Kl (Klotho) - Rat Genome Database

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Gene: Kl (Klotho) Rattus norvegicus
Symbol: Kl
Name: Klotho
RGD ID: 620396
Description: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in apical plasma membrane and extracellular region. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN fibroblast growth factor signaling pathway; pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.212490,402 - 531,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12490,399 - 530,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,064,277 - 1,103,820 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,586,514 - 1,626,063 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012486,601 - 526,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.012942,974 - 987,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Celera122,195,730 - 2,234,485 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(Z)-ligustilide  (ISO)
1,1-dichloroethene  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol 3-glucosiduronic acid  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
androsterone 3-glucosiduronic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cocaine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
estriol 3-O-(beta-D-glucuronide)  (ISO)
estrone 3-O-(beta-D-glucuronide)  (ISO)
ethanol  (ISO)
fosinopril  (EXP)
genistein  (ISO)
glycidol  (EXP)
guggulsterone  (ISO)
indoxyl sulfate  (EXP,ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
melatonin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nitrates  (EXP)
Osajin  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Pomiferin  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rosavin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
SL-327  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
streptozocin  (EXP)
taurocholic acid  (ISO)
testosterone 17-glucosiduronic acid  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Aizawa H, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):865-71.
2. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Arking DE, etal., Circ Res. 2005 Mar 4;96(4):412-8. Epub 2005 Jan 27.
3. The parathyroid is a target organ for FGF23 in rats. Ben-Dov IZ, etal., J Clin Invest. 2007 Dec;117(12):4003-8.
4. Vitamin D-deficient diet rescues hearing loss in Klotho mice. Carpinelli MR, etal., Hear Res. 2011 May;275(1-2):105-9. doi: 10.1016/j.heares.2010.12.009. Epub 2010 Dec 16.
5. Fosinopril and valsartan intervention in gene expression of Klotho, MMP-9, TIMP-1, and PAI-1 in the kidney of spontaneously hypertensive rats. Cheng X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1048-56. doi: 10.3969/j.issn.1672-7347.2010.10.004.
6. Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors. Farinelli P, etal., J Neurochem. 2013 Dec;127(6):868-79. doi: 10.1111/jnc.12353. Epub 2013 Jul 22.
7. Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction. Fletcher JA, etal., Appl Physiol Nutr Metab. 2012 Dec;37(6):1054-62. doi: 10.1139/h2012-091. Epub 2012 Aug 15.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Increased parathyroid expression of klotho in uremic rats. Hofman-Bang J, etal., Kidney Int. 2010 Dec;78(11):1119-27. doi: 10.1038/ki.2010.215. Epub 2010 Jul 14.
11. Klotho deficiency causes vascular calcification in chronic kidney disease. Hu MC, etal., J Am Soc Nephrol. 2011 Jan;22(1):124-36. doi: 10.1681/ASN.2009121311. Epub 2010 Nov 29.
12. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Huang KC, etal., Horm Metab Res. 2014 Apr;46(4):240-4. doi: 10.1055/s-0033-1357161. Epub 2013 Oct 17.
13. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Imamura A, etal., Clin Chim Acta. 2006 Sep;371(1-2):66-70. Epub 2006 Mar 6.
14. Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice. Inoue S, etal., Shock. 2013 Mar;39(3):311-6. doi: 10.1097/SHK.0b013e3182845445.
15. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Kim Y, etal., Neurosci Lett. 2006 Oct 30;407(3):189-94. Epub 2006 Sep 14.
16. Severely reduced production of klotho in human chronic renal failure kidney. Koh N, etal., Biochem Biophys Res Commun. 2001 Feb 2;280(4):1015-20.
17. Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model. Kuang X, etal., Neurobiol Aging. 2014 Jan;35(1):169-78. doi: 10.1016/j.neurobiolaging.2013.07.019. Epub 2013 Aug 21.
18. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Kuro-o M, etal., Nature. 1997 Nov 6;390(6655):45-51.
19. Regulation of fibroblast growth factor-23 signaling by klotho. Kurosu H, etal., J Biol Chem. 2006 Mar 10;281(10):6120-3. Epub 2006 Jan 25.
20. [Klotho gene attenuates the progression of hypertension and heart damage in spontaneous hypertensive rats]. Li BS, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Dec;29(6):662-8. doi: 10.3760/cma.j.issn.1003-9406.2012.06.008.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Mitani H, etal., Hypertension 2002 Apr;39(4):838-43.
23. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Nagai R, etal., Cell Mol Life Sci. 2000 May;57(5):738-46.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Ogata N, etal., Bone. 2002 Jul;31(1):37-42.
26. Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Ohyama Y, etal., Biochem Biophys Res Commun 1998 Oct 29;251(3):920-5.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Rhee EJ, etal., Metabolism. 2006 Oct;55(10):1344-51.
33. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Saito Y, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):767-72.
34. N-acetylcysteine attenuates renal alterations induced by senescence in the rat. Shimizu MH, etal., Exp Gerontol. 2013 Feb;48(2):298-303. doi: 10.1016/j.exger.2012.11.006. Epub 2012 Nov 23.
35. Klotho reduces apoptosis in experimental ischaemic acute renal failure. Sugiura H, etal., Nephrol Dial Transplant. 2005 Dec;20(12):2636-45. Epub 2005 Oct 4.
36. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Takeshita K, etal., Circulation. 2004 Apr 13;109(14):1776-82. Epub 2004 Mar 22.
37. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Thurston RD, etal., Gastroenterology. 2010 Apr;138(4):1384-94, 1394.e1-2. doi: 10.1053/j.gastro.2009.12.002. Epub 2009 Dec 11.
38. Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. Tsezou A, etal., J Orthop Res. 2008 Nov;26(11):1466-70. doi: 10.1002/jor.20634.
39. RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway. Wang X and Sun Z, Physiol Genomics. 2010 Apr 1;41(2):120-6. doi: 10.1152/physiolgenomics.00192.2009. Epub 2010 Jan 19.
40. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. Zanchi C, etal., PLoS One. 2013 Aug 14;8(8):e70775. doi: 10.1371/journal.pone.0070775. eCollection 2013.
Additional References at PubMed
PMID:10631108   PMID:11095966   PMID:11792841   PMID:12965205   PMID:15135068   PMID:17086194   PMID:18056631   PMID:18829467   PMID:19056867   PMID:19349416   PMID:19367378   PMID:19756714  
PMID:19955715   PMID:20360647   PMID:20625492   PMID:20830528   PMID:21038689   PMID:21209102   PMID:21276773   PMID:21311136   PMID:21389697   PMID:21646815   PMID:22285620   PMID:22551380  
PMID:23041151   PMID:23365232   PMID:23376485   PMID:23533145   PMID:23838326   PMID:24304882   PMID:24721634   PMID:24867139   PMID:24979306   PMID:25695625   PMID:26093264   PMID:26880455  
PMID:26970306   PMID:28515153   PMID:29187373   PMID:29226550   PMID:31001900   PMID:31422095   PMID:31578871   PMID:32438076   PMID:32699940   PMID:32869899   PMID:33737505   PMID:34050772  
PMID:34360633   PMID:34730891   PMID:35104732   PMID:35436879   PMID:35900650   PMID:36041714   PMID:36641458   PMID:36674721   PMID:37704925   PMID:37793463  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.212490,402 - 531,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12490,399 - 530,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,064,277 - 1,103,820 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,586,514 - 1,626,063 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012486,601 - 526,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.012942,974 - 987,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Celera122,195,730 - 2,234,485 (+)NCBICelera
Cytogenetic Map12p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381333,016,243 - 33,066,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1333,016,423 - 33,066,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371333,590,561 - 33,640,280 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,488,571 - 32,538,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 341332,488,570 - 32,538,279NCBI
Celera1314,657,386 - 14,707,106 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1314,401,659 - 14,452,070 (+)NCBIHuRef
CHM1_11333,558,119 - 33,607,832 (+)NCBICHM1_1
T2T-CHM13v2.01332,233,557 - 32,283,464 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395150,876,072 - 150,917,282 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,876,072 - 150,917,282 (+)EnsemblGRCm39 Ensembl
GRCm385150,952,607 - 150,993,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,755,182 - 151,796,392 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365151,221,078 - 151,262,196 (+)NCBIMGSCv36mm8
Celera5148,957,067 - 148,998,277 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.77NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543112,782,846 - 12,833,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543112,782,913 - 12,833,215 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11323,685,802 - 23,735,607 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01314,272,463 - 14,321,122 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,697,381 - 32,752,578 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,702,336 - 32,751,458 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1257,154,359 - 7,201,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,190,325 - 7,236,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0257,256,203 - 7,302,574 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,255,966 - 7,302,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,155,694 - 7,201,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,148,224 - 7,195,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,211,791 - 7,258,193 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945168,294,810 - 168,347,489 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647227,604,517 - 27,650,086 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647227,604,681 - 27,649,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl119,427,037 - 9,479,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1119,427,236 - 9,479,251 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,357,470 - 9,390,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1311,755,015 - 11,799,537 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,755,016 - 11,797,596 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605732,549,747 - 32,594,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462491595,155 - 110,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Kl
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:146
Interacting mature miRNAs:158
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 4 27 10
Low 9 1 2 1 53 4 23 1
Below cutoff 2 38 21 13 16 13 8 11 7 4 16 8


RefSeq Acc Id: ENSRNOT00000001449   ⟹   ENSRNOP00000001449
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl12490,399 - 530,080 (+)Ensembl
Rnor_6.0 Ensembl12943,006 - 987,551 (+)Ensembl
RefSeq Acc Id: NM_031336   ⟹   NP_112626
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.212490,402 - 530,080 (+)NCBI
Rnor_6.012942,974 - 987,206 (+)NCBI
Rnor_5.012929,158 - 972,144 (+)NCBI
RGSC_v3.4123,732,712 - 3,772,371 (-)RGD
Celera122,195,730 - 2,234,485 (+)RGD
RefSeq Acc Id: XM_039089808   ⟹   XP_038945736
Rat AssemblyChrPosition (strand)Source
mRatBN7.212508,585 - 531,417 (+)NCBI
RefSeq Acc Id: XM_039089809   ⟹   XP_038945737
Rat AssemblyChrPosition (strand)Source
mRatBN7.212510,542 - 531,417 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112626 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945736 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945737 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA34740 (Get FASTA)   NCBI Sequence Viewer  
  EDL74914 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001449
GenBank Protein Q9Z2Y9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112626   ⟸   NM_031336
- Peptide Label: precursor
- UniProtKB: Q9Z2Y9 (UniProtKB/Swiss-Prot),   A6KSV6 (UniProtKB/TrEMBL),   A0A0H2UH96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001449   ⟸   ENSRNOT00000001449
RefSeq Acc Id: XP_038945736   ⟸   XM_039089808
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UH96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945737   ⟸   XM_039089809
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Y9-F1-model_v2 AlphaFold Q9Z2Y9 1-1014 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698360
Promoter ID:EPDNEW_R8885
Type:multiple initiation site
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.012942,995 - 943,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620396 AgrOrtholog
BioCyc Gene G2FUF-20507 BioCyc
Ensembl Genes ENSRNOG00000001092 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001449 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000001449.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83504 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10353:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kl PhenoGen
RatGTEx ENSRNOG00000001092 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kl  Klotho      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kl  Klotho      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in arteriosclerosis, osteoporosis, infertility, pulmonary emphysema 70544
gene_expression expressed in kidney 70544
gene_process has a role in protection against Ang II-induced renal damage 70544
gene_regulation downregulated by Ang II 70544
gene_regulation expression decreased by lipopolysaccharide 633145