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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kl
Name: Klotho
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kldecreases expressionISOKL (Homo sapiens)6480464CTDOxygen deficiency results in decreased expression of KL proteinPMID:35123992
Klmultiple interactionsISOKL (Homo sapiens)6480464CTDKL protein affects the reaction [Oxygen deficiency results in increased expression of ACTA2 protein]; KL protein affects the reaction [Oxygen deficiency results in increased expression of TGFB1 protein]; KL protein affects the reaction [pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [Oxygen deficiency results in decreased expression of KL protein]PMID:35123992
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