KL (klotho) - Rat Genome Database

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Advanced Search (OLGA)
Gene: KL (klotho) Canis lupus familiaris
Analyze
Symbol: KL
Name: klotho
RGD ID: 12176814
Description: ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor binding (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN calcium ion homeostasis (ortholog); determination of adult lifespan (ortholog); energy reserve metabolic process (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amenorrhea (ortholog); Animal Disease Models (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,154,359 - 7,201,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,190,325 - 7,236,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0257,256,203 - 7,302,574 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,255,966 - 7,302,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,155,694 - 7,201,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,148,224 - 7,195,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,211,791 - 7,258,193 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,154,359 - 7,201,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,190,325 - 7,236,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0257,256,203 - 7,302,574 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,255,966 - 7,302,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,155,694 - 7,201,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,148,224 - 7,195,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,211,791 - 7,258,193 (-)NCBIUU_Cfam_GSD_1.0
KL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381333,016,243 - 33,066,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1333,016,423 - 33,066,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371333,590,561 - 33,640,280 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,488,571 - 32,538,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 341332,488,570 - 32,538,279NCBI
Celera1314,657,386 - 14,707,106 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1314,401,659 - 14,452,070 (+)NCBIHuRef
CHM1_11333,558,119 - 33,607,832 (+)NCBICHM1_1
T2T-CHM13v2.01332,233,557 - 32,283,464 (+)NCBIT2T-CHM13v2.0
Kl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,876,072 - 150,917,282 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,876,072 - 150,917,282 (+)EnsemblGRCm39 Ensembl
GRCm385150,952,607 - 150,993,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,755,182 - 151,796,392 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365151,221,078 - 151,262,196 (+)NCBIMGSCv36mm8
Celera5148,957,067 - 148,998,277 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.77NCBI
Kl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8125,326,003 - 5,367,016 (+)NCBIGRCr8
mRatBN7.212490,402 - 531,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12490,399 - 530,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,064,277 - 1,103,820 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,586,514 - 1,626,063 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012486,601 - 526,810 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.012942,974 - 987,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Celera122,195,730 - 2,234,485 (+)NCBICelera
Cytogenetic Map12p12NCBI
Kl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543112,782,846 - 12,833,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543112,782,913 - 12,833,215 (-)NCBIChiLan1.0ChiLan1.0
KL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21432,579,481 - 32,629,284 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11323,685,802 - 23,735,607 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01314,272,463 - 14,321,122 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,697,381 - 32,752,578 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,702,336 - 32,751,458 (+)Ensemblpanpan1.1panPan2
Kl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945168,294,810 - 168,347,489 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647227,604,517 - 27,650,086 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647227,604,681 - 27,649,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,427,037 - 9,479,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1119,427,236 - 9,479,251 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,357,470 - 9,390,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,755,015 - 11,799,537 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,755,016 - 11,797,596 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605732,549,747 - 32,594,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462491595,155 - 110,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KL
491 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010228   ⟹   ENSCAFP00000009488
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845026540   ⟹   ENSCAFP00845020922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl257,255,966 - 7,302,141 (-)Ensembl
RefSeq Acc Id: XM_038434663   ⟹   XP_038290591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0257,256,203 - 7,302,574 (-)NCBI
RefSeq Acc Id: XM_038458582   ⟹   XP_038314510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha257,190,325 - 7,236,623 (-)NCBI
RefSeq Acc Id: XM_038511001   ⟹   XP_038366929
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1257,155,694 - 7,201,964 (-)NCBI
RefSeq Acc Id: XM_038574487   ⟹   XP_038430415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0257,211,791 - 7,258,193 (-)NCBI
RefSeq Acc Id: XM_038637348   ⟹   XP_038493276
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0257,148,224 - 7,195,654 (-)NCBI
Ensembl Acc Id: ENSCAFP00000009488   ⟸   ENSCAFT00000010228
RefSeq Acc Id: XP_038366929   ⟸   XM_038511001
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038493276   ⟸   XM_038637348
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038290591   ⟸   XM_038434663
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PVA6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038314510   ⟸   XM_038458582
- Peptide Label: isoform X3
- UniProtKB: A0A8C0PVA6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038430415   ⟸   XM_038574487
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PVA6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845020922   ⟸   ENSCAFT00845026540


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006322 Ensembl
  ENSCAFG00000056331 UniProtKB/TrEMBL
  ENSCAFG00030025104 UniProtKB/TrEMBL
  ENSCAFG00845014839 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000100875.1 UniProtKB/TrEMBL
  ENSCAFT00030046333.1 UniProtKB/TrEMBL
  ENSCAFT00845026540 ENTREZGENE
  ENSCAFT00845026540.1 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro Glyco_hydro_1 UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
NCBI Gene KL ENTREZGENE
PANTHER KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG UniProtKB/TrEMBL
  PTHR10353 UniProtKB/TrEMBL
  PTHR10353:SF10 UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/TrEMBL
PRINTS GLHYDRLASE1 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A0A8C0PVA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKX5_CANLF UniProtKB/TrEMBL
  A0A8P0PHW2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42425 ENTREZGENE