 - 601,556 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19597,427 - 601,469 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019591,892 - 596,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419307,961 - 312,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119306,317 - 312,004 (-)NCBI
Celera19386,151 - 390,194 (-)NCBICelera
Cytogenetic Map19p14NCBI
PDP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,880,515 - 66,891,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1666,878,589 - 66,895,754 (+)EnsemblGRCh38hg38GRCh38
GRCh371666,914,418 - 66,925,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,471,937 - 65,479,356 (+)NCBINCBI36Build 36hg18NCBI36
Celera1651,422,733 - 51,430,152 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1652,788,461 - 52,799,146 (+)NCBIHuRef
CHM1_11668,321,484 - 68,332,039 (+)NCBICHM1_1
T2T-CHM13v2.01672,674,823 - 72,685,405 (+)NCBIT2T-CHM13v2.0
Pdp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,318,104 - 105,325,658 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,318,083 - 105,325,658 (+)EnsemblGRCm39 Ensembl
GRCm388104,591,472 - 104,599,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,591,451 - 104,599,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,115,368 - 107,120,749 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,480,597 - 107,485,978 (+)NCBIMGSCv36mm8
Celera8108,824,065 - 108,829,447 (+)NCBICelera
Cytogenetic Map8D3NCBI
Pdp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543323,392,193 - 23,396,229 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543323,392,193 - 23,396,229 (+)NCBIChiLan1.0ChiLan1.0
PDP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11666,297,210 - 66,303,667 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,301,453 - 66,303,042 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01647,195,850 - 47,205,214 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,421,531 - 82,428,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,424,978 - 82,426,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,410,231 - 82,417,312 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,858,158 - 82,865,247 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,858,163 - 82,865,178 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,681,322 - 82,688,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,368,074 - 82,375,160 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0583,007,116 - 83,014,215 (-)NCBIUU_Cfam_GSD_1.0
Pdp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934942,443,092 - 42,450,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,139,521 - 17,143,304 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647517,139,135 - 17,146,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,565,450 - 27,575,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,565,423 - 27,572,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PDP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,575,280 - 52,583,614 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl552,580,423 - 52,582,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604723,327,764 - 23,334,143 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474619,618,748 - 19,622,755 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474619,605,201 - 19,623,089 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdp2
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:70
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000016462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat

Markers in Region
Pdp2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.219390,950 - 391,618 (+)MAPPERmRatBN7.2
Rnor_6.019598,433 - 599,100NCBIRnor6.0
Rnor_5.019592,898 - 593,565UniSTSRnor5.0
RGSC_v3.419308,967 - 309,634UniSTSRGSC3.4
Celera19387,157 - 387,824UniSTS
Cytogenetic Map19p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 25 53 41 10 41 53 35 23 10
Low 1 18 4 9 8 11 21 17 1 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016462   ⟹   ENSRNOP00000016462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19386,406 - 394,074 (-)Ensembl
Rnor_6.0 Ensembl19597,427 - 601,469 (-)Ensembl
RefSeq Acc Id: NM_145091   ⟹   NP_659559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.219389,945 - 393,989 (-)NCBI
Rnor_6.019597,427 - 601,469 (-)NCBI
Rnor_5.019591,892 - 596,017 (-)NCBI
RGSC_v3.419307,961 - 312,004 (-)RGD
Celera19386,151 - 390,194 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255048   ⟹   XP_006255110
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.219386,408 - 394,068 (-)NCBI
Rnor_6.019597,427 - 601,556 (-)NCBI
Rnor_5.019591,892 - 596,017 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_659559 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40168 (Get FASTA)   NCBI Sequence Viewer  
  AAH72485 (Get FASTA)   NCBI Sequence Viewer  
  EDL87227 (Get FASTA)   NCBI Sequence Viewer  
  O88484 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_659559   ⟸   NM_145091
- Peptide Label: precursor
- UniProtKB: O88484 (UniProtKB/Swiss-Prot),   A0A0G2JSL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255110   ⟸   XM_006255048
- Peptide Label: isoform X1
- UniProtKB: O88484 (UniProtKB/Swiss-Prot),   A0A0G2JSL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016462   ⟸   ENSRNOT00000016462
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88484-F1-model_v2 AlphaFold O88484 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700908
Promoter ID:EPDNEW_R11432
Type:multiple initiation site
Name:Pdp2_1
Description:pyruvate dehyrogenase phosphatase catalytic subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.019601,486 - 601,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628812 AgrOrtholog
BioCyc Gene G2FUF-6652 BioCyc
Ensembl Genes ENSRNOG00000012343 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016462 ENTREZGENE
  ENSRNOP00000016462.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016462 ENTREZGENE
  ENSRNOT00000016462.6 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105072 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246311 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91445 IMAGE-MGC_LOAD
NCBI Gene 246311 ENTREZGENE
PANTHER PTHR13832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdp2 PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSL7 ENTREZGENE, UniProtKB/TrEMBL
  O88484 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6IN27 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-19 Pdp2  pyruvate dehydrogenase phosphatase catalytic subunit 2  Pdp2  pyruvate dehyrogenase phosphatase catalytic subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pdp2  pyruvate dehyrogenase phosphatase catalytic subunit 2  Pdp2  pyruvate dehydrogenase phosphatase isoenzyme 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pdp2  pyruvate dehydrogenase phosphatase isoenzyme 2      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Pdp2  pyruvate dehydrogenase phosphatase isoenzyme 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation enzyme activity is Mg2+ dependent with lower Mg2+ ion sensitivity that that of catalytic subunit Pdp1 729524
gene_regulation enzyme activity is not regulated by Ca+2 ions, in contrast to Ca+2 sensitivity of subunit Pdp1 729524