Kl (klotho) - Rat Genome Database
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Gene: Kl (klotho) Mus musculus
Analyze
Symbol: Kl
Name: klotho
RGD ID: 732784
MGI Page MGI
Description: Exhibits fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including calcium ion homeostasis; energy reserve metabolic process; and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Predicted to localize to endoplasmic reticulum; extracellular region; and integral component of membrane. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN fibroblast growth factor signaling pathway; pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH (Z)-ligustilide; 1,1-dichloroethene; 17beta-estradiol 3-glucosiduronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alp; alpha-kl; secreted form of Klotho protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,876,072 - 150,917,282 (+)NCBIGRCm39mm39
GRCm385150,952,607 - 150,993,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,755,182 - 151,796,392 (+)NCBIGRCm37mm9NCBIm37
MGSCv365151,221,078 - 151,262,196 (+)NCBImm8
Celera5148,957,067 - 148,998,277 (+)NCBICelera
Cytogenetic Map5G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(Z)-ligustilide  (EXP,ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol 3-glucosiduronic acid  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
amino acid  (EXP)
ammonium chloride  (ISO)
androsterone 3-glucosiduronic acid  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cocaine  (ISO)
cyclosporin A  (EXP,ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
estriol 3-O-(beta-D-glucuronide)  (EXP)
estrone 3-O-(beta-D-glucuronide)  (EXP)
ethanol  (EXP)
fosinopril  (ISO)
genistein  (ISO)
glycidol  (ISO)
indoxyl sulfate  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP)
malonaldehyde  (EXP)
melatonin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
nitrates  (ISO)
Osajin  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
Pomiferin  (ISO)
potassium dichromate  (EXP)
propanal  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
Rosavin  (ISO)
selenium atom  (ISO)
SL-327  (EXP)
sodium chlorate  (ISO)
streptozocin  (ISO)
taurocholic acid  (EXP)
testosterone 17-glucosiduronic acid  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (EXP)
vitamin D  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis morphology  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal autopod morphology  (IEA)
abnormal blood circulation  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal bone mineral density  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating mineral level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal definitive hematopoiesis  (IEA)
abnormal digestive system morphology  (IAGP)
abnormal duodenum morphology  (IEA)
abnormal femur morphology  (IAGP)
abnormal gametogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadotroph morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart valve morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal kidney collecting duct morphology  (IEA)
abnormal kidney cortex morphology  (IEA)
abnormal kidney medulla morphology  (IEA)
abnormal kidney morphology  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal liver physiology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long term object recognition memory  (IAGP)
abnormal lung morphology  (IAGP)
abnormal malleus manubrium morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary interalveolar septum morphology  (IAGP)
abnormal respiratory mechanics  (IAGP)
abnormal retina morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sinoatrial node conduction  (IAGP)
abnormal skin condition  (IAGP)
abnormal smooth muscle morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal stomach morphology  (IEA)
abnormal trabecular bone morphology  (IAGP)
abnormal tracheal cartilage morphology  (IEA)
abnormal vertebrae morphology  (IAGP)
abnormal vitamin D level  (IAGP)
absent bone trabeculae  (IEA)
absent mature ovarian follicles  (IAGP)
absent pinna reflex  (IAGP)
alopecia  (IAGP)
arrest of male meiosis  (IAGP)
arteriosclerosis  (IAGP)
azoospermia  (IAGP)
calcified aorta  (IAGP)
calcified aortic valve  (IAGP)
calcified artery  (IAGP)
calcified mitral valve  (IAGP)
calcified muscle  (IAGP)
calcified pulmonary alveolus  (IAGP)
calcified skin  (IAGP)
calcinosis  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased B cell number  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased brown fat cell lipid droplet size  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased femur compact bone thickness  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart rate  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver weight  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased somatotroph cell size  (IAGP)
decreased somatotroph secretory granule number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased tidal volume  (IAGP)
decreased white adipose tissue amount  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
dehydration  (IEA)
diaphragmatic hernia  (IEA)
dilated gastric glands  (IEA)
dilated pulmonary alveolar ducts  (IAGP)
emphysema  (IAGP)
external male genitalia atrophy  (IAGP)
hemorrhage  (IEA)
hunched posture  (IAGP)
hypoactivity  (IAGP)
hypoglycemia  (IAGP)
impaired hearing  (IAGP)
improved glucose tolerance  (IAGP)
increased a-wave latency  (IAGP)
increased alkaline phosphatase activity  (IAGP)
increased b-wave latency  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating noradrenaline level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating phosphate level  (IAGP)
increased insulin sensitivity  (IAGP)
increased lung compliance  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased urine calcium level  (IAGP)
increased vitamin D level  (IAGP)
infertility  (IAGP)
kidney cortex hypoplasia  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lung inflammation  (IAGP)
nephrocalcinosis  (IAGP)
osteopetrosis  (IAGP)
osteoporosis  (IAGP)
ovary atrophy  (IAGP)
oxidative stress  (IAGP)
postnatal growth retardation  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
prolonged RR interval  (IAGP)
Purkinje cell degeneration  (IAGP)
renal fibrosis  (IAGP)
renal necrosis  (IAGP)
respiratory distress  (IEA)
short femur  (IAGP)
short malleus  (IAGP)
short malleus manubrium  (IAGP)
short stride length  (IAGP)
skin atrophy  (IAGP)
small kidney  (IAGP)
small pancreatic islets  (IAGP)
small spleen  (IEA)
small stapes obturator foramen  (IAGP)
sparse hair  (IAGP)
testicular atrophy  (IAGP)
thick zygomatic arch  (IAGP)
thin epidermis  (IAGP)
thymus atrophy  (IAGP)
uterus atrophy  (IAGP)
vulva atrophy  (IAGP)
wide ribs  (IAGP)
References

References - curated
1. Aizawa H, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):865-71.
2. Arking DE, etal., Circ Res. 2005 Mar 4;96(4):412-8. Epub 2005 Jan 27.
3. Carpinelli MR, etal., Hear Res. 2011 May;275(1-2):105-9. doi: 10.1016/j.heares.2010.12.009. Epub 2010 Dec 16.
4. Cheng X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1048-56. doi: 10.3969/j.issn.1672-7347.2010.10.004.
5. Farinelli P, etal., J Neurochem. 2013 Dec;127(6):868-79. doi: 10.1111/jnc.12353. Epub 2013 Jul 22.
6. Hofman-Bang J, etal., Kidney Int. 2010 Dec;78(11):1119-27. doi: 10.1038/ki.2010.215. Epub 2010 Jul 14.
7. Hu MC, etal., J Am Soc Nephrol. 2011 Jan;22(1):124-36. doi: 10.1681/ASN.2009121311. Epub 2010 Nov 29.
8. Huang KC, etal., Horm Metab Res. 2014 Apr;46(4):240-4. doi: 10.1055/s-0033-1357161. Epub 2013 Oct 17.
9. Imamura A, etal., Clin Chim Acta. 2006 Sep;371(1-2):66-70. Epub 2006 Mar 6.
10. Inoue S, etal., Shock. 2013 Mar;39(3):311-6. doi: 10.1097/SHK.0b013e3182845445.
11. Kim Y, etal., Neurosci Lett. 2006 Oct 30;407(3):189-94. Epub 2006 Sep 14.
12. Koh N, etal., Biochem Biophys Res Commun. 2001 Feb 2;280(4):1015-20.
13. Kuang X, etal., Neurobiol Aging. 2014 Jan;35(1):169-78. doi: 10.1016/j.neurobiolaging.2013.07.019. Epub 2013 Aug 21.
14. Kuro-o M, etal., Nature. 1997 Nov 6;390(6655):45-51.
15. Kurosu H, etal., J Biol Chem. 2006 Mar 10;281(10):6120-3. Epub 2006 Jan 25.
16. Li BS, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Dec;29(6):662-8. doi: 10.3760/cma.j.issn.1003-9406.2012.06.008.
17. MGD data from the GO Consortium
18. MGD IEA
19. Mitani H, etal., Hypertension 2002 Apr;39(4):838-43.
20. Nagai R, etal., Cell Mol Life Sci. 2000 May;57(5):738-46.
21. Ogata N, etal., Bone. 2002 Jul;31(1):37-42.
22. OMIM Disease Annotation Pipeline
23. Pipeline to import KEGG annotations from KEGG into RGD
24. RGD automated import pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Rhee EJ, etal., Metabolism. 2006 Oct;55(10):1344-51.
28. Saito Y, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):767-72.
29. Sugiura H, etal., Nephrol Dial Transplant. 2005 Dec;20(12):2636-45. Epub 2005 Oct 4.
30. Takeshita K, etal., Circulation. 2004 Apr 13;109(14):1776-82. Epub 2004 Mar 22.
31. Thurston RD, etal., Gastroenterology. 2010 Apr;138(4):1384-94, 1394.e1-2. doi: 10.1053/j.gastro.2009.12.002. Epub 2009 Dec 11.
32. Tsezou A, etal., J Orthop Res. 2008 Nov;26(11):1466-70. doi: 10.1002/jor.20634.
33. Zanchi C, etal., PLoS One. 2013 Aug 14;8(8):e70775. doi: 10.1371/journal.pone.0070775. eCollection 2013.
Additional References at PubMed
PMID:8889548   PMID:9537505   PMID:9795335   PMID:9988222   PMID:10349636   PMID:10430604   PMID:10614667   PMID:10615062   PMID:10631108   PMID:10657859   PMID:10837414   PMID:10892339  
PMID:11016890   PMID:11042159   PMID:11044614   PMID:11076861   PMID:11095966   PMID:11137391   PMID:11182773   PMID:11217851   PMID:11411791   PMID:11509604   PMID:11796525   PMID:12054604  
PMID:12119304   PMID:12120757   PMID:12204354   PMID:12208660   PMID:12446599   PMID:12466851   PMID:12475907   PMID:12477932   PMID:12536348   PMID:12565878   PMID:12771308   PMID:14511659  
PMID:14528024   PMID:14681479   PMID:14701853   PMID:15135068   PMID:15485693   PMID:15520879   PMID:15564564   PMID:15665504   PMID:15834732   PMID:15976510   PMID:16123266   PMID:16141072  
PMID:16141073   PMID:16144705   PMID:16179415   PMID:16186101   PMID:16239475   PMID:16458526   PMID:16505583   PMID:16602821   PMID:16709611   PMID:16819151   PMID:16985213   PMID:17086194  
PMID:17114649   PMID:17138819   PMID:17284608   PMID:17287345   PMID:17569864   PMID:17690294   PMID:17709902   PMID:18085632   PMID:18248363   PMID:18343589   PMID:18528324   PMID:18547997  
PMID:18606998   PMID:18678710   PMID:18729805   PMID:18753255   PMID:18835926   PMID:18984852   PMID:19063940   PMID:19098446   PMID:19184092   PMID:19225558   PMID:19230844   PMID:19444269  
PMID:19480830   PMID:19584304   PMID:19591273   PMID:19635988   PMID:19713312   PMID:19730882   PMID:19737556   PMID:19745103   PMID:19749165   PMID:19906978   PMID:19912987   PMID:19922080  
PMID:19933269   PMID:19952276   PMID:19966287   PMID:20080590   PMID:20166550   PMID:20418498   PMID:20466874   PMID:20562737   PMID:20581042   PMID:20719979   PMID:20844314   PMID:20855613  
PMID:20861825   PMID:20966350   PMID:21037388   PMID:21082218   PMID:21209102   PMID:21267068   PMID:21276773   PMID:21336305   PMID:21354104   PMID:21382979   PMID:21427221   PMID:21590742  
PMID:21593200   PMID:21605285   PMID:21605558   PMID:21677750   PMID:21719790   PMID:21734097   PMID:21865732   PMID:21873635   PMID:21876757   PMID:21939436   PMID:21951615   PMID:21982773  
PMID:21985788   PMID:22037453   PMID:22217880   PMID:22245317   PMID:22248532   PMID:22285620   PMID:22319626   PMID:22338084   PMID:22396160   PMID:22396163   PMID:22597535   PMID:22615584  
PMID:22647968   PMID:22688076   PMID:22782974   PMID:22878961   PMID:22879941   PMID:22932118   PMID:22986347   PMID:23034937   PMID:23139829   PMID:23187128   PMID:23212367   PMID:23216570  
PMID:23235154   PMID:23298834   PMID:23365232   PMID:23389690   PMID:23577141   PMID:23596175   PMID:23746979   PMID:23747339   PMID:23884339   PMID:23928372   PMID:23945089   PMID:23954506  
PMID:24030242   PMID:24045987   PMID:24088960   PMID:24107965   PMID:24217253   PMID:24304882   PMID:24340070   PMID:24348262   PMID:24386260   PMID:24412515   PMID:24434184   PMID:24470103  
PMID:24522202   PMID:24525546   PMID:24704992   PMID:24723043   PMID:24778222   PMID:24797667   PMID:24904083   PMID:24911970   PMID:24939736   PMID:25037225   PMID:25063799   PMID:25130652  
PMID:25163025   PMID:25337236   PMID:25377875   PMID:25475745   PMID:25550330   PMID:25673831   PMID:25682161   PMID:25722432   PMID:25860694   PMID:25923845   PMID:25926573   PMID:26061549  
PMID:26067431   PMID:26093264   PMID:26155844   PMID:26201096   PMID:26235988   PMID:26273529   PMID:26324504   PMID:26340932   PMID:26452228   PMID:26471128   PMID:26475416   PMID:26531128  
PMID:26538435   PMID:26586006   PMID:26701976   PMID:26781278   PMID:26865060   PMID:26872488   PMID:27001421   PMID:27021580   PMID:27037022   PMID:27109615   PMID:27154199   PMID:27174564  
PMID:27194721   PMID:27199449   PMID:27226196   PMID:27242197   PMID:27292223   PMID:27330715   PMID:27498418   PMID:27543985   PMID:27576165   PMID:27620389   PMID:27703201   PMID:27808000  
PMID:27837149   PMID:27914707   PMID:27929669   PMID:27941311   PMID:28094278   PMID:28122194   PMID:28152512   PMID:28183805   PMID:28215989   PMID:28259911   PMID:28264799   PMID:28315683  
PMID:28349330   PMID:28387374   PMID:28396120   PMID:28416226   PMID:28428174   PMID:28442546   PMID:28600880   PMID:28615093   PMID:28693719   PMID:28771227   PMID:28771600   PMID:28798354  
PMID:28837861   PMID:28885690   PMID:28900153   PMID:28924605   PMID:29195509   PMID:29197521   PMID:29285593   PMID:29363324   PMID:29493420   PMID:29542092   PMID:29544758   PMID:29550818  
PMID:29581213   PMID:29618612   PMID:29638159   PMID:29654213   PMID:29667913   PMID:29693450   PMID:29720668   PMID:29849149   PMID:29889103   PMID:29977226   PMID:29993278   PMID:30054990  
PMID:30316188   PMID:30373854   PMID:30413620   PMID:30442365   PMID:30451844   PMID:30516423   PMID:30592280   PMID:30671592   PMID:30716541   PMID:30818059   PMID:30851437   PMID:30853453  
PMID:30920112   PMID:30945158   PMID:30991103   PMID:31042083   PMID:31207271   PMID:31250273   PMID:31310795   PMID:31325434   PMID:31386628   PMID:31422095   PMID:31536138   PMID:31539519  
PMID:31575945   PMID:31801907   PMID:31812067   PMID:31895692   PMID:31907991   PMID:31908069   PMID:31984794   PMID:32026654   PMID:32235720   PMID:32325033   PMID:32332158   PMID:32597829  


Genomics

Comparative Map Data
Kl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,876,072 - 150,917,282 (+)NCBIGRCm39mm39
GRCm385150,952,607 - 150,993,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,755,182 - 151,796,392 (+)NCBIGRCm37mm9NCBIm37
MGSCv365151,221,078 - 151,262,196 (+)NCBImm8
Celera5148,957,067 - 148,998,277 (+)NCBICelera
Cytogenetic Map5G3NCBI
KL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1333,016,423 - 33,066,143 (+)EnsemblGRCh38hg38GRCh38
GRCh381333,016,063 - 33,066,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371333,590,571 - 33,640,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,488,571 - 32,538,279 (+)NCBINCBI36hg18NCBI36
Build 341332,488,570 - 32,538,279NCBI
Celera1314,657,386 - 14,707,106 (+)NCBI
Cytogenetic Map13q13.1NCBI
HuRef1314,401,659 - 14,452,070 (+)NCBIHuRef
CHM1_11333,558,119 - 33,607,832 (+)NCBICHM1_1
Kl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.012942,974 - 987,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Celera122,195,730 - 2,234,485 (+)NCBICelera
Cytogenetic Map12p12NCBI
Kl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543112,782,846 - 12,833,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543112,782,913 - 12,833,215 (-)NCBIChiLan1.0ChiLan1.0
KL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11332,697,381 - 32,752,578 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,702,336 - 32,751,458 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01314,272,463 - 14,321,122 (+)NCBIMhudiblu_PPA_v0panPan3
KL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1257,154,359 - 7,201,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647227,604,681 - 27,649,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,427,198 - 9,478,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1119,427,236 - 9,479,251 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,357,470 - 9,390,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,755,015 - 11,799,537 (+)NCBI
ChlSab1.1 Ensembl311,755,016 - 11,797,596 (+)Ensembl
Kl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462491595,155 - 110,834 (+)NCBI

Position Markers
AB010088  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385150,985,189 - 150,985,338UniSTSGRCm38
MGSCv375151,787,764 - 151,787,913UniSTSGRCm37
Celera5148,989,649 - 148,989,798UniSTS
Cytogenetic Map5G3UniSTS
Whitehead/MRC_RH51787.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:596
Count of miRNA genes:398
Interacting mature miRNAs:456
Transcripts:ENSMUST00000078856
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000078856   ⟹   ENSMUSP00000077899
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202096
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5150,952,704 - 150,986,981 (+)Ensembl
RefSeq Acc Id: NM_013823   ⟹   NP_038851
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395150,876,072 - 150,917,282 (+)NCBI
GRCm385150,952,607 - 150,993,817 (+)ENTREZGENE
MGSCv375151,755,182 - 151,796,392 (+)RGD
Celera5148,957,067 - 148,998,277 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504917   ⟹   XP_006504980
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395150,876,114 - 150,908,908 (+)NCBI
GRCm385150,952,649 - 150,985,443 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038851   ⟸   NM_013823
- Peptide Label: precursor
- UniProtKB: O35082 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006504980   ⟸   XM_006504917
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000077899   ⟸   ENSMUST00000078856

Promoters
RGD ID:6888902
Promoter ID:EPDNEW_M7902
Type:multiple initiation site
Name:Kl_1
Description:Mus musculus klotho , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385150,952,705 - 150,952,765EPDNEW
RGD ID:6837778
Promoter ID:MM_KWN:45047
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009AUK.1,   UC009AUL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365151,755,226 - 151,755,726 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1101771 AgrOrtholog
Ensembl Genes ENSMUSG00000058488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000077899 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000078856 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_1_N_CS UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Klotho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16591 UniProtKB/Swiss-Prot
MGD MGI:1101771 ENTREZGENE
NCBI Gene 16591 ENTREZGENE
PANTHER PTHR10353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10353:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kl PhenoGen
PRINTS GLHYDRLASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.6500 ENTREZGENE
UniProt KLOT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UYK1_MOUSE UniProtKB/TrEMBL
UniProt Secondary B2RR78 UniProtKB/Swiss-Prot
  O70175 UniProtKB/Swiss-Prot
  O70621 UniProtKB/Swiss-Prot