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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.15.* (peptidyl-dipeptidase) inhibitor
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Accession:CHEBI:76782 term browser browse the term
Definition:Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a peptidyl dipeptidase (EC 3.4.15.*).
Synonyms:related_synonym: EC 3.4.15.* (peptidyl-dipeptidase) inhibitors;   EC 3.4.15.* inhibitor;   EC 3.4.15.* inhibitors;   inhibitor of peptidyl-dipeptidases;   inhibitor of peptidyl-dipeptidases (EC 3.4.15.*);   inhibitors of peptidyl-dipeptidases;   inhibitors of peptidyl-dipeptidases (EC 3.4.15.*);   peptidyl-dipeptidase inhibitor;   peptidyl-dipeptidase inhibitors



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(S,S,S)-nicotianamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO nicotianamine results in decreased activity of ACE protein CTD PMID:26106051 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases activity ISO nicotianamine results in decreased activity of ACE2 protein CTD PMID:26106051 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
affects response to substance
ISO benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril
CTD PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 More... NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance
increases response to substance
multiple interactions
ISO ACE2 gene SNP affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:20559404 PMID:21449848 PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:15149348 PMID:20493835 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 protein polymorphism affects the susceptibility to benazepril CTD PMID:15554460 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein CTD PMID:19018797 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
affects response to substance
ISO
EXP
benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]
AGT gene SNP affects the susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]
CTD PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
EXP
ISO
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]
benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:9596920 PMID:15157388 PMID:21449848 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions
ISO benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP benazepril results in decreased expression of BAX protein CTD PMID:20026869 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP benazepril results in increased expression of BCL2 protein CTD PMID:20026869 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb2 bradykinin receptor B2 increases activity
multiple interactions
ISO
EXP
benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril
CTD PMID:15339989 PMID:16982965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein] CTD PMID:16284884 PMID:19553526 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP benazepril results in decreased expression of CCN2 mRNA CTD PMID:17121042 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cd36 CD36 molecule increases expression EXP benazepril results in increased expression of CD36 mRNA CTD PMID:14871019 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression
multiple interactions
EXP benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]
CTD PMID:11798618 PMID:16191423 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to benazepril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
increases activity
EXP benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein
CTD PMID:7528292 PMID:11136700 PMID:16191423 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP benazepril results in increased expression of EGLN3 mRNA CTD PMID:14871019 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
CTD PMID:10515446 PMID:11798618 PMID:16191423 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP benazepril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP benazepril results in increased expression of GOT2 mRNA CTD PMID:14871019 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP benazepril results in increased expression of HGF mRNA CTD PMID:16696918 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP benazepril results in increased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Il6 interleukin 6 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein] CTD PMID:16284884 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP benazepril results in increased expression of MAPK1 mRNA CTD PMID:14871019 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Me1 malic enzyme 1 increases expression EXP benazepril results in increased expression of ME1 mRNA CTD PMID:14871019 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein] CTD PMID:16732983 PMID:19357873 PMID:20821936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in decreased expression of MMP9 protein
benazepril results in increased activity of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]
CTD PMID:15339989 PMID:19357873 PMID:20981132 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril CTD PMID:16081343 PMID:20445573 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects response to substance ISO MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 PMID:20445573 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP benazepril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA CTD PMID:11136700 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP benazepril results in decreased expression of NCF1 mRNA CTD PMID:19018797 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA] CTD PMID:17900838 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein CTD PMID:16191423 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA
CTD PMID:8763405 PMID:11136700 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA
CTD PMID:11136700 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP benazepril results in decreased expression of PCNA protein CTD PMID:17121042 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP benazepril results in increased expression of PDK4 mRNA CTD PMID:14871019 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression EXP benazepril results in decreased expression of PLA2G5 mRNA CTD PMID:14871019 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA] CTD PMID:15322501 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA] CTD PMID:15322501 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plg plasminogen increases activity
multiple interactions
ISO benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]
CTD PMID:15339989 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Prcp prolylcarboxypeptidase affects response to substance ISO PRCP gene SNP affects the susceptibility to benazepril CTD PMID:20079160 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
decreases phosphorylation
EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein
benazepril results in decreased phosphorylation of RELA protein
CTD PMID:15157388 PMID:17900838 PMID:19018797 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in increased expression of REN protein
benazepril results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein
CTD PMID:1316404 PMID:10836730 PMID:11501062 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP benazepril results in decreased expression of RSAD2 mRNA CTD PMID:14871019 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]
CTD PMID:15322501 PMID:15339989 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinh1 serpin family H member 1 increases expression EXP benazepril results in increased expression of SERPINH1 mRNA CTD PMID:14871019 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Smad2 SMAD family member 2 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
CTD PMID:16635409 PMID:19487956 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N decreases expression EXP benazepril results in decreased expression of SNRPN mRNA CTD PMID:14871019 NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression
ISO
EXP
benazepril results in decreased expression of TGFB1 protein
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
benazepril affects the expression of TGFB1 mRNA
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
CTD PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein] CTD PMID:11798618 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]
CTD PMID:11867951 PMID:18471418 PMID:19357873 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein] CTD PMID:16732983 PMID:20821936 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein
CTD PMID:16775501 PMID:20981132 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein CTD PMID:19018797 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:20844835 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
captopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity
EXP
ISO
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Captopril results in decreased activity of ACE protein
CTD PMID:26851370 PMID:31629013 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases response to substance
multiple interactions
ISO
EXP
ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
CTD PMID:17473847 PMID:31629013 PMID:33007385 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:31181250 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
CTD PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
CTD PMID:28130181 PMID:31629013 PMID:33007385 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] CTD PMID:28130181 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] CTD PMID:28130181 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] CTD PMID:28130181 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]
CTD PMID:31181250 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]
CTD PMID:31181250 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]
CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Lepr leptin receptor multiple interactions
affects response to substance
ISO Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril
CTD PMID:28130181 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP
ISO
Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]
CTD PMID:31629013 PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] CTD PMID:28130181 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] CTD PMID:31629013 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]
CTD PMID:31181250 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Pth parathyroid hormone multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] CTD PMID:28130181 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] CTD PMID:28130181 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]
CTD PMID:31181250 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO
EXP
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]
CTD PMID:31181250 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] CTD PMID:28130181 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] CTD PMID:28130181 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Cilazapril CTD PMID:15498266 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Cilazapril results in increased expression of ADIPOQ protein CTD PMID:19789415 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA] CTD PMID:15331931 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein CTD PMID:9640960 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Nppa natriuretic peptide A multiple interactions
affects secretion
ISO [Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein
CTD PMID:1457087 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Ren renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2425185 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:15331931 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
corilagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30582900 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells RGD PMID:29235094 RGD:15042872 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO corilagin results in decreased secretion of TNF protein CTD PMID:12628509 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Angiotensin-Converting Enzyme Inhibitors CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ace angiotensin I converting enzyme decreases activity EXP Angiotensin-Converting Enzyme Inhibitors results in decreased activity of ACE protein CTD PMID:15667801 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of ACE2 mRNA CTD PMID:25534429 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Agt angiotensinogen affects expression
increases metabolic processing
multiple interactions
decreases expression
increases expression
ISO
EXP
Angiotensin-Converting Enzyme Inhibitors affects the expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors affects the expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in increased metabolism of AGT protein
7-Ala-angiotensin (1-7) inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]]; AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein alternative form]
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein modified form
CTD PMID:1668233 PMID:2474097 PMID:3078272 PMID:6105291 PMID:6388325 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGTR1 mRNA CTD PMID:9533614 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Avp arginine vasopressin decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AVP protein CTD PMID:1773493 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:22429817 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:22429817 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP 7-Ala-angiotensin (1-7) inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]]; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein] CTD PMID:19793108 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of COL1A1 mRNA CTD PMID:15667801 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of COL3A1 mRNA CTD PMID:15667801 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Angiotensin-Converting Enzyme Inhibitors results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Epo erythropoietin decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of EPO protein CTD PMID:2474097 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G F11 coagulation factor XI decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of F11 protein CTD PMID:6383834 NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F12 coagulation factor XII decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of F12 protein CTD PMID:6383834 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of FAS protein CTD PMID:10971519 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of FASLG protein CTD PMID:10971519 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of GAS6 protein CTD PMID:19126665 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Il2 interleukin 2 decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of IL2 protein CTD PMID:10971519 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Kng2 kininogen 2 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of KNG1 protein CTD PMID:8009499 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of MMP2 protein CTD PMID:21697605 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of MMP9 protein CTD PMID:21697605 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Angiotensin-Converting Enzyme Inhibitors affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of MYH7 mRNA CTD PMID:15667801 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NPPA protein CTD PMID:1647690 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
ISO
EXP
[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of NPPB protein
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NPPB mRNA
CTD PMID:15667801 PMID:21697605 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 mRNA; Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 protein CTD PMID:16413583 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form] CTD PMID:22429817 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and affects the activity of REN protein; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and results in increased activity of REN protein; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]
Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN mRNA; Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein
AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]
CTD PMID:231700 PMID:1330361 PMID:1647690 PMID:1668233 PMID:3071592 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Angiotensin-Converting Enzyme Inhibitors affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Angiotensin-Converting Enzyme Inhibitors affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Slc15a1 solute carrier family 15 member 1 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC15A1 mRNA CTD PMID:25534429 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc36a1 solute carrier family 36 member 1 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC36A1 mRNA CTD PMID:25534429 NCBI chr10:39,319,062...39,357,374
Ensembl chr10:39,324,337...39,354,217
JBrowse link
G Slc6a19 solute carrier family 6 member 19 increases expression ISO Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC6A19 mRNA CTD PMID:25534429 NCBI chr 1:29,586,205...29,604,960
Ensembl chr 1:29,586,195...29,604,962
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Angiotensin-Converting Enzyme Inhibitors results in decreased expression of TGFB1 mRNA CTD PMID:15667801 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Xpnpep2 X-prolyl aminopeptidase 2 affects response to substance ISO XPNPEP2 gene SNP affects the susceptibility to Angiotensin-Converting Enzyme Inhibitors CTD PMID:16175507 NCBI chr  X:127,287,765...127,317,036
Ensembl chr  X:127,287,979...127,317,223
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Enalapril CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ace angiotensin I converting enzyme decreases activity
multiple interactions
increases expression
ISO
EXP
Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]
Enalapril results in increased expression of ACE mRNA
CTD PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 More... NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Enalapril results in decreased expression of ACTA2 protein CTD PMID:19349682 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Enalapril results in decreased expression of ACVRL1 protein CTD PMID:12883979 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Enalapril results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Enalapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Agt angiotensinogen decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression
EXP
ISO
Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA
CTD PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
decreases expression
affects expression
EXP
ISO
Enalapril results in increased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril affects the expression of AGTR1A mRNA
CTD PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
decreases expression
EXP Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA
CTD PMID:9740612 PMID:18403896 PMID:18765277 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:18806606 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Ang angiogenin decreases expression ISO Enalapril results in decreased expression of ANG protein CTD PMID:3038326 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] CTD PMID:19958114 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
CTD PMID:19603250 PMID:25037058 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Enalapril results in increased expression of ATF2 protein CTD PMID:15531746 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Enalapril results in decreased expression of BAX protein CTD PMID:21153712 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
CTD PMID:21153712 PMID:30623541 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression
multiple interactions
EXP Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril
CTD PMID:18796534 PMID:21430409 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression EXP Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein CTD PMID:18190998 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Enalapril results in decreased activity of CA2 protein CTD PMID:28126276 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]
CTD PMID:21153712 PMID:30623541 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 decreases activity EXP Enalapril results in decreased activity of CASP9 protein CTD PMID:21153712 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
CTD PMID:12124199 PMID:30623541 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 protein
Enalapril results in decreased expression of CCL2 mRNA
CTD PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
CTD PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression EXP Enalapril results in decreased expression of CELA2A mRNA CTD PMID:21602471 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
JBrowse link
G Cltrn collectrin, amino acid transport regulator decreases expression EXP Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein CTD PMID:12887829 NCBI chr  X:30,361,967...30,395,264
Ensembl chr  X:30,361,967...30,395,349
JBrowse link
G Clu clusterin decreases expression EXP Enalapril results in decreased expression of CLU protein CTD PMID:12193663 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cma1 chymase 1 decreases expression EXP Enalapril results in decreased expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] CTD PMID:12003776 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
increases expression
EXP
ISO
Enalapril results in decreased expression of COL3A1 mRNA
Enalapril results in increased expression of COL3A1 mRNA
CTD PMID:17164399 PMID:25037058 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein
CTD PMID:9175058 PMID:18682491 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
Enalapril results in decreased expression of CYBA protein
CTD PMID:20720404 PMID:25037058 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP Enalapril affects the localization of CYCS protein CTD PMID:21153712 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Epo erythropoietin decreases expression
multiple interactions
ISO
EXP
Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]
CTD PMID:2474097 PMID:9434678 PMID:19958114 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] CTD PMID:19958114 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
ISO Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]
CTD PMID:18060435 PMID:22188725 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Faslg Fas ligand decreases expression EXP Enalapril results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gh1 growth hormone 1 increases response to substance ISO GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions ISO GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gjc1 gap junction protein, gamma 1 multiple interactions ISO GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] CTD PMID:18806606 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Enalapril results in increased expression of HAS2 mRNA CTD PMID:20933085 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]
CTD PMID:19114890 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Enalapril results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hyal1 hyaluronidase 1 decreases expression EXP Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein CTD PMID:20933085 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of ICAM1 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form
CTD PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
decreases expression
EXP Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA
CTD PMID:12883983 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Enalapril results in increased expression of IGFBP1 mRNA CTD PMID:12883983 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] CTD PMID:17299153 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA
CTD PMID:17167242 PMID:21265103 PMID:25037058 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
affects response to substance
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril
CTD PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Enalapril results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kng2 kininogen 2 increases response to substance EXP Enalapril results in increased susceptibility to KNG1 protein modified form CTD PMID:18190998 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:9175058 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:9175058 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
JBrowse link
G Lep leptin increases response to substance ISO LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
increases phosphorylation
EXP Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein
CTD PMID:15531746 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Enalapril results in decreased expression of MMP3 mRNA CTD PMID:25037058 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] CTD PMID:19114890 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression
multiple interactions
EXP Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]
CTD PMID:15362513 PMID:21423293 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression EXP Enalapril results in decreased expression of NFE2L2 mRNA CTD PMID:18765277 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]
CTD PMID:19225048 PMID:21265102 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:19114890 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Noa1 nitric oxide associated 1 increases expression
increases activity
EXP Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein
CTD PMID:14588141 NCBI chr14:30,835,012...30,851,296
Ensembl chr14:30,835,247...30,851,293
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of NOS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression
EXP
ISO
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
Enalapril results in increased expression of NOS3 protein
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril affects the expression of NOS3 mRNA
CTD PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO
EXP
Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA
CTD PMID:2136812 PMID:8112904 PMID:21423293 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:18806606 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Enalapril results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Enalapril results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Pdpn podoplanin increases expression EXP Enalapril results in increased expression of PDPN protein CTD PMID:20933085 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
EXP Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
CTD PMID:19225048 PMID:30623541 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Enalapril results in increased expression of PPARGC1A mRNA CTD PMID:18765277 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO Enalapril results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Enalapril results in decreased expression of PRKCA protein modified form CTD PMID:21565836 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Enalapril results in decreased expression of PTGS1 mRNA CTD PMID:25037058 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
CTD PMID:20720404 PMID:21377515 PMID:25037058 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
decreases activity
increases activity
ISO
EXP
[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein
CTD PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 PMID:31887396 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sele selectin E multiple interactions ISO Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Selp selectin P multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA
CTD PMID:14716214 PMID:25037058 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Enalapril results in decreased expression of SERPINB2 mRNA CTD PMID:25037058 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein
CTD PMID:18682491 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15100168 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein CTD PMID:19197123 PMID:19349682 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO [paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
Enalapril results in increased expression of SOD1 protein
CTD PMID:20720404 PMID:25037058 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased activity of SOD2 protein
Enalapril results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
CTD PMID:18765277 PMID:20720404 PMID:25037058 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]
CTD PMID:25037058 PMID:30423288 PMID:31887396 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression EXP Enalapril results in increased expression of SSBP1 mRNA CTD PMID:18765277 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:19958114 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] CTD PMID:19958114 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein
CTD PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Enalapril results in decreased expression of TGFB2 mRNA CTD PMID:17164399 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions
EXP Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
CTD PMID:18682491 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein CTD PMID:12883979 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Thbs4 thrombospondin 4 increases expression ISO Enalapril results in increased expression of THBS4 mRNA CTD PMID:25037058 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
CTD PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
decreases expression
ISO Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form
CTD PMID:17347482 PMID:19939336 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein
CTD PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vwf von Willebrand factor decreases expression ISO Enalapril results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adrb1 adrenoceptor beta 1 affects expression EXP Enalaprilat affects the expression of ADRB1 protein CTD PMID:9260993 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Enalaprilat affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP
ISO
Enalaprilat results in decreased expression of AGT protein modified form
Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein]
CTD PMID:16452552 PMID:21795644 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Enalaprilat results in increased expression of BCL2 mRNA CTD PMID:17342403 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions
increases activity
ISO bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein] CTD PMID:11880373 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Enalaprilat results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP
ISO
Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein
Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]
CTD PMID:14520012 PMID:21795644 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA] CTD PMID:32494933 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA] CTD PMID:32494933 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA CTD PMID:23834779 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ren renin increases expression EXP Enalaprilat results in increased expression of REN mRNA CTD PMID:21795644 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Enalaprilat results in decreased expression of SERPINE1 mRNA CTD PMID:21795644 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein CTD PMID:21795644 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Enalaprilat results in decreased expression of TNF mRNA CTD PMID:17342403 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
fosinopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fosinopril CTD PMID:22095822 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions
increases export
ISO ABCC2 protein results in decreased susceptibility to Fosinopril
ABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]
desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]
CTD PMID:22095822 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP fosinopril increases expression of adipor2 mRNA in rat liver RGD PMID:19076162 RGD:2307264 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agt angiotensinogen decreases expression EXP Fosinopril results in decreased expression of AGT protein CTD PMID:12411096 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions EXP Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA] CTD PMID:17803470 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] CTD PMID:29859236 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Kl Klotho increases expression EXP Fosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] CTD PMID:29859236 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
EXP Fosinopril results in decreased expression of MMP9 mRNA; Fosinopril results in decreased expression of MMP9 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
CTD PMID:21051829 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] CTD PMID:29859236 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Fosinopril affects the expression of NOS3 mRNA; Fosinopril affects the expression of NOS3 protein CTD PMID:18209565 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pde1a phosphodiesterase 1A affects expression EXP Fosinopril affects the expression of PDE1A mRNA; Fosinopril affects the expression of PDE1A protein CTD PMID:18209565 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
JBrowse link
G Pde1c phosphodiesterase 1C affects expression EXP Fosinopril affects the expression of PDE1C mRNA; Fosinopril affects the expression of PDE1C protein CTD PMID:18209565 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein] CTD PMID:29859236 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions
EXP Fosinopril results in decreased expression of SERPINE1 mRNA; Fosinopril results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein
CTD PMID:21051829 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein] CTD PMID:29859236 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions
EXP Fosinopril results in decreased expression of TIMP1 mRNA; Fosinopril results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein
CTD PMID:21051829 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein] CTD PMID:29859236 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] CTD PMID:29859236 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
imidapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases response to substance ISO ACE2 gene SNP results in increased susceptibility to imidapril CTD PMID:27121444 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril] CTD PMID:9300133 PMID:31268531 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to imidapril CTD PMID:16765146 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
imidaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] CTD PMID:16257180 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
lisinopril dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Lisinopril analog results in decreased activity of ACE protein CTD PMID:22200082 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression
increases activity
EXP Lisinopril results in increased expression of ACE2 mRNA
Lisinopril results in increased activity of ACE2 protein
CTD PMID:15897343 PMID:16221218 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]
CTD PMID:23060470 PMID:31710167 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
decreases secretion
increases secretion
affects response to substance
increases expression
ISO
EXP
Lisinopril results in decreased expression of AGT protein
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA
Lisinopril results in decreased secretion of AGT protein
Lisinopril results in increased secretion of AGT protein alternative form
AGT gene alternative form affects the susceptibility to Lisinopril
Lisinopril results in increased expression of AGT mRNA
CTD PMID:8393685 PMID:8915971 PMID:15897343 PMID:16221218 PMID:16685205 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lisinopril results in decreased expression of BCL2 CTD PMID:10075388 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Lisinopril results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:19225054 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Lisinopril results in increased expression of IGFBP1 protein CTD PMID:9663927 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] CTD PMID:20051877 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] CTD PMID:20051877 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Lisinopril results in decreased expression of NPPA protein CTD PMID:8393685 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Ren renin increases expression
multiple interactions
ISO
EXP
Lisinopril results in increased expression of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA
Lisinopril results in increased expression of REN mRNA
CTD PMID:2550029 PMID:8915971 PMID:16221218 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Lisinopril affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] CTD PMID:20051877 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
perindopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Perindopril CTD PMID:11007831 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA]; Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein] CTD PMID:19793108 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP Perindopril results in decreased expression of ACTA2 protein
[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]
CTD PMID:12076858 PMID:16596278 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agt angiotensinogen decreases expression
increases expression
multiple interactions
ISO
EXP
Perindopril results in decreased expression of AGT protein alternative form
Perindopril results in increased expression of AGT protein alternative form
[Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form; Perindopril inhibits the reaction [Methotrexate results in decreased expression of AGT protein alternative form]; Perindopril inhibits the reaction [Methotrexate results in increased expression of AGT protein]
Perindopril results in decreased expression of AGT protein; Perindopril results in decreased expression of AGT protein alternative form
CTD PMID:2549899 PMID:2605800 PMID:9808682 PMID:34737150 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance
multiple interactions
ISO
EXP
AGTR1 gene SNP affects the susceptibility to Perindopril
[Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]
CTD PMID:8952600 PMID:12930639 PMID:16097048 PMID:30184259 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein]
CTD PMID:16872305 PMID:30184259 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]] CTD PMID:30184259 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form] CTD PMID:16116328 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdkrb1 bradykinin receptor B1 affects expression EXP Perindopril affects the expression of BDKRB1 protein CTD PMID:18806609 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects expression EXP Perindopril affects the expression of BDKRB2 protein CTD PMID:18806609 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Cat catalase increases activity EXP Perindopril results in increased activity of CAT protein CTD PMID:26878793 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Perindopril results in decreased expression of CCL2 protein
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
CTD PMID:19840533 PMID:30184259 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]] CTD PMID:30184259 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA] CTD PMID:30184259 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd163 CD163 molecule multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]] CTD PMID:30184259 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]] CTD PMID:30184259 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP [Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA] CTD PMID:16596278 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Perindopril results in decreased expression of COL3A1 mRNA CTD PMID:12076858 PMID:14871039 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:30184259 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
EXP Perindopril results in decreased expression of FOS protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of FOS protein]
CTD PMID:34737150 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] CTD PMID:29859236 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]] CTD PMID:30184259 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO
EXP
Perindopril results in increased expression of IL10 protein
Perindopril inhibits the reaction [Methotrexate results in decreased expression of IL10 protein]
CTD PMID:19840533 PMID:34737150 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Perindopril results in decreased expression of IL1B protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL1B protein]
CTD PMID:19840533 PMID:34737150 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO
EXP
Perindopril results in decreased expression of IL6 protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL6 protein]
CTD PMID:19840533 PMID:34737150 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Perindopril inhibits the reaction [Methotrexate results in increased expression of JUN protein] CTD PMID:34737150 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kng2 kininogen 2 decreases expression
increases expression
multiple interactions
ISO
EXP
Perindopril results in decreased expression of KNG1 protein modified form
Perindopril results in increased expression of KNG1 protein alternative form
Perindopril promotes the reaction [racecadotril affects the metabolism of KNG1 protein alternative form]
CTD PMID:9808682 PMID:11855668 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lep leptin decreases expression EXP Perindopril results in decreased expression of LEP protein CTD PMID:18083506 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of MAS1 mRNA] CTD PMID:19793108 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mfn2 mitofusin 2 increases expression EXP Perindopril results in increased expression of MFN2 mRNA; Perindopril results in increased expression of MFN2 protein CTD PMID:25464244 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]
CTD PMID:12930639 PMID:14761280 PMID:16097048 PMID:29859236 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein] CTD PMID:16097048 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]] CTD PMID:30184259 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] CTD PMID:29859236 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]] CTD PMID:30184259 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]] CTD PMID:30184259 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:14761280 PMID:16097048 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
EXP Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]
Perindopril results in increased expression of PPARG mRNA; Perindopril results in increased expression of PPARG protein
CTD PMID:34737150 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression EXP Perindopril results in decreased expression of PPP3CA protein CTD PMID:18344631 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Perindopril results in decreased expression of PPP3R1 mRNA CTD PMID:18344631 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Perindopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
Perindopril inhibits the reaction [Methotrexate results in increased expression of RELA protein]
CTD PMID:29859236 PMID:34737150 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases expression
increases activity
EXP
ISO
Perindopril results in increased expression of REN protein
Perindopril results in increased activity of REN protein
CTD PMID:2549899 PMID:2605800 PMID:9383173 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression
EXP carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein] CTD PMID:19620082 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 affects binding ISO Perindopril binds to SFRP4 protein CTD PMID:25019556 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
EXP Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein]
Perindopril results in increased expression of SIRT1 mRNA; Perindopril results in increased expression of SIRT1 protein
CTD PMID:34737150 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Perindopril results in decreased expression of SMAD3 protein
CTD PMID:15619341 PMID:16872305 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 increases expression
multiple interactions
EXP Perindopril results in increased expression of SMAD7 protein
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
CTD PMID:15619341 PMID:16872305 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP
ISO
Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
Perindopril results in decreased expression of TGFB1 mRNA; Perindopril results in decreased expression of TGFB1 protein
CTD PMID:12930639 PMID:14761280 PMID:14871039 PMID:15619341 PMID:16097048 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
EXP Perindopril results in decreased expression of TGFBR2 mRNA
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
CTD PMID:15619341 PMID:16872305 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 mRNA]; Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 protein] CTD PMID:34737150 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
increases expression
ISO
EXP
Perindopril results in decreased expression of TNF protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of TNF protein]
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
Perindopril results in increased expression of TNF protein
CTD PMID:19840533 PMID:26878793 PMID:29859236 PMID:30184259 PMID:34737150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] CTD PMID:29859236 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vwf von Willebrand factor decreases expression ISO Perindopril results in decreased expression of VWF protein CTD PMID:12224817 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
quinapril hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP
ISO
Quinapril results in decreased activity of ACE protein CTD PMID:8227822 PMID:15728788 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adm adrenomedullin decreases expression EXP Quinapril results in decreased expression of ADM protein CTD PMID:10334802 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Agt angiotensinogen decreases activity
multiple interactions
EXP Quinapril results in decreased activity of AGT protein
Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]
CTD PMID:11709406 PMID:15728788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Quinapril results in decreased expression of CXCL10 CTD PMID:15831368 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Quinapril results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein CTD PMID:12149661 PMID:12425201 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G F2 coagulation factor II decreases activity ISO Quinapril results in decreased activity of F2 protein CTD PMID:16907931 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F5 coagulation factor V decreases activity ISO Quinapril results in decreased activity of F5 protein CTD PMID:16907931 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinapril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Quinapril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Quinapril affects the expression of NOS3 mRNA CTD PMID:12176110 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion
EXP Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein
CTD PMID:14639023 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ren renin multiple interactions
increases expression
EXP Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]
Quinapril results in increased expression of REN protein
CTD PMID:10334802 PMID:11709406 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP
ISO
Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein CTD PMID:16549154 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
quinaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO quinaprilat inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
quinaprilat inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
ramipril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Ramipril results in decreased activity of ACE protein CTD PMID:3034026 PMID:10543928 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
Ramipril results in decreased expression of ADIPOQ
CTD PMID:17483542 PMID:19059660 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression EXP Ramipril affects the expression of BAX protein CTD PMID:10728395 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression EXP Ramipril affects the expression of BCL2 protein CTD PMID:10728395 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein CTD PMID:15184351 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein CTD PMID:31062909 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of Ramipril CTD PMID:25445008 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Ramipril results in decreased expression of COL1A1 mRNA CTD PMID:11851355 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]
Ramipril results in decreased expression of CYBA mRNA
CTD PMID:12352326 PMID:16891913 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO Ramipril results in decreased expression of CYBB mRNA CTD PMID:16891913 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein CTD PMID:31062909 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Kng2 kininogen 2 decreases degradation EXP Ramipril results in decreased degradation of KNG1 protein CTD PMID:2535056 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
Ramipril results in decreased expression of LEP
CTD PMID:17483542 PMID:19059660 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:31062909 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP Ramipril results in decreased expression of MMP2 mRNA CTD PMID:11851355 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Ramipril results in decreased expression of MYH7 mRNA CTD PMID:15667801 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] CTD PMID:11832429 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO NOS3 protein affects the reaction [Ramipril results in increased abundance of Cyclic GMP] CTD PMID:16891913 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Ramipril results in decreased expression of NPPB mRNA CTD PMID:15667801 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]
Ramipril results in decreased expression of PDGFA mRNA
CTD PMID:10352363 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases expression
ISO Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]
Ramipril results in decreased expression of PDGFB mRNA
CTD PMID:10352363 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA] CTD PMID:11832429 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ren renin increases activity
increases expression
multiple interactions
ISO
EXP
Ramipril results in increased activity of REN protein
Ramipril results in increased expression of REN protein
Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]
Ramipril results in increased expression of REN mRNA
CTD PMID:1327051 PMID:9179393 PMID:9539862 PMID:11832429 PMID:14504926 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of RHOA protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of RHOA protein] CTD PMID:31062909 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein] CTD PMID:31062909 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein CTD PMID:31062909 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein CTD PMID:31062909 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases activity
ISO
EXP
Ramipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Ramipril results in decreased expression of TGFB1 mRNA
[Streptozocin co-treated with Ramipril] results in increased expression of TGFB1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of TGFB1 protein; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Ramipril results in decreased activity of TGFB1 protein
CTD PMID:12352326 PMID:12631109 PMID:15667801 PMID:17703430 PMID:20551625 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 multiple interactions EXP [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of TGFBR3 protein CTD PMID:31062909 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression EXP Ramipril results in increased expression of TIMP4 mRNA CTD PMID:11851355 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
ramiprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 results in increased susceptibility to ramiprilat CTD PMID:10523327 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Kng2 kininogen 2 decreases degradation EXP ramiprilat results in decreased degradation of KNG1 protein CTD PMID:2535056 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
spirapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ren renin increases expression
multiple interactions
EXP spirapril results in increased expression of REN mRNA; spirapril results in increased expression of REN protein
spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
CTD PMID:1764812 PMID:9300315 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
telmisartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO telmisartan results in decreased activity of ABCB11 protein
telmisartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
ISO PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA] CTD PMID:22124178 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Ace angiotensin I converting enzyme decreases expression
multiple interactions
EXP Telmisartan results in decreased expression of ACE mRNA; Telmisartan results in decreased expression of ACE protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein]
CTD PMID:19171132 PMID:25973029 PMID:29909460 PMID:31629013 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
decreases expression
increases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
Telmisartan results in decreased expression of ACE2 mRNA; Telmisartan results in decreased expression of ACE2 protein
Telmisartan results in increased expression of ACE2 mRNA; Telmisartan results in increased expression of ACE2 protein
CTD PMID:21381899 PMID:25973029 PMID:28656296 PMID:29909460 PMID:31629013 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:23060470 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO telmisartan results in increased expression of ADIPOQ mRNA
telmisartan results in increased expression of ADIPOQ protein
CTD PMID:19730415 PMID:20555330 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]
telmisartan results in decreased expression of AGT mRNA; telmisartan results in decreased expression of AGT protein
Telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; Telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
CTD PMID:9533614 PMID:17620961 PMID:18487452 PMID:19171132 PMID:19289654 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects binding
decreases expression
multiple interactions
increases expression
EXP
ISO
telmisartan binds to AGTR1 protein
telmisartan results in decreased expression of AGTR1A mRNA
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
telmisartan binds to and results in decreased activity of AGTR1 protein
Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
telmisartan results in increased expression of AGTR1 mRNA
CTD PMID:8220885 PMID:9533614 PMID:9728324 PMID:17620961 PMID:19171132 More... NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions ISO telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity EXP Telmisartan results in increased activity of AHR protein CTD PMID:28728110 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alb albumin affects expression
multiple interactions
ISO telmisartan affects the expression of ALB protein modified form
Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]
CTD PMID:16671338 PMID:34464088 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of ANG2 protein] CTD PMID:23750309 NCBI chr15:24,398,383...24,415,837
Ensembl chr15:24,398,419...24,398,922
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA] CTD PMID:24831514 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA] CTD PMID:24831514 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein] CTD PMID:23747572 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
Telmisartan results in decreased expression of CASP3 protein
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 mRNA]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
CTD PMID:18565324 PMID:19452295 PMID:21620867 PMID:21819444 PMID:22750630 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Telmisartan inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:23750309 PMID:26929000 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
telmisartan results in decreased expression of CCL2 protein
CTD PMID:17922026 PMID:22124178 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases response to substance ISO telmisartan results in decreased susceptibility to CCL5 protein CTD PMID:18158351 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP telmisartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO telmisartan results in increased expression of CD36 mRNA
PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; T 0070907 inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]
CTD PMID:22124178 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]] CTD PMID:19289654 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein] CTD PMID:33872574 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crp C-reactive protein decreases expression ISO telmisartan results in decreased expression of CRP protein CTD PMID:20555330 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases response to substance
ISO PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
telmisartan results in decreased susceptibility to CXCL12 protein
CTD PMID:18158351 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
ISO
EXP
telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]
CTD PMID:16141465 PMID:19171132 PMID:21054405 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB protein]
telmisartan results in decreased expression of CYBB mRNA
CTD PMID:19171132 PMID:21381899 PMID:34464088 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CYCS mRNA] CTD PMID:24831514 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Telmisartan results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression EXP telmisartan results in decreased expression of DDIT3 protein CTD PMID:19102871 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein] CTD PMID:20888384 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein] CTD PMID:20888384 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Faslg Fas ligand multiple interactions ISO
EXP
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASL protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASLG protein]
CTD PMID:21620867 PMID:21819444 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein] CTD PMID:33872574 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein] CTD PMID:23747572 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
Telmisartan results in decreased expression of GFAP protein
CTD PMID:23747572 PMID:29909460 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein] CTD PMID:23750309 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:26929000 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO telmisartan results in increased expression of HGF mRNA CTD PMID:21479465 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP telmisartan results in decreased expression of HSPA5 protein CTD PMID:19102871 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
CTD PMID:17724226 PMID:20888384 PMID:22124178 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
Telmisartan results in increased expression of IL10 protein
CTD PMID:24831514 PMID:29909460 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]
CTD PMID:22124178 PMID:33872574 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Telmisartan results in decreased expression of IL6 protein
telmisartan results in decreased expression of IL6 mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:19289654 PMID:21479465 PMID:22124178 PMID:29909460 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases expression ISO telmisartan results in decreased expression of INS protein CTD PMID:15892894 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Lepr leptin receptor multiple interactions ISO Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]; Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA] CTD PMID:34464088 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein] CTD PMID:20176998 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:22124178 PMID:33872574 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases phosphorylation
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
telmisartan results in decreased phosphorylation of MAPK14 protein
CTD PMID:19292980 PMID:22124178 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:22124178 PMID:33872574 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form] CTD PMID:21381899 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions
increases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Telmisartan results in increased expression of MAS1 protein
CTD PMID:21381899 PMID:28656296 PMID:31629013 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP telmisartan results in decreased expression of MMP2 protein CTD PMID:21054405 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]
Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased activity of MPO protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:23060470 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mylk myosin light chain kinase multiple interactions ISO MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK protein] CTD PMID:34464088 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein]
Telmisartan results in decreased expression of NCF1 mRNA; Telmisartan results in decreased expression of NCF1 protein
telmisartan results in decreased expression of NCF1 mRNA; telmisartan results in decreased expression of NCF1 protein
CTD PMID:16141465 PMID:19171132 PMID:21054405 PMID:21381899 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]
telmisartan results in decreased expression of NCF2 mRNA; telmisartan results in decreased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
CTD PMID:16141465 PMID:21054405 PMID:21381899 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein] CTD PMID:21620867 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA] CTD PMID:22124178 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
CTD PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased phosphorylation of NOS3 protein] CTD PMID:21156825 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein] CTD PMID:21054405 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppb natriuretic peptide B affects expression
multiple interactions
decreases expression
ISO
EXP
telmisartan affects the expression of NPPB protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]
telmisartan results in decreased expression of NPPB protein
CTD PMID:16671338 PMID:18712048 PMID:31629013 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ocln occludin multiple interactions ISO MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN protein]
Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA]
CTD PMID:34464088 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 mRNA]; Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 protein] CTD PMID:22124178 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
multiple interactions
EXP
ISO
telmisartan results in increased expression of PPARD protein
PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein]
CTD PMID:20176998 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
ISO
EXP
PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]
telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
telmisartan results in increased expression of PPARG protein
telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
Telmisartan results in increased activity of PPARG protein
CTD PMID:18158351 PMID:20176998 PMID:20888384 PMID:21381899 PMID:22124178 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein] CTD PMID:21381899 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
[Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
CTD PMID:20223228 PMID:20888384 PMID:22124178 PMID:22750630 PMID:24831514 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTH1R protein] CTD PMID:23750309 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23750309 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
[telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
telmisartan inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD PMID:20223228 PMID:22124178 PMID:24831514 PMID:26929000 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases expression EXP telmisartan results in increased expression of REN mRNA; telmisartan results in increased expression of REN protein CTD PMID:9533614 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases activity ISO telmisartan results in increased activity of SCN5A protein CTD PMID:29306026 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sema3b semaphorin 3B multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein] CTD PMID:21933904 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
JBrowse link
G Sema3f semaphorin 3F multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3F protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3F protein] CTD PMID:21933904 NCBI chr 8:108,357,629...108,387,083
Ensembl chr 8:108,357,629...108,387,083
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO
EXP
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]
telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]
CTD PMID:17620961 PMID:19706694 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:23747572 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO telmisartan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:23747572 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein] CTD PMID:23747572 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]
CTD PMID:18487452 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
telmisartan results in decreased expression of TGFB1 mRNA
telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein]
CTD PMID:19171132 PMID:19706694 PMID:20888384 PMID:21381899 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23747572 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
affects localization
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]
telmisartan results in decreased expression of TJP1 mRNA; telmisartan results in decreased expression of TJP1 protein
CTD PMID:19252288 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Telmisartan results in decreased expression of TNF protein
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF]; telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
CTD PMID:19289654 PMID:20223228 PMID:21620867 PMID:21819444 PMID:22124178 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein] CTD PMID:20176998 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein] CTD PMID:20176998 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein] CTD PMID:20176998 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein] CTD PMID:20888384 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of VEGFA]
telmisartan results in decreased expression of VEGFA mRNA
CTD PMID:17724226 PMID:19171132 PMID:26439596 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
trandolapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP trandolapril results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions ISO trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] CTD PMID:25445565 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP trandolapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression
EXP
ISO
trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]
trandolapril results in decreased expression of AGT protein modified form
trandolapril inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
CTD PMID:1534315 PMID:27428043 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Cat catalase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:25445565 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
EXP [trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA
trandolapril results in decreased expression of CYBA mRNA
CTD PMID:17324946 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression
EXP [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
trandolapril results in decreased expression of NCF1 mRNA; trandolapril results in decreased expression of NCF1 protein
CTD PMID:17324946 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ren renin multiple interactions
increases expression
ISO
EXP
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein
trandolapril results in increased expression of REN protein
CTD PMID:16635047 PMID:27428043 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP trandolapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP trandolapril results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        biochemical role 19624
          enzyme inhibitor 18568
            EC 3.* (hydrolase) inhibitor 18137
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4279
                EC 3.4.15.* (peptidyl-dipeptidase) inhibitor 288
                  EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor + 288
paths to the root