Dnase2b (deoxyribonuclease 2 beta) - Rat Genome Database

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Gene: Dnase2b (deoxyribonuclease 2 beta) Rattus norvegicus
Analyze
Symbol: Dnase2b
Name: deoxyribonuclease 2 beta
RGD ID: 70901
Description: Enables deoxyribonuclease II activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and extracellular region. Orthologous to human DNASE2B (deoxyribonuclease 2 beta); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyribonuclease DLAD; deoxyribonuclease II beta; deoxyribonuclease-2-beta; Dlad; DNA for uricase; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; DNaseII-like acid DNase; endonuclease DLAD; UOX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,131,182 - 238,168,041 (-)NCBIGRCr8
mRatBN7.22235,470,915 - 235,515,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,470,919 - 235,486,295 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,266,728 - 243,282,451 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,158,072 - 241,173,456 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,024,382 - 236,040,107 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,436,363 - 252,475,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,436,332 - 252,451,999 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,962,863 - 271,001,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,779,607 - 244,794,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,766,347 - 244,781,720 (-)NCBI
Celera2227,450,011 - 227,465,378 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus. Goto K and Kondo H, Proc Natl Acad Sci U S A 1996 Oct 1;93(20):11196-201.
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cloning of a cDNA encoding a rat DNase II-like acid DNase. Tanuma S and Shiokawa D, Biochem Biophys Res Commun 1999 Nov 19;265(2):395-9.
Additional References at PubMed
PMID:8566790   PMID:10497274  


Genomics

Comparative Map Data
Dnase2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,131,182 - 238,168,041 (-)NCBIGRCr8
mRatBN7.22235,470,915 - 235,515,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,470,919 - 235,486,295 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,266,728 - 243,282,451 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,158,072 - 241,173,456 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,024,382 - 236,040,107 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,436,363 - 252,475,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,436,332 - 252,451,999 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,962,863 - 271,001,803 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,779,607 - 244,794,980 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,766,347 - 244,781,720 (-)NCBI
Celera2227,450,011 - 227,465,378 (-)NCBICelera
Cytogenetic Map2q44NCBI
DNASE2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,398,484 - 84,415,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl184,398,484 - 84,415,018 (+)EnsemblGRCh38hg38GRCh38
GRCh37184,864,167 - 84,880,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36184,636,803 - 84,653,279 (+)NCBINCBI36Build 36hg18NCBI36
Celera183,108,430 - 83,124,879 (+)NCBICelera
Cytogenetic Map1p31.1-p22.3NCBI
HuRef182,974,227 - 82,990,695 (+)NCBIHuRef
CHM1_1184,979,052 - 84,995,532 (+)NCBICHM1_1
T2T-CHM13v2.0184,238,948 - 84,255,454 (+)NCBIT2T-CHM13v2.0
Dnase2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393146,275,488 - 146,322,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3146,286,740 - 146,321,351 (-)EnsemblGRCm39 Ensembl
GRCm383146,569,733 - 146,617,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,580,985 - 146,615,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv373146,244,337 - 146,278,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363146,518,371 - 146,552,984 (-)NCBIMGSCv36mm8
Celera3153,031,860 - 153,066,077 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map372.0NCBI
Dnase2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,467,245 - 9,481,223 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,467,245 - 9,481,223 (-)NCBIChiLan1.0ChiLan1.0
DNASE2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,527,419 - 142,544,351 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11141,681,918 - 141,698,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01116,946,513 - 116,963,483 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,807,300 - 85,824,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,807,300 - 85,824,257 (+)Ensemblpanpan1.1panPan2
DNASE2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,465,477 - 63,481,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,466,106 - 63,481,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha666,113,707 - 66,130,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0664,005,309 - 64,021,750 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl664,005,938 - 64,021,583 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1663,533,264 - 63,549,678 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0663,501,952 - 63,518,371 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0664,008,051 - 64,024,465 (-)NCBIUU_Cfam_GSD_1.0
Dnase2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505895,105,214 - 95,118,364 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366081,187,668 - 1,200,727 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366081,187,679 - 1,200,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6129,329,867 - 129,340,980 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16129,329,737 - 129,343,003 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DNASE2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12048,939,012 - 48,955,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2048,938,973 - 48,956,045 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603368,805,854 - 68,822,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474213,052,261 - 13,066,563 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474213,052,355 - 13,066,284 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnase2b
343 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:132
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000021861
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
RH134990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,471,116 - 235,471,301 (+)MAPPERmRatBN7.2
Rnor_6.02252,436,565 - 252,436,749NCBIRnor6.0
Rnor_5.02270,963,065 - 270,963,249UniSTSRnor5.0
RGSC_v3.42244,779,806 - 244,779,990UniSTSRGSC3.4
Celera2227,450,210 - 227,450,394UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 1 1 1
Low 34 34 10 34 3 7
Below cutoff 2 7 10 4 6 4 1 1 27 20 4 1

Sequence


RefSeq Acc Id: ENSRNOT00000021861   ⟹   ENSRNOP00000021861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,470,919 - 235,486,295 (-)Ensembl
Rnor_6.0 Ensembl2252,436,332 - 252,451,999 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099823   ⟹   ENSRNOP00000086872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,470,919 - 235,483,169 (-)Ensembl
RefSeq Acc Id: NM_021664   ⟹   NP_067696
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,131,185 - 238,146,558 (-)NCBI
mRatBN7.22235,470,918 - 235,486,295 (-)NCBI
Rnor_6.02252,436,366 - 252,451,739 (-)NCBI
Rnor_5.02270,962,863 - 271,001,803 (-)NCBI
RGSC_v3.42244,779,607 - 244,794,980 (-)RGD
Celera2227,450,011 - 227,465,378 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591060   ⟹   XP_017446549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,131,182 - 238,168,041 (-)NCBI
mRatBN7.22235,470,915 - 235,515,211 (-)NCBI
Rnor_6.02252,436,363 - 252,475,506 (-)NCBI
Sequence:
RefSeq Acc Id: NP_067696   ⟸   NM_021664
- Peptide Label: precursor
- UniProtKB: Q9QZK9 (UniProtKB/Swiss-Prot),   G3V825 (UniProtKB/TrEMBL),   A6HWE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446549   ⟸   XM_017591060
- Peptide Label: isoform X1
- UniProtKB: Q9QZK9 (UniProtKB/Swiss-Prot),   G3V825 (UniProtKB/TrEMBL),   A6HWE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021861   ⟸   ENSRNOT00000021861
RefSeq Acc Id: ENSRNOP00000086872   ⟸   ENSRNOT00000099823

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZK9-F1-model_v2 AlphaFold Q9QZK9 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70901 AgrOrtholog
BioCyc Gene G2FUF-50898 BioCyc
Ensembl Genes ENSRNOG00000016262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00060000871 UniProtKB/Swiss-Prot
  ENSRNOG00065012859 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021861 ENTREZGENE
  ENSRNOT00000021861.5 UniProtKB/TrEMBL
  ENSRNOT00000099823.1 UniProtKB/TrEMBL
  ENSRNOT00060001093 UniProtKB/Swiss-Prot
  ENSRNOT00065021019 UniProtKB/Swiss-Prot
InterPro DNase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59296 UniProtKB/Swiss-Prot
NCBI Gene 59296 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE-2-BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10858 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnase2b PhenoGen
RatGTEx ENSRNOG00000016262 RatGTEx
  ENSRNOG00060000871 RatGTEx
  ENSRNOG00065012859 RatGTEx
UniProt A0A8I6GEI2_RAT UniProtKB/TrEMBL
  A6HWE1 ENTREZGENE, UniProtKB/TrEMBL
  DNS2B_RAT UniProtKB/Swiss-Prot
  G3V825 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZK9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Dnase2b  deoxyribonuclease 2 beta  Dnase2b  deoxyribonuclease II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dnase2b  deoxyribonuclease II beta  Dlad  DNaseII-like acid DNase  Symbol and Name updated 1299863 APPROVED
2002-07-09 Dlad  DNaseII-like acid DNase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a putative N-terminal signal peptide, 5 potential N-glycosylation sites and a predicted catalytic domain 70721
gene_expression expressed only in liver 70721
gene_protein 356 amino acids 70721