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Gene: MCAM (melanoma cell adhesion molecule) Homo sapiens
Symbol: MCAM
Name: melanoma cell adhesion molecule
Description: Involved in glomerular filtration and vascular wound healing. Localizes to external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma; INTERACTS WITH 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine; acetylsalicylic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD146; cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; l-gicerin; melanoma adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18; MelCAM; METCAM; MUC18; S-endo 1 endothelial-associated antigen
Mus musculus (house mouse) : Mcam (melanoma cell adhesion molecule)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcam (melanoma cell adhesion molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcam (melanoma cell adhesion molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : MCAM (melanoma cell adhesion molecule)
Canis lupus familiaris (dog) : MCAM (melanoma cell adhesion molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcam (melanoma cell adhesion molecule)
Sus scrofa (pig) : MCAM (melanoma cell adhesion molecule)
Chlorocebus sabaeus (African green monkey) : MCAM (melanoma cell adhesion molecule)
Heterocephalus glaber (naked mole-rat) : Mcam (melanoma cell adhesion molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11119,308,529 - 119,321,521 (-)EnsemblGRCh38hg38GRCh38
GRCh3811119,305,759 - 119,317,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711119,179,234 - 119,189,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,684,444 - 118,693,050 (-)NCBINCBI36hg18NCBI36
Build 3411118,684,187 - 118,693,050NCBI
Celera11116,339,434 - 116,348,037 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11115,119,937 - 115,128,540 (-)NCBIHuRef
CHM1_111119,065,786 - 119,074,389 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MCAM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732868
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.