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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxypropane
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Accession:CHEBI:53505 term browser browse the term
Definition:An ether compound having methyl and isopropyl as the two alkyl groups.
Synonyms:related_synonym: Formula=C4H10O;   InChI=1S/C4H10O/c1-4(2)5-3/h4H,1-3H3;   InChIKey=RMGHERXMTMUMMV-UHFFFAOYSA-N;   Methyl isopropyl ether;   SMILES=COC(C)C;   i-C3H7OCH3
 xref: Beilstein:1696912;   CAS:598-53-8;   Gmelin:1420129;   PMID:10826603;   PMID:10923823;   PMID:20989225;   Reaxys:1696912


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sevoflurane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase affects expression EXP sevoflurane affects the expression of AASS mRNA CTD PMID:15967596 NCBI chr 4:51,606,461...51,663,136 JBrowse link
G Aatf apoptosis antagonizing transcription factor affects expression EXP sevoflurane affects the expression of AATF mRNA CTD PMID:15967596 NCBI chr10:69,299,029...69,392,207 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression EXP sevoflurane affects the expression of ABCB1A mRNA CTD PMID:15967596 NCBI chr 4:25,357,467...25,529,941 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression EXP sevoflurane affects the expression of ABCC2 mRNA CTD PMID:15967596 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Aco2 aconitase 2 affects expression EXP sevoflurane affects the expression of ACO2 mRNA CTD PMID:15967596 NCBI chr 7:113,385,677...113,428,794 JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 affects expression EXP sevoflurane affects the expression of ADAMTS1 mRNA CTD PMID:15967596 NCBI chr11:24,932,227...24,941,068 JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP sevoflurane results in increased phosphorylation of AKT1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of AKT1 protein]
CTD PMID:19881297 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alas1 5'-aminolevulinate synthase 1 affects expression EXP sevoflurane affects the expression of ALAS1 mRNA CTD PMID:15967596 NCBI chr 8:106,876,514...106,889,852 JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 affects expression EXP sevoflurane affects the expression of AMD1 mRNA CTD PMID:15967596 NCBI chr20:43,695,783...43,711,476 JBrowse link
G App amyloid beta precursor protein affects cleavage
increases expression
multiple interactions
ISO sevoflurane affects the cleavage of APP protein
sevoflurane results in increased expression of APP protein modified form
sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane affects the cleavage of APP protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased expression of APP protein modified form]
CTD PMID:19433662 NCBI chr11:24,019,774...24,236,584 JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) affects expression EXP sevoflurane affects the expression of AQP3 mRNA CTD PMID:15967596 NCBI chr 5:56,239,200...56,244,718 JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP sevoflurane affects the expression of ARC mRNA CTD PMID:15967596 NCBI chr 7:106,555,968...106,559,697 JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like affects expression EXP sevoflurane affects the expression of ARNTL mRNA CTD PMID:15967596 NCBI chr 1:167,331,756...167,430,235 JBrowse link
G Asl argininosuccinate lyase affects expression EXP sevoflurane affects the expression of ASL mRNA CTD PMID:15967596 NCBI chr12:26,659,664...26,677,136 JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation ISO sevoflurane results in increased phosphorylation of ATF2 protein CTD PMID:18349187 NCBI chr 3:58,718,323...58,795,280 JBrowse link
G Avpr1a arginine vasopressin receptor 1A affects expression EXP sevoflurane affects the expression of AVPR1A mRNA CTD PMID:15967596 NCBI chr 7:58,114,306...58,118,230 JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase affects expression EXP sevoflurane affects the expression of BAAT mRNA CTD PMID:15967596 NCBI chr 5:63,851,668...63,860,641 JBrowse link
G Bace1 beta-secretase 1 increases expression ISO sevoflurane results in increased expression of BACE1 protein CTD PMID:19433662 NCBI chr 8:46,142,060...46,166,268 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Nimodipine inhibits the reaction [Sevoflurane results in increased expression of BAX protein] CTD PMID:33171207 PMID:33928466 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP Nimodipine inhibits the reaction [Sevoflurane results in decreased expression of BCL2 protein] CTD PMID:33171207 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 affects expression EXP sevoflurane affects the expression of BHLHE41 mRNA CTD PMID:15967596 NCBI chr 4:178,833,085...178,838,685 JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO sevoflurane inhibits the reaction [CALCA protein modified form results in increased abundance of Cyclic AMP] CTD PMID:15297469 NCBI chr 1:168,878,212...168,883,176 JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
increases cleavage
ISO
EXP
sevoflurane results in increased activity of CASP3 protein
Sevoflurane results in increased expression of CASP3 protein modified form
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP3 protein modified form]; Roscovitine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]
Sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein]; Sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
sevoflurane results in increased expression of CASP3 mRNA
sevoflurane results in increased cleavage of CASP3 protein
APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; L 685458 inhibits the reaction [sevoflurane results in increased cleavage of CASP3 protein]; sevoflurane results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:15915027 PMID:16678324 PMID:18349187 PMID:18852026 PMID:19212262 PMID:19433662 PMID:19572936 PMID:33171207 PMID:33548343 PMID:33928466 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 increases activity ISO sevoflurane results in increased activity of CASP7 protein CTD PMID:16678324 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP9 protein modified form] CTD PMID:33171207 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cckbr cholecystokinin B receptor affects expression EXP sevoflurane affects the expression of CCKBR mRNA CTD PMID:15967596 NCBI chr 1:159,771,733...159,781,738 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP sevoflurane results in decreased expression of CCL2 mRNA CTD PMID:15564938 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccnd1 cyclin D1 affects expression EXP sevoflurane affects the expression of CCND1 mRNA CTD PMID:15967596 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cd274 CD274 molecule decreases expression ISO Sevoflurane results in decreased expression of CD274 mRNA; Sevoflurane results in decreased expression of CD274 protein CTD PMID:34018092 NCBI chr 1:227,116,627...227,137,379 JBrowse link
G Cdh17 cadherin 17 affects expression EXP sevoflurane affects the expression of CDH17 mRNA CTD PMID:15967596 NCBI chr 5:25,262,820...25,314,884 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP Roscovitine inhibits the reaction [Sevoflurane results in increased expression of CDKN1A protein] CTD PMID:33548343 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects expression EXP sevoflurane affects the expression of CEBPB mRNA CTD PMID:15967596 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Ces2c carboxylesterase 2C affects expression EXP sevoflurane affects the expression of CES2C mRNA CTD PMID:15967596 NCBI chr 1:260,391,190...260,398,757 JBrowse link
G Cgrrf1 cell growth regulator with ring finger domain 1 affects expression EXP sevoflurane affects the expression of CGRRF1 mRNA CTD PMID:15967596 NCBI chr15:20,088,564...20,109,042 JBrowse link
G Chka choline kinase alpha affects expression EXP sevoflurane affects the expression of CHKA mRNA CTD PMID:15967596 NCBI chr 1:201,076,804...201,125,517 JBrowse link
G Cnga4 cyclic nucleotide gated channel subunit alpha 4 affects expression EXP sevoflurane affects the expression of CNGA4 mRNA CTD PMID:15967596 NCBI chr 1:159,752,357...159,756,369 JBrowse link
G Cntn2 contactin 2 affects expression EXP sevoflurane affects the expression of CNTN2 mRNA CTD PMID:15967596 NCBI chr13:43,942,868...43,975,973 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression EXP sevoflurane affects the expression of CPT1A mRNA CTD PMID:15967596 NCBI chr 1:200,564,634...200,627,059 JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
multiple interactions
EXP Sevoflurane results in decreased expression of CREB1 mRNA
Sevoflurane results in decreased phosphorylation of CREB1 protein
Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of CREB1 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased phosphorylation of CREB1 protein]
CTD PMID:30842370 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Crem cAMP responsive element modulator affects expression EXP sevoflurane affects the expression of CREM mRNA CTD PMID:15967596 NCBI chr17:54,238,889...54,305,989 JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression EXP sevoflurane affects the expression of CRY2 mRNA CTD PMID:15967596 NCBI chr 3:78,374,995...78,405,001 JBrowse link
G Ctsl cathepsin L affects expression EXP sevoflurane affects the expression of CTSL mRNA CTD PMID:15967596 NCBI chr17:764,370...770,533 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP sevoflurane results in decreased expression of CXCL1 mRNA
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr14:17,193,364...17,195,143 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP sevoflurane results in decreased expression of CXCL10 mRNA CTD PMID:15564938 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
EXP sevoflurane results in increased expression of CXCL2 mRNA
sevoflurane results in decreased expression of CXCL2 mRNA
CTD PMID:10422944 PMID:15564938 NCBI chr14:17,181,030...17,183,075 JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
EXP Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CYCS protein] CTD PMID:33171207 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 affects expression EXP sevoflurane affects the expression of CYP2B12 mRNA CTD PMID:15967596 NCBI chr 1:82,007,609...82,019,409 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression EXP sevoflurane affects the expression of CYP2B2 mRNA CTD PMID:15967596 NCBI chr 1:81,594,534...81,608,567 JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 affects expression EXP sevoflurane affects the expression of CYP2B21 mRNA CTD PMID:15967596 NCBI chr 1:81,886,097...81,915,066 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP sevoflurane affects the expression of CYP2C mRNA; sevoflurane affects the expression of CYP2C11 mRNA CTD PMID:15967596 NCBI chr 1:236,762,719...236,799,069 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of sevoflurane CTD PMID:7879937 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression EXP sevoflurane affects the expression of CYP2F4 mRNA CTD PMID:15967596 NCBI chr 1:82,416,108...82,429,897 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 affects expression EXP sevoflurane affects the expression of CYP7A1 mRNA CTD PMID:15967596 NCBI chr 5:19,376,979...19,386,676 JBrowse link
G Dbn1 drebrin 1 decreases expression
multiple interactions
EXP Sevoflurane results in decreased expression of DBN1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]
CTD PMID:33548343 NCBI chr17:9,150,608...9,164,982 JBrowse link
G Dbp D-box binding PAR bZIP transcription factor affects expression EXP sevoflurane affects the expression of DBP mRNA CTD PMID:15967596 NCBI chr 1:96,175,796...96,180,745 JBrowse link
G Dhx30 DExH-box helicase 30 affects expression EXP sevoflurane affects the expression of DHX30 mRNA CTD PMID:15967596 NCBI chr 8:110,064,751...110,096,954 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
EXP Sevoflurane results in decreased expression of DLG4 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]
CTD PMID:33548343 NCBI chr10:54,740,700...54,769,097 JBrowse link
G Dnase2b deoxyribonuclease 2 beta affects expression EXP sevoflurane affects the expression of DNASE2B mRNA CTD PMID:15967596 NCBI chr 2:235,470,915...235,515,211 JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in increased expression of DNM1L protein] CTD PMID:27684054 NCBI chr11:84,581,216...84,632,382 JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
increases phosphorylation
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein] CTD PMID:33548343 NCBI chr15:41,005,551...41,111,724 JBrowse link
G Dusp16 dual specificity phosphatase 16 affects expression EXP sevoflurane affects the expression of DUSP16 mRNA CTD PMID:15967596 NCBI chr 4:167,546,780...167,629,949 JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP sevoflurane affects the expression of DUSP6 mRNA CTD PMID:15967596 NCBI chr 7:34,092,848...34,097,186 JBrowse link
G Dynll1 dynein light chain LC8-type 1 affects expression EXP sevoflurane affects the expression of DYNLL1 mRNA CTD PMID:15967596 NCBI chr12:41,312,367...41,314,742 JBrowse link
G Edn1 endothelin 1 affects expression EXP sevoflurane affects the expression of EDN1 mRNA CTD PMID:15967596 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Efna1 ephrin A1 affects expression EXP sevoflurane affects the expression of EFNA1 mRNA CTD PMID:15967596 NCBI chr 2:174,681,676...174,690,306 JBrowse link
G Egr1 early growth response 1 affects expression EXP sevoflurane affects the expression of EGR1 mRNA CTD PMID:15967596 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Egr2 early growth response 2 affects expression EXP sevoflurane affects the expression of EGR2 mRNA CTD PMID:15967596 NCBI chr20:21,051,270...21,056,322 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP sevoflurane affects the expression of EPHX1 mRNA CTD PMID:15967596 NCBI chr13:92,714,315...92,744,124 JBrowse link
G Fads2 fatty acid desaturase 2 affects expression EXP sevoflurane affects the expression of FADS2 mRNA CTD PMID:15967596 NCBI chr 1:206,707,384...206,747,333 JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 affects expression EXP sevoflurane affects the expression of FMO2 mRNA CTD PMID:15967596 NCBI chr13:75,221,149...75,244,377 JBrowse link
G Foxa3 forkhead box A3 affects expression EXP sevoflurane affects the expression of FOXA3 mRNA CTD PMID:15967596 NCBI chr 1:78,662,067...78,672,321 JBrowse link
G Fst follistatin affects expression EXP sevoflurane affects the expression of FST mRNA CTD PMID:15967596 NCBI chr 2:46,123,260...46,130,584 JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO sevoflurane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114 JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,096,995...37,230,030 JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO sevoflurane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946 JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects expression EXP sevoflurane affects the expression of GABRG2 mRNA CTD PMID:15967596 NCBI chr10:26,376,805...26,463,680 JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Sevoflurane results in increased expression of GAD2 mRNA; Sevoflurane results in increased expression of GAD2 protein CTD PMID:30502404 NCBI chr17:84,763,630...84,826,155 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression EXP sevoflurane affects the expression of GADD45A mRNA CTD PMID:15967596 NCBI chr 4:96,154,789...96,157,091 JBrowse link
G Gch1 GTP cyclohydrolase 1 affects expression EXP sevoflurane affects the expression of GCH1 mRNA CTD PMID:15967596 NCBI chr15:20,404,267...20,437,727 JBrowse link
G Gck glucokinase affects expression EXP sevoflurane affects the expression of GCK mRNA CTD PMID:15967596 NCBI chr14:80,785,060...80,829,842 JBrowse link
G Gja4 gap junction protein, alpha 4 affects expression EXP sevoflurane affects the expression of GJA4 mRNA CTD PMID:15967596 NCBI chr 5:139,633,324...139,635,857 JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO sevoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:39,625,853...39,727,897 JBrowse link
G Gmfb glia maturation factor, beta affects expression EXP sevoflurane affects the expression of GMFB mRNA CTD PMID:15967596 NCBI chr15:20,069,923...20,081,005 JBrowse link
G Gnb5 G protein subunit beta 5 affects expression EXP sevoflurane affects the expression of GNB5 mRNA CTD PMID:15967596 NCBI chr 8:76,076,227...76,104,151 JBrowse link
G Gnl3 G protein nucleolar 3 affects expression EXP sevoflurane affects the expression of GNL3 mRNA CTD PMID:15967596 NCBI chr16:6,207,402...6,213,491 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression EXP sevoflurane affects the expression of GOT1 mRNA CTD PMID:15967596 NCBI chr 1:242,357,293...242,381,535 JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial affects expression EXP sevoflurane affects the expression of GPAM mRNA CTD PMID:15967596 NCBI chr 1:254,106,323...254,170,755 JBrowse link
G Gphn gephyrin increases expression ISO Sevoflurane results in increased expression of GPHN mRNA; Sevoflurane results in increased expression of GPHN protein CTD PMID:30502404 NCBI chr 6:96,954,365...97,483,617 JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B affects expression EXP sevoflurane affects the expression of GPRC5B mRNA CTD PMID:15967596 NCBI chr 1:173,316,398...173,340,951 JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression ISO Sevoflurane results in increased expression of GRIA1 protein CTD PMID:30502404 NCBI chr10:41,210,713...41,527,283 JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression ISO Sevoflurane results in increased expression of GRIA2 protein CTD PMID:30502404 NCBI chr 2:165,949,379...166,069,510 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
decreases expression
ISO GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]
Sevoflurane results in decreased expression of GRIN2A mRNA
CTD PMID:15731593 PMID:33928466 NCBI chr10:5,630,684...6,043,341 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression
EXP Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased expression of GRIN2B protein]
Sevoflurane results in decreased expression of GRIN2B mRNA; Sevoflurane results in decreased expression of GRIN2B protein
CTD PMID:30842370 NCBI chr 4:168,580,824...169,044,110 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein] CTD PMID:20807582 PMID:33548343 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Gys2 glycogen synthase 2 affects expression EXP sevoflurane affects the expression of GYS2 mRNA CTD PMID:15967596 NCBI chr 4:175,365,054...175,406,228 JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
increases expression
EXP Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 protein]
Sevoflurane results in increased expression of HDAC2 mRNA; Sevoflurane results in increased expression of HDAC2 protein
CTD PMID:30842370 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hhex hematopoietically expressed homeobox affects expression EXP sevoflurane affects the expression of HHEX mRNA CTD PMID:15967596 NCBI chr 1:235,190,455...235,196,042 JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression EXP sevoflurane affects the expression of HNRNPD mRNA CTD PMID:15967596 NCBI chr14:9,615,375...9,638,975 JBrowse link
G Hoxa4 homeo box A4 affects expression EXP sevoflurane affects the expression of HOXA4 mRNA CTD PMID:15967596 NCBI chr 4:81,289,677...81,291,685 JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects expression EXP sevoflurane affects the expression of HSD17B2 mRNA CTD PMID:15967596 NCBI chr19:45,753,576...45,825,203 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects expression EXP sevoflurane affects the expression of HSPA8 mRNA CTD PMID:15967596 NCBI chr 8:41,183,397...41,187,260 JBrowse link
G Htt huntingtin multiple interactions ISO sevoflurane promotes the reaction [HTT protein mutant form binds to HTT protein mutant form] CTD PMID:21059370 NCBI chr14:75,845,836...75,996,094 JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP sevoflurane results in decreased expression of ICAM1 mRNA; sevoflurane results in decreased expression of ICAM1 protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Id2 inhibitor of DNA binding 2 affects expression EXP sevoflurane affects the expression of ID2 mRNA CTD PMID:15967596 NCBI chr 6:41,740,556...41,742,393 JBrowse link
G Ifrd1 interferon-related developmental regulator 1 affects expression EXP sevoflurane affects the expression of IFRD1 mRNA CTD PMID:15967596 NCBI chr 6:57,269,395...57,317,833 JBrowse link
G Il1b interleukin 1 beta increases expression EXP sevoflurane results in increased expression of IL1B mRNA CTD PMID:10422944 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Inhba inhibin subunit beta A affects expression EXP sevoflurane affects the expression of INHBA mRNA CTD PMID:15967596 NCBI chr17:49,091,635...49,111,573 JBrowse link
G Klf15 Kruppel-like factor 15 affects expression EXP sevoflurane affects the expression of KLF15 mRNA CTD PMID:15967596 NCBI chr 4:122,965,718...122,978,403 JBrowse link
G Klf9 Kruppel-like factor 9 affects expression EXP sevoflurane affects the expression of KLF9 mRNA CTD PMID:15967596 NCBI chr 1:220,700,108...220,725,029 JBrowse link
G Limk2 LIM domain kinase 2 affects expression EXP sevoflurane affects the expression of LIMK2 mRNA CTD PMID:15967596 NCBI chr14:78,208,182...78,286,106 JBrowse link
G Lox lysyl oxidase affects expression EXP sevoflurane affects the expression of LOX mRNA CTD PMID:15967596 NCBI chr18:45,964,311...46,041,477 JBrowse link
G Mafb MAF bZIP transcription factor B affects expression EXP sevoflurane affects the expression of MAFB mRNA CTD PMID:15967596 NCBI chr 3:148,998,111...149,000,031 JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K3 protein CTD PMID:18349187 NCBI chr10:45,608,145...45,629,492 JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP2K6 protein CTD PMID:18349187 NCBI chr10:95,373,304...95,490,406 JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation ISO sevoflurane results in increased phosphorylation of MAP3K5 protein CTD PMID:18349187 NCBI chr 1:14,685,776...14,904,935 JBrowse link
G Map7 microtubule-associated protein 7 affects expression EXP sevoflurane affects the expression of MAP7 mRNA CTD PMID:15967596 NCBI chr 1:14,910,433...15,037,574 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK1 protein] CTD PMID:19881297 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sevoflurane results in increased phosphorylation of MAPK3 protein] CTD PMID:19881297 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP sevoflurane affects the expression of MAT1A mRNA CTD PMID:15967596 NCBI chr16:16,983,084...17,001,284 JBrowse link
G Mettl3 methyltransferase-like 3 decreases expression ISO Sevoflurane results in decreased expression of METTL3 mRNA CTD PMID:33928466 NCBI chr15:25,002,505...25,014,097 JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency inhibits the reaction [Glucose results in increased expression of MFN2 protein]]; sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein] CTD PMID:27684054 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A affects expression EXP sevoflurane affects the expression of MFSD2A mRNA CTD PMID:15967596 NCBI chr 5:135,225,801...135,240,744 JBrowse link
G Mir34a microRNA 34a multiple interactions
increases response to substance
EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]
MIR34A mRNA results in increased susceptibility to Sevoflurane
CTD PMID:32147387 NCBI chr 5:160,533,002...160,533,103 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]] CTD PMID:32147387 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase decreases activity
multiple interactions
EXP sevoflurane results in decreased activity of MPO protein
MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]
CTD PMID:15564938 PMID:32147387 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 affects expression EXP sevoflurane affects the expression of NAT8F3 mRNA CTD PMID:15967596 NCBI chr 4:118,241,792...118,246,010 JBrowse link
G Neu1 neuraminidase 1 affects expression EXP sevoflurane affects the expression of NEU1 mRNA CTD PMID:15967596 NCBI chr20:3,897,480...3,901,745 JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated affects expression EXP sevoflurane affects the expression of NFIL3 mRNA CTD PMID:15967596 NCBI chr17:12,280,499...12,295,728 JBrowse link
G Ngfr nerve growth factor receptor affects expression EXP sevoflurane affects the expression of NGFR mRNA CTD PMID:15967596 NCBI chr10:80,515,287...80,533,518 JBrowse link
G Nlgn1 neuroligin 1 decreases expression ISO Sevoflurane results in decreased expression of NLGN1 mRNA CTD PMID:33928466 NCBI chr 2:108,256,236...109,181,530 JBrowse link
G Noct nocturnin affects expression EXP sevoflurane affects the expression of NOCT mRNA CTD PMID:15967596 NCBI chr 2:135,271,189...135,291,407 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:32147387 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nostrin nitric oxide synthase trafficking affects expression EXP sevoflurane affects the expression of NOSTRIN mRNA CTD PMID:15967596 NCBI chr 3:53,904,746...53,970,995 JBrowse link
G Nptx1 neuronal pentraxin 1 decreases expression ISO Sevoflurane results in decreased expression of NPTX1 mRNA CTD PMID:33928466 NCBI chr10:104,811,107...104,820,358 JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 affects expression EXP sevoflurane affects the expression of NR1D1 mRNA CTD PMID:15967596 NCBI chr10:83,728,348...83,735,562 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects expression EXP sevoflurane affects the expression of NR1I2 mRNA CTD PMID:15967596 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 affects expression EXP sevoflurane affects the expression of NR4A1 mRNA CTD PMID:15967596 NCBI chr 7:132,368,399...132,389,300 JBrowse link
G Omd osteomodulin affects expression EXP sevoflurane affects the expression of OMD mRNA CTD PMID:15967596 NCBI chr17:15,060,217...15,068,441 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of OPA1 protein] CTD PMID:27684054 NCBI chr11:71,108,100...71,185,170 JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 affects expression EXP sevoflurane affects the expression of OSGIN1 mRNA CTD PMID:15967596 NCBI chr19:47,471,750...47,500,517 JBrowse link
G P2rx7 purinergic receptor P2X 7 affects expression EXP sevoflurane affects the expression of P2RX7 mRNA CTD PMID:15967596 NCBI chr12:33,889,709...33,934,168 JBrowse link
G Pde3b phosphodiesterase 3B affects expression EXP sevoflurane affects the expression of PDE3B mRNA CTD PMID:15967596 NCBI chr 1:168,606,762...168,770,078 JBrowse link
G Pde4b phosphodiesterase 4B affects expression EXP sevoflurane affects the expression of PDE4B mRNA CTD PMID:15967596 NCBI chr 5:116,799,827...117,367,707 JBrowse link
G Pdgfd platelet derived growth factor D affects expression EXP sevoflurane affects the expression of PDGFD mRNA CTD PMID:15967596 NCBI chr 8:3,488,448...3,722,395 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression EXP sevoflurane affects the expression of PDK4 mRNA CTD PMID:15967596 NCBI chr 4:33,591,796...33,601,798 JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 affects expression EXP sevoflurane affects the expression of PDP2 mRNA CTD PMID:15967596 NCBI chr19:386,408...394,068 JBrowse link
G Per2 period circadian regulator 2 affects expression EXP sevoflurane affects the expression of PER2 mRNA CTD PMID:15967596 NCBI chr 9:92,007,289...92,049,551 JBrowse link
G Pex14 peroxisomal biogenesis factor 14 affects expression EXP sevoflurane affects the expression of PEX14 mRNA CTD PMID:15967596 NCBI chr 5:159,399,776...159,536,260 JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 affects expression EXP sevoflurane affects the expression of PFKFB3 mRNA CTD PMID:15967596 NCBI chr17:66,983,629...67,064,702 JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha affects expression EXP sevoflurane affects the expression of PKIA mRNA CTD PMID:15967596 NCBI chr 2:94,398,869...94,473,638 JBrowse link
G Plk3 polo-like kinase 3 affects expression EXP sevoflurane affects the expression of PLK3 mRNA CTD PMID:15967596 NCBI chr 5:130,607,142...130,612,317 JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 affects expression EXP sevoflurane affects the expression of PNPLA7 mRNA CTD PMID:15967596 NCBI chr 3:7,782,572...7,861,504 JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP sevoflurane affects the expression of POR mRNA CTD PMID:15967596 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP sevoflurane affects the expression of PPARA mRNA CTD PMID:15967596 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B affects expression EXP sevoflurane affects the expression of PPP1R3B mRNA CTD PMID:15967596 NCBI chr16:56,830,011...56,842,395 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:32147387 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 affects expression EXP sevoflurane affects the expression of PTP4A1 mRNA CTD PMID:15967596 NCBI chr 9:33,214,201...33,245,046 JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R affects expression EXP sevoflurane affects the expression of PTPRR mRNA CTD PMID:15967596 NCBI chr 7:51,662,595...51,929,605 JBrowse link
G Pxmp4 peroxisomal membrane protein 4 affects expression EXP sevoflurane affects the expression of PXMP4 mRNA CTD PMID:15967596 NCBI chr 3:143,093,371...143,110,620 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects expression EXP sevoflurane affects the expression of RAF1 mRNA CTD PMID:15967596 NCBI chr 4:148,679,534...148,740,265 JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 affects expression EXP sevoflurane affects the expression of RAPGEF4 mRNA CTD PMID:15967596 NCBI chr 3:56,809,388...57,101,332 JBrowse link
G Rbm3 RNA binding motif protein 3 affects expression EXP sevoflurane affects the expression of RBM3 mRNA CTD PMID:15967596 NCBI chr  X:14,348,909...14,352,387 JBrowse link
G Rgcc regulator of cell cycle affects expression EXP sevoflurane affects the expression of RGCC mRNA CTD PMID:15967596 NCBI chr15:54,662,483...54,675,320 JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of RHOA protein] CTD PMID:12960549 NCBI chr 8:108,991,926...109,025,746 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein] CTD PMID:12960549 NCBI chr 6:39,679,116...39,774,033 JBrowse link
G S100a9 S100 calcium binding protein A9 affects expression EXP sevoflurane affects the expression of S100A9 mRNA CTD PMID:15967596 NCBI chr 2:176,190,361...176,193,182 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 affects expression EXP sevoflurane affects the expression of S1PR1 mRNA CTD PMID:15967596 NCBI chr 2:203,624,752...203,629,110 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 affects expression EXP sevoflurane affects the expression of SCN2B mRNA CTD PMID:15967596 NCBI chr 8:45,425,629...45,437,765 JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha affects expression EXP sevoflurane affects the expression of SCNN1A mRNA CTD PMID:15967596 NCBI chr 4:158,122,962...158,146,184 JBrowse link
G Sdc4 syndecan 4 affects expression EXP sevoflurane affects the expression of SDC4 mRNA CTD PMID:15967596 NCBI chr 3:153,154,888...153,173,576 JBrowse link
G Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 affects expression EXP sevoflurane affects the expression of SDR42E1 mRNA CTD PMID:15967596 NCBI chr19:45,715,366...45,727,901 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP sevoflurane affects the expression of SGK1 mRNA CTD PMID:15967596 NCBI chr 1:22,980,257...23,098,122 JBrowse link
G Sik1 salt-inducible kinase 1 affects expression EXP sevoflurane affects the expression of SIK1 mRNA CTD PMID:15967596 NCBI chr20:9,949,407...9,959,036 JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP sevoflurane affects the expression of SLC13A2 mRNA CTD PMID:15967596 NCBI chr10:63,291,813...63,319,127 JBrowse link
G Slc17a6 solute carrier family 17 member 6 affects expression EXP sevoflurane affects the expression of SLC17A6 mRNA CTD PMID:15967596 NCBI chr 1:101,212,489...101,252,543 JBrowse link
G Slc20a1 solute carrier family 20 member 1 affects expression EXP sevoflurane affects the expression of SLC20A1 mRNA CTD PMID:15967596 NCBI chr 3:116,427,095...116,441,049 JBrowse link
G Slc25a25 solute carrier family 25 member 25 affects expression EXP sevoflurane affects the expression of SLC25A25 mRNA CTD PMID:15967596 NCBI chr 3:15,708,702...15,742,195 JBrowse link
G Slc25a32 solute carrier family 25 member 32 affects expression EXP sevoflurane affects the expression of SLC25A32 mRNA CTD PMID:15967596 NCBI chr 7:70,142,958...70,160,726 JBrowse link
G Slc28a2 solute carrier family 28 member 2 affects expression EXP sevoflurane affects the expression of SLC28A2 mRNA CTD PMID:15967596 NCBI chr 3:109,324,815...109,387,702 JBrowse link
G Slc38a2 solute carrier family 38, member 2 affects expression EXP sevoflurane affects the expression of SLC38A2 mRNA CTD PMID:15967596 NCBI chr 7:127,851,267...127,863,482 JBrowse link
G Slc3a2 solute carrier family 3 member 2 affects expression EXP sevoflurane affects the expression of SLC3A2 mRNA CTD PMID:15967596 NCBI chr 1:205,604,468...205,618,931 JBrowse link
G Slc6a9 solute carrier family 6 member 9 affects expression EXP sevoflurane affects the expression of SLC6A9 mRNA CTD PMID:15967596 NCBI chr 5:131,374,562...131,408,733 JBrowse link
G Slc7a10 solute carrier family 7 member 10 affects expression EXP sevoflurane affects the expression of SLC7A10 mRNA CTD PMID:15967596 NCBI chr 1:87,829,084...87,845,073 JBrowse link
G Slc7a2 solute carrier family 7 member 2 affects expression EXP sevoflurane affects the expression of SLC7A2 mRNA CTD PMID:15967596 NCBI chr16:51,417,478...51,470,784 JBrowse link
G Smad3 SMAD family member 3 affects response to substance
multiple interactions
ISO SMAD3 protein affects the susceptibility to sevoflurane
TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]
CTD PMID:18434384 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 decreases activity ISO sevoflurane results in decreased activity of SMPD1 protein CTD PMID:19572936 NCBI chr 1:159,892,946...159,896,789 JBrowse link
G Sqle squalene epoxidase affects expression EXP sevoflurane affects the expression of SQLE mRNA CTD PMID:15967596 NCBI chr 7:90,867,973...90,883,623 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases response to substance
EXP MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]]; MIR34A mRNA promotes the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]; Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR34A mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; STAT1 inhibits the reaction [Sevoflurane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
STAT1 results in decreased susceptibility to Sevoflurane
CTD PMID:32147387 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects expression EXP sevoflurane affects the expression of SULT1A1 mRNA CTD PMID:15967596 NCBI chr 1:181,272,022...181,276,750 JBrowse link
G Susd3 sushi domain containing 3 affects expression EXP sevoflurane affects the expression of SUSD3 mRNA CTD PMID:15967596 NCBI chr17:15,400,845...15,417,851 JBrowse link
G Syp synaptophysin decreases expression
multiple interactions
EXP
ISO
Sevoflurane results in decreased expression of SYP protein
YTHDF1 protein inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; DPYSL2 protein affects the reaction [Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]]; Roscovitine inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
CTD PMID:33548343 PMID:33928466 NCBI chr  X:14,849,444...14,864,553 JBrowse link
G Syt11 synaptotagmin 11 increases expression ISO Sevoflurane results in increased expression of SYT11 mRNA CTD PMID:33928466 NCBI chr 2:174,206,032...174,232,540 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression EXP sevoflurane affects the expression of TDO2 mRNA CTD PMID:15967596 NCBI chr 2:167,269,581...167,287,511 JBrowse link
G Tef TEF transcription factor, PAR bZIP family member affects expression EXP sevoflurane affects the expression of TEF mRNA CTD PMID:15967596 NCBI chr 7:113,317,191...113,341,783 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
affects response to substance
ISO TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]
TGFB1 protein affects the susceptibility to sevoflurane
CTD PMID:18434384 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Tnf tumor necrosis factor decreases expression EXP sevoflurane results in decreased expression of TNF mRNA CTD PMID:15564938 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 increases expression ISO sevoflurane results in increased expression of TP53 mRNA CTD PMID:19572936 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Trib3 tribbles pseudokinase 3 affects expression EXP sevoflurane affects the expression of TRIB3 mRNA CTD PMID:15967596 NCBI chr 3:140,809,634...140,815,230 JBrowse link
G Tuba1a tubulin, alpha 1A affects expression EXP sevoflurane affects the expression of TUBA1A mRNA CTD PMID:15967596 NCBI chr 7:130,113,214...130,116,880 JBrowse link
G Tuba1b tubulin, alpha 1B affects expression EXP sevoflurane affects the expression of TUBA1B mRNA CTD PMID:15967596 NCBI chr 7:130,090,669...130,093,644 JBrowse link
G Tuba3b tubulin, alpha 3B affects expression EXP sevoflurane affects the expression of TUBA3B mRNA CTD PMID:15967596 NCBI chr 4:178,588,779...178,594,328 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP sevoflurane affects the expression of UGT1A1 mRNA CTD PMID:15967596 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects expression EXP sevoflurane affects the expression of UGT1A2 mRNA; sevoflurane affects the expression of UGT1A3 mRNA CTD PMID:15967596 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 affects expression EXP sevoflurane affects the expression of UGT1A5 mRNA CTD PMID:15967596 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects expression EXP sevoflurane affects the expression of UGT1A6 mRNA CTD PMID:15967596 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 affects expression EXP sevoflurane affects the expression of UGT1A8 mRNA CTD PMID:15967596 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects expression EXP sevoflurane affects the expression of UGT1A9 mRNA CTD PMID:15967596 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Usp2 ubiquitin specific peptidase 2 affects expression EXP sevoflurane affects the expression of USP2 mRNA CTD PMID:15967596 NCBI chr 8:44,411,457...44,439,668 JBrowse link
G Ythdf1 YTH N(6)-methyladenosine RNA binding protein 1 multiple interactions
decreases expression
ISO YTHDF1 protein inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]
Sevoflurane results in decreased expression of YTHDF1 mRNA; Sevoflurane results in decreased expression of YTHDF1 protein
CTD PMID:33928466 NCBI chr 3:168,024,660...168,040,172 JBrowse link
G Zfp354a zinc finger protein 354A affects expression EXP sevoflurane affects the expression of ZFP354A mRNA CTD PMID:15967596 NCBI chr10:35,396,242...35,408,065 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        pharmaceutical 19294
          drug 19294
            anaesthetic 5971
              2-methoxypropane 210
                sevoflurane 210
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            heteroorganic entity 19203
                              organochalcogen compound 18961
                                organooxygen compound 18894
                                  ether 16903
                                    2-methoxypropane 210
                                      sevoflurane 210
paths to the root