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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kl
Name: Klotho
Acc ID: CHEBI:5163
Term: fosinopril
Definition: A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
Chemical ID: MESH:D017328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klincreases expressionEXP 6480464CTDFosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL proteinPMID:21051829
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