EC 3.4.15.* (peptidyl-dipeptidase) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 3.4.15. (peptidyl-dipeptidase) inhibitor**	go back to main search page
Accession:	CHEBI:76782	browse the term
Definition:	Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a peptidyl dipeptidase (EC 3.4.15.*).
Synonyms:	related_synonym:	EC 3.4.15.* (peptidyl-dipeptidase) inhibitors; EC 3.4.15.* inhibitor; EC 3.4.15.* inhibitors; inhibitor of peptidyl-dipeptidases; inhibitor of peptidyl-dipeptidases (EC 3.4.15.); inhibitors of peptidyl-dipeptidases; inhibitors of peptidyl-dipeptidases (EC 3.4.15.); peptidyl-dipeptidase inhibitor; peptidyl-dipeptidase inhibitors

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Rat (328) Mouse (329) Human (330) Chinchilla (0) Bonobo (0) Dog (11) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (328)

(S,S,S)-nicotianamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity

nicotianamine results in decreased activity of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

decreases activity

nicotianamine results in decreased activity of ACE2 protein

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

benazepril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity
affects response to substance

benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril

PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 More...

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

affects response to substance
increases response to substance
multiple interactions

ACE2 gene SNP affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril

PMID:20559404 PMID:21449848 PMID:27121444

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

[irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA]

PMID:15149348 PMID:20493835

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adrenoceptor beta 2

affects response to substance

ADRB2 protein polymorphism affects the susceptibility to benazepril

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

advanced glycosylation end product-specific receptor

decreases expression

benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

decreases expression
multiple interactions
affects response to substance

benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]
AGT gene SNP affects the susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]

PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions
decreases expression

benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]
benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril

PMID:9596920 PMID:15157388 PMID:21449848

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

alpha-1-microglobulin/bikunin precursor

decreases expression
multiple interactions

benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

apolipoprotein B

multiple interactions

[Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

aquaporin 1

multiple interactions

benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 4

multiple interactions

benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA]

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

BCL2 associated X, apoptosis regulator

decreases expression

benazepril results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression

benazepril results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B2

increases activity
multiple interactions

benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril

PMID:15339989 PMID:16982965

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

C-C motif chemokine ligand 2

multiple interactions

benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]

PMID:16284884 PMID:19553526

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

decreases expression

benazepril results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

CD36 molecule

increases expression

benazepril results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

collagen type IV alpha 1 chain

decreases expression
multiple interactions

benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]

PMID:11798618 PMID:16191423

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

C-X-C motif chemokine ligand 1

multiple interactions

benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cytochrome P450, family 11, subfamily b, polypeptide 3

affects response to substance

CYP11B2 gene polymorphism affects the susceptibility to benazepril

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

endothelin 1

decreases expression
multiple interactions
increases activity

benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein

PMID:7528292 PMID:11136700 PMID:16191423

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

egl-9 family hypoxia-inducible factor 3

increases expression

benazepril results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

Fas cell surface death receptor

multiple interactions

benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibronectin 1

decreases expression
multiple interactions

benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]

PMID:10515446 PMID:11798618 PMID:16191423

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

benazepril results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamic-oxaloacetic transaminase 2

increases expression

benazepril results in increased expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

hepatocyte growth factor

increases expression

benazepril results in increased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

heat shock protein family E (Hsp10) member 1

increases expression

benazepril results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interleukin 6

multiple interactions

benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

benazepril inhibits the reaction [Glucose results in increased secretion of INS1 protein]; benazepril promotes the reaction [INS1 protein results in increased metabolism of Glucose]

PMID:7498292 PMID:9030901

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

kininogen 1

increases expression
multiple interactions

benazepril results in increased expression of KNG1 protein modified form
benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

mitogen activated protein kinase 1

increases expression

benazepril results in increased expression of MAPK1 mRNA

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

malic enzyme 1

increases expression

benazepril results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 2

multiple interactions

benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein]

PMID:16732983 PMID:19357873 PMID:20821936

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
increases activity
multiple interactions

benazepril results in decreased expression of MMP9 protein
benazepril results in increased activity of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]

PMID:15339989 PMID:19357873 PMID:20981132

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

methylenetetrahydrofolate reductase

affects response to substance

MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril

PMID:16081343 PMID:20445573

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

5-methyltetrahydrofolate-homocysteine methyltransferase

affects response to substance

MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril

PMID:15148588 PMID:20445573

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

MYC proto-oncogene, bHLH transcription factor

increases expression

benazepril results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 6

multiple interactions

[Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

neutrophil cytosolic factor 1

decreases expression

benazepril results in decreased expression of NCF1 mRNA

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nuclear factor kappa B subunit 1

multiple interactions

benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

decreases expression

benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide A

multiple interactions
decreases expression

[Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA

PMID:8763405 PMID:11136700

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
decreases expression

[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

proliferating cell nuclear antigen

decreases expression

benazepril results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

pyruvate dehydrogenase kinase 4

increases expression

benazepril results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

phospholipase A2, group V

decreases expression

benazepril results in decreased expression of PLA2G5 mRNA

NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658

G

plasminogen activator, urokinase

multiple interactions

benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA]

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

multiple interactions

benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA]

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

plasminogen

increases activity
multiple interactions

benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

prolylcarboxypeptidase

affects response to substance

PRCP gene SNP affects the susceptibility to benazepril

NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
decreases phosphorylation

benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein
benazepril results in decreased phosphorylation of RELA protein

PMID:15157388 PMID:17900838 PMID:19018797

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

increases expression
increases activity
multiple interactions

benazepril results in increased expression of REN protein
benazepril results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein

PMID:1316404 PMID:10836730 PMID:11501062

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

radical S-adenosyl methionine domain containing 2

decreases expression

benazepril results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

serpin family E member 1

decreases expression
multiple interactions

benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]

PMID:15322501 PMID:15339989

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family H member 1

increases expression

benazepril results in increased expression of SERPINH1 mRNA

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

solute carrier family 15 member 1

multiple interactions

benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

SMAD family member 2

affects expression
multiple interactions

benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

affects expression
multiple interactions

benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein

PMID:16635409 PMID:19487956

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

small nuclear ribonucleoprotein polypeptide N

decreases expression

benazepril results in decreased expression of SNRPN mRNA

NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634

G

superoxide dismutase 1

multiple interactions

[benazepril co-treated with Valsartan] results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

secreted phosphoprotein 1

decreases expression

benazepril results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transforming growth factor, beta 1

decreases expression
multiple interactions
affects expression

benazepril results in decreased expression of TGFB1 protein
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
benazepril affects the expression of TGFB1 mRNA
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein

PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

multiple interactions

benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein]

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

TIMP metallopeptidase inhibitor 1

decreases expression
multiple interactions

benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]

PMID:11867951 PMID:18471418 PMID:19357873

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein]

PMID:16732983 PMID:20821936

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

toll-like receptor 4

decreases expression

benazepril results in decreased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression
multiple interactions

benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein

PMID:16775501 PMID:20981132

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

decreases expression

benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions

benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

captopril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions
decreases activity

Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Captopril results in decreased activity of ACE protein

PMID:26851370 PMID:31629013 PMID:33007385

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

decreases response to substance
multiple interactions

ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]

PMID:17473847 PMID:31629013 PMID:33007385

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]

PMID:31181250 PMID:33007385

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

angiotensinogen

multiple interactions

[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]

PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 PMID:35844137 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]

PMID:28130181 PMID:31629013 PMID:33007385

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

multiple interactions

Captopril inhibits the reaction [Glucose results in increased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, biomineralization associated

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

bradykinin receptor B2

multiple interactions

Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

calbindin 1

multiple interactions

Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

carbonic anhydrase 2

multiple interactions

Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase 3

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Captopril inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]

PMID:27269004 PMID:38115276

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cadherin 1

multiple interactions

Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

collagen type III alpha 1 chain

multiple interactions

Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

GLI family zinc finger 1

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

GLI family zinc finger 3

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]

NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 6

multiple interactions

[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of IL6 protein]
Captopril inhibits the reaction [Glucose results in increased expression of IL6 mRNA]

PMID:38027817 PMID:38115276

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kininogen 1

multiple interactions

[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leptin receptor

multiple interactions
affects response to substance

Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions

Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]

PMID:31629013 PMID:33007385

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

microRNA 146a

multiple interactions

captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney]

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 320a

multiple interactions

captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney]

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

mixed lineage kinase domain like pseudokinase

multiple interactions

Captopril inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein]

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

matrix metallopeptidase 9

multiple interactions

Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nitric oxide synthase 2

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide B

multiple interactions

Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein]

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

patched 1

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Captopril inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]

PMID:27269004 PMID:38115276

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

multiple interactions

Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Captopril inhibits the reaction [Glucose results in increased phosphorylation of and results in increased localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

receptor-interacting serine-threonine kinase 3

multiple interactions

Captopril inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein]

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

G

RUNX family transcription factor 2

multiple interactions

Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sonic hedgehog signaling molecule

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]

NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170

G

smoothened, frizzled class receptor

multiple interactions

[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

superoxide dismutase 1

multiple interactions

Captopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

transforming growth factor, beta 1

multiple interactions

[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TNF protein]
Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA]

PMID:38027817 PMID:38115276

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

multiple interactions

Captopril inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vitamin D receptor

multiple interactions

Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

multiple interactions

Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions

Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

cilazapril monohydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects response to substance

ACE gene polymorphism affects the susceptibility to Cilazapril

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

adiponectin, C1Q and collagen domain containing

increases expression

Cilazapril results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensin II receptor, type 1a

multiple interactions

[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions

[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

fibroblast growth factor 2

decreases expression

Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

natriuretic peptide A

multiple interactions
affects secretion

[Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein
Cilazapril affects the secretion of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

renin

increases activity

Cilazapril results in increased activity of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

solute carrier family 15 member 1

multiple interactions

Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

transforming growth factor, beta 1

multiple interactions

[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

corilagin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

corilagin inhibits the reaction [Doxorubicin results in increased expression of AKT1 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]
corilagin results in decreased expression of AKT1 protein

PMID:34369273 PMID:34605098 PMID:35084093 PMID:35103375

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activating transcription factor 4

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2 associated X, apoptosis regulator

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]

PMID:34605098 PMID:35103375

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]

PMID:34605098 PMID:35103375

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basigin

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA]

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

caspase 3

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]

PMID:34605098 PMID:35103375 PMID:37394652

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein]; corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]

PMID:30582900 PMID:34605098 PMID:35103375 PMID:35307913

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

DNA-damage inducible transcript 3

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

fatty acid binding protein 3

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutathione-disulfide reductase

multiple interactions

[corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased activity of HMGCR protein]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions

corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

corilagin inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
corilagin results in decreased expression of IL6 protein

PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

corilagin inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

lactate dehydrogenase A

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

myoglobin

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of MB protein]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

nuclear factor of activated T-cells 1

multiple interactions

corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

multiple interactions

corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

corilagin results in decreased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

decreases expression
multiple interactions

corilagin results in decreased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]

PMID:35084093 PMID:37394652

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

natriuretic peptide B

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

corilagin inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; corilagin increases expression of nr1h4 mRNA and protein in rat embryonic liver cells

RGD

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA]

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

peroxisome proliferator-activated receptor gamma

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

corilagin results in decreased expression of PTGS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]

PMID:35084093 PMID:37394652

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

solute carrier family 16 member 3

multiple interactions

corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA]

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

transforming growth factor, beta 1

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 2

multiple interactions

corilagin inhibits the reaction [Morphine results in increased expression of TLR2 mRNA]; corilagin inhibits the reaction [Morphine results in increased expression of TLR2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

tumor necrosis factor

decreases secretion
multiple interactions
decreases expression

corilagin results in decreased secretion of TNF protein
corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]
corilagin results in decreased expression of TNF protein
corilagin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]

PMID:12628509 PMID:34369273 PMID:34605098 PMID:35084093 PMID:37394652

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

[corilagin co-treated with TNFSF11 protein] results in increased expression of GSR mRNA; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of CAT mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]; corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of NFE2L2 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; corilagin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; tin protoporphyrin IX inhibits the reaction [corilagin inhibits the reaction [TNFSF11 protein results in decreased expression of HMOX1 protein]]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin I3, cardiac type

multiple interactions

corilagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

increases transport

ABCC4 protein results in increased transport of Angiotensin-Converting Enzyme Inhibitors

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

angiotensin I converting enzyme

decreases activity

Angiotensin-Converting Enzyme Inhibitors results in decreased activity of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

angiotensinogen

affects expression
increases metabolic processing
multiple interactions
decreases expression
increases expression

Angiotensin-Converting Enzyme Inhibitors affects the expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors affects the expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in increased metabolism of AGT protein
7-Ala-angiotensin (1-7) inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]]; AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein alternative form]
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein; Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGT protein alternative form
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AGT protein modified form

PMID:1668233 PMID:2474097 PMID:3078272 PMID:6105291 PMID:6388325 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of AGTR1 mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

arginine vasopressin

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of AVP protein

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

multiple interactions

Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

cellular communication network factor 2

multiple interactions

7-Ala-angiotensin (1-7) inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]]; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [AGT protein results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

collagen type I alpha 1 chain

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

endothelin 1

decreases secretion

Angiotensin-Converting Enzyme Inhibitors results in decreased secretion of EDN1 protein

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

erythropoietin

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of EPO protein

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

coagulation factor XI

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of F11 protein

NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437

G

coagulation factor XII

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of F12 protein

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

Fas cell surface death receptor

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

growth arrest specific 6

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of GAS6 protein

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

interleukin 2

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

kininogen 1

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

matrix metallopeptidase 2

multiple interactions

[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

major histocompatibility complex, class I-related

affects expression

Angiotensin-Converting Enzyme Inhibitors affects the expression of MR1 mRNA

NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970

G

myosin heavy chain 7

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

natriuretic peptide A

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
decreases expression

[Adrenergic beta-Antagonists co-treated with Angiotensin-Converting Enzyme Inhibitors] results in decreased expression of NPPB protein
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NPPB mRNA

PMID:15667801 PMID:21697605

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 3, group C, member 2

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 mRNA; Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 protein

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in increased expression of PPP1R12A protein modified form]

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

renin

multiple interactions
increases expression
increases activity

Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and affects the activity of REN protein; Angiotensin-Converting Enzyme Inhibitors results in increased expression of and results in increased activity of REN protein; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]
Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN mRNA; Angiotensin-Converting Enzyme Inhibitors results in increased expression of REN protein
AGT protein alternative form inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased secretion of REN protein]; Indomethacin inhibits the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]

PMID:231700 PMID:1330361 PMID:1647690 PMID:1668233 PMID:3071592 More...

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

RT1 class II, locus Db1

affects expression

Angiotensin-Converting Enzyme Inhibitors affects the expression of HLA-DRB1 mRNA

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class Ib, locus M3, gene 1

affects expression

Angiotensin-Converting Enzyme Inhibitors affects the expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

solute carrier family 15 member 1

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC15A1 mRNA

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 36 member 1

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC36A1 mRNA

NCBI chr10:39,319,062...39,357,374
Ensembl chr10:39,324,337...39,354,217

G

solute carrier family 6 member 19

increases expression

Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC6A19 mRNA

NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962

G

transforming growth factor, beta 1

decreases expression

Angiotensin-Converting Enzyme Inhibitors results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

X-prolyl aminopeptidase 2

affects response to substance

XPNPEP2 gene SNP affects the susceptibility to Angiotensin-Converting Enzyme Inhibitors

NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223

enalapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

increases transport

ABCC4 protein results in increased transport of Enalapril

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

angiotensin I converting enzyme

decreases activity
multiple interactions
increases expression

Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of ACE protein]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril results in increased expression of ACE mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]

PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 More...

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

actin alpha 2, smooth muscle

decreases expression

Enalapril results in decreased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

activin A receptor like type 1

decreases expression

Enalapril results in decreased expression of ACVRL1 protein

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

adiponectin, C1Q and collagen domain containing

increases expression

Enalapril results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenoceptor beta 1

increases expression

Enalapril results in increased expression of ADRB1 protein

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

angiotensinogen

decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression

Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA

PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

increases expression
multiple interactions
decreases expression
affects expression

Enalapril results in increased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of AGTR1 protein]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril affects the expression of AGTR1A mRNA

PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 More...

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

increases expression
decreases expression

Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA

PMID:9740612 PMID:18403896 PMID:18765277

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

AKT serine/threonine kinase 1

multiple interactions

Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

alkaline phosphatase, biomineralization associated

multiple interactions

Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA]

PMID:30423288 PMID:31887396

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiogenin

decreases expression

Enalapril results in decreased expression of ANG protein

NCBI chr15:24,312,711...24,323,361

G

angiopoietin 2

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA]

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

apolipoprotein E

multiple interactions

[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]

PMID:19603250 PMID:25037058

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

activating transcription factor 2

increases expression

Enalapril results in increased expression of ATF2 protein

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

arginine vasopressin

multiple interactions

Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

decreases expression

Enalapril results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions

Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]

PMID:21153712 PMID:30623541

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B1

increases expression
multiple interactions

Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril

PMID:18796534 PMID:21430409

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

increases expression

Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

beclin 1

increases expression

Enalapril results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions

Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA]

PMID:30423288 PMID:31887396

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

carbonic anhydrase 2

decreases activity

Enalapril results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase 3

decreases activity
multiple interactions

Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]

PMID:21153712 PMID:30623541

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases activity

Enalapril results in decreased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
multiple interactions

Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]

PMID:12124199 PMID:30623541

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 protein
Enalapril results in decreased expression of CCL2 mRNA

PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cellular communication network factor 2

decreases expression
multiple interactions

Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

chymotrypsin like elastase 2A

decreases expression

Enalapril results in decreased expression of CELA2A mRNA

NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632

G

collectrin, amino acid transport regulator

decreases expression

Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein

NCBI chr X:30,361,967...30,395,264
Ensembl chr X:30,361,967...30,395,349

G

clusterin

decreases expression

Enalapril results in decreased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

chymase 1

decreases expression

Enalapril results in decreased expression of CMA1 mRNA

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

G

collagen type I alpha 1 chain

multiple interactions

Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression
increases expression

Enalapril results in decreased expression of COL3A1 mRNA
Enalapril results in increased expression of COL3A1 mRNA

PMID:17164399 PMID:25037058

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

multiple interactions
decreases expression

[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein

PMID:9175058 PMID:18682491

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

citrate synthase

increases activity

Enalapril results in increased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
Enalapril results in decreased expression of CYBA protein

PMID:20720404 PMID:25037058

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

affects localization

Enalapril affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

endothelin 1

multiple interactions

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endoglin

multiple interactions

[Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

erythropoietin

decreases expression
multiple interactions

Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]

PMID:2474097 PMID:9434678 PMID:19958114

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein]

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

coagulation factor III, tissue factor

decreases expression
multiple interactions

Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]

PMID:18060435 PMID:22188725

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

Fas ligand

decreases expression

Enalapril results in decreased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

growth hormone 1

increases response to substance

GH1 protein results in increased susceptibility to Enalapril

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

gap junction protein, alpha 5

multiple interactions

GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gap junction protein, gamma 1

multiple interactions

GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]

NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867

G

glycogen synthase kinase 3 beta

multiple interactions

Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hyaluronan synthase 2

increases expression

Enalapril results in increased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

high mobility group box 1

multiple interactions

Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression

Enalapril results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hyaluronidase 1

decreases expression

Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein

NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

Enalapril results in decreased expression of ICAM1 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form

PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 1

affects expression
decreases expression

Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 1

increases expression

Enalapril results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 1 alpha

multiple interactions

Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA

PMID:17167242 PMID:21265103 PMID:25037058

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
affects response to substance

Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril

PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin-1 receptor-associated kinase 1

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

integrin subunit alpha 2

decreases expression

Enalapril results in decreased expression of ITGA2 mRNA

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

kinase insert domain receptor

multiple interactions

Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kininogen 1

increases response to substance

Enalapril results in increased susceptibility to KNG1 protein modified form

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

laminin subunit beta 1

multiple interactions

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA]

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit beta 2

multiple interactions

Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA]

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

leptin

increases response to substance

LEP protein results in increased susceptibility to Enalapril

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen-activated protein kinase 9

increases expression
increases phosphorylation

Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

mitofusin 2

increases expression

Enalapril results in increased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

microRNA 146a

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 146b

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

G

matrix metallopeptidase 3

decreases expression

Enalapril results in decreased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myeloperoxidase

multiple interactions

Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myosin heavy chain 6

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein]

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

decreases expression
multiple interactions

Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]

PMID:15362513 PMID:21423293

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

N-deacetylase and N-sulfotransferase 1

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein]

NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191

G

NFE2 like bZIP transcription factor 2

decreases expression

Enalapril results in decreased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases activity
multiple interactions

Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]

PMID:19225048 PMID:21265102

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide associated 1

increases expression
increases activity

Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein

NCBI chr14:30,835,264...30,851,294
Ensembl chr14:30,835,247...30,851,293

G

nitric oxide synthase 2

decreases expression
multiple interactions

Enalapril results in decreased expression of NOS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein

PMID:20720404 PMID:21377515 PMID:25037058

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
increases expression
affects expression

[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
Enalapril results in increased expression of NOS3 protein
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril affects the expression of NOS3 mRNA

PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 More...

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

decreases expression

Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA

PMID:2136812 PMID:8112904 PMID:21423293

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions

Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 3, group C, member 2

increases expression

Enalapril results in increased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

nuclear respiratory factor 1

increases expression

Enalapril results in increased expression of NRF1 mRNA

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

podoplanin

increases expression

Enalapril results in increased expression of PDPN protein

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]

PMID:19225048 PMID:30623541

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

increases expression

Enalapril results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

peroxiredoxin 3

increases expression

Enalapril results in increased expression of PRDX3 protein

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

protein kinase AMP-activated catalytic subunit alpha 1

increases expression

Enalapril results in increased expression of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, alpha

decreases expression

Enalapril results in decreased expression of PRKCA protein modified form

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

prostaglandin-endoperoxide synthase 1

decreases expression

Enalapril results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein

PMID:20720404 PMID:21377515 PMID:25037058

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone 1 receptor

multiple interactions

Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]

NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729

G

parathyroid hormone-like hormone

multiple interactions

Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions
increases expression
increases secretion
decreases activity
increases activity

[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein

PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 More...

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

RUNX family transcription factor 2

multiple interactions

Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA]

PMID:30423288 PMID:31887396

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

selectin E

multiple interactions

Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selectin L

multiple interactions

[Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

selectin P

multiple interactions
decreases expression

Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA

PMID:14716214 PMID:25037058

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family B member 2

decreases expression

Enalapril results in decreased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family E member 1

multiple interactions
decreases expression

[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 15 member 2

multiple interactions

Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

solute carrier family 22 member 12

multiple interactions

Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22 member 7

multiple interactions

Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

multiple interactions

Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

SMAD family member 2

multiple interactions

Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 7

increases expression

Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein

PMID:19197123 PMID:19349682

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

superoxide dismutase 1

multiple interactions
increases expression

[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
Enalapril results in increased expression of SOD1 protein

PMID:20720404 PMID:25037058

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases activity
increases expression
decreases expression
multiple interactions

Enalapril results in decreased activity of SOD2 protein
Enalapril results in increased expression of SOD2 protein
Enalapril results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein

PMID:18765277 PMID:20720404 PMID:25037058 PMID:30563025

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions

[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA]

PMID:25037058 PMID:30423288 PMID:31887396

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

increases expression

Enalapril results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

single stranded DNA binding protein 1

increases expression

Enalapril results in increased expression of SSBP1 mRNA

NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135

G

signal transducer and activator of transcription 3

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TEK receptor tyrosine kinase

multiple interactions

Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA]

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transcription factor A, mitochondrial

increases expression

Enalapril results in increased expression of TFAM protein

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transforming growth factor, beta 1

multiple interactions
decreases expression

[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein

PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

Enalapril results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta induced

decreases secretion
multiple interactions

Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transforming growth factor, beta receptor 1

decreases expression

Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

thrombospondin 4

increases expression

Enalapril results in increased expression of THBS4 mRNA

NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313

G

toll-like receptor 4

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression
multiple interactions

Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]

PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

translocase of outer mitochondrial membrane 20

decreases expression

Enalapril results in decreased expression of TOMM20 mRNA

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

TNF receptor associated factor 6

multiple interactions

[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

vascular cell adhesion molecule 1

affects expression
decreases expression

Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form

PMID:17347482 PMID:19939336

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions
increases expression

Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein

PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Willebrand factor

decreases expression

Enalapril results in decreased expression of VWF mRNA

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

enalaprilat dihydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

adrenoceptor beta 1

affects expression

Enalaprilat affects the expression of ADRB1 protein

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

affects expression

Enalaprilat affects the expression of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiotensinogen

decreases expression
multiple interactions

Enalaprilat results in decreased expression of AGT protein modified form
Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein]

PMID:16452552 PMID:21795644

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

BCL2, apoptosis regulator

increases expression

Enalaprilat results in increased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B1

multiple interactions
increases activity

bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein]

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

endothelin 1

decreases secretion

Enalaprilat results in decreased secretion of EDN1 protein

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

fibronectin 1

decreases expression
multiple interactions

Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein
Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]

PMID:14520012 PMID:21795644

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glutamate dehydrogenase 1

multiple interactions

Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA]

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutamate metabotropic receptor 1

multiple interactions

Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA]

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

high mobility group box 1

multiple interactions

Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

insulin 2

multiple interactions

Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

peroxisome proliferator-activated receptor delta

multiple interactions

[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

renin

increases expression

Enalaprilat results in increased expression of REN mRNA

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

serpin family E member 1

decreases expression

Enalaprilat results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 22 member 8

multiple interactions
increases uptake

verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

transforming growth factor, beta 1

decreases expression

Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

multiple interactions

Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression

Enalaprilat results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

fosinopril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to Fosinopril

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases response to substance
multiple interactions
increases export

ABCC2 protein results in decreased susceptibility to Fosinopril
ABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]
desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

adiponectin receptor 2

increases expression

fosinopril increases expression of adipor2 mRNA in rat liver

RGD

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

alpha-fetoprotein

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

angiotensinogen

decreases expression

Fosinopril results in decreased expression of AGT protein

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

bone morphogenetic protein receptor type 2

multiple interactions

Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA]

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

cyclin D1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

glutamic--pyruvic transaminase

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

Klotho

increases expression

Fosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL protein

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

matrix metallopeptidase 2

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Fosinopril results in decreased expression of MMP9 mRNA; Fosinopril results in decreased expression of MMP9 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

nuclear factor kappa B subunit 1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 3

affects expression

Fosinopril affects the expression of NOS3 mRNA; Fosinopril affects the expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

phosphodiesterase 1A

affects expression

Fosinopril affects the expression of PDE1A mRNA; Fosinopril affects the expression of PDE1A protein

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 1C

affects expression

Fosinopril affects the expression of PDE1C mRNA; Fosinopril affects the expression of PDE1C protein

NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family E member 1

decreases expression
multiple interactions

Fosinopril results in decreased expression of SERPINE1 mRNA; Fosinopril results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 15 member 1

multiple interactions

Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

transforming growth factor, beta 1

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

decreases expression
multiple interactions

Fosinopril results in decreased expression of TIMP1 mRNA; Fosinopril results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

imidapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

increases response to substance

ACE2 gene SNP results in increased susceptibility to imidapril

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

carboxylesterase 1D

multiple interactions

CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]

PMID:9300133 PMID:31268531

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cytochrome P450, family 11, subfamily b, polypeptide 3

affects response to substance

CYP11B2 gene polymorphism affects the susceptibility to imidapril

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

imidaprilat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

protein kinase C, alpha

multiple interactions

imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

lisinopril dihydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity

Lisinopril analog results in decreased activity of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

increases expression
multiple interactions
increases activity

Lisinopril results in increased expression of ACE2 mRNA
ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]
Lisinopril results in increased activity of ACE2 protein

PMID:15897343 PMID:16221218 PMID:27649628

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein]

PMID:23060470 PMID:31710167

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

angiotensinogen

decreases expression
multiple interactions
affects metabolic processing
decreases secretion
increases secretion
affects response to substance
increases expression

Lisinopril results in decreased expression of AGT protein
[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7); [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein; ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]; Thiorphan inhibits the reaction [[Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7)]
[[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA
Lisinopril results in decreased secretion of AGT protein
Lisinopril results in increased secretion of AGT protein alternative form
AGT gene alternative form affects the susceptibility to Lisinopril
Lisinopril results in increased expression of AGT mRNA

PMID:8393685 PMID:8915971 PMID:15897343 PMID:16221218 PMID:16685205 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

BCL2, apoptosis regulator

decreases expression

Lisinopril results in decreased expression of BCL2

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

CD2-associated protein

multiple interactions

Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]

NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199

G

endothelin 1

decreases secretion

Lisinopril results in decreased secretion of EDN1 protein

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

growth hormone 1

multiple interactions

[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

hepatitis A virus cellular receptor 1

multiple interactions

Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

heparanase

multiple interactions

[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

insulin-like growth factor binding protein 1

increases expression

Lisinopril results in increased expression of IGFBP1 protein

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

matrix metallopeptidase 2

multiple interactions

[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

myeloperoxidase

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NPHS2 stomatin family member, podocin

multiple interactions

Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

natriuretic peptide A

decreases expression

Lisinopril results in decreased expression of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

renin

increases expression
multiple interactions

Lisinopril results in increased expression of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA
Lisinopril results in increased expression of REN mRNA

PMID:2550029 PMID:8915971 PMID:16221218

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

RT1 class Ib, locus M3, gene 1

affects expression

Lisinopril affects the expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

sperm microtubule inner protein 11

multiple interactions

Lisinopril inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein]

PMID:16636307 PMID:19293598

NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

vascular endothelial growth factor A

multiple interactions

Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

perindopril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects response to substance

ACE gene polymorphism affects the susceptibility to Perindopril

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions

Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA]; Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein]

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Perindopril results in decreased expression of ACTA2 protein
[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]

PMID:12076858 PMID:16596278

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

alpha-fetoprotein

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

angiotensinogen

decreases expression
increases expression
multiple interactions

Perindopril results in decreased expression of AGT protein alternative form
Perindopril results in increased expression of AGT protein alternative form
Perindopril results in decreased expression of AGT protein; Perindopril results in decreased expression of AGT protein alternative form
[Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form; Perindopril inhibits the reaction [Methotrexate results in decreased expression of AGT protein alternative form]; Perindopril inhibits the reaction [Methotrexate results in increased expression of AGT protein]

PMID:2549899 PMID:2605800 PMID:9808682 PMID:34737150

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects response to substance
multiple interactions

AGTR1 gene SNP affects the susceptibility to Perindopril
[Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]

PMID:8952600 PMID:12930639 PMID:16097048 PMID:30184259

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

albumin

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein]

PMID:16872305 PMID:30184259

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arginase 1

multiple interactions

Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]]

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Bcl2-like 1

multiple interactions

Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bradykinin receptor B1

affects expression

Perindopril affects the expression of BDKRB1 protein

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

affects expression

Perindopril affects the expression of BDKRB2 protein

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

catalase

increases activity

Perindopril results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Perindopril results in decreased expression of CCL2 protein
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]

PMID:19840533 PMID:30184259

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cyclin D1

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 2

multiple interactions

[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD163 molecule

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

Cd68 molecule

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

collagen type I alpha 2 chain

multiple interactions

[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases expression

Perindopril results in decreased expression of COL3A1 mRNA

PMID:12076858 PMID:14871039

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

fibronectin 1

multiple interactions

[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Perindopril results in decreased expression of FOS protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamic--pyruvic transaminase

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

intercellular adhesion molecule 1

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

increases expression
multiple interactions

Perindopril results in increased expression of IL10 protein
Perindopril inhibits the reaction [Methotrexate results in decreased expression of IL10 protein]

PMID:19840533 PMID:34737150

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

decreases expression
multiple interactions

Perindopril results in decreased expression of IL1B protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL1B protein]

PMID:19840533 PMID:34737150

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
multiple interactions

Perindopril results in decreased expression of IL6 protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL6 protein]

PMID:19840533 PMID:34737150

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Perindopril inhibits the reaction [Methotrexate results in increased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kininogen 1

decreases expression
multiple interactions
increases expression

Perindopril results in decreased expression of KNG1 protein modified form
Perindopril promotes the reaction [racecadotril affects the metabolism of KNG1 protein alternative form]
Perindopril results in increased expression of KNG1 protein alternative form

PMID:9808682 PMID:11855668

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leptin

decreases expression

Perindopril results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions

Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of MAS1 mRNA]

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

mitofusin 2

increases expression

Perindopril results in increased expression of MFN2 mRNA; Perindopril results in increased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 2

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]

PMID:12930639 PMID:14761280 PMID:16097048 PMID:29859236

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose receptor, C type 1

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

nuclear factor kappa B subunit 1

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NPHS2 stomatin family member, podocin

multiple interactions

AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

platelet derived growth factor subunit B

multiple interactions

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]

PMID:12930639 PMID:14761280 PMID:16097048

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]
Perindopril results in increased expression of PPARG mRNA; Perindopril results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

Perindopril results in decreased expression of PPP3CA protein

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Perindopril results in decreased expression of PPP3R1 mRNA

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
Perindopril inhibits the reaction [Methotrexate results in increased expression of RELA protein]

PMID:29859236 PMID:34737150

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

increases expression
increases activity

Perindopril results in increased expression of REN protein
Perindopril results in increased activity of REN protein

PMID:2549899 PMID:2605800 PMID:9383173

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ryanodine receptor 2

multiple interactions
increases expression

carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

secreted frizzled-related protein 4

affects binding

Perindopril binds to SFRP4 protein

NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736

G

sirtuin 1

multiple interactions
increases expression

Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein]
Perindopril results in increased expression of SIRT1 mRNA; Perindopril results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 15 member 1

multiple interactions

Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

SMAD family member 3

multiple interactions
decreases expression

Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Perindopril results in decreased expression of SMAD3 protein

PMID:15619341 PMID:16872305

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

increases expression
multiple interactions

Perindopril results in increased expression of SMAD7 protein
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]

PMID:15619341 PMID:16872305

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
Perindopril results in decreased expression of TGFB1 mRNA; Perindopril results in decreased expression of TGFB1 protein

PMID:12930639 PMID:14761280 PMID:14871039 PMID:15619341 PMID:16097048 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 2

decreases expression
multiple interactions

Perindopril results in decreased expression of TGFBR2 mRNA
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]

PMID:15619341 PMID:16872305

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

toll-like receptor 4

multiple interactions

Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 mRNA]; Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

Perindopril results in decreased expression of TNF protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of TNF protein]
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
Perindopril results in increased expression of TNF protein

PMID:19840533 PMID:26878793 PMID:29859236 PMID:30184259 PMID:34737150

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Willebrand factor

decreases expression

Perindopril results in decreased expression of VWF protein

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

quinapril hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity

Quinapril results in decreased activity of ACE protein

PMID:8227822 PMID:15728788

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

adrenomedullin

decreases expression

Quinapril results in decreased expression of ADM protein

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

angiotensinogen

decreases activity
multiple interactions

Quinapril results in decreased activity of AGT protein
Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]

PMID:11709406 PMID:15728788

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

C-X-C motif chemokine ligand 10

decreases expression

Quinapril results in decreased expression of CXCL10

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

Quinapril results in decreased activity of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

endothelin 1

decreases expression

Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein

PMID:12149661 PMID:12425201

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

coagulation factor II, thrombin

decreases activity

Quinapril results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor V

decreases activity

Quinapril results in decreased activity of F5 protein

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Quinapril results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interleukin 6

multiple interactions

[Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Quinapril results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nitric oxide synthase 3

affects expression

Quinapril affects the expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

increases expression
increases secretion

Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

parathyroid hormone-like hormone

multiple interactions

Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

renin

multiple interactions
increases expression

Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]
Quinapril results in increased expression of REN protein

PMID:10334802 PMID:11709406

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

solute carrier family 15 member 1

multiple interactions

Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

transforming growth factor, beta 1

multiple interactions

[Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

quinaprilat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 15 member 1

multiple interactions

quinaprilat inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

quinaprilat inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

ramipril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases activity
multiple interactions

Ramipril results in decreased activity of ACE protein
Ramipril inhibits the reaction [Doxorubicin results in increased expression of ACE mRNA]

PMID:3034026 PMID:10543928 PMID:36636964

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

actin alpha 2, smooth muscle

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression
increases expression

candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
Ramipril results in decreased expression of ADIPOQ

PMID:17483542 PMID:19059660

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensin II receptor, type 1a

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of AGTR1A mRNA]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

alkaline phosphatase, biomineralization associated

multiple interactions

Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

affects expression

Ramipril affects the expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

affects expression

Ramipril affects the expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 7

multiple interactions

Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

catalase

multiple interactions

Ramipril inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cellular communication network factor 2

multiple interactions

[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

carboxylesterase 1D

increases hydrolysis

CES1 protein results in increased hydrolysis of Ramipril

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

collagen type I alpha 1 chain

decreases expression

Ramipril results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

catenin beta 1

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased phosphorylation of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA]
Ramipril results in decreased expression of CYBA mRNA

PMID:12352326 PMID:16891913

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

decreases expression

Ramipril results in decreased expression of CYBB mRNA

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

fibronectin 1

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box O3

multiple interactions

[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 1 beta

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kininogen 1

decreases degradation

Ramipril results in decreased degradation of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leptin

multiple interactions
decreases expression

candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
Ramipril results in decreased expression of LEP

PMID:17483542 PMID:19059660

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen-activated protein kinase 8

multiple interactions

[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

matrix metallopeptidase 2

decreases expression

Ramipril results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

myosin heavy chain 7

decreases expression
multiple interactions

Ramipril results in decreased expression of MYH7 mRNA
Ramipril inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA]

PMID:15667801 PMID:36636964

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

nitric oxide synthase 1

multiple interactions

[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 3

multiple interactions

NOS3 protein affects the reaction [Ramipril results in increased abundance of Cyclic GMP]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide B

decreases expression

Ramipril results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

platelet derived growth factor subunit A

multiple interactions
decreases expression

Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]
Ramipril results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

multiple interactions
decreases expression

Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]
Ramipril results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

renin

increases activity
increases expression
multiple interactions

Ramipril results in increased activity of REN protein
Ramipril results in increased expression of REN protein
Ramipril inhibits the reaction [Doxorubicin results in increased expression of REN mRNA]; Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA]
Ramipril results in increased expression of REN mRNA

PMID:1327051 PMID:9179393 PMID:9539862 PMID:11832429 PMID:14504926 More...

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ras homolog family member A

multiple interactions

[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of RHOA protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions

[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

sirtuin 1

multiple interactions

[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 15 member 1

multiple interactions

Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

SMAD family member 2

multiple interactions

[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

transforming growth factor, beta 1

multiple interactions
decreases expression
decreases activity

Ramipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Ramipril results in decreased expression of TGFB1 mRNA
[Streptozocin co-treated with Ramipril] results in increased expression of TGFB1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of TGFB1 protein; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Ramipril results in decreased activity of TGFB1 protein

PMID:12352326 PMID:12631109 PMID:15667801 PMID:17703430 PMID:20551625 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor beta receptor 3

multiple interactions

[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of TGFBR3 protein

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

TIMP metallopeptidase inhibitor 4

increases expression

Ramipril results in increased expression of TIMP4 mRNA

NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558

G

tumor necrosis factor

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

Wnt family member 3A

multiple interactions

Ramipril inhibits the reaction [Doxorubicin results in increased expression of WNT3A protein]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

ramiprilat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bradykinin receptor B2

increases response to substance

BDKRB2 results in increased susceptibility to ramiprilat

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

kininogen 1

decreases degradation

ramiprilat results in decreased degradation of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

spirapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

renin

increases expression
multiple interactions

spirapril results in increased expression of REN mRNA; spirapril results in increased expression of REN protein
spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]

PMID:1764812 PMID:9300315

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

solute carrier family 15 member 1

multiple interactions

spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 2

multiple interactions

spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

telmisartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

telmisartan results in decreased activity of ABCB11 protein
telmisartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20829430 PMID:23956101 PMID:24014644

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily G member 1

multiple interactions
increases expression

PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

angiotensin I converting enzyme

decreases expression
multiple interactions

Telmisartan results in decreased expression of ACE mRNA; Telmisartan results in decreased expression of ACE protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein]

PMID:19171132 PMID:25973029 PMID:29909460 PMID:31629013

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions
decreases expression
increases expression

telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
Telmisartan results in decreased expression of ACE2 mRNA; Telmisartan results in decreased expression of ACE2 protein
Telmisartan results in increased expression of ACE2 mRNA; Telmisartan results in increased expression of ACE2 protein

CTD
RGD

PMID:21381899 PMID:25973029 PMID:28656296 PMID:29909460 PMID:31629013 More...

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 5, tartrate resistant

decreases activity

telmisartan decreases enzyme activity of Trap, Acp5 in serum of rats with periodontal disease

RGD

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

adiponectin, C1Q and collagen domain containing

increases expression

telmisartan results in increased expression of ADIPOQ mRNA
telmisartan results in increased expression of ADIPOQ protein

PMID:19730415 PMID:20555330

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

multiple interactions
decreases expression

telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]
telmisartan results in decreased expression of AGT mRNA; telmisartan results in decreased expression of AGT protein
Telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; Telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]

PMID:9533614 PMID:17620961 PMID:18487452 PMID:19171132 PMID:19289654 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects binding
decreases expression
multiple interactions
increases expression

telmisartan binds to AGTR1 protein
telmisartan decreases expression of mRNA in mandible of rats with periodontal disease
telmisartan results in decreased expression of AGTR1A mRNA
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
telmisartan binds to and results in decreased activity of AGTR1 protein
Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
telmisartan results in increased expression of AGTR1 mRNA

CTD
RGD

PMID:8220885 PMID:9533614 PMID:9728324 PMID:17620961 PMID:19171132 More...

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 1b

multiple interactions

telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]

NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232

G

angiotensin II receptor, type 2

increases expression

telmisartan increases expression of mRNA in mandible of rats with periodontal disease

RGD

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

aryl hydrocarbon receptor

increases activity

Telmisartan results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects expression
multiple interactions

telmisartan affects the expression of ALB protein modified form
Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]

PMID:16671338 PMID:34464088

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alkaline phosphatase, biomineralization associated

increases activity
multiple interactions

telmisartan increases enzyme activity of Alpl in serum of rats with periodontal disease
Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein]

CTD
RGD

PMID:27269004 PMID:33364953

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiogenin, ribonuclease A family, member 2

multiple interactions

telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of ANG2 protein]

NCBI chr15:24,398,330...24,415,909
Ensembl chr15:24,398,419...24,398,922

G

BCL2 associated X, apoptosis regulator

multiple interactions

telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions

telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

caspase 3

multiple interactions
decreases expression

telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
Telmisartan results in decreased expression of CASP3 protein
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 mRNA]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]

PMID:18565324 PMID:19452295 PMID:21620867 PMID:21819444 PMID:22750630 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Telmisartan inhibits the reaction [arsenite results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:23750309 PMID:26929000 PMID:34339004

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
telmisartan results in decreased expression of CCL2 protein

PMID:17922026 PMID:22124178

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

decreases response to substance

telmisartan results in decreased susceptibility to CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine receptor 2

decreases expression

telmisartan results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD36 molecule

increases expression
multiple interactions

telmisartan results in increased expression of CD36 mRNA
PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; T 0070907 inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CCAAT/enhancer binding protein beta

multiple interactions

telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

corticotropin releasing hormone

multiple interactions

Telmisartan inhibits the reaction [AGT protein results in increased expression of CRH protein]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

C-reactive protein

decreases expression

telmisartan results in decreased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cathepsin K

decreases expression

telmisartan decreases expression of mRNA in mandible of rats with periodontal disease

RGD

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 12

multiple interactions
decreases response to substance

PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
telmisartan results in decreased susceptibility to CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 3

decreases expression

telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease

RGD

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b-245 alpha chain

decreases expression
multiple interactions

telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]

PMID:16141465 PMID:19171132 PMID:21054405

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
Telmisartan inhibits the reaction [arsenite results in increased expression of CYBB mRNA]
Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of CYBB protein]
telmisartan results in decreased expression of CYBB mRNA

PMID:19171132 PMID:21381899 PMID:34339004 PMID:34464088

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

multiple interactions

telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CYCS mRNA]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

Telmisartan results in decreased activity of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

DNA-damage inducible transcript 3

decreases expression

telmisartan results in decreased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

endothelin 1

multiple interactions

telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions

telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

multiple interactions

telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

Fas ligand

multiple interactions

telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASL protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASLG protein]

PMID:21620867 PMID:21819444

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibronectin 1

multiple interactions

telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Telmisartan inhibits the reaction [AGT protein results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glial cell derived neurotrophic factor

multiple interactions

Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

multiple interactions
decreases expression

telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
Telmisartan results in decreased expression of GFAP protein

PMID:23747572 PMID:29909460

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gamma-glutamyltransferase 1

multiple interactions

telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, alpha 1

multiple interactions

Telmisartan inhibits the reaction [Dibutyl Phthalate results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein]

PMID:26929000 PMID:27269004

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Telmisartan results in decreased activity of GSR protein
Telmisartan inhibits the reaction [arsenite results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hepatocyte growth factor

increases expression

telmisartan results in increased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

heat shock protein family A (Hsp70) member 5

decreases expression

telmisartan results in decreased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

integrin-binding sialoprotein

increases expression

telmisartan increases expression of mRNA in mandible of WKY rats with periodontal disease

RGD

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

intercellular adhesion molecule 1

multiple interactions

telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]

PMID:17724226 PMID:20888384 PMID:22124178

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

multiple interactions
decreases expression
increases expression

telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
telmisartan decreases expression of protein in mandible of WKY rats with periodontal disease
Telmisartan results in increased expression of IL10 protein

CTD
RGD

PMID:24831514 PMID:29909460 PMID:33364953

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
decreases expression

telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
telmisartan decreases expression of protein in mandible of SHR rats with periodontal disease
Telmisartan inhibits the reaction [AGT protein results in increased expression of IL1B protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL1B protein]

CTD
RGD

PMID:22124178 PMID:33872574 PMID:34339004 PMID:33364953

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Telmisartan results in decreased expression of IL6 protein
telmisartan results in decreased expression of IL6 mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [arsenite results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]

PMID:19289654 PMID:21479465 PMID:22124178 PMID:29909460 PMID:34339004

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

increases expression

Telmisartan results in increased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

decreases expression

telmisartan results in decreased expression of INS protein

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

interleukin-1 receptor-associated kinase 1

multiple interactions

[Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

potassium calcium-activated channel subfamily N member 4

decreases expression

telmisartan decreases expression of KCNN4 mRNA and protein in CD4-positive alpha-beta T cell

RGD

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

leptin receptor

multiple interactions

Telmisartan affects the reaction [LEPR protein affects the abundance of ALB protein]; Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lipase E, hormone sensitive type

multiple interactions
increases expression

PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

mitogen activated protein kinase 1

multiple interactions

telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]

PMID:22124178 PMID:33872574

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions
decreases phosphorylation

telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
telmisartan results in decreased phosphorylation of MAPK14 protein

PMID:19292980 PMID:22124178

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Telmisartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

PMID:22124178 PMID:33872574

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MAPK activated protein kinase 2

multiple interactions

telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form]

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

MAS1 proto-oncogene, G protein-coupled receptor

multiple interactions
increases expression

telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Telmisartan results in increased expression of MAS1 protein

PMID:21381899 PMID:28656296 PMID:31629013

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

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microRNA 146a

multiple interactions

[Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A
telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney]

CTD
RGD

PMID:20524934 PMID:27760486

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

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microRNA 146b

multiple interactions

[Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

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microRNA 320a

multiple interactions

telmisartan inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney]

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

matrix metallopeptidase 2

decreases expression
decreases expression

telmisartan results in decreased expression of MMP2 protein
telmisartan decreases expression of mRNA in mandible of WKY rats with periodontal disease

CTD
RGD

PMID:21054405 PMID:33364953

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

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matrix metallopeptidase 9

decreases expression

telmisartan decreases expression of mRNA in mandible of SHR rats with periodontal disease

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]
Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased activity of MPO protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:23060470 PMID:24831514 PMID:26439596 PMID:26929000

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

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myosin light chain kinase

multiple interactions

MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK mRNA]; Telmisartan inhibits the reaction [Glucose results in increased expression of MYLK protein]

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

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neutrophil cytosolic factor 1

multiple interactions
decreases expression

telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein]
Telmisartan results in decreased expression of NCF1 mRNA; Telmisartan results in decreased expression of NCF1 protein
telmisartan results in decreased expression of NCF1 mRNA; telmisartan results in decreased expression of NCF1 protein

PMID:16141465 PMID:19171132 PMID:21054405 PMID:21381899

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

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neutrophil cytosolic factor 2

multiple interactions
decreases expression

telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
telmisartan results in decreased expression of NCF2 mRNA; telmisartan results in decreased expression of NCF2 protein

PMID:16141465 PMID:21054405 PMID:21381899

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

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nuclear factor kappa B subunit 1

multiple interactions

telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

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NFKB inhibitor alpha

multiple interactions

PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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nitric oxide synthase 2

multiple interactions

telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]

PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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nitric oxide synthase 3

multiple interactions
increases phosphorylation
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

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NADPH oxidase 4

multiple interactions

telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

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natriuretic peptide B

affects expression
multiple interactions
decreases expression

telmisartan affects the expression of NPPB protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]
telmisartan results in decreased expression of NPPB protein

PMID:16671338 PMID:18712048 PMID:31629013

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

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occludin

multiple interactions

MYLK protein inhibits the reaction [Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN mRNA]; Telmisartan inhibits the reaction [Glucose results in decreased expression of OCLN protein]
Telmisartan affects the reaction [LEPR protein affects the expression of OCLN mRNA]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

oxidized low density lipoprotein receptor 1

multiple interactions

Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 mRNA]; Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 protein]

NCBI chr 4:162,926,436...162,949,057