Dnase2b (deoxyribonuclease 2 beta)

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Gene: Dnase2b (deoxyribonuclease 2 beta) Rattus norvegicus

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Symbol:

Dnase2b

Name:

deoxyribonuclease 2 beta

RGD ID:

70901

Description:

Enables deoxyribonuclease II activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and extracellular region. Orthologous to human DNASE2B (deoxyribonuclease 2 beta); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

deoxyribonuclease DLAD; deoxyribonuclease II beta; deoxyribonuclease-2-beta; Dlad; DNA for uricase; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; DNaseII-like acid DNase; endonuclease DLAD; UOX

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DNASE2B (deoxyribonuclease 2 beta)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dnase2b (deoxyribonuclease II beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dnase2b (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DNASE2B (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DNASE2B (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dnase2b (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DNASE2B (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DNASE2B (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dnase2b (deoxyribonuclease 2 beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OXNAD1 (oxidoreductase NAD binding domain containing 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Dnase2b (deoxyribonuclease II beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DNASE2B (deoxyribonuclease 2 beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dnase2b (deoxyribonuclease II beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	DNaseII	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	crn-7	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	nuc-1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dnase2b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	238,131,182 - 238,168,041 (-)	NCBI		GRCr8
mRatBN7.2	2	235,470,915 - 235,515,211 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	235,470,919 - 235,486,295 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	243,266,728 - 243,282,451 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	241,158,072 - 241,173,456 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	236,024,382 - 236,040,107 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	252,436,363 - 252,475,506 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	252,436,332 - 252,451,999 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,962,863 - 271,001,803 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	244,779,607 - 244,794,980 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	244,766,347 - 244,781,720 (-)	NCBI
Celera	2	227,450,011 - 227,465,378 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cataract (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

cobalt dichloride (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

furan (EXP)

glyphosate (EXP)

graphite (EXP)

inulin (ISO)

methotrexate (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

pravastatin (EXP,ISO)

sevoflurane (EXP)

tetrachloromethane (EXP,ISO)

Theaflavin 3,3'-digallate (ISO)

ursodeoxycholic acid (EXP)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic DNA fragmentation (IBA,IEA)

Cellular Component

cytoplasm (ISO)

extracellular region (ISO)

lysosome (IEA)

Molecular Function

deoxyribonuclease II activity (IBA,IDA,IEA)

DNA endonuclease activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.	Goto K and Kondo H, Proc Natl Acad Sci U S A 1996 Oct 1;93(20):11196-201.
3.	Gene Data Set	MGD Curation, June 12, 2002
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning of a cDNA encoding a rat DNase II-like acid DNase.	Tanuma S and Shiokawa D, Biochem Biophys Res Commun 1999 Nov 19;265(2):395-9.

Additional References at PubMed

PMID:8566790	PMID:10497274

Genomics

Comparative Map Data

Dnase2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	238,131,182 - 238,168,041 (-)	NCBI		GRCr8
mRatBN7.2	2	235,470,915 - 235,515,211 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	235,470,919 - 235,486,295 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	243,266,728 - 243,282,451 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	241,158,072 - 241,173,456 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	236,024,382 - 236,040,107 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	252,436,363 - 252,475,506 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	252,436,332 - 252,451,999 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	270,962,863 - 271,001,803 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	244,779,607 - 244,794,980 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	244,766,347 - 244,781,720 (-)	NCBI
Celera	2	227,450,011 - 227,465,378 (-)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

DNASE2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	84,398,484 - 84,415,018 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	84,398,484 - 84,415,018 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	84,864,167 - 84,880,701 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	84,636,803 - 84,653,279 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	83,108,430 - 83,124,879 (+)	NCBI		Celera
Cytogenetic Map	1	p31.1-p22.3	NCBI
HuRef	1	82,974,227 - 82,990,695 (+)	NCBI		HuRef
CHM1_1	1	84,979,052 - 84,995,532 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	84,238,948 - 84,255,454 (+)	NCBI		T2T-CHM13v2.0

Dnase2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	146,275,488 - 146,322,815 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	146,286,740 - 146,321,351 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	146,569,733 - 146,617,060 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	146,580,985 - 146,615,596 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	146,244,337 - 146,278,562 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	146,518,371 - 146,552,984 (-)	NCBI		MGSCv36	mm8
Celera	3	153,031,860 - 153,066,077 (-)	NCBI		Celera
Cytogenetic Map	3	H2	NCBI
cM Map	3	72.0	NCBI

Dnase2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	9,467,245 - 9,481,223 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	9,467,245 - 9,481,223 (-)	NCBI	ChiLan1.0	ChiLan1.0

DNASE2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	142,527,419 - 142,544,351 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	141,681,918 - 141,698,823 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	116,946,513 - 116,963,483 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	85,807,300 - 85,824,257 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	85,807,300 - 85,824,257 (+)	Ensembl	panpan1.1		panPan2

DNASE2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	63,465,477 - 63,481,893 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	63,466,106 - 63,481,723 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	66,113,707 - 66,130,124 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	64,005,309 - 64,021,750 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	64,005,938 - 64,021,583 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	63,533,264 - 63,549,678 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	63,501,952 - 63,518,371 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	64,008,051 - 64,024,465 (-)	NCBI		UU_Cfam_GSD_1.0

Dnase2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	95,105,214 - 95,118,364 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936608	1,187,668 - 1,200,727 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936608	1,187,679 - 1,200,658 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNASE2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	129,329,867 - 129,340,980 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	129,329,737 - 129,343,003 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DNASE2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	48,939,012 - 48,955,940 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	48,938,973 - 48,956,045 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	68,805,854 - 68,822,815 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnase2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	13,052,261 - 13,066,563 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	13,052,355 - 13,066,284 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dnase2b
376 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	186
Count of miRNA genes:	132
Interacting mature miRNAs:	149
Transcripts:	ENSRNOT00000021861
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	229059610	249053267	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	217139753	236660713	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	221136523	241305619	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat

Markers in Region

RH134990

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	235,471,116 - 235,471,301 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	252,436,565 - 252,436,749	NCBI	Rnor6.0
Rnor_5.0	2	270,963,065 - 270,963,249	UniSTS	Rnor5.0
RGSC_v3.4	2	244,779,806 - 244,779,990	UniSTS	RGSC3.4
Celera	2	227,450,210 - 227,450,394	UniSTS
Cytogenetic Map	2	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	1	13	57	77	84	57	22	57	6	110	43	45	1	39	27

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC118117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF178974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021861 ⟹ ENSRNOP00000021861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	235,470,919 - 235,486,295 (-)	Ensembl
Rnor_6.0 Ensembl	2	252,436,332 - 252,451,999 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099823 ⟹ ENSRNOP00000086872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	235,470,919 - 235,483,169 (-)	Ensembl

RefSeq Acc Id:

NM_021664 ⟹ NP_067696

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	238,131,185 - 238,146,558 (-)	NCBI
mRatBN7.2	2	235,470,918 - 235,486,295 (-)	NCBI
Rnor_6.0	2	252,436,366 - 252,451,739 (-)	NCBI
Rnor_5.0	2	270,962,863 - 271,001,803 (-)	NCBI
RGSC_v3.4	2	244,779,607 - 244,794,980 (-)	RGD
Celera	2	227,450,011 - 227,465,378 (-)	RGD

Sequence:

show sequence

AGAAGCATCAGATGACATGAGACTCAGCCTCTTCTGTTTGTGCCCAAGCAGTGAACGGCAGGAG
TGGATAGAACCCGCAGCGGACCGGTGCGGCCTGAGAGAGATTTGACGCTCTGACTCCACAGTCT
GAGGCATGGAATGAAAGCCACAGACAGAAAATGACAGCCCAGCCTCTAAAAGCAGCTCTTCCTT
TGCTCTTCGTTGCCCTGTCCGGAGTCCTGGGGACACCAGTAATCTCGTGCATAAACGAAGATGG
TAAAGCCGTGGACTGGTTTGCCTTTTATAAGTTACCCAGAAGGACCAGCAGAGGAGGTACAGGG
ATGGGGCTGGATTACCTGTACCTGGACTCCACAATGAGAACCTGGAGCAAGAGCCACCACCTGA
TTAACAGCAGCAGGAGCTCCCTGGGAAGGACCCTGGAGCAGCTGTATGAAGCACACAATGCCAA
GAATGACACAGCCTATCTGATATACAATGACGCTGTCCCTGCATCTGTGAATTACAGCGGAAAT
TACGGGCATGCCAAAGGTCTGCTGGTATGGAACAGAGTGCAGGGGTTCTGGCTGATTCATTCTA
TTCCCAAGTTTCCCCCAGTTCCGGAAAAAGGCTATGAATACCCAAGCTCGGGGAGGCAATATGC
ACAAAGTGGCCTCTGCATCACTCTCAAATACAGCCAGTATGAGACAATAGATTCTCAGCTCTTG
GTCTTCCAGCCAAACATCTACAGCTGTTTCATCCCAAACATCTTTCGCTGGGAACTCATCCACA
TGCCTCAGATGTGTGCCAAGTCCAGTGCCTCAAAGATCCCTAGCCGGCGCCTCACTGTACTTCA
GTCAGCCCAGGGTCTAAACTTCCTCCATTTTGCGAAATCAACTTTTTATACTGATGACATCTTT
GCAGCCTGGATAGCTCAAAAGCTGAAGGTGCATTTGCTGGTAGAATCCTGGCAGCGAAAGAACC
ACGAGCTTCCTTCAAACTGTTCCCTGCCTTACCATGTCTACAACATCAAGGCCATTCGGGGACC
TCTGCAGTCCGACTTCCCTTCTCATCACGACCATTCCAAATGGTGTGTTTCCACAAAGGACTCT
CAGGCTCGCTGGACCTGTATTGGAGACCTAAATCGGAGCCCACATCAAGCCTTGAGAAGTGGAG
GATTTATCTGTTCGAAGAATCGGTACATTTACCAGTCATTTGATAGGTTAGTTTCCCATTATGC
CTCCTGTAACTAAGCTTGGGGAAAGGTCCCACCCACTGCCCTTAAAGACACTGGCTCTGGGACA
TCTTGCCTTGGATCTATTCTCCATATGTTAAAGGTTTCTGAGTGTCCTAACATCTCATCCAATA
AAAAACTATGAGTCCACATTTACCATTCTGCGTTCACATCAGGAGAAATCTGAGCCATTTGTGT
TTATCAAATTAGAAATCCAAATCATGGTATGTAAATAGCATGGGGGAAATAGAATAAAATATTT
TCTTCCAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017591060 ⟹ XP_017446549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	238,131,182 - 238,168,041 (-)	NCBI
mRatBN7.2	2	235,470,915 - 235,515,211 (-)	NCBI
Rnor_6.0	2	252,436,363 - 252,475,506 (-)	NCBI

Sequence:

show sequence

GGTTCGGGTCATCACAACACAAGGAACTGTATGAAAGGGTCACAGTGTTAGGAAGGGTGAGAGC
CACTGAATTAAAGGGTCTGCCTCTGTGGATCCATTCTGCACCCCCAAGAATCTTCAAAGTCCAT
GCTGAGAGATTCTGGGAGTGAAAGAGATGACGTCACCAGGCAGAGGGCTAACTCAGCTTTACTT
CAACTTGGCGCCAAGCAAGGTGATTTTAGGACATGGTGTCTGCCAAGAACCAAAGAGCTGCAGT
CTCTCTTGACCACCCCCTCCTTACTTCTTCATTTTCCGCTTGTCACCCCTTAAATCTACCTGCC
CTGCTTTGATTACATCATGTCCTTTGCTTATCTCTGCCTGCCAGTAGCCTTCAGTAAATGGGAG
GACTTTCTTTATCCGACATCTAAGATGGTATCTCTTATCTGCAACCGCTCTTTCACCTTCTGCC
TTTCTATCTAGCTCTGTGTGAGCTGGTACACTTTTGTTGTTTGGCTTTGCTTTGTTTTGTAGTT
AAGAGTCAGAACGGGAGCCATTGAAATGCTTAAATAATTGTGAATTTTTAATTCAAATATCTCA
AAGGCTCAGGGACTAATTCAGTTCAAATTAGTGATTCAGATCACGGTGGTGCCCGGGCTCAGCT
AAGCTCCTGGTTTAGCAGAGCCTCAGGGCTCAGCACTCGTCCTGAAGATCCAATGACACTTACA
CTAGCAGCCTCTGCCGTGTCTTGTATGAAAAGCTTAGTTCTCTTATCAGGGCATAGGATGTTAC
CAACATCAGAGCAGCCTTTGACCATAGTGTTGGTAATTTCTCTTCCCTGATTCTCTCAAGGAAA
TATCAGACATTTAAATACTCAAATTTTCAACATGCTGAGGTCTCTGTAAAGGATACACCAAGAA
CAAACCATATAGTGAGTTGTAGAGCAGCATCAGGATCCACATCATCCAAGACTCAGAAACTTTC
CCTGAACCAAAATTCAGGGAAACAGGAAGGAGTTGAGTCCACCAAGTGAAACTCATTCTCTTGT
AAGGACCCCTGGGGACTCACATGGGTGACTACGTGTTGTGGGGGGAGGGCAGGATTCTCACCAT
TCTTTCTGGCCCCCAACACACCACAAGGGCATGTAGCACTGGCCTGCGCTGTAAACGTTGGAGT
ATATGGATTGACACAAGGACATTTCTTCTTTTTTCTTTGTTTTGCATGTTGGCACATGTGTTAT
GGATACATGTGAGTATGTGAGTGTATGCACCCCTGTGCACGTGTACAGTAGCCAGCACAGGATG
CCAAGCGTCTTCTAACACTCTCCTCCTAACTGCCTGGAGACAAAGTCTTTTGGGAAGCTCACTG
ATTTTACTAGACTGGCTGACCAGAAAGCTCTTGGGATCAAAGTGTCTTTTCCTCAGTGTATGGA
GGTTTCATGCGCAAACATCCATGCAACGAGTGTTAGGAATCCAAACCCAAGTTCTCGTGCCTTC
ACCGCAGGAGTTCTGACCCACTGAGCCGTCTCTCCAATGCTCCACTGCTTACAAAGATGATGAC
ACCATGGATTCGTATCCGTTCCTTCCAGTTTAGCACTTAGATAATAAGCAAATTAGGAATTGGA
CTTTGCCACAAAGAGAATGTCCACCTGTACTCTCAAAAGAGGGGCTGAGTGGAAATGGTCTCAC
ACACAGAGCCCTGTGTACACACGTTTGCATCCAGTGCACACAGGGACCTGAATTCACTTACTTC
ACATCAATCTTCTTACCCCAACCCTGCTAGCCCTGCAGGATATCAGGTCAGAGCGGCCTGAGCT
TTAGCTCAGTTGACTGGAACTTCTGGACAACTGCCACAGATCTGTGTGTACCCAGAAGCTTGGG
AGCCATCTGCAGAGACAAAAGACTTGAACCGCTCTGAGGCCGATCTCTCTACTCGGCAGTGCTG
GCCTAGTGATCAGAACTCAGGCAAATGCTACCTCCTGGCATGCAGGCCTGAAGAGAAGTCTGTG
CTCTTTGATCATCAGCAGTGTCCTGGACTTAACCACTGTCACATCCTCATCCACTCCCCTGCCC
GAAGATATCTTTGTGGAAATCACCAAGGATGTTTACCAAGTCTAGAGTTCCTCTCCAGGCCGCT
TTTAACCAAGATTTCTTAACCTTTTGTGGCAAATATCAAACCAGTTTCCACTTCTGCTTGGACA
CTAGATGAGAATACATTTCCGTGGCCTCCTGCAGTCAAATGTGACTGTTGGAATCTCCGCAGGG
GACGTGCTAGGGGCCATTTATGACCTTGTGTCTGAGGGGTCTTGCCTGCTTTTCTTCTTCAGTG
TCTGCATCTCCTACTTATCCAGTGTGGCAATTTATGACCAAGGTGAACCCCAAAATAAGGAGTA
GCAACGTAAGATGGCCAAGGATTCTGTCCGACTTCCCCACAACCGAGATGTATCACCTGTTACT
CCCCCTCCCCAAACTGGGCTTACAGGAAGAAGTCCTTCTGCCAAGCCATTCACATATGTGGCTC
TTTGCTTCATGCTATCCCAAAAAAACATAGTTTTCTTCTATTTCCATGATACCACTTTATCTAG
ACATCTTCTTCTGCCAAAGTCTTGAACTAAGGAATGTCCCCAGAGCCTTATCATCTTATCTCAC
CTTTCCTCGTGCCACTATCTTGGTTGTCAACTGGACTGGATCGGGACACAGCTCCAACCCAAGG
CACTAGGCATTCCTGTGAGAGACTCTCAATCAGATTATCTGAAGCAGGAAGACCCACCCTAACT
GTGGGCAGTGCATACTGGAGGCAGCGCAGATAAAAGAGCACGGAAGATGGAAAGATCTGCTTTT
TGCTTGCTTGCCTTTACTCTTGCTGGCAAGTGCATCCATCCTGTGGTGGAGGCATCCCTTCACG
GGCATCAGAAGCTTGTCCTTGGGGCCTTCCAACACATACTGAAGACCAGCAGCTCTGCAGGAAC
GCTCCAGGCCTTCCAAGCCAGGTCAGGCTGCTGAGACATCCAGCCTTACAGACTAGGAAACTAA
CTACAGGCTGCAATTGTTGGACCACCAGGAGCAAATCATTGAACGGCAGGAGTGGATAGAACCC
GCAGCGGAGCCGGTGCGGCCTGAGAGAGATTTGACGCTCTGACTCCACAGTCTGAGGCATGGAA
TGAAAGCCACAGACAGAAAATGACAGCCCAGCCTCTAAAAGCAGCTCTTCCTTTGCTCTTCGTT
GCCCTGTCCGGAGTCCTGGGGACACCAGTAATCTCGTGCATAAACGAAGATGGTAAAGCCGTGG
ACTGGTTTGCCTTTTATAAGTTACCCAGAAGGACCAGCAGAGGAGGTACAGGGATGGGGCTGGA
TTACCTGTACCTGGACTCCACAATGAGAACCTGGAGCAAGAGCCACCACCTGATTAACAGCAGC
AGGAGCTCCCTGGGAAGGACCCTGGAGCAGCTGTATGAAGCACACAATGCCAAGAATGACACAG
CCTATCTGATATACAATGACGCTGTCCCTGCATCTGTGAATTACAGCGGAAATTACGGGCATGC
CAAAGGTCTGCTGGTATGGAACAGAGTGCAGGGGTTCTGGCTGATTCATTCTATTCCCAAGTTT
CCCCCAGTTCCGGAAAAAGGCTATGAATACCCAAACTCGGGGAGGCAATATGCACAAAGTGGCC
TCTGCATCACTCTCAAATACAGCCAGTATGAGACAATAGATTCTCAGCTCTTGGTCTTCCAGCC
AAACATCTACAGCTGTTTCATCCCAAACATCTTTCGCTGGGAACTCATCCACATGCCTCAGATG
TGTGCCAAGTCCAGTGCCTCAAAGATCCCTAGCCGGCGCCTCACTGTACTTCAGTCAGCCCAGG
GTCTAAACTTCCTCCATTTTGCGAAATCAACTTTTTATACTGATGACATCTTTGCAGCCTGGAT
AGCTCAAAAGCTGAAGGTGCATTTGCTGGTAGAATCCTGGCAGCGAAAGAACCACGAGCTTCCT
TCAAACTGTTCCCTGCCTTACCATGTCTACAACATCAAGGCCATTCGGGGACCTCTGCAGTCCG
ACTTCCCTTCTCATCACGACCATTCCAAATGGTGTGTTTCCACAAAGGACTCTCAGGCTCGCTG
GACCTGTATTGGAGACCTAAATCGGAGCCCACATCAAGCCTTGAGAAGTGGAGGATTTATCTGT
TCGAAGAATCGGTACATTTACCAGTCATTTGATAGGTTAGTTTCCCATTATGCCTCCTGTAACT
AAGCTTGGGGAAAGGTCCCACCCACTGCCCTTAAAGACACTGGCTCTGGGACATCTTGCCTTGG
ATCTATTCTCCATATGTTAAAGGTTTCTGAGTGTCCTAACATCTCATCCAATAAAAAACTATGA
GTCCACATTTACCATTCTGCGTTCACATCAGGAGAAATCTGAGCCATTTGTGTTTATCAAATTA
GAAATCCAAATCATGGTATGTAAATAGCATGGGGGAAATAGAATAAAATATTTTCTTCCACCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_067696	(Get FASTA)	NCBI Sequence Viewer
	XP_017446549	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF13596	(Get FASTA)	NCBI Sequence Viewer
	EDL82427	(Get FASTA)	NCBI Sequence Viewer
	EDL82428	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021861.2
	ENSRNOP00000086872.1
	ENSRNOP00060000397
	ENSRNOP00065016222
GenBank Protein	Q9QZK9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_067696 ⟸ NM_021664
- Peptide Label:	precursor
- UniProtKB:	Q9QZK9 (UniProtKB/Swiss-Prot), G3V825 (UniProtKB/TrEMBL), A6HWE1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTAQPLKAALPLLFVALSGVLGTPVISCINEDGKAVDWFAFYKLPRRTSRGGTGMGLDYLYLDS TMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAYLIYNDAVPASVNYSGNYGHAKGLLVW NRVQGFWLIHSIPKFPPVPEKGYEYPSSGRQYAQSGLCITLKYSQYETIDSQLLVFQPNIYSCF IPNIFRWELIHMPQMCAKSSASKIPSRRLTVLQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKV HLLVESWQRKNHELPSNCSLPYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDL NRSPHQALRSGGFICSKNRYIYQSFDRLVSHYASCN hide sequence

RefSeq Acc Id:	XP_017446549 ⟸ XM_017591060
- Peptide Label:	isoform X1
- UniProtKB:	Q9QZK9 (UniProtKB/Swiss-Prot), G3V825 (UniProtKB/TrEMBL), A6HWE1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTAQPLKAALPLLFVALSGVLGTPVISCINEDGKAVDWFAFYKLPRRTSRGGTGMGLDYLYLDS TMRTWSKSHHLINSSRSSLGRTLEQLYEAHNAKNDTAYLIYNDAVPASVNYSGNYGHAKGLLVW NRVQGFWLIHSIPKFPPVPEKGYEYPNSGRQYAQSGLCITLKYSQYETIDSQLLVFQPNIYSCF IPNIFRWELIHMPQMCAKSSASKIPSRRLTVLQSAQGLNFLHFAKSTFYTDDIFAAWIAQKLKV HLLVESWQRKNHELPSNCSLPYHVYNIKAIRGPLQSDFPSHHDHSKWCVSTKDSQARWTCIGDL NRSPHQALRSGGFICSKNRYIYQSFDRLVSHYASCN hide sequence

Ensembl Acc Id:

ENSRNOP00000021861 ⟸ ENSRNOT00000021861

Ensembl Acc Id:

ENSRNOP00000086872 ⟸ ENSRNOT00000099823

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QZK9-F1-model_v2	AlphaFold	Q9QZK9	1-356	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70901	AgrOrtholog
BioCyc Gene	G2FUF-50898	BioCyc
Ensembl Genes	ENSRNOG00000016262	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00060000871	UniProtKB/Swiss-Prot
	ENSRNOG00065012859	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021861.5	UniProtKB/TrEMBL
	ENSRNOT00000099823.1	UniProtKB/TrEMBL
	ENSRNOT00060001093	UniProtKB/Swiss-Prot
	ENSRNOT00065021019	UniProtKB/Swiss-Prot
InterPro	DNase_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:59296	UniProtKB/Swiss-Prot
NCBI Gene	59296	ENTREZGENE
PANTHER	DEOXYRIBONUCLEASE-2-BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10858	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DNase_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dnase2b	PhenoGen
RatGTEx	ENSRNOG00000016262	RatGTEx
	ENSRNOG00060000871	RatGTEx
	ENSRNOG00065012859	RatGTEx
UniProt	A0A8I6GEI2_RAT	UniProtKB/TrEMBL
	A6HWE1	ENTREZGENE, UniProtKB/TrEMBL
	DNS2B_RAT	UniProtKB/Swiss-Prot
	G3V825	ENTREZGENE, UniProtKB/TrEMBL
	Q9QZK9	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-27	Dnase2b	deoxyribonuclease 2 beta	Dnase2b	deoxyribonuclease II beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dnase2b	deoxyribonuclease II beta	Dlad	DNaseII-like acid DNase	Symbol and Name updated	1299863	APPROVED
2002-07-09	Dlad	DNaseII-like acid DNase			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a putative N-terminal signal peptide, 5 potential N-glycosylation sites and a predicted catalytic domain	70721
gene_expression	expressed only in liver	70721
gene_protein	356 amino acids	70721

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI