Kiss1r (KISS1 receptor) - Rat Genome Database

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Gene: Kiss1r (KISS1 receptor) Rattus norvegicus
Analyze
Symbol: Kiss1r
Name: KISS1 receptor
RGD ID: 70930
Description: Enables G protein-coupled peptide receptor activity and neuropeptide binding activity. Involved in several processes, including arachidonate secretion; positive regulation of cell communication; and positive regulation of stress fiber assembly. Predicted to be located in several cellular components, including cell surface; cilium; and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; GPR54; kiSS-; kiSS-1 receptor; kiSS-1R; kisspeptins receptor; metastin receptor; orphan G protein-coupled receptor GPR54; rOT7T175
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,435,766 - 10,439,424 (-)NCBIGRCr8
mRatBN7.279,785,135 - 9,790,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,785,135 - 9,788,793 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,667,118 - 12,670,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,542,438 - 14,546,096 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,403,615 - 12,407,273 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,606,210 - 12,609,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,606,210 - 12,609,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,776,069 - 12,779,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,297,840 - 11,301,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,297,839 - 11,301,187 (-)NCBI
Celera77,960,079 - 7,963,737 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells. Arai AC, etal., J Neurophysiol. 2005 Nov;94(5):3648-52.
2. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Clements MK, etal., Biochem Biophys Res Commun. 2001 Jun 29;284(5):1189-93.
3. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. de Roux N, etal., Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10972-6. Epub 2003 Aug 27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. Kotani M, etal., J Biol Chem 2001 Sep 14;276(37):34631-6. Epub 2001 Jul 16.
7. Discovery of a receptor related to the galanin receptors. Lee DK, etal., FEBS Lett 1999 Mar 5;446(1):103-7.
8. High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors. Marot D, etal., Endocr Relat Cancer. 2007 Sep;14(3):691-702.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Navarro VM, etal., Endocrinology 2004 Oct;145(10):4565-74. Epub 2004 Jul 8.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder. Nicolle G, etal., Ann Oncol. 2007 Mar;18(3):605-7. Epub 2006 Dec 12.
14. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Ohtaki T, etal., Nature 2001 May 31;411(6837):613-7.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. Ringel MD, etal., J Clin Endocrinol Metab. 2002 May;87(5):2399.
Additional References at PubMed
PMID:11387329   PMID:12359743   PMID:15157736   PMID:15219839   PMID:15375028   PMID:15486019   PMID:15500545   PMID:15593369   PMID:15637288   PMID:15665556   PMID:17289848   PMID:17698953  
PMID:18208554   PMID:18834866   PMID:19094090   PMID:19111911   PMID:19228890   PMID:19500221   PMID:20621140   PMID:20807723   PMID:21074602   PMID:22132116   PMID:22193294   PMID:23312234  
PMID:23668015   PMID:23684378   PMID:24978951   PMID:26853724   PMID:27373140   PMID:27589336   PMID:27981646   PMID:28154160   PMID:28552864   PMID:29244919   PMID:30255291   PMID:30668693  
PMID:31672553   PMID:31724927   PMID:35180577   PMID:35718292   PMID:36094166   PMID:37614139  


Genomics

Comparative Map Data
Kiss1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,435,766 - 10,439,424 (-)NCBIGRCr8
mRatBN7.279,785,135 - 9,790,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,785,135 - 9,788,793 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,667,118 - 12,670,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,542,438 - 14,546,096 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,403,615 - 12,407,273 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,606,210 - 12,609,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,606,210 - 12,609,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,776,069 - 12,779,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,297,840 - 11,301,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,297,839 - 11,301,187 (-)NCBI
Celera77,960,079 - 7,963,737 (-)NCBICelera
Cytogenetic Map7q11NCBI
KISS1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819917,333 - 921,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19917,287 - 921,005 (+)EnsemblGRCh38hg38GRCh38
GRCh3719917,333 - 921,005 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619868,358 - 872,013 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419868,502 - 872,001NCBI
Celera19849,702 - 853,371 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19690,992 - 694,661 (+)NCBIHuRef
CHM1_119916,929 - 920,598 (+)NCBICHM1_1
T2T-CHM13v2.019880,072 - 883,744 (+)NCBIT2T-CHM13v2.0
Kiss1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,752,786 - 79,759,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,752,805 - 79,758,107 (+)EnsemblGRCm39 Ensembl
GRCm381079,916,952 - 79,924,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,916,971 - 79,922,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,379,716 - 79,385,018 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,320,100 - 79,325,312 (+)NCBIMGSCv36mm8
Celera1080,931,781 - 80,937,083 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Kiss1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554956,918,632 - 6,921,891 (-)NCBIChiLan1.0ChiLan1.0
KISS1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,247,832 - 5,251,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,487,168 - 4,491,344 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019211,563 - 215,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119889,152 - 891,739 (+)NCBIpanpan1.1PanPan1.1panPan2
KISS1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,756,046 - 57,758,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,756,197 - 57,758,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,558,011 - 57,560,904 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,498,289 - 58,501,191 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,498,289 - 58,501,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,553,142 - 57,556,035 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,032,791 - 58,035,680 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,235,792 - 58,238,682 (-)NCBIUU_Cfam_GSD_1.0
Kiss1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,446,523 - 217,452,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588384,195 - 386,820 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588384,195 - 387,625 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KISS1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,472,362 - 77,479,204 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,472,361 - 77,479,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,518,436 - 77,525,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21-q24NCBI
KISS1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16666,386 - 670,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6667,210 - 670,563 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,246,899 - 8,251,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kiss1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,677,395 - 7,680,355 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,677,467 - 7,680,508 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kiss1r
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:127
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000016396
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 8 98 29 35 11 13 11 4 74 29 87 27 53 24

Sequence


Ensembl Acc Id: ENSRNOT00000016396   ⟹   ENSRNOP00000016395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,785,135 - 9,788,793 (-)Ensembl
Rnor_6.0 Ensembl712,606,210 - 12,609,868 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079485   ⟹   ENSRNOP00000075438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,606,347 - 12,609,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093287   ⟹   ENSRNOP00000076298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,606,347 - 12,609,694 (-)Ensembl
RefSeq Acc Id: NM_001301151   ⟹   NP_001288080
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,435,766 - 10,439,424 (-)NCBI
mRatBN7.279,785,135 - 9,788,793 (-)NCBI
Rnor_6.0712,606,210 - 12,609,868 (-)NCBI
Celera77,960,079 - 7,963,737 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023992   ⟹   NP_076482
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,435,766 - 10,439,424 (-)NCBI
mRatBN7.279,785,135 - 9,788,793 (-)NCBI
Rnor_6.0712,606,210 - 12,609,868 (-)NCBI
Rnor_5.0712,776,069 - 12,779,416 (-)NCBI
RGSC_v3.4711,297,840 - 11,301,187 (-)RGD
Celera77,960,079 - 7,963,737 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001288080 (Get FASTA)   NCBI Sequence Viewer  
  NP_076482 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD19664 (Get FASTA)   NCBI Sequence Viewer  
  BAB55447 (Get FASTA)   NCBI Sequence Viewer  
  EDL89368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016395.3
GenBank Protein Q924U1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_076482   ⟸   NM_023992
- Peptide Label: isoform 1
- UniProtKB: Q9Z0T7 (UniProtKB/Swiss-Prot),   Q924U1 (UniProtKB/Swiss-Prot),   A0A1W2Q6L7 (UniProtKB/TrEMBL),   A0A0G2JSL6 (UniProtKB/TrEMBL),   A6K8U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288080   ⟸   NM_001301151
- Peptide Label: isoform 2
- UniProtKB: Q9Z0T7 (UniProtKB/Swiss-Prot),   Q924U1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075438   ⟸   ENSRNOT00000079485
Ensembl Acc Id: ENSRNOP00000016395   ⟸   ENSRNOT00000016396
Ensembl Acc Id: ENSRNOP00000076298   ⟸   ENSRNOT00000093287
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924U1-F1-model_v2 AlphaFold Q924U1 1-396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70930 AgrOrtholog
BioCyc Gene G2FUF-34901 BioCyc
Ensembl Genes ENSRNOG00000011954 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016396.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KiSS_1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78976 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 78976 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KISS-1 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kiss1r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KISS1RECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011954 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6L7 ENTREZGENE
  A6K8U8 ENTREZGENE, UniProtKB/TrEMBL
  KISSR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z0T7 ENTREZGENE
UniProt Secondary A0A1W2Q6L7 UniProtKB/TrEMBL
  Q9Z0T7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kiss1r  KISS1 receptor  Gpr54  G protein-coupled receptor 54  Symbol and Name updated 1299863 APPROVED
2002-07-09 Gpr54  G protein-coupled receptor 54      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression rat gene is expressed in most areas of the brain, including the hypothalamus, as well as in peripheral regions such as liver and intestine 70752
gene_expression human gene is expressed in placenta, pituitary, pancreas and spinal cord, suggesting involvement in regulation of endocrine function 1357971
gene_homology protein related to galanin receptors with highest homology (44-45%) in the transmembrane regions 70752
gene_pathway coupled to phospholipase C and intracellular calcium release; also stimulates the arachidonic acid, ERK 1/2 and p38 signalling pathways 1357971
gene_regulation expressed in the hypothalamus under both developmental and hormonal control 1357970