Mcam (melanoma cell adhesion molecule) - Rat Genome Database

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Gene: Mcam (melanoma cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Mcam
Name: melanoma cell adhesion molecule
RGD ID: 620463
Description: Involved in positive regulation of cell migration. Located in extracellular space. Biomarker of impotence and malignant mesothelioma. Orthologous to human MCAM (melanoma cell adhesion molecule); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD146; cell surface glycoprotein MUC18; gicerin; l-gicerin; melanoma-associated antigen MUC18; Muc18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,376,225 - 53,384,407 (+)NCBIGRCr8
mRatBN7.2844,479,391 - 44,487,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,479,376 - 44,487,571 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx849,974,482 - 49,982,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,253,193 - 48,261,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,124,029 - 46,132,210 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,472,824 - 48,481,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,091,191 - 47,099,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,105,632 - 47,127,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1847,130,370 - 47,135,903 (+)NCBI
Celera844,066,232 - 44,074,417 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
nitrofen  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenylmercury acetate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
profenofos  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells. Adachi K, etal., Oncol Rep. 2010 Dec;24(6):1427-31.
2. Possible implications of MCAM expression in metastasis and non-metastatic of primary uveal melanoma patients. Beutel J, etal., Curr Eye Res. 2009 Nov;34(11):1004-9. doi: 10.3109/02713680903262205.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. Kratzer A, etal., J Pathol. 2013 Aug;230(4):388-98. doi: 10.1002/path.4197.
6. Expression of gicerin, a novel cell adhesion molecule, is upregulated in the astrocytes after hypoglossal nerve injury in rats. Li BS, etal., Neurosci Lett. 1999 Feb 5;260(3):149-52.
7. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. Liu G, etal., PLoS One. 2013 Aug 30;8(8):e72790. doi: 10.1371/journal.pone.0072790.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma. Okazaki Y, etal., Cancer Sci. 2013 Aug;104(8):989-95. doi: 10.1111/cas.12185. Epub 2013 May 26.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Gicerin, an Ig-superfamily cell adhesion molecule, promotes the invasive and metastatic activities of a mouse fibroblast cell line. Tsukamoto Y, etal., J Cell Physiol 2003 Oct;197(1):103-9.
Additional References at PubMed
PMID:14706627   PMID:14755543   PMID:15489334   PMID:15880440   PMID:20354148   PMID:21423176   PMID:22871113   PMID:23878390   PMID:27068509   PMID:33515199   PMID:34477225   PMID:34575887  


Genomics

Comparative Map Data
Mcam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,376,225 - 53,384,407 (+)NCBIGRCr8
mRatBN7.2844,479,391 - 44,487,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,479,376 - 44,487,571 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx849,974,482 - 49,982,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,253,193 - 48,261,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,124,029 - 46,132,210 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,472,824 - 48,481,005 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,091,191 - 47,099,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,105,632 - 47,127,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1847,130,370 - 47,135,903 (+)NCBI
Celera844,066,232 - 44,074,417 (+)NCBICelera
Cytogenetic Map8q22NCBI
MCAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,308,529 - 119,317,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,308,529 - 119,321,521 (-)EnsemblGRCh38hg38GRCh38
GRCh3711119,179,239 - 119,187,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,684,444 - 118,693,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411118,684,187 - 118,693,050NCBI
Celera11116,339,434 - 116,348,037 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,119,937 - 115,128,540 (-)NCBIHuRef
CHM1_111119,065,786 - 119,074,389 (-)NCBICHM1_1
T2T-CHM13v2.011119,329,165 - 119,337,763 (-)NCBIT2T-CHM13v2.0
Mcam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,045,958 - 44,054,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,045,766 - 44,054,024 (+)EnsemblGRCm39 Ensembl
GRCm38944,134,658 - 44,142,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,134,469 - 44,142,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv37943,942,741 - 43,950,809 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36943,885,666 - 43,893,719 (+)NCBIMGSCv36mm8
Celera941,392,205 - 41,400,272 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.68NCBI
Mcam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,397,051 - 20,404,780 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,396,056 - 20,404,777 (-)NCBIChiLan1.0ChiLan1.0
MCAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29120,016,269 - 120,024,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111121,119,769 - 121,128,446 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,149,583 - 114,158,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111118,076,841 - 118,084,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11118,078,179 - 118,083,893 (-)Ensemblpanpan1.1panPan2
MCAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,590,252 - 14,598,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,567,238 - 14,598,149 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,643,495 - 14,652,026 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0514,533,623 - 14,542,154 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,510,591 - 14,542,153 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,672,708 - 14,680,319 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,575,921 - 14,584,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,616,078 - 14,624,610 (+)NCBIUU_Cfam_GSD_1.0
Mcam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,314,589 - 101,328,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,237,010 - 4,244,462 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,235,914 - 4,244,981 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,512,784 - 46,522,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,506,375 - 46,522,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,546,351 - 51,557,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,682,631 - 110,691,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,684,458 - 110,691,707 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604315,343,344 - 15,351,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,673,060 - 14,681,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478414,671,524 - 14,681,151 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcam
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:79
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000010463
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
BE118163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,476,273 - 44,476,441 (+)MAPPERmRatBN7.2
Rnor_6.0848,468,837 - 48,469,004NCBIRnor6.0
Rnor_5.0847,083,769 - 47,083,936UniSTSRnor5.0
RGSC_v3.4847,116,102 - 47,116,269UniSTSRGSC3.4
Celera844,063,171 - 44,063,338UniSTS
RH 3.4 Map8435.7UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000010463   ⟹   ENSRNOP00000010464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,479,376 - 44,487,566 (+)Ensembl
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090780   ⟹   ENSRNOP00000069860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,479,391 - 44,487,571 (+)Ensembl
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105992   ⟹   ENSRNOP00000091494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl844,479,376 - 44,487,566 (+)Ensembl
RefSeq Acc Id: NM_001034009   ⟹   NP_001029181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,376,225 - 53,384,407 (+)NCBI
mRatBN7.2844,479,391 - 44,487,575 (+)NCBI
Rnor_6.0848,472,824 - 48,481,005 (+)NCBI
Rnor_5.0847,091,191 - 47,099,630 (+)NCBI
RGSC_v3.4847,105,632 - 47,127,936 (+)RGD
Celera844,066,232 - 44,074,417 (+)RGD
Sequence:
RefSeq Acc Id: NM_023983   ⟹   NP_076473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,376,225 - 53,384,407 (+)NCBI
mRatBN7.2844,479,391 - 44,487,575 (+)NCBI
Rnor_6.0848,472,824 - 48,481,005 (+)NCBI
Rnor_5.0847,091,191 - 47,099,630 (+)NCBI
RGSC_v3.4847,105,632 - 47,127,936 (+)RGD
Celera844,066,232 - 44,074,417 (+)RGD
Sequence:
RefSeq Acc Id: NP_076473   ⟸   NM_023983
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6IRH8 (UniProtKB/Swiss-Prot),   Q9ESS8 (UniProtKB/Swiss-Prot),   Q9EPF2 (UniProtKB/Swiss-Prot),   A6J3W0 (UniProtKB/TrEMBL),   A0A8I6AFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029181   ⟸   NM_001034009
- Peptide Label: isoform 2 precursor
- UniProtKB: A6J3W1 (UniProtKB/TrEMBL),   A0A8I6AFJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069860   ⟸   ENSRNOT00000090780
Ensembl Acc Id: ENSRNOP00000010464   ⟸   ENSRNOT00000010463
Ensembl Acc Id: ENSRNOP00000091494   ⟸   ENSRNOT00000105992
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPF2-F1-model_v2 AlphaFold Q9EPF2 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695884
Promoter ID:EPDNEW_R6408
Type:single initiation site
Name:Mcam_1
Description:melanoma cell adhesion molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,472,814 - 48,472,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620463 AgrOrtholog
BioCyc Gene G2FUF-30734 BioCyc
Ensembl Genes ENSRNOG00000007726 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018180 UniProtKB/Swiss-Prot
  ENSRNOG00060018405 UniProtKB/Swiss-Prot
  ENSRNOG00065022994 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010463.7 UniProtKB/Swiss-Prot
  ENSRNOT00000090780.2 UniProtKB/Swiss-Prot
  ENSRNOT00000105992.1 UniProtKB/TrEMBL
  ENSRNOT00055030831 UniProtKB/Swiss-Prot
  ENSRNOT00060031664 UniProtKB/Swiss-Prot
  ENSRNOT00065039317 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105099 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Surface_Rcpt/Adhesion_Mol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78967 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91447 IMAGE-MGC_LOAD
NCBI Gene 78967 ENTREZGENE
PANTHER CELL SURFACE GLYCOPROTEIN MUC18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL SURFACE GLYCOPROTEIN MUC18-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcam PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007726 RatGTEx
  ENSRNOG00055018180 RatGTEx
  ENSRNOG00060018405 RatGTEx
  ENSRNOG00065022994 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AFJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6J3W0 ENTREZGENE, UniProtKB/TrEMBL
  A6J3W1 ENTREZGENE, UniProtKB/TrEMBL
  MUC18_RAT UniProtKB/Swiss-Prot
  Q6IRH8 ENTREZGENE
  Q9EPF2 ENTREZGENE
  Q9ESS8 ENTREZGENE
UniProt Secondary Q6IRH8 UniProtKB/Swiss-Prot
  Q9ESS8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mcam  melanoma cell adhesion molecule    l-gicerin  Name updated 1299863 APPROVED
2002-08-07 Mcam  l-gicerin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Ig superfamily 724438