RGD Reference Report - Expression of gicerin, a novel cell adhesion molecule, is upregulated in the astrocytes after hypoglossal nerve injury in rats. - Rat Genome Database

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Expression of gicerin, a novel cell adhesion molecule, is upregulated in the astrocytes after hypoglossal nerve injury in rats.

Authors: Li, BS  Su, QN  Kiyama, H  Miki, N  Robinow, DR  Zhang, L 
Citation: Li BS, etal., Neurosci Lett. 1999 Feb 5;260(3):149-52.
RGD ID: 7364787
Pubmed: (View Article at PubMed) PMID:10076889

Gicerin is an integral membrane glycoprotein which mediates cell-cell and cell-extracellular matrix (ECM) interactions in the nervous system. We studied gicerin expression in the hypoglossal nucleus post transection using in situ hybridization and immunocytochemistry. We found that hypoglossal nerve injury resulted in a significant increase in gicerin expression. Its expression levels reached peak values in reactive astrocytes surrounding axotomized motoneurons of the ipsilateral hypoglossal nucleus 14 days after hypoglossal nerve injury. The results indicate that gicerin is up-regulated during nerve regeneration, suggesting that gicerin expressed in the reactive astrocytes might be involved in the processes of nerve regeneration.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Mcam  (melanoma cell adhesion molecule)

Genes (Mus musculus)
Mcam  (melanoma cell adhesion molecule)

Genes (Homo sapiens)
MCAM  (melanoma cell adhesion molecule)


Additional Information