Ang2 (angiogenin, ribonuclease A family, member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ang2 (angiogenin, ribonuclease A family, member 2) Rattus norvegicus
Analyze
Symbol: Ang2
Name: angiogenin, ribonuclease A family, member 2
RGD ID: 1359373
Description: Predicted to enable RNA nuclease activity. Involved in cellular response to mechanical stimulus. Predicted to be located in nucleolus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ang; angiogenin ribonuclease 2; angiogenin, ribonuclease, RNase A family, 5; angiogenin-like; LOC108348324; Raa2; ribonuclease A a2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,871,842 - 26,889,421 (-)NCBIGRCr8
mRatBN7.21524,398,330 - 24,415,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,169,575 - 27,170,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,128,732 - 28,129,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,378,138 - 26,378,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,103,688 - 28,121,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,932,500 - 31,950,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,160,401 - 27,160,904 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,176,101 - 27,176,604 (-)NCBI
Celera1524,715,687 - 24,716,190 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15676279   PMID:17670746   PMID:19666176   PMID:23073804   PMID:23170778   PMID:24337645   PMID:29065170   PMID:29769424  


Genomics

Comparative Map Data
Ang2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,871,842 - 26,889,421 (-)NCBIGRCr8
mRatBN7.21524,398,330 - 24,415,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,169,575 - 27,170,078 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,128,732 - 28,129,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,378,138 - 26,378,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,103,688 - 28,121,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,932,500 - 31,950,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,160,401 - 27,160,904 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,176,101 - 27,176,604 (-)NCBI
Celera1524,715,687 - 24,716,190 (-)NCBICelera
Cytogenetic Map15p14NCBI
Ang2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,432,781 - 51,436,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,432,781 - 51,436,605 (-)EnsemblGRCm39 Ensembl
GRCm381451,195,486 - 51,195,923 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,195,324 - 51,199,148 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,815,161 - 51,815,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,117,437 - 50,117,874 (-)NCBIMGSCv36mm8
Celera1447,495,482 - 47,495,919 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.42NCBI

Variants

.
Variants in Ang2
421 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000032536
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 3 26 35 35 30 5 30 4 67 11 20 20 21 5

Sequence


Ensembl Acc Id: ENSRNOT00000032536   ⟹   ENSRNOP00000034383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,398,419 - 24,398,922 (-)Ensembl
Rnor_6.0 Ensembl1528,103,703 - 28,104,206 (-)Ensembl
RefSeq Acc Id: NM_001012359   ⟹   NP_001012359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,871,842 - 26,889,421 (-)NCBI
mRatBN7.21524,398,330 - 24,415,909 (-)NCBI
Rnor_6.01528,103,703 - 28,104,206 (-)NCBI
Rnor_5.01531,932,500 - 31,950,362 (-)NCBI
RGSC_v3.41527,160,401 - 27,160,904 (-)RGD
Celera1524,715,687 - 24,716,190 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV87194 (Get FASTA)   NCBI Sequence Viewer  
  CDG32032 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034383
  ENSRNOP00000034383.4
RefSeq Acc Id: NP_001012359   ⟸   NM_001012359
- Peptide Label: precursor
- UniProtKB: Q5GAM5 (UniProtKB/TrEMBL),   Q5WRG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034383   ⟸   ENSRNOT00000032536
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAM5-F1-model_v2 AlphaFold Q5GAM5 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359373 AgrOrtholog
BioCyc Gene G2FUF-14019 BioCyc
Ensembl Genes ENSRNOG00000025562 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032536 ENTREZGENE
  ENSRNOT00000032536.5 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:497229 UniProtKB/TrEMBL
NCBI Gene 497229 ENTREZGENE
PANTHER ANGIOGENIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Ang2 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025562 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt Q5GAM5 ENTREZGENE, UniProtKB/TrEMBL
  Q5WRG2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ang2  angiogenin, ribonuclease A family, member 2  LOC108348324  angiogenin-like  Data merged from RGD:11486822 737654 PROVISIONAL
2016-08-02 LOC108348324  angiogenin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-02-03 Ang2  angiogenin, ribonuclease A family, member 2  Ang2  angiogenin ribonuclease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Ang  angiogenin, ribonuclease, RNase A family, 5  Ang2  angiogenin ribonuclease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ang2  angiogenin ribonuclease 2      Symbol and Name updated 1559027 APPROVED
2005-07-29 Ang2  angiogenin ribonuclease 2      Symbol and Name status set to provisional 70820 PROVISIONAL