Il12rb1 (interleukin 12 receptor subunit beta 1) - Rat Genome Database

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Gene: Il12rb1 (interleukin 12 receptor subunit beta 1) Rattus norvegicus
Analyze
Symbol: Il12rb1
Name: interleukin 12 receptor subunit beta 1
RGD ID: 620025
Description: Predicted to enable coreceptor activity; cytokine binding activity; and cytokine receptor activity. Predicted to contribute to cytokine receptor activity; interleukin-12 receptor binding activity; and interleukin-23 binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; positive regulation of activated T cell proliferation; and positive regulation of defense response to virus by host. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of primary biliary cholangitis. Human ortholog(s) of this gene implicated in immunodeficiency 30. Orthologous to human IL12RB1 (interleukin 12 receptor subunit beta 1); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il12rb; interleukin 12 receptor, beta 1; interleukin-12 receptor subunit beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,654,207 - 18,668,887 (-)NCBIGRCr8
mRatBN7.21618,620,228 - 18,633,207 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,620,770 - 18,632,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,662,883 - 18,675,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,795,557 - 19,807,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,715,823 - 18,728,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,370,722 - 20,383,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,371,338 - 20,383,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,227,894 - 20,240,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,126,653 - 19,137,584 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,126,957 - 19,128,305 (-)NCBI
Celera1618,812,772 - 18,825,080 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Role of beta1 and beta2 subunits of the interleukin-12 receptor in determining T helper 1/T helper 2 responses in vivo in the rat. Gillespie KM, etal., Immunology 2000 Jan;99(1):109-12.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis. Qian C, etal., Cytokine. 2013 Oct;64(1):172-80. doi: 10.1016/j.cyto.2013.07.005. Epub 2013 Jul 31.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8943050   PMID:11114383   PMID:11489994   PMID:12023369   PMID:12421946   PMID:14635048   PMID:15114670   PMID:15220916  


Genomics

Comparative Map Data
Il12rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,654,207 - 18,668,887 (-)NCBIGRCr8
mRatBN7.21618,620,228 - 18,633,207 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,620,770 - 18,632,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,662,883 - 18,675,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,795,557 - 19,807,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,715,823 - 18,728,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,370,722 - 20,383,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,371,338 - 20,383,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,227,894 - 20,240,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,126,653 - 19,137,584 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,126,957 - 19,128,305 (-)NCBI
Celera1618,812,772 - 18,825,080 (-)NCBICelera
Cytogenetic Map16p14NCBI
IL12RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,058,995 - 18,098,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,058,995 - 18,098,944 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,169,805 - 18,209,626 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,031,371 - 18,058,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,042,372 - 18,058,697NCBI
Celera1918,072,103 - 18,099,423 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,735,230 - 17,761,934 (-)NCBIHuRef
CHM1_11918,169,971 - 18,197,251 (-)NCBICHM1_1
T2T-CHM13v2.01918,193,086 - 18,232,890 (-)NCBIT2T-CHM13v2.0
Il12rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,261,005 - 71,276,186 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,261,093 - 71,274,068 (+)EnsemblGRCm39 Ensembl
GRCm38870,808,360 - 70,823,542 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,808,449 - 70,821,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,332,348 - 73,345,323 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,737,483 - 73,750,411 (+)NCBIMGSCv36mm8
Celera873,369,767 - 73,382,761 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.21NCBI
Il12rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,276,932 - 3,299,617 (+)NCBIChiLan1.0ChiLan1.0
IL12RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,918,044 - 22,948,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,925,488 - 21,957,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,536,709 - 17,547,665 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,513,585 - 18,541,383 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,513,585 - 18,541,383 (-)Ensemblpanpan1.1panPan2
IL12RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,885,410 - 44,908,139 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,885,337 - 44,904,538 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,798,850 - 44,821,426 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,370,928 - 45,393,501 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,370,906 - 45,389,856 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,608,042 - 44,630,592 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,018,340 - 45,040,923 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,294,319 - 45,317,108 (+)NCBIUU_Cfam_GSD_1.0
Il12rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,512,974 - 203,527,983 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365963,062,620 - 3,076,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,707,961 - 59,736,282 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,707,958 - 59,736,282 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,276,610 - 59,305,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL12RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,527,392 - 16,557,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,528,271 - 16,556,840 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,834,014 - 2,850,939 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,472,059 - 1,481,423 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il12rb1
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:46
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000025977
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 19 50 60 59 28 25 28 6 152 64 30 45 52 31

Sequence


Ensembl Acc Id: ENSRNOT00000025977   ⟹   ENSRNOP00000025977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,620,770 - 18,632,769 (-)Ensembl
Rnor_6.0 Ensembl1620,371,338 - 20,383,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106514   ⟹   ENSRNOP00000080150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,620,770 - 18,632,769 (-)Ensembl
RefSeq Acc Id: NM_001170604   ⟹   NP_001164075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,654,207 - 18,666,824 (-)NCBI
mRatBN7.21618,620,228 - 18,632,845 (-)NCBI
Rnor_6.01620,371,338 - 20,383,337 (-)NCBI
Rnor_5.01620,227,894 - 20,240,670 (-)NCBI
Celera1618,812,772 - 18,825,080 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252821   ⟹   XP_006252883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,654,207 - 18,668,886 (-)NCBI
mRatBN7.21618,620,228 - 18,633,207 (-)NCBI
Rnor_6.01620,370,722 - 20,383,576 (-)NCBI
Rnor_5.01620,227,894 - 20,240,670 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010058275
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,655,894 - 18,668,887 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001164075 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252883 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16039 (Get FASTA)   NCBI Sequence Viewer  
  EDL90740 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025977.6
  ENSRNOP00000080150.1
RefSeq Acc Id: NP_001164075   ⟸   NM_001170604
- Peptide Label: precursor
- UniProtKB: E9PSU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252883   ⟸   XM_006252821
- Peptide Label: isoform X1
- UniProtKB: E9PSU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025977   ⟸   ENSRNOT00000025977
Ensembl Acc Id: ENSRNOP00000080150   ⟸   ENSRNOT00000106514
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSU7-F1-model_v2 AlphaFold E9PSU7 1-738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620025 AgrOrtholog
BioCyc Gene G2FUF-11810 BioCyc
Ensembl Genes ENSRNOG00000019216 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025977.7 UniProtKB/TrEMBL
  ENSRNOT00000106514.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Type-I_Cytokine_Rcpt UniProtKB/TrEMBL
KEGG Report rno:171333 UniProtKB/TrEMBL
NCBI Gene 171333 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
PhenoGen Il12rb1 PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019216 RatGTEx
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A8I5ZPZ3_RAT UniProtKB/TrEMBL
  A6K9Z7_RAT UniProtKB/TrEMBL
  E9PSU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il12rb1  interleukin 12 receptor subunit beta 1  Il12rb1  interleukin 12 receptor, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Il12rb1  interleukin 12 receptor, beta 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il12rb1  interleukin 12 receptor, beta 1      Symbol and Name status set to provisional 70820 PROVISIONAL