Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620007
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2j4
Name: cytochrome P450, family 2, subfamily j, polypeptide 4
Acc ID: CHEBI:8714
Term: quinapril hydrochloride
Definition: A hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride. A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:C041125
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2j4decreases activityISORGD:13544676480464CTDQuinapril results in decreased activity of CYP2J2 protein

PMID:30965050
Go Back to source page   Continue to Ontology report