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Gene: Kl (Klotho) Rattus norvegicus
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Symbol: Kl
Name: Klotho
Description: Predicted to have beta-glucosidase activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to localize to the membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Prinzmetal angina; coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Orthologs:
Homo sapiens (human) : KL (klotho)  HGNC  Alliance
Mus musculus (house mouse) : Kl (klotho)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kl (klotho)
Pan paniscus (bonobo/pygmy chimpanzee) : KL (klotho)
Canis lupus familiaris (dog) : KL (klotho)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kl (klotho)
Sus scrofa (pig) : KL (klotho)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.012942,974 - 987,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)Ensembl
Rnor_5.012929,158 - 972,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Celera122,195,730 - 2,234,485 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620396
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.