Cntn2 (contactin 2) - Rat Genome Database

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Gene: Cntn2 (contactin 2) Rattus norvegicus
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Symbol: Cntn2
Name: contactin 2
RGD ID: 3821
Description: Predicted to enable carbohydrate binding activity and cell-cell adhesion mediator activity. Involved in axonogenesis and cell-matrix adhesion. Located in plasma membrane and synapse. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 5. Orthologous to human CNTN2 (contactin 2); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: axonal glycoprotein TAG-1; axonin-1; contactin 2 (axonal); contactin-2; TAG-1; TAG-564; TAG1; Tax; TAX-1; transient axonal glycoprotein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,497,269 - 46,528,112 (-)NCBIGRCr8
mRatBN7.21343,942,868 - 43,975,973 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,947,265 - 43,975,887 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,554,249 - 46,582,887 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,842,379 - 47,871,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,103,086 - 45,131,717 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,280,913 - 49,314,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,285,310 - 49,313,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,356,315 - 54,389,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,399,915 - 45,428,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,413,957 - 45,442,832 (-)NCBI
Celera1344,281,845 - 44,310,387 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Cntn2Rathigh grade glioma severityISORGD:734311734799mRNA, protein:increased expression:brain (human)RGD 
Cntn2Ratlung disease  ISORGD:73431136947872associated with HTLV-I Infections;mRNA:increased expression:bronchoalveolar lavage:RGD 
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Original Reference(s)
Cntn2Ratautistic disorder  ISORGD:7343118554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Cntn2Ratfamilial adult myoclonic epilepsy 5  ISORGD:7343118554872ClinVar Annotator: match by term: Epilepsy, familial adult myoclonic, 5ClinVarPMID:11178983|PMID:16199547|PMID:17576681|PMID:23518707|PMID:25741868|PMID:28492532|PMID:34691156|PMID:36553572|PMID:37359369|PMID:9536098
Cntn2Ratgastrointestinal stromal tumor  ISORGD:7343118554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Cntn2RatHypokalemic Periodic Paralysis, Type 1  ISORGD:7343118554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis, type 1ClinVarPMID:28492532
Cntn2Ratparathyroid carcinoma  ISORGD:7343118554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
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Original Reference(s)
Cntn2RatT-cell adult acute lymphocytic leukemia  ISSRGD:1139213592920 MouseDO 
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Original Reference(s)
Cntn2Ratfamilial adult myoclonic epilepsy 5  ISORGD:7343117240710 OMIM 

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Original Reference(s)
Cntn2Rat1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactionsISORGD:113926480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Cntn2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISORGD:113926480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Cntn2Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:73431164804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of CNTN2 mRNACTDPMID:31326446
Cntn2Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISORGD:113926480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Cntn2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:113926480464Tetrachlorodibenzodioxin results in increased expression of CNTN2 proteinCTDPMID:18227101
Cntn2Rat2,4,4'-trichlorobiphenyl multiple interactionsISORGD:113926480464[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...CTDPMID:25510870
Cntn2Rat3,3',5,5'-tetrabromobisphenol A increases expressionISORGD:7343116480464tetrabromobisphenol A results in increased expression of CNTN2 mRNACTDPMID:31326446
Cntn2Rat3,4-methylenedioxymethamphetamine increases expressionISORGD:113926480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CNTN2 mRNACTDPMID:26251327
Cntn2Rat3,4-methylenedioxymethamphetamine affects methylationISORGD:113926480464N-Methyl-3,4-methylenedioxyamphetamine affects the methylation of CNTN2 promoterCTDPMID:26251327
Cntn2Rat4-hydroxyphenyl retinamide decreases expressionISORGD:113926480464Fenretinide results in decreased expression of CNTN2 mRNACTDPMID:28973697
Cntn2Rat5-aza-2'-deoxycytidine affects expressionISORGD:7343116480464Decitabine affects the expression of CNTN2 mRNACTDPMID:18791715
Cntn2Rat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of CNTN2 mRNACTDPMID:24780913
Cntn2Rat6-propyl-2-thiouracil increases methylationEXP 6480464Propylthiouracil results in increased methylation of CNTN2 promoterCTDPMID:33150595
Cntn2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CNTN2 mRNACTDPMID:33150595
Cntn2Ratacrylamide decreases expressionISORGD:7343116480464Acrylamide results in decreased expression of CNTN2 mRNACTDPMID:32763439
Cntn2Ratall-trans-retinoic acid multiple interactionsISORGD:113926480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of CNTN2 mRNACTDPMID:36189433
Cntn2Ratalpha-amanitin affects expressionISORGD:113926480464Alpha-Amanitin affects the expression of CNTN2 mRNACTDPMID:38531469
Cntn2Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of CNTN2 mRNACTDPMID:35163327
Cntn2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CNTN2 mRNACTDPMID:16483693
Cntn2Rataristolochic acid A increases expressionISORGD:7343116480464aristolochic acid I results in increased expression of CNTN2 mRNACTDPMID:33212167

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Biological Process
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Original Reference(s)
Cntn2Ratadult walking behavior acts_upstream_of_or_withinISORGD:113921624291MGI:2181052 PMID:18760366RGDPMID:18760366
Cntn2Ratadult walking behavior acts_upstream_of_or_withinIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Rataxon guidance acts_upstream_of_or_withinISORGD:113921624291MGI:107558|MGI:2677610|MGI:96721 PMID:18550718RGDPMID:18550718
Cntn2Rataxon guidance acts_upstream_of_or_withinIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Rataxon guidance involved_inIBAMGI:104518|MGI:104753|PANTHER:PTN008688141|WB:WBGene000047291600115GO_REF:0000033GO_CentralGO_REF:0000033
Cntn2Rataxonal fasciculation acts_upstream_of_or_withinISORGD:113921624291MGI:2181052 PMID:18650339RGDPMID:18650339
Cntn2Rataxonal fasciculation acts_upstream_of_or_withinIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Rataxonogenesis  IDA 727707 RGD 
Cntn2Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Cntn2Ratcell-cell adhesion involved_inIBAFB:FBgn0021764|FB:FBgn0031872|MGI:2135283|PANTHER:PTN002548291|UniProtKB:P28685|UniProtKB:P35331|UniProtKB:Q9HCK41600115GO_REF:0000033GO_CentralGO_REF:0000033
Cntn2Ratcell-matrix adhesion  IDA 727707 RGD 
Cntn2Ratcentral nervous system myelination acts_upstream_of_or_withinISORGD:113921624291MGI:2181052 PMID:18650339RGDPMID:18650339
Cntn2Ratcentral nervous system myelination acts_upstream_of_or_withinIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcentral nervous system neuron differentiation acts_upstream_ofIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcentral nervous system neuron differentiation acts_upstream_ofISORGD:113921624291MGI:88059 PMID:18278038RGDPMID:18278038
Cntn2Ratcerebral cortex GABAergic interneuron migration acts_upstream_of_or_withinISORGD:113921624291 PMID:11714688RGDPMID:11714688
Cntn2Ratcerebral cortex GABAergic interneuron migration acts_upstream_of_or_withinIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratclustering of voltage-gated potassium channels involved_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratclustering of voltage-gated potassium channels involved_inISORGD:113921624291 PMID:12963709RGDPMID:12963709
Cntn2Ratestablishment of localization in cell acts_upstream_of_or_withinISORGD:113921624291 PMID:18550718RGDPMID:18550718
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Cellular Component
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Original Reference(s)
Cntn2Rataxon located_inISORGD:113921624291 PMID:12950086, PMID:15964824, PMID:16701205, PMID:17086203, PMID:18650339, PMID:8089271RGDPMID:12950086|PMID:15964824|PMID:16701205|PMID:17086203|PMID:18650339|PMID:8089271
Cntn2Rataxon is_active_inIBAMGI:104518|MGI:104753|PANTHER:PTN008688141|RGD:620911|WB:WBGene000047321600115GO_REF:0000033GO_CentralGO_REF:0000033
Cntn2Rataxon located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Rataxon initial segment is_active_inISORGD:113921624291 PMID:18509034RGDPMID:18509034
Cntn2Rataxon initial segment is_active_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcell surface  TAS 727707 RGD 
Cntn2Ratcell surface located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcell surface located_inISORGD:113921624291 PMID:17086203, PMID:8089271RGDPMID:17086203|PMID:8089271
Cntn2Ratjuxtaparanode region of axon located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratjuxtaparanode region of axon located_inISORGD:113921624291 PMID:12963709RGDPMID:12963709
Cntn2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cntn2Ratmyelin sheath located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratmyelin sheath located_inISORGD:113921624291 PMID:12963709RGDPMID:12963709
Cntn2Ratneuron projection located_inISORGD:113921624291 PMID:18650339RGDPMID:18650339
Cntn2Ratneuron projection located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratneuronal cell body located_inISORGD:113921624291 PMID:8089271RGDPMID:8089271
Cntn2Ratneuronal cell body located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratnode of Ranvier located_inIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratnode of Ranvier located_inISORGD:113921624291 PMID:12963709RGDPMID:12963709
Cntn2Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  
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Original Reference(s)
Cntn2Ratcarbohydrate binding enablesISORGD:113921624291 PMID:19458237RGDPMID:19458237
Cntn2Ratcarbohydrate binding enablesIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcell adhesion mediator activity enablesISORGD:113921624291MGI:2181052 PMID:18650339RGDPMID:18650339
Cntn2Ratcell adhesion mediator activity enablesIEAUniProtKB:Q61330|ensembl:ENSMUSP000000837071600115GO_REF:0000107EnsemblGO_REF:0000107
Cntn2Ratcell-cell adhesion mediator activity enablesIBAMGI:104753|PANTHER:PTN0028917471600115GO_REF:0000033GO_CentralGO_REF:0000033
Cntn2Ratprotein binding enablesISORGD:113921624291PR:P11627|PR:P12023|PR:P24807|PR:P63141|PR:Q9CPW0|UniProtKB:Q9CPW0 PMID:18550718, PMID:19029034, PMID:19458237, PMID:20962216, PMID:25707359RGDPMID:18550718|PMID:19029034|PMID:19458237|PMID:20962216|PMID:25707359
Cntn2Ratprotein binding enablesISORGD:7343111624291UniProtKB:P05067 PMID:32814053RGDPMID:32814053


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Reference Title
Reference Citation
1. Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons. Backer S, etal., Neuroscience 2002;113(4):743-8.
2. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
3. The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity. Furley AJ, etal., Cell 1990 Apr 6;61(1):157-70.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Increased expression of HBZ and Foxp3 mRNA in bronchoalveolar lavage cells taken from human T-lymphotropic virus type 1-associated lung disorder patients. Nakayama Y, etal., Intern Med. 2013;52(23):2599-609. doi: 10.2169/internalmedicine.52.0845.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. Rickman DS, etal., Cancer Res 2001 Mar 1;61(5):2162-8.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers. Traka M, etal., J Neurosci 2002 Apr 15;22(8):3016-24.
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PMID:8089271   PMID:11178983   PMID:11714688   PMID:11807022   PMID:12950086   PMID:12963709   PMID:12975355   PMID:15964824   PMID:16225856   PMID:16701205   PMID:17086203   PMID:18278038  
PMID:18550718   PMID:18650339   PMID:18760366   PMID:19109503   PMID:19416878   PMID:19458237   PMID:20962216   PMID:23518707   PMID:26217189   PMID:26722394   PMID:30078168   PMID:33044326  



Cntn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,497,269 - 46,528,112 (-)NCBIGRCr8
mRatBN7.21343,942,868 - 43,975,973 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,947,265 - 43,975,887 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,554,249 - 46,582,887 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,842,379 - 47,871,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,103,086 - 45,131,717 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,280,913 - 49,314,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,285,310 - 49,313,940 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,356,315 - 54,389,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,399,915 - 45,428,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,413,957 - 45,442,832 (-)NCBI
Celera1344,281,845 - 44,310,387 (-)NCBICelera
Cytogenetic Map13q13NCBI
CNTN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381205,042,949 - 205,078,289 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1205,042,937 - 205,078,289 (+)EnsemblGRCh38hg38GRCh38
GRCh371205,012,077 - 205,047,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,278,963 - 203,313,761 (+)NCBINCBI36Build 36hg18NCBI36
Build 341201,743,996 - 201,778,793NCBI
Celera1178,147,407 - 178,182,200 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1176,177,847 - 176,212,673 (+)NCBIHuRef
CHM1_11206,435,687 - 206,470,502 (+)NCBICHM1_1
T2T-CHM13v2.01204,307,317 - 204,342,659 (+)NCBIT2T-CHM13v2.0
Cntn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,437,163 - 132,470,989 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,437,165 - 132,470,994 (-)EnsemblGRCm39 Ensembl
GRCm381132,509,425 - 132,543,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,509,427 - 132,543,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv371134,406,002 - 134,439,517 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,336,973 - 134,370,462 (-)NCBIMGSCv36mm8
Celera1135,118,092 - 135,152,003 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.42NCBI
Cntn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,831,850 - 40,858,569 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,831,897 - 40,862,445 (+)NCBIChiLan1.0ChiLan1.0
CNTN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2144,298,727 - 44,333,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1144,264,002 - 44,298,806 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01180,645,259 - 180,680,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,931,902 - 184,966,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,931,497 - 184,966,482 (+)Ensemblpanpan1.1panPan2
CNTN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,570,598 - 1,600,524 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,576,898 - 1,596,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,661,917 - 1,694,727 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,564,191 - 1,597,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,563,948 - 1,596,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,560,461 - 1,593,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,951,695 - 1,980,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,151,770 - 2,184,597 (+)NCBIUU_Cfam_GSD_1.0
Cntn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934470,057,146 - 70,080,384 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365577,297,422 - 7,320,846 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365577,297,429 - 7,320,666 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNTN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,736,740 - 65,776,396 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,737,488 - 65,776,412 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CNTN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,262,092 - 24,296,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,261,651 - 24,296,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,018,404 - 25,053,686 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cntn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,056,339 - 6,073,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,052,591 - 6,080,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cntn2
200 total Variants

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:170
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000012190
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat

1 to 10 of 35 rows
RH142422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,959,548 - 43,960,824 (+)MAPPERmRatBN7.2
Rnor_6.01349,297,603 - 49,298,877NCBIRnor6.0
Rnor_5.01354,373,249 - 54,374,523UniSTSRnor5.0
RGSC_v3.41345,412,454 - 45,413,728UniSTSRGSC3.4
Celera1344,294,052 - 44,295,326UniSTS
Cytogenetic Map13q13UniSTS
AW528446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,947,330 - 43,947,474 (+)MAPPERmRatBN7.2
Rnor_6.01349,285,376 - 49,285,519NCBIRnor6.0
Rnor_5.01354,360,776 - 54,360,919UniSTSRnor5.0
RGSC_v3.41345,399,981 - 45,400,124UniSTSRGSC3.4
Celera1344,281,911 - 44,282,054UniSTS
Cytogenetic Map13q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 64 63 32 24 32 6 190 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012190   ⟹   ENSRNOP00000012190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,947,265 - 43,975,887 (-)Ensembl
Rnor_6.0 Ensembl1349,285,310 - 49,313,940 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109604   ⟹   ENSRNOP00000076834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1343,947,265 - 43,962,830 (-)Ensembl
RefSeq Acc Id: NM_012884   ⟹   NP_037016
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,499,396 - 46,528,025 (-)NCBI
mRatBN7.21343,947,265 - 43,975,885 (-)NCBI
Rnor_6.01349,285,310 - 49,313,938 (-)NCBI
Rnor_5.01354,356,315 - 54,389,667 (-)NCBI
RGSC_v3.41345,399,915 - 45,428,789 (-)RGD
Celera1344,281,845 - 44,310,387 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249746   ⟹   XP_006249808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,497,269 - 46,528,110 (-)NCBI
mRatBN7.21343,942,868 - 43,975,972 (-)NCBI
Rnor_6.01349,280,913 - 49,314,061 (-)NCBI
Rnor_5.01354,356,315 - 54,389,667 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090383   ⟹   XP_038946311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,497,269 - 46,528,112 (-)NCBI
mRatBN7.21343,942,868 - 43,975,973 (-)NCBI
RefSeq Acc Id: XR_010056901
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,497,269 - 46,528,110 (-)NCBI
Protein RefSeqs NP_037016 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249808 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946311 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42201 (Get FASTA)   NCBI Sequence Viewer  
  EDM09793 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012190
GenBank Protein P22063 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037016   ⟸   NM_012884
- Peptide Label: precursor
- UniProtKB: P22063 (UniProtKB/Swiss-Prot),   G3V758 (UniProtKB/TrEMBL),   A6IC54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249808   ⟸   XM_006249746
- Peptide Label: isoform X1
- UniProtKB: P22063 (UniProtKB/Swiss-Prot),   G3V758 (UniProtKB/TrEMBL),   A6IC54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012190   ⟸   ENSRNOT00000012190
RefSeq Acc Id: XP_038946311   ⟸   XM_039090383
- Peptide Label: isoform X2
- UniProtKB: P22063 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000076834   ⟸   ENSRNOT00000109604
Name Modeler Protein Id AA Range Protein Structure
AF-P22063-F1-model_v2 AlphaFold P22063 1-1040 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698816
Promoter ID:EPDNEW_R9339
Type:single initiation site
Name:Cntn2_1
Description:contactin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01349,313,950 - 49,314,010EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18313 BioCyc
Ensembl Genes ENSRNOG00000009033 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012190 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Contactin-1_2_Ig1 UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
KEGG Report rno:25356 UniProtKB/Swiss-Prot
NCBI Gene 25356 ENTREZGENE
PANTHER CONTACTIN-2 UniProtKB/Swiss-Prot
  PROTEIN SIDEKICK UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
PhenoGen Cntn2 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009033 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
TIGR TC232614
UniProt A0A8I5ZJA8_RAT UniProtKB/TrEMBL
  A6IC54 ENTREZGENE, UniProtKB/TrEMBL
  CNTN2_RAT UniProtKB/Swiss-Prot
  G3V758 ENTREZGENE, UniProtKB/TrEMBL
  P22063 ENTREZGENE
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Cntn2  contactin 2  Cntn2  contactin 2 (axonal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Cntn2  contactin 2 (axonal)  Cntn2  contactin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-11-29 Cntn2  Contactin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

Note Type Note Reference
gene_expression expressed by Schwann cells and oligodendrocytes 625462