CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sotorasib
Accession: CHEBI:178199
browse the term
Definition: A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.
Synonyms: exact_synonym: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one
related_synonym: AMG-510; AMG510; Formula=C30H30F2N6O3; InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1; InChIKey=NXQKSXLFSAEQCZ-SFHVURJKSA-N; Lumakras; SMILES=CC(C)C1=NC=CC(C)=C1N1C(=O)N=C(N2CCN(C[C@@H]2C)C(=O)C=C)C2=C1N=C(C(F)=C2)C1=C(F)C=CC=C1O; sotorasibum
xref: CAS:2296729-00-3; Chemspider:72380148; DrugBank:DB15569; KEGG:D12055
xref_mesh: MESH:C000706028
xref: PMID:31189530; PMID:31666701; PMID:31820981; PMID:32540954; PMID:32686745; PMID:32955176; PMID:33283304; PMID:33466360; PMID:33547148; PMID:33957355; PMID:33971321; PMID:34004237; PMID:34043291; PMID:34094546; PMID:34096690; PMID:34137282; PMID:34140669; PMID:34144959; PMID:34158284; PMID:34219153; PMID:34301758; PMID:34357500; PMID:34359807; Wikipedia:Sotorasib
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Aadat
aminoadipate aminotransferase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AADAT mRNA
CTD
PMID:36139627
NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
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Abhd11
abhydrolase domain containing 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ABHD11 mRNA
CTD
PMID:36139627
NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
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Ache
acetylcholinesterase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACHE mRNA
CTD
PMID:36139627
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acp7
acid phosphatase 7, tartrate resistant
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACP7 mRNA
CTD
PMID:36139627
NCBI chr 1:83,896,485...83,923,436
Ensembl chr 1:83,898,153...83,920,634
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Acsl5
acyl-CoA synthetase long-chain family member 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACSL5 mRNA
CTD
PMID:36139627
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acsm3
acyl-CoA synthetase medium-chain family member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACSM3 mRNA
CTD
PMID:36139627
NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACTA2 mRNA
CTD
PMID:36139627
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Actbl2
actin, beta-like 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ACTBL2 mRNA
CTD
PMID:36139627
NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
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Acy3
aminoacylase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ACY3 mRNA
CTD
PMID:36139627
NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS1 mRNA
CTD
PMID:36139627
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS16 mRNA
CTD
PMID:36139627
NCBI chr 1:32,430,436...32,562,481
Ensembl chr 1:32,430,436...32,560,494
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Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADAMTS4 mRNA
CTD
PMID:36139627
NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADAMTS6 mRNA
CTD
PMID:36139627
NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
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Adgrg1
adhesion G protein-coupled receptor G1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADGRG1 mRNA
CTD
PMID:36139627
NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108
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Adgrl3
adhesion G protein-coupled receptor L3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADGRL3 mRNA
CTD
PMID:36139627
NCBI chr14:26,336,320...27,104,060
Ensembl chr14:26,368,277...27,105,860
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Adrb2
adrenoceptor beta 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ADRB2 mRNA
CTD
PMID:36139627
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Afap1l1
actin filament associated protein 1-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AFAP1L1 mRNA
CTD
PMID:36139627
NCBI chr18:55,183,786...55,244,174
Ensembl chr18:55,183,786...55,244,146
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Agr2
anterior gradient 2, protein disulphide isomerase family member
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AGR2 mRNA
CTD
PMID:36139627
NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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Akap5
A-kinase anchoring protein 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AKAP5 mRNA
CTD
PMID:36139627
NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
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Akna
AT-hook transcription factor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AKNA mRNA
CTD
PMID:36139627
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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Akt3
AKT serine/threonine kinase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AKT3 mRNA
CTD
PMID:36139627
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ALDH1A2 mRNA
CTD
PMID:36139627
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Aldoc
aldolase, fructose-bisphosphate C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ALDOC mRNA
CTD
PMID:36139627
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Aloxe3
arachidonate lipoxygenase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ALOXE3 mRNA
CTD
PMID:36139627
NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328
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Alpg
alkaline phosphatase, germ cell
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ALPG mRNA
CTD
PMID:36139627
NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836
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Amn1
antagonist of mitotic exit network 1 homolog
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AMN1 mRNA
CTD
PMID:36139627
NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
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Ampd3
adenosine monophosphate deaminase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AMPD3 mRNA
CTD
PMID:36139627
NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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Ang
angiogenin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANG mRNA
CTD
PMID:36139627
NCBI chr15:24,312,711...24,323,361
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Angptl4
angiopoietin-like 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANGPTL4 mRNA
CTD
PMID:36139627
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Ank3
ankyrin 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANK3 mRNA
CTD
PMID:36139627
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Ankef1
ankyrin repeat and EF-hand domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKEF1 mRNA
CTD
PMID:36139627
NCBI chr 3:123,847,832...123,883,060
Ensembl chr 3:123,847,817...123,883,059
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Ankrd2
ankyrin repeat domain 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKRD2 mRNA
CTD
PMID:36139627
NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566
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Ankrd24
ankyrin repeat domain 24
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANKRD24 mRNA
CTD
PMID:36139627
NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142
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Ankrd37
ankyrin repeat domain 37
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANKRD37 mRNA
CTD
PMID:36139627
NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
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Ankrd65
ankyrin repeat domain 65
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ANKRD65 mRNA
CTD
PMID:36139627
NCBI chr 5:166,398,359...166,400,616
Ensembl chr 5:166,397,748...166,400,953
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Ano7
anoctamin 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANO7 mRNA
CTD
PMID:36139627
NCBI chr 9:93,917,524...93,945,323
Ensembl chr 9:93,917,524...93,945,323
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Anpep
alanyl aminopeptidase, membrane
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ANPEP mRNA
CTD
PMID:36139627
NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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Aoc3
amine oxidase, copper containing 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of AOC3 mRNA
CTD
PMID:36139627
NCBI chr10:86,272,757...86,280,702
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Apln
apelin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of APLN mRNA
CTD
PMID:36139627
NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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Apobr
apolipoprotein B receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of APOBR mRNA
CTD
PMID:36139627
NCBI chr 1:181,169,019...181,173,206
Ensembl chr 1:181,168,916...181,173,528
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Arfgef3
ARFGEF family member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARFGEF3 mRNA
CTD
PMID:36139627
NCBI chr 1:13,245,578...13,404,319
Ensembl chr 1:13,244,830...13,404,084
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Arhgap31
Rho GTPase activating protein 31
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARHGAP31 mRNA
CTD
PMID:36139627
NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
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Arhgap8
Rho GTPase activating protein 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARHGAP8 mRNA
CTD
PMID:36139627
NCBI chr 7:115,842,223...115,902,094
Ensembl chr 7:115,850,654...115,902,093
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Armh1
armadillo-like helical domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ARMH1 mRNA
CTD
PMID:36139627
NCBI chr 5:130,680,955...130,722,062
Ensembl chr 5:130,682,485...130,722,062
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Atg9b
autophagy related 9B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATG9B mRNA
CTD
PMID:36139627
NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
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Atp10d
ATPase phospholipid transporting 10D (putative)
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ATP10D mRNA
CTD
PMID:36139627
NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
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Atp13a3
ATPase 13A3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP13A3 mRNA
CTD
PMID:36139627
NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP2A3 mRNA
CTD
PMID:36139627
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp6v0d2
ATPase H+ transporting V0 subunit D2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ATP6V0D2 mRNA
CTD
PMID:36139627
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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Avil
advillin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of AVIL mRNA
CTD
PMID:36139627
NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071
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Bach2
BTB domain and CNC homolog 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BACH2 mRNA
CTD
PMID:36139627
NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
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Bambi
BMP and activin membrane-bound inhibitor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BAMBI mRNA
CTD
PMID:36139627
NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
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Barx2
BARX homeobox 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BARX2 mRNA
CTD
PMID:36139627
NCBI chr 8:30,251,132...30,319,105
Ensembl chr 8:30,251,132...30,319,013
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Batf3
basic leucine zipper ATF-like transcription factor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BATF3 mRNA
CTD
PMID:36139627
NCBI chr13:102,689,657...102,701,241
Ensembl chr13:102,689,657...102,701,139
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Bcl2l14
Bcl2-like 14
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BCL2L14 mRNA
CTD
PMID:36139627
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
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Bco2
beta-carotene oxygenase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BCO2 mRNA
CTD
PMID:36139627
NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
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Bex1
brain expressed X-linked 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BEX2 mRNA
CTD
PMID:36139627
NCBI chr X:99,219,014...99,220,518
Ensembl chr X:99,219,014...99,220,958
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Bicdl2
BICD family like cargo adaptor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BICDL2 mRNA
CTD
PMID:36139627
NCBI chr10:12,691,610...12,700,049
Ensembl chr10:12,691,610...12,700,049
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Bin2
bridging integrator 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BIN2 mRNA
CTD
PMID:36139627
NCBI chr 7:131,742,001...131,768,208
Ensembl chr 7:131,742,002...131,786,285
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Blacat1
BLACAT1 overlapping LEMD1 locus
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BLACAT1 mRNA
CTD
PMID:36139627
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Blnk
B-cell linker
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BLNK mRNA
CTD
PMID:36139627
NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
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Bmp6
bone morphogenetic protein 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of BMP6 mRNA
CTD
PMID:36139627
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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Borcs8
BLOC-1 related complex subunit 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BORCS8 mRNA
CTD
PMID:36139627
NCBI chr16:19,274,305...19,280,969
Ensembl chr16:19,274,023...19,280,339
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Btc
betacellulin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BTC mRNA
CTD
PMID:36139627
NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
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Btg2
BTG anti-proliferation factor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of BTG2 mRNA
CTD
PMID:36139627
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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C13h1orf116
similar to human chromosome 1 open reading frame 116
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of C1ORF116 mRNA
CTD
PMID:36139627
NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426
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C14h7orf57
similar to human chromosome 7 open reading frame 57
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of C7ORF57 mRNA
CTD
PMID:36139627
NCBI chr14:83,748,478...83,768,293
Ensembl chr14:83,748,478...83,767,435
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C1r
complement C1r
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C1R mRNA
CTD
PMID:36139627
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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C1s
complement C1s
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C1S mRNA
CTD
PMID:36139627
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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C3h15orf48
similar to human chromosome 15 open reading frame 48
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C15ORF48 mRNA
CTD
PMID:36139627
NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006 Ensembl chr 3:109,719,897...109,724,006
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C7
complement C7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C7 mRNA
CTD
PMID:36139627
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CACNA1D mRNA
CTD
PMID:36139627
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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Cacna1f
calcium voltage-gated channel subunit alpha1 F
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CACNA1F mRNA
CTD
PMID:36139627
NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413
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Cacnb4
calcium voltage-gated channel auxiliary subunit beta 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CACNB4 mRNA
CTD
PMID:36139627
NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944
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Calb2
calbindin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CALB2 mRNA
CTD
PMID:36139627
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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Capn12
calpain 12
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CAPN12 mRNA
CTD
PMID:36139627
NCBI chr 1:84,171,059...84,183,161
Ensembl chr 1:84,171,059...84,183,119
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Capn8
calpain 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CAPN8 mRNA
CTD
PMID:36139627
NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146
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Car9
carbonic anhydrase 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CA9 mRNA
CTD
PMID:36139627
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Casp1
caspase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CASP1 mRNA
CTD
PMID:36139627
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases cleavage
ISO
sotorasib results in increased cleavage of CASP3 protein
CTD
PMID:31666701
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Catspere
catsper channel auxiliary subunit epsilon
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CATSPERE mRNA
CTD
PMID:36139627
NCBI chr13:89,799,669...89,954,723
Ensembl chr13:89,819,244...89,950,979
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Ccdc110
coiled-coil domain containing 110
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCDC110 mRNA
CTD
PMID:36139627
NCBI chr16:46,315,745...46,337,050
Ensembl chr16:46,315,745...46,337,021
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Ccdc87
coiled-coil domain containing 87
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCDC87 mRNA
CTD
PMID:36139627
NCBI chr 1:202,135,021...202,137,717
Ensembl chr 1:202,134,963...202,138,337
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Ccdc89
coiled-coil domain containing 89
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCDC89 mRNA
CTD
PMID:36139627
NCBI chr 1:144,386,252...144,387,514
Ensembl chr 1:144,386,158...144,389,850
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Ccdc96
coiled-coil domain containing 96
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CFAP184 mRNA
CTD
PMID:36139627
NCBI chr14:74,276,568...74,279,072
Ensembl chr14:74,276,960...74,278,888
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Ccl22
C-C motif chemokine ligand 22
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCL22 mRNA
CTD
PMID:36139627
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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Ccm2l
CCM2 like scaffold protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCM2L mRNA
CTD
PMID:36139627
NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
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Ccne2
cyclin E2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CCNE2 mRNA
CTD
PMID:36139627
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Ccr1
C-C motif chemokine receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CCR1 mRNA
CTD
PMID:36139627
NCBI chr 8:123,556,286...123,561,841
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Cd22
CD22 molecule
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD22 mRNA
CTD
PMID:36139627
NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
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Cd274
CD274 molecule
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD274 mRNA
CTD
PMID:36139627
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd72
Cd72 molecule
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CD72 mRNA
CTD
PMID:36139627
NCBI chr 5:57,697,361...57,704,980
Ensembl chr 5:57,697,367...57,704,725
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Cd74
CD74 molecule
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CD74 mRNA
CTD
PMID:36139627
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Cd82
Cd82 molecule
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CD82 mRNA
CTD
PMID:36139627
NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809
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Cdcp1
CUB domain containing protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDCP1 mRNA
CTD
PMID:36139627
NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388
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Cdh15
cadherin 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDH15 mRNA
CTD
PMID:36139627
NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
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Cdh3
cadherin 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDH3 mRNA
CTD
PMID:36139627
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CDKN1A mRNA
CTD
PMID:36139627
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CDKN1C mRNA
CTD
PMID:36139627
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cenps
centromere protein S
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CENPS mRNA
CTD
PMID:36139627
NCBI chr 5:159,563,917...159,573,534
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Cfap45
cilia and flagella associated protein 45
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CFAP45 mRNA
CTD
PMID:36139627
NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878
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Cfap92
cilia and flagella associated protein 92
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CFAP92 mRNA
CTD
PMID:36139627
NCBI chr 4:120,126,565...120,181,575
Ensembl chr 4:120,126,567...120,181,546
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Cfap96
cilia and flagella associated protein 96
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CFAP96 mRNA
CTD
PMID:36139627
NCBI chr16:46,291,075...46,315,616
Ensembl chr16:46,291,311...46,315,625
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Cfh
complement factor H
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CFH mRNA
CTD
PMID:36139627
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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Chd7
chromodomain helicase DNA binding protein 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CHD7 mRNA
CTD
PMID:36139627
NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358
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Chd9nb
CHD9 neighbor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CHD9NB mRNA
CTD
PMID:36139627
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Chgb
chromogranin B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CHGB mRNA
CTD
PMID:36139627
NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
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Chrm4
cholinergic receptor, muscarinic 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CHRM4 mRNA
CTD
PMID:36139627
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Chrna10
cholinergic receptor nicotinic alpha 10 subunit
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CHRNA10 mRNA
CTD
PMID:36139627
NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
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Ciart
circadian associated repressor of transcription
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CIART mRNA
CTD
PMID:36139627
NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313
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Cimip2a
ciliary microtubule inner protein 2A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CIMIP2A mRNA
CTD
PMID:36139627
NCBI chr 3:8,030,548...8,038,370
Ensembl chr 3:8,033,246...8,037,961
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Cldn9
claudin 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CLDN9 mRNA
CTD
PMID:36139627
NCBI chr10:12,714,137...12,715,568
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Cnih2
cornichon family AMPA receptor auxiliary protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CNIH2 mRNA
CTD
PMID:36139627
NCBI chr 1:202,399,416...202,405,110
Ensembl chr 1:202,399,419...202,405,089
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Col13a1
collagen type XIII alpha 1 chain
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of COL13A1 mRNA
CTD
PMID:36139627
NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032
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Col1a2
collagen type I alpha 2 chain
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL1A2 mRNA
CTD
PMID:36139627
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Col5a3
collagen type V alpha 3 chain
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL5A3 mRNA
CTD
PMID:36139627
NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
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Col6a3
collagen type VI alpha 3 chain
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of COL6A3 mRNA
CTD
PMID:36139627
NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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Col9a2
collagen type IX alpha 2 chain
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COL9A2 mRNA
CTD
PMID:36139627
NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677
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Colq
collagen like tail subunit of asymmetric acetylcholinesterase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of COLQ mRNA
CTD
PMID:36139627
NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107
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Cpe
carboxypeptidase E
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CPE mRNA
CTD
PMID:36139627
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
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Cracr2b
calcium release activated channel regulator 2B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CRACR2B mRNA
CTD
PMID:36139627
NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771
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Creb3l1
cAMP responsive element binding protein 3-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREB3L1 mRNA
CTD
PMID:36139627
NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
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Creb3l3
cAMP responsive element binding protein 3-like 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREB3L3 mRNA
CTD
PMID:36139627
NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
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Creg2
cellular repressor of E1A-stimulated genes 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CREG2 mRNA
CTD
PMID:36139627
NCBI chr 9:41,872,000...41,945,413
Ensembl chr 9:41,902,304...41,945,095
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Crybg1
crystallin beta-gamma domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CRYBG1 mRNA
CTD
PMID:36139627
NCBI chr20:47,425,030...47,496,918
Ensembl chr20:47,426,183...47,621,392
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Crym
crystallin, mu
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CRYM mRNA
CTD
PMID:36139627
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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Csad
cysteine sulfinic acid decarboxylase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CSAD mRNA
CTD
PMID:36139627
NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
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Csf3
colony stimulating factor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CSF3 mRNA
CTD
PMID:36139627
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Ctsc
cathepsin C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CTSC mRNA
CTD
PMID:36139627
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Ctsl
cathepsin L
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of CTSL mRNA
CTD
PMID:36139627
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Ctso
cathepsin O
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CTSO mRNA
CTD
PMID:36139627
NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702
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Cx3cl1
C-X3-C motif chemokine ligand 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CX3CL1 mRNA
CTD
PMID:36139627
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
sotorasib results in increased expression of CXCL10 mRNA
CTD
PMID:31666701
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl11
C-X-C motif chemokine ligand 11
increases expression
ISO
sotorasib results in increased expression of CXCL11 mRNA
CTD
PMID:31666701
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of CYP26B1 mRNA
CTD
PMID:36139627
NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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Ddit4l
DNA-damage-inducible transcript 4-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DDIT4L mRNA
CTD
PMID:36139627
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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Ddx60
DEXD/H-box helicase 60
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DDX60 mRNA
CTD
PMID:36139627
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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Dennd3
DENN domain containing 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DENND3 mRNA
CTD
PMID:36139627
NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592
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Depp1
DEPP autophagy regulator 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DEPP1 mRNA
CTD
PMID:36139627
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Deptor
DEP domain containing MTOR-interacting protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DEPTOR mRNA
CTD
PMID:36139627
NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
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Dhrs2
dehydrogenase/reductase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DHRS2 mRNA
CTD
PMID:36139627
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
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Dio2
iodothyronine deiodinase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DIO2 mRNA
CTD
PMID:36139627
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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Dkk3
dickkopf WNT signaling pathway inhibitor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DKK3 mRNA
CTD
PMID:36139627
NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
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Dlc1
DLC1 Rho GTPase activating protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DLC1 mRNA
CTD
PMID:36139627
NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
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Dmkn
dermokine
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DMKN mRNA
CTD
PMID:36139627
NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006
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Dnaaf8
dynein axonemal assembly factor 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DNAAF8 mRNA
CTD
PMID:36139627
NCBI chr10:10,600,747...10,614,891
Ensembl chr10:10,600,734...10,614,891
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Dnah11
dynein, axonemal, heavy chain 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DNAH11 mRNA
CTD
PMID:36139627
NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
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Doc2b
double C2 domain beta
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DOC2B mRNA
CTD
PMID:36139627
NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
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Dok3
docking protein 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DOK3 mRNA
CTD
PMID:36139627
NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188
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Drc3
dynein regulatory complex subunit 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DRC3 mRNA
CTD
PMID:36139627
NCBI chr10:45,149,094...45,200,659
Ensembl chr10:45,157,354...45,199,369
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Duox1
dual oxidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of DUOX1 mRNA
CTD
PMID:36139627
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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Duox2
dual oxidase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUOX2 mRNA
CTD
PMID:36139627
NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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Duoxa1
dual oxidase maturation factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUOXA1 mRNA
CTD
PMID:36139627
NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
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Dusp4
dual specificity phosphatase 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP4 mRNA
CTD
PMID:36139627
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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Dusp5
dual specificity phosphatase 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP5 mRNA
CTD
PMID:36139627
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dusp6
dual specificity phosphatase 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP6 mRNA
CTD
PMID:36139627
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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E2f2
E2F transcription factor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of E2F2 mRNA
CTD
PMID:36139627
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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E2f7
E2F transcription factor 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of E2F7 mRNA
CTD
PMID:36139627
NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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Efemp2
EGF containing fibulin extracellular matrix protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EFEMP2 mRNA
CTD
PMID:36139627
NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414
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Efna3
ephrin A3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EFNA3 mRNA
CTD
PMID:36139627
NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
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Egf
epidermal growth factor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EGF mRNA
CTD
PMID:36139627
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Egfr
epidermal growth factor receptor
increases phosphorylation
ISO
sotorasib results in increased phosphorylation of EGFR protein
CTD
PMID:31666701
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Eif4e3
eukaryotic translation initiation factor 4E family member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EIF4E3 mRNA
CTD
PMID:36139627
NCBI chr 4:132,258,502...132,301,808
Ensembl chr 4:132,258,502...132,301,808
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Elf5
E74 like ETS transcription factor 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ELF5 mRNA
CTD
PMID:36139627
NCBI chr 3:89,808,837...89,836,977
Ensembl chr 3:89,797,880...89,836,973
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Elmod1
ELMO domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ELMOD1 mRNA
CTD
PMID:36139627
NCBI chr 8:54,298,363...54,355,348
Ensembl chr 8:54,298,363...54,355,140
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Eno2
enolase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ENO2 mRNA
CTD
PMID:36139627
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Eno4
enolase 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ENO4 mRNA
CTD
PMID:36139627
NCBI chr 1:258,096,406...258,119,811
Ensembl chr 1:258,096,432...258,128,984
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Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ENPP1 mRNA
CTD
PMID:36139627
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
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Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ENTPD2 mRNA
CTD
PMID:36139627
NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
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Epas1
endothelial PAS domain protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPAS1 mRNA
CTD
PMID:36139627
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epha3
Eph receptor A3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPHA3 mRNA
CTD
PMID:36139627
NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
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Epha8
Eph receptor A8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPHA8 mRNA
CTD
PMID:36139627
NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399
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Eppk1
epiplakin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EPPK1 mRNA
CTD
PMID:36139627
NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
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Erap1
endoplasmic reticulum aminopeptidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ERAP1 mRNA
CTD
PMID:36139627
NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
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Erfl
ETS repressor factor like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ERFL mRNA
CTD
PMID:36139627
NCBI chr 1:80,521,378...80,526,262
Ensembl chr 1:80,521,854...80,526,262
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ERO1A mRNA
CTD
PMID:36139627
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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Esrp1
epithelial splicing regulatory protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ESRP1 mRNA
CTD
PMID:36139627
NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
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Etv2
ETS variant transcription factor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ETV2 mRNA
CTD
PMID:36139627
NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
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Etv4
ETS variant transcription factor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ETV4 mRNA
CTD
PMID:36139627
NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
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Evi2a
ecotropic viral integration site 2A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EVI2A mRNA
CTD
PMID:36139627
NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
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Exoc3l1
exocyst complex component 3-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EXOC3L1 mRNA
CTD
PMID:36139627
NCBI chr19:33,166,836...33,174,371
Ensembl chr19:33,166,837...33,172,486
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Exoc3l4
exocyst complex component 3-like 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of EXOC3L4 mRNA
CTD
PMID:36139627
NCBI chr 6:130,452,680...130,466,684
Ensembl chr 6:130,452,661...130,466,683
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Exph5
exophilin 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of EXPH5 mRNA
CTD
PMID:36139627
NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169
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F2rl1
F2R like trypsin receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of F2RL1 mRNA
CTD
PMID:36139627
NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
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Fam107b
family with sequence similarity 107, member B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAM107B mRNA
CTD
PMID:36139627
NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989
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Fam186b
family with sequence similarity 186, member B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAM186B mRNA
CTD
PMID:36139627
NCBI chr 7:130,408,830...130,424,261
Ensembl chr 7:130,408,830...130,424,261
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Fam241a
family with sequence similarity 241 member A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FAM241A mRNA
CTD
PMID:36139627
NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242
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Fat2
FAT atypical cadherin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FAT2 mRNA
CTD
PMID:36139627
NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216
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Fbxo36
F-box protein 36
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FBXO36 mRNA
CTD
PMID:36139627
NCBI chr 9:86,042,522...86,107,220
Ensembl chr 9:86,040,862...86,107,229
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Fdxr
ferredoxin reductase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FDXR mRNA
CTD
PMID:36139627
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Fgf19
fibroblast growth factor 19
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FGF19 mRNA
CTD
PMID:36139627
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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Fhip1a
FHF complex subunit HOOK interacting protein 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FHIP1A mRNA
CTD
PMID:36139627
NCBI chr 2:171,016,951...171,265,715
Ensembl chr 2:171,021,246...171,265,848
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Flacc1
flagellum associated containing coiled-coil domains 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FLACC1 mRNA
CTD
PMID:36139627
NCBI chr 9:60,315,581...60,343,692
Ensembl chr 9:60,315,582...60,343,648
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Flnc
filamin C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FLNC mRNA
CTD
PMID:36139627
NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
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Fmn1
formin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FMN1 mRNA
CTD
PMID:36139627
NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
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Fndc11
fibronectin type III domain containing 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FNDC11 mRNA
CTD
PMID:36139627
NCBI chr 3:168,330,607...168,333,111
Ensembl chr 3:168,330,602...168,334,617
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Foxd4
forkhead box D4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FOXD4 mRNA
CTD
PMID:36139627
NCBI chr 1:222,557,494...222,559,189
Ensembl chr 1:222,557,360...222,559,159
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Foxq1
forkhead box Q1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FOXQ1 mRNA
CTD
PMID:36139627
NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377 Ensembl chr17:32,912,744...32,915,377
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Frmd4b
FERM domain containing 4B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FRMD4B mRNA
CTD
PMID:36139627
NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
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Fscn1
fascin actin-bundling protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FSCN1 mRNA
CTD
PMID:36139627
NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
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Fut11
fucosyltransferase 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of FUT11 mRNA
CTD
PMID:36139627
NCBI chr15:3,598,768...3,602,328
Ensembl chr15:3,598,758...3,602,356
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Fyb2
FYN binding protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of FYB2 mRNA
CTD
PMID:36139627
NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910
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Gab2
GRB2-associated binding protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAB2 mRNA
CTD
PMID:36139627
NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
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Gad1
glutamate decarboxylase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAD1 mRNA
CTD
PMID:36139627
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gal3st1
galactose-3-O-sulfotransferase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GAL3ST1 mRNA
CTD
PMID:36139627
NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
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Galnt7
polypeptide N-acetylgalactosaminyltransferase 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GALNT7 mRNA
CTD
PMID:36139627
NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690
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Gas6
growth arrest specific 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GAS6 mRNA
CTD
PMID:36139627
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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Gask1b
golgi associated kinase 1B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GASK1B mRNA
CTD
PMID:36139627
NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477
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Gbp2
guanylate binding protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GBP2 mRNA
CTD
PMID:36139627
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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Gckr
glucokinase regulator
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GCKR mRNA
CTD
PMID:36139627
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GCNT3 mRNA
CTD
PMID:36139627
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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Gdap1
ganglioside-induced differentiation-associated-protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GDAP1 mRNA
CTD
PMID:36139627
NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
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Ghr
growth hormone receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GHR mRNA
CTD
PMID:36139627
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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Gipc3
GIPC PDZ domain containing family, member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GIPC3 mRNA
CTD
PMID:36139627
NCBI chr 7:8,374,941...8,383,281
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Gipr
gastric inhibitory polypeptide receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GIPR mRNA
CTD
PMID:36139627
NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462
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Gjb3
gap junction protein, beta 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GJB3 mRNA
CTD
PMID:36139627
NCBI chr 5:139,649,227...139,654,970
Ensembl chr 5:139,649,195...139,654,980
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Gjb4
gap junction protein, beta 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GJB4 mRNA
CTD
PMID:36139627
NCBI chr 5:139,675,776...139,679,551
Ensembl chr 5:139,675,780...139,679,667
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Gldc
glycine decarboxylase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GLDC mRNA
CTD
PMID:36139627
NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
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Glul
glutamate-ammonia ligase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GLUL mRNA
CTD
PMID:36139627
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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Gpnmb
glycoprotein nmb
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPNMB mRNA
CTD
PMID:36139627
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gpr146
G protein-coupled receptor 146
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPR146 mRNA
CTD
PMID:36139627
NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
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Gpr37l1
G protein-coupled receptor 37-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GPR37L1 mRNA
CTD
PMID:36139627
NCBI chr13:46,598,574...46,605,421
Ensembl chr13:46,598,578...46,605,421
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Gpr39
G protein-coupled receptor 39
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GPR39 mRNA
CTD
PMID:36139627
NCBI chr13:37,115,258...37,327,312
Ensembl chr13:37,115,102...37,328,267
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Gpr87
G protein-coupled receptor 87
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GPR87 mRNA
CTD
PMID:36139627
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
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Gramd1b
GRAM domain containing 1B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRAMD1B mRNA
CTD
PMID:36139627
NCBI chr 8:40,654,492...40,893,869
Ensembl chr 8:40,659,182...40,893,925
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Grb7
growth factor receptor bound protein 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRB7 mRNA
CTD
PMID:36139627
NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
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Grin2d
glutamate ionotropic receptor NMDA type subunit 2D
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GRIN2D mRNA
CTD
PMID:36139627
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
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Gsdmc
gasdermin C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GSDMC mRNA
CTD
PMID:36139627
NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344
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Gtf2ird2
GTF2I repeat domain containing 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of GTF2IRD2 mRNA
CTD
PMID:36139627
NCBI chr12:22,497,767...22,536,455
Ensembl chr12:22,498,091...22,536,263
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Guca1b
guanylate cyclase activator 1B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of GUCA1B mRNA
CTD
PMID:36139627
NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455
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H1f2
H1.2 linker histone, cluster member
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H1-2 mRNA
CTD
PMID:36139627
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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Hal
histidine ammonia lyase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HAL mRNA
CTD
PMID:36139627
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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Hapln2
hyaluronan and proteoglycan link protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HAPLN2 mRNA
CTD
PMID:36139627
NCBI chr 2:173,488,909...173,496,824
Ensembl chr 2:173,491,160...173,496,588
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Has3
hyaluronan synthase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HAS3 mRNA
CTD
PMID:36139627
NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592
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Hbegf
heparin-binding EGF-like growth factor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HBEGF mRNA
CTD
PMID:36139627
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HECW2 mRNA
CTD
PMID:36139627
NCBI chr 9:55,359,462...55,753,106
Ensembl chr 9:55,365,203...55,580,327
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Herc6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HERC6 mRNA
CTD
PMID:36139627
NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
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Hey1
hes-related family bHLH transcription factor with YRPW motif 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HEY1 mRNA
CTD
PMID:36139627
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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Heyl
hes-related family bHLH transcription factor with YRPW motif-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HEYL mRNA
CTD
PMID:36139627
NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152
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Hic1
HIC ZBTB transcriptional repressor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HIC1 mRNA
CTD
PMID:36139627
NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475
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Hilpda
hypoxia inducible lipid droplet-associated
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HILPDA mRNA
CTD
PMID:36139627
NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
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Hist1h2ah
histone cluster 1 H2A family member H
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H2AC11 mRNA
CTD
PMID:36139627
NCBI chr17:41,384,521...41,385,018
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Hist1h2al1
histone cluster 1 H2A family like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of H2AC6 mRNA
CTD
PMID:36139627
NCBI chr17:42,707,954...42,708,420
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Hivep2
HIVEP zinc finger 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HIVEP2 mRNA
CTD
PMID:36139627
NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
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Hk2
hexokinase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HK2 mRNA
CTD
PMID:36139627
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Hkdc1
hexokinase domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HKDC1 mRNA
CTD
PMID:36139627
NCBI chr20:30,335,322...30,373,792
Ensembl chr20:30,335,628...30,373,867
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Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HOGA1 mRNA
CTD
PMID:36139627
NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
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Hoxa13
homeo box A13
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HOXA13 mRNA
CTD
PMID:36139627
NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091
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Hoxb9
homeo box B9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HOXB9 mRNA
CTD
PMID:36139627
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
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Hoxc4
homeo box C4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HOXC4 mRNA
CTD
PMID:36139627
NCBI chr 7:134,135,279...134,173,133
Ensembl chr 7:134,170,591...134,173,133
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Hpcal4
hippocalcin-like 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HPCAL4 mRNA
CTD
PMID:36139627
NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
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Hs3st3b1
heparan sulfate-glucosamine 3-sulfotransferase 3B1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HS3ST3B1 mRNA
CTD
PMID:36139627
NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970
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Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HSD17B14 mRNA
CTD
PMID:36139627
NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HSPA1A mRNA
CTD
PMID:36139627
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Htra1
HtrA serine peptidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HTRA1 mRNA
CTD
PMID:36139627
NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
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Hunk
hormonally upregulated Neu-associated kinase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HUNK mRNA
CTD
PMID:36139627
NCBI chr11:29,641,122...29,758,392
Ensembl chr11:29,640,775...29,757,526
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Hyal1
hyaluronidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of HYAL1 mRNA
CTD
PMID:36139627
NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
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Ifi35
interferon-induced protein 35
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IFI35 mRNA
CTD
PMID:36139627
NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
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Ifnlr1
interferon, lambda receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IFNLR1 mRNA
CTD
PMID:36139627
NCBI chr 5:147,919,547...147,942,328
Ensembl chr 5:147,919,908...147,942,332
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Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IGF2BP3 mRNA
CTD
PMID:36139627
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
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Igfbp1
insulin-like growth factor binding protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IGFBP1 mRNA
CTD
PMID:36139627
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Il1b
interleukin 1 beta
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL1B mRNA
CTD
PMID:36139627
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rapl1
interleukin 1 receptor accessory protein-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL1RAPL1 mRNA
CTD
PMID:36139627
NCBI chr X:51,371,969...52,876,726
Ensembl chr X:51,378,215...52,876,772
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Il6r
interleukin 6 receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IL6R mRNA
CTD
PMID:36139627
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Inka1
inka box actin regulator 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of INKA1 mRNA
CTD
PMID:36139627
NCBI chr 8:108,674,263...108,675,953
Ensembl chr 8:108,674,263...108,675,953
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Inpp5d
inositol polyphosphate-5-phosphatase D
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of INPP5D mRNA
CTD
PMID:36139627
NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
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Insyn1
inhibitory synaptic factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of INSYN1 mRNA
CTD
PMID:36139627
NCBI chr 8:58,904,153...58,914,850
Ensembl chr 8:58,904,153...58,914,843
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Iqank1
IQ motif and ankyrin repeat containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IQANK1 mRNA
CTD
PMID:36139627
NCBI chr 7:107,724,962...107,759,163
Ensembl chr 7:107,724,997...107,759,162
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Iqcn
IQ motif containing N
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IQCN mRNA
CTD
PMID:36139627
NCBI chr16:18,716,519...18,733,971
Ensembl chr16:18,716,519...18,726,261
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Irak2
interleukin-1 receptor-associated kinase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of IRAK2 mRNA
CTD
PMID:36139627
NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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Irf1
interferon regulatory factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of IRF1 mRNA
CTD
PMID:36139627
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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Ism2
isthmin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ISM2 mRNA
CTD
PMID:36139627
NCBI chr 6:106,921,213...106,944,291
Ensembl chr 6:106,926,175...106,944,514
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Itga10
integrin subunit alpha 10
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGA10 mRNA
CTD
PMID:36139627
NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172
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Itga2
integrin subunit alpha 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGA2 mRNA
CTD
PMID:36139627
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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Itgax
integrin subunit alpha X
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGAX mRNA
CTD
PMID:36139627
NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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Itgb3
integrin subunit beta 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGB3 mRNA
CTD
PMID:36139627
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Itgb4
integrin subunit beta 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ITGB4 mRNA
CTD
PMID:36139627
NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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Jak3
Janus kinase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of JAK3 mRNA
CTD
PMID:36139627
NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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Jam2
junctional adhesion molecule 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of JAM2 mRNA
CTD
PMID:36139627
NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063
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Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KCNJ4 mRNA
CTD
PMID:36139627
NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
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Kcnk5
potassium two pore domain channel subfamily K member 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KCNK5 mRNA
CTD
PMID:36139627
NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718
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Kdm7a
lysine demethylase 7A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KDM7A mRNA
CTD
PMID:36139627
NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
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Kiaa1755
KIAA1755 ortholog
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KIAA1755 mRNA
CTD
PMID:36139627
NCBI chr 3:146,850,558...146,884,238
Ensembl chr 3:146,850,557...146,884,871
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Kif17
kinesin family member 17
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KIF17 mRNA
CTD
PMID:36139627
NCBI chr 5:150,482,288...150,521,471
Ensembl chr 5:150,481,578...150,519,638
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Klf7
KLF transcription factor 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of KLF7 mRNA
CTD
PMID:36139627
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
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Klhdc7a
kelch domain containing 7A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KLHDC7A mRNA
CTD
PMID:36139627
NCBI chr 5:152,218,604...152,224,707
Ensembl chr 5:152,221,033...152,224,551
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Klhdc7b
kelch domain containing 7B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KLHDC7B mRNA
CTD
PMID:36139627
NCBI chr 7:120,452,081...120,455,737
Ensembl chr 7:120,453,932...120,455,737
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Kras
KRAS proto-oncogene, GTPase
increases response to substance multiple interactions affects binding
ISO
KRAS protein mutant form results in increased susceptibility to sotorasib KRAS protein affects the reaction [sotorasib results in decreased phosphorylation of MAPK1 protein]; KRAS protein affects the reaction [sotorasib results in decreased phosphorylation of MAPK3 protein] sotorasib binds to KRAS protein mutant form
CTD
PMID:31666701
NCBI chr 4:178,185,418...178,218,484
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Krt15
keratin 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT15 mRNA
CTD
PMID:36139627
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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Krt7
keratin 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT7 mRNA
CTD
PMID:36139627
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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Krt86
keratin 86
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of KRT86 mRNA
CTD
PMID:36139627
NCBI chr 7:132,591,489...132,598,142
Ensembl chr 7:132,591,545...132,598,021
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Lad1
ladinin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAD1 mRNA
CTD
PMID:36139627
NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
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Lama2
laminin subunit alpha 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMA2 mRNA
CTD
PMID:36139627
NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
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Lama4
laminin subunit alpha 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMA4 mRNA
CTD
PMID:36139627
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
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Lamc2
laminin subunit gamma 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LAMC2 mRNA
CTD
PMID:36139627
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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Laptm5
lysosomal protein transmembrane 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LAPTM5 mRNA
CTD
PMID:36139627
NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
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Lat2
linker for activation of T cells family, member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LAT2 mRNA
CTD
PMID:36139627
NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288
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Lcp1
lymphocyte cytosolic protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LCP1 mRNA
CTD
PMID:36139627
NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
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Ldlr
low density lipoprotein receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LDLR mRNA
CTD
PMID:36139627
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Ldlrad1
low density lipoprotein receptor class A domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LDLRAD1 mRNA
CTD
PMID:36139627
NCBI chr 5:121,984,245...122,000,941
Ensembl chr 5:121,991,690...122,000,944
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Ldlrad4
low density lipoprotein receptor class A domain containing 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LDLRAD4 mRNA
CTD
PMID:36139627
NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238
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Lemd1
LEM domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LEMD1 mRNA
CTD
PMID:36139627
NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948
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Lgals9
galectin 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LGALS9 mRNA
CTD
PMID:36139627
NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
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Lgi3
leucine-rich repeat LGI family, member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LGI3 mRNA
CTD
PMID:36139627
NCBI chr15:45,605,611...45,612,739
Ensembl chr15:45,605,611...45,612,739
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Lhx1
LIM homeobox 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX1 mRNA
CTD
PMID:36139627
NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
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Lhx6
LIM homeobox 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LHX6 mRNA
CTD
PMID:36139627
NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061
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Lipg
lipase G, endothelial type
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LIPG mRNA
CTD
PMID:36139627
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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Liph
lipase H
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LIPH mRNA
CTD
PMID:36139627
NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625
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Lonrf3
LON peptidase N-terminal domain and ring finger 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LONRF3 mRNA
CTD
PMID:36139627
NCBI chr X:115,565,214...115,603,886
Ensembl chr X:115,565,267...115,598,809
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Lox
lysyl oxidase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LOX mRNA
CTD
PMID:36139627
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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Lratd2
LRAT domain containing 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LRATD2 mRNA
CTD
PMID:36139627
NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189
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Lrrc37a
leucine rich repeat containing 37A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LRRC37A3 mRNA
CTD
PMID:36139627
NCBI chr10:88,395,837...88,433,519
Ensembl chr10:88,396,663...88,433,323
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Lsr
lipolysis stimulated lipoprotein receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LSR mRNA
CTD
PMID:36139627
NCBI chr 1:86,185,769...86,201,952
Ensembl chr 1:86,186,431...86,201,952
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Ltbp1
latent transforming growth factor beta binding protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LTBP1 mRNA
CTD
PMID:36139627
NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349
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Ltbp2
latent transforming growth factor beta binding protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LTBP2 mRNA
CTD
PMID:36139627
NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
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Lyst
lysosomal trafficking regulator
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LYST mRNA
CTD
PMID:36139627
NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
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Lzts1
leucine zipper tumor suppressor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of LZTS1 mRNA
CTD
PMID:36139627
NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
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Mad1l1
mitotic arrest deficient 1 like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAD1L1 mRNA
CTD
PMID:36139627
NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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Maff
MAF bZIP transcription factor F
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAFF mRNA
CTD
PMID:36139627
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Map1a
microtubule-associated protein 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MAP1A mRNA
CTD
PMID:36139627
NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
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Map4k1
mitogen activated protein kinase kinase kinase kinase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MAP4K1 mRNA
CTD
PMID:36139627
NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493
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Mapk1
mitogen activated protein kinase 1
multiple interactions decreases phosphorylation
ISO
KRAS protein affects the reaction [sotorasib results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:31666701
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation multiple interactions
ISO
sotorasib results in decreased phosphorylation of MAPK3 protein KRAS protein affects the reaction [sotorasib results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:31666701
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Marchf4
membrane associated ring-CH-type finger 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MARCHF4 mRNA
CTD
PMID:36139627
NCBI chr 9:74,078,437...74,196,070
Ensembl chr 9:74,078,434...74,198,199
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Mast4
microtubule associated serine/threonine kinase family member 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MAST4 mRNA
CTD
PMID:36139627
NCBI chr 2:33,893,241...34,483,682
Ensembl chr 2:33,894,436...34,483,723
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Matn2
matrilin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MATN2 mRNA
CTD
PMID:36139627
NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113
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Mctp1
multiple C2 and transmembrane domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MCTP1 mRNA
CTD
PMID:36139627
NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
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Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MDGA1 mRNA
CTD
PMID:36139627
NCBI chr20:7,900,327...7,964,309
Ensembl chr20:7,904,358...7,963,471
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Meis1
Meis homeobox 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MEIS1 mRNA
CTD
PMID:36139627
NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
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Mest
mesoderm specific transcript
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MEST mRNA
CTD
PMID:36139627
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
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MGC94891
hypothetical protein LOC681210
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of C6ORF118 mRNA
CTD
PMID:36139627
NCBI chr 1:51,740,328...51,764,041
Ensembl chr 1:51,740,330...51,763,989
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Mid1
midline 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MID1 mRNA
CTD
PMID:36139627
NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353
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Milr1
mast cell immunoglobulin-like receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MILR1 mRNA
CTD
PMID:36139627
NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282
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Mlph
melanophilin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MLPH mRNA
CTD
PMID:36139627
NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983
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Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP1 mRNA
CTD
PMID:36139627
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp12
matrix metallopeptidase 12
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP12 mRNA
CTD
PMID:36139627
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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Mmp13
matrix metallopeptidase 13
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP13 mRNA
CTD
PMID:36139627
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mmp14
matrix metallopeptidase 14
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP14 mRNA
CTD
PMID:36139627
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Mmp19
matrix metallopeptidase 19
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MMP19 mRNA
CTD
PMID:36139627
NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
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Mmp3
matrix metallopeptidase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP3 mRNA
CTD
PMID:36139627
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MMP9 mRNA
CTD
PMID:36139627
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Morn3
MORN repeat containing 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MORN3 mRNA
CTD
PMID:36139627
NCBI chr12:33,505,654...33,529,918
Ensembl chr12:33,514,230...33,529,931
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Mpzl2
myelin protein zero-like 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MPZL2 mRNA
CTD
PMID:36139627
NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298
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Mrap2
melanocortin 2 receptor accessory protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MRAP2 mRNA
CTD
PMID:36139627
NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886
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Muc3a
mucin 3A, cell surface associated
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MUC3A mRNA
CTD
PMID:36139627
NCBI chr12:19,450,679...19,454,753
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MUC5B mRNA
CTD
PMID:36139627
NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
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Mybph
myosin binding protein H
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYBPH mRNA
CTD
PMID:36139627
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Myh15
myosin, heavy chain 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYH15 mRNA
CTD
PMID:36139627
NCBI chr11:51,621,924...51,763,037
Ensembl chr11:51,622,413...51,762,971
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Myo10
myosin X
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO10 mRNA
CTD
PMID:36139627
NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030
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Myo15a
myosin XVA
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO15A mRNA
CTD
PMID:36139627
NCBI chr10:45,277,619...45,335,953
Ensembl chr10:45,278,737...45,335,340
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Myo15b
myosin XVB
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO15B mRNA
CTD
PMID:36139627
NCBI chr10:101,088,734...101,126,159
Ensembl chr10:101,104,209...101,125,693
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Myo5c
myosin VC
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of MYO5C mRNA
CTD
PMID:36139627
NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483
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Myo7b
myosin VIIb
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of MYO7B mRNA
CTD
PMID:36139627
NCBI chr18:23,588,307...23,669,841
Ensembl chr18:23,588,307...23,669,809
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N4bp3
Nedd4 binding protein 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of N4BP3 mRNA
CTD
PMID:36139627
NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001
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Nav3
neuron navigator 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NAV3 mRNA
CTD
PMID:36139627
NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698
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Ndrg1
N-myc downstream regulated 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDRG1 mRNA
CTD
PMID:36139627
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Ndrg4
NDRG family member 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDRG4 mRNA
CTD
PMID:36139627
NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914
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Ndufv2
NADH:ubiquinone oxidoreductase core subunit V2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NDUFV2 mRNA
CTD
PMID:36139627
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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Nedd9
neural precursor cell expressed, developmentally down-regulated 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NEDD9 mRNA
CTD
PMID:36139627
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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Nes
nestin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NES mRNA
CTD
PMID:36139627
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Neurl3
neuralized E3 ubiquitin protein ligase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NEURL3 mRNA
CTD
PMID:36139627
NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
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Ngef
neuronal guanine nucleotide exchange factor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NGEF mRNA
CTD
PMID:36139627
NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
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Nhsl1
NHS-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL1 mRNA
CTD
PMID:36139627
NCBI chr 1:12,956,525...13,188,580
Ensembl chr 1:12,956,021...13,187,547
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Nhsl2
NHS-like 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NHSL2 mRNA
CTD
PMID:36139627
NCBI chr X:66,969,953...67,209,464
Ensembl chr X:66,970,151...67,200,911
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Nim1k
NIM1 serine/threonine protein kinase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NIM1K mRNA
CTD
PMID:36139627
NCBI chr 2:51,670,764...51,714,782
Ensembl chr 2:51,670,772...51,714,762
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Nipal4
NIPA-like domain containing 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NIPAL4 mRNA
CTD
PMID:36139627
NCBI chr10:30,583,926...30,600,640
Ensembl chr10:30,583,926...30,600,640
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Nkx2-1
NK2 homeobox 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NKX2-1 mRNA
CTD
PMID:36139627
NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
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Nlgn1
neuroligin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLGN1 mRNA
CTD
PMID:36139627
NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
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Nlrp1a
NLR family, pyrin domain containing 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NLRP1 mRNA
CTD
PMID:36139627
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
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Nmnat2
nicotinamide nucleotide adenylyltransferase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NMNAT2 mRNA
CTD
PMID:36139627
NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484
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Nog
noggin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NOG mRNA
CTD
PMID:36139627
NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
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Notch4
notch receptor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NOTCH4 mRNA
CTD
PMID:36139627
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
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Npas1
neuronal PAS domain protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPAS1 mRNA
CTD
PMID:36139627
NCBI chr 1:77,167,375...77,187,887
Ensembl chr 1:77,167,381...77,186,762
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Npb
neuropeptide B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NPB mRNA
CTD
PMID:36139627
NCBI chr10:105,883,992...105,887,689
Ensembl chr10:105,874,708...105,887,254
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Npr3
natriuretic peptide receptor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPR3 mRNA
CTD
PMID:36139627
NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
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Nptx1
neuronal pentraxin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NPTX1 mRNA
CTD
PMID:36139627
NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NR1D1 mRNA
CTD
PMID:36139627
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NR3C2 mRNA
CTD
PMID:36139627
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Nrep
neuronal regeneration related protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NREP mRNA
CTD
PMID:36139627
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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Nrp1
neuropilin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of NRP1 mRNA
CTD
PMID:36139627
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Nrp2
neuropilin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NRP2 mRNA
CTD
PMID:36139627
NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
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Nt5e
5' nucleotidase, ecto
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NT5E mRNA
CTD
PMID:36139627
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Ntsr1
neurotensin receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NTSR1 mRNA
CTD
PMID:36139627
NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377
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Nyap1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of NYAP1 mRNA
CTD
PMID:36139627
NCBI chr12:18,956,192...18,967,624
Ensembl chr12:18,956,268...18,967,543
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Oas1a
2'-5' oligoadenylate synthetase 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OAS1 mRNA
CTD
PMID:36139627
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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Oas3
2'-5'-oligoadenylate synthetase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OAS3 mRNA
CTD
PMID:36139627
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
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Oasl
2'-5'-oligoadenylate synthetase-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of OASL mRNA
CTD
PMID:36139627
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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Obscn
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of OBSCN mRNA
CTD
PMID:36139627
NCBI chr10:43,774,113...43,919,718
Ensembl chr10:43,789,293...43,919,723
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Onecut3
one cut homeobox 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ONECUT3 mRNA
CTD
PMID:36139627
NCBI chr 7:9,199,997...9,219,303
Ensembl chr 7:9,200,035...9,219,158 Ensembl chr 7:9,200,035...9,219,158
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Osgin1
oxidative stress induced growth inhibitor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of OSGIN1 mRNA
CTD
PMID:36139627
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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P2rx6
purinergic receptor P2X 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P2RX6 mRNA
CTD
PMID:36139627
NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481
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P3h2
prolyl 3-hydroxylase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of P3H2 mRNA
CTD
PMID:36139627
NCBI chr11:74,634,267...74,775,422
Ensembl chr11:74,634,267...74,775,421
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Pag1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PAG1 mRNA
CTD
PMID:36139627
NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
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Paqr5
progestin and adipoQ receptor family member 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PAQR5 mRNA
CTD
PMID:36139627
NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688
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Paqr9
progestin and adipoQ receptor family member 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PAQR9 mRNA
CTD
PMID:36139627
NCBI chr 8:96,114,249...96,116,546
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Pbld1
phenazine biosynthesis-like protein domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PBLD mRNA
CTD
PMID:36139627
NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
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Pcdhb19
protocadherin beta 19
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PCDHB12 mRNA
CTD
PMID:36139627
NCBI chr18:29,204,838...29,207,646
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Pde2a
phosphodiesterase 2A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PDE2A mRNA
CTD
PMID:36139627
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
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Pdp2
pyruvate dehydrogenase phosphatase catalytic subunit 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PDP2 mRNA
CTD
PMID:36139627
NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
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Per1
period circadian regulator 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PER1 mRNA
CTD
PMID:36139627
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Pfkfb4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PFKFB4 mRNA
CTD
PMID:36139627
NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
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Pfn4
profilin family, member 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PFN4 mRNA
CTD
PMID:36139627
NCBI chr 6:27,786,619...27,796,710
Ensembl chr 6:27,786,619...27,796,710
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Pgbd5
piggyBac transposable element derived 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PGBD5 mRNA
CTD
PMID:36139627
NCBI chr19:52,336,751...52,401,906
Ensembl chr19:52,336,751...52,402,397
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Phlda2
pleckstrin homology-like domain, family A, member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PHLDA2 mRNA
CTD
PMID:36139627
NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
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Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PHOSPHO1 mRNA
CTD
PMID:36139627
NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
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Phtf1
putative homeodomain transcription factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PHTF1 mRNA
CTD
PMID:36139627
NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078
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Phyhip
phytanoyl-CoA 2-hydroxylase interacting protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PHYHIP mRNA
CTD
PMID:36139627
NCBI chr15:45,533,974...45,545,223
Ensembl chr15:45,533,974...45,545,221
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Piezo2
piezo-type mechanosensitive ion channel component 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIEZO2 mRNA
CTD
PMID:36139627
NCBI chr18:56,468,449...56,844,984
Ensembl chr18:56,469,680...56,844,216
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Pik3ip1
phosphoinositide-3-kinase interacting protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3IP1 mRNA
CTD
PMID:36139627
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3R3 mRNA
CTD
PMID:36139627
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Piwil2
piwi-like RNA-mediated gene silencing 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PIWIL2 mRNA
CTD
PMID:36139627
NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
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Pkd1l2
polycystin 1 like 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PKD1L2 mRNA
CTD
PMID:36139627
NCBI chr19:45,049,713...45,136,503
Ensembl chr19:45,049,719...45,135,532
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Plac1
placenta enriched 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAC1 mRNA
CTD
PMID:36139627
NCBI chr X:132,821,347...132,955,143
Ensembl chr X:132,821,347...132,985,668
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Plag1
PLAG1 zinc finger
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAG1 mRNA
CTD
PMID:36139627
NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647
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Plat
plasminogen activator, tissue type
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLAT mRNA
CTD
PMID:36139627
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plaur
plasminogen activator, urokinase receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLAUR mRNA
CTD
PMID:36139627
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLCXD3 mRNA
CTD
PMID:36139627
NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384
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Pld1
phospholipase D1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLD1 mRNA
CTD
PMID:36139627
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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Plek2
pleckstrin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLEK2 mRNA
CTD
PMID:36139627
NCBI chr 6:97,700,123...97,719,417
Ensembl chr 6:97,701,106...97,719,326
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Plin1
perilipin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLIN1 mRNA
CTD
PMID:36139627
NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
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Plin4
perilipin 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PLIN4 mRNA
CTD
PMID:36139627
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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Plxna2
plexin A2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PLXNA2 mRNA
CTD
PMID:36139627
NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979
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Podxl
podocalyxin-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PODXL mRNA
CTD
PMID:36139627
NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
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Pou2f2
POU class 2 homeobox 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F2 mRNA
CTD
PMID:36139627
NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
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Pou2f3
POU class 2 homeobox 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU2F3 mRNA
CTD
PMID:36139627
NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795
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Pou6f1
POU class 6 homeobox 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of POU6F1 mRNA
CTD
PMID:36139627
NCBI chr 7:131,677,719...131,700,869
Ensembl chr 7:131,680,141...131,686,843 Ensembl chr 7:131,680,141...131,686,843
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Ppfia3
PTPRF interacting protein alpha 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPFIA3 mRNA
CTD
PMID:36139627
NCBI chr 1:95,817,110...95,845,950
Ensembl chr 1:95,817,110...95,845,798
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Ppm1n
protein phosphatase, Mg2+/Mn2+ dependent 1N
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPM1N mRNA
CTD
PMID:36139627
NCBI chr 1:78,929,350...78,934,435
Ensembl chr 1:78,929,351...78,932,685
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Ppp1r16b
protein phosphatase 1, regulatory subunit 16B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPP1R16B mRNA
CTD
PMID:36139627
NCBI chr 3:147,323,652...147,419,658
Ensembl chr 3:147,324,126...147,418,937
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Prag1
PEAK1 related kinase activating pseudokinase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRAG1 mRNA
CTD
PMID:36139627
NCBI chr16:56,087,885...56,141,153
Ensembl chr16:56,087,885...56,141,153
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Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PREX1 mRNA
CTD
PMID:36139627
NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688
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Prickle1
prickle planar cell polarity protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRICKLE1 mRNA
CTD
PMID:36139627
NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113
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Prkg2
protein kinase cGMP-dependent 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRKG2 mRNA
CTD
PMID:36139627
NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
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Prnd
prion like protein doppel
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRND mRNA
CTD
PMID:36139627
NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745
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Prodh
proline dehydrogenase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PRODH mRNA
CTD
PMID:36139627
NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
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Prodh2
proline dehydrogenase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRODH2 mRNA
CTD
PMID:36139627
NCBI chr 1:85,753,558...85,767,165
Ensembl chr 1:85,753,644...85,767,162
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Prr5l
proline rich 5 like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRR5L mRNA
CTD
PMID:36139627
NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763
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Prss22
serine protease 22
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS22 mRNA
CTD
PMID:36139627
NCBI chr10:13,029,153...13,033,863
Ensembl chr10:13,029,153...13,033,863
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Prss53
serine protease 53
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRSS53 mRNA
CTD
PMID:36139627
NCBI chr 1:182,494,944...182,501,607
Ensembl chr 1:182,494,955...182,500,115
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Prtn3
proteinase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PRTN3 mRNA
CTD
PMID:36139627
NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944
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Psd3
pleckstrin and Sec7 domain containing 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PSD3 mRNA
CTD
PMID:36139627
NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547
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Psmb10
proteasome 20S subunit beta 10
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PSMB10 mRNA
CTD
PMID:36139627
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
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Psmb9
proteasome 20S subunit beta 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PSMB9 mRNA
CTD
PMID:36139627
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Ptgir
prostaglandin I2 receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PTGIR mRNA
CTD
PMID:36139627
NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
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Ptk6
protein tyrosine kinase 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PTK6 mRNA
CTD
PMID:36139627
NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664
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Pxmp2
peroxisomal membrane protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PXMP2 mRNA
CTD
PMID:36139627
NCBI chr12:46,394,051...46,404,561
Ensembl chr12:46,394,193...46,404,557
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Pygb
glycogen phosphorylase B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PYGB mRNA
CTD
PMID:36139627
NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
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Rab11fip4
RAB11 family interacting protein 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB11FIP4 mRNA
CTD
PMID:36139627
NCBI chr10:64,550,109...64,658,123
Ensembl chr10:64,550,177...64,654,759
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Rab38
RAB38, member RAS oncogene family
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB38 mRNA
CTD
PMID:36139627
NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
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Rab39a
RAB39A, member RAS oncogene family
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB39A mRNA
CTD
PMID:36139627
NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483
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Rab7b
Rab7b, member RAS oncogene family
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAB7B mRNA
CTD
PMID:36139627
NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581
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Rac2
Rac family small GTPase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAC2 mRNA
CTD
PMID:36139627
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
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Rapgef5
Rap guanine nucleotide exchange factor 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RAPGEF5 mRNA
CTD
PMID:36139627
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
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Rasa4
RAS p21 protein activator 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RASA4B mRNA
CTD
PMID:36139627
NCBI chr12:20,552,805...20,580,177
Ensembl chr12:20,552,806...20,580,147
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Rasl11a
RAS-like family 11 member A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RASL11A mRNA
CTD
PMID:36139627
NCBI chr12:8,258,148...8,260,909
Ensembl chr12:8,258,159...8,262,576
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Rassf9
Ras association domain family member 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RASSF9 mRNA
CTD
PMID:36139627
NCBI chr 7:37,599,720...37,631,553
Ensembl chr 7:37,599,720...37,635,245
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Reep1
receptor accessory protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of REEP1 mRNA
CTD
PMID:36139627
NCBI chr 4:103,746,004...103,862,347
Ensembl chr 4:103,745,633...103,862,338
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Rem2
RRAD and GEM like GTPase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of REM2 mRNA
CTD
PMID:36139627
NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
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Rgmb
repulsive guidance molecule BMP co-receptor b
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RGMB mRNA
CTD
PMID:36139627
NCBI chr 1:56,766,598...56,792,396
Ensembl chr 1:56,767,850...56,792,425
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Ribc2
RIB43A domain with coiled-coils 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RIBC2 mRNA
CTD
PMID:36139627
NCBI chr 7:116,242,863...116,257,868
Ensembl chr 7:116,242,863...116,257,863
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Rimkla
ribosomal modification protein rimK-like family member A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RIMKLA mRNA
CTD
PMID:36139627
NCBI chr 5:133,072,179...133,098,840
Ensembl chr 5:133,073,960...133,098,792
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Rnf182
ring finger protein 182
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RNF182 mRNA
CTD
PMID:36139627
NCBI chr17:21,026,110...21,081,760
Ensembl chr17:21,030,214...21,094,911
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Rnf223
ring finger protein 223
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RNF223 mRNA
CTD
PMID:36139627
NCBI chr 5:166,723,346...166,726,236
Ensembl chr 5:166,724,984...166,725,751
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Robo4
roundabout guidance receptor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ROBO4 mRNA
CTD
PMID:36139627
NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519
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Ror2
receptor tyrosine kinase-like orphan receptor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ROR2 mRNA
CTD
PMID:36139627
NCBI chr17:11,972,830...12,148,152
Ensembl chr17:11,972,830...12,148,152
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Rora
RAR-related orphan receptor A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RORA mRNA
CTD
PMID:36139627
NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
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Rps6
ribosomal protein S6
decreases phosphorylation
ISO
sotorasib results in decreased phosphorylation of RPS6 protein
CTD
PMID:31666701
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Rragd
Ras-related GTP binding D
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RRAGD mRNA
CTD
PMID:36139627
NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
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Rspo1
R-spondin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RSPO1 mRNA
CTD
PMID:36139627
NCBI chr 5:137,251,629...137,273,273
Ensembl chr 5:137,251,659...137,272,933
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RT1-Ha
RT1 class II, locus Ha
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of HLA-DPA1 mRNA
CTD
PMID:36139627
NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
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Rtn2
reticulon 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RTN2 mRNA
CTD
PMID:36139627
NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069
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Rtp4
receptor (chemosensory) transporter protein 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of RTP4 mRNA
CTD
PMID:36139627
NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
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Runx2
RUNX family transcription factor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RUNX2 mRNA
CTD
PMID:36139627
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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Rxfp4
relaxin family peptide/INSL5 receptor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RXFP4 mRNA
CTD
PMID:36139627
NCBI chr 2:174,123,510...174,124,664
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Ryr1
ryanodine receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of RYR1 mRNA
CTD
PMID:36139627
NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812
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S100a2
S100 calcium binding protein A2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of S100A2 mRNA
CTD
PMID:36139627
NCBI chr 2:176,077,081...176,078,325
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Sall4
spalt-like transcription factor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SALL4 mRNA
CTD
PMID:36139627
NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
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Samd15
sterile alpha motif domain containing 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SAMD15 mRNA
CTD
PMID:36139627
NCBI chr 6:106,841,405...106,856,197
Ensembl chr 6:106,840,781...106,860,423
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Samd9l
sterile alpha motif domain containing 9 like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SAMD9L mRNA
CTD
PMID:36139627
NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415
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Saxo5
stabilizer of axonemal microtubules 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SAXO5 mRNA
CTD
PMID:36139627
NCBI chr12:1,520,983...1,538,127
Ensembl chr12:1,521,014...1,538,118
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Scarf1
scavenger receptor class F, member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SCARF1 mRNA
CTD
PMID:36139627
NCBI chr10:60,359,213...60,371,516
Ensembl chr10:60,359,197...60,371,516
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Scnn1b
sodium channel epithelial 1 subunit beta
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SCNN1B mRNA
CTD
PMID:36139627
NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
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Sdcbp2
syndecan binding protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SDCBP2 mRNA
CTD
PMID:36139627
NCBI chr 3:140,060,746...140,098,063
Ensembl chr 3:140,070,540...140,098,057
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Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEC14L2 mRNA
CTD
PMID:36139627
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
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Sema3c
semaphorin 3C
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SEMA3C mRNA
CTD
PMID:36139627
NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
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Sema7a
semaphorin 7A (John Milton Hagen blood group)
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SEMA7A mRNA
CTD
PMID:36139627
NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINA3 mRNA
CTD
PMID:36139627
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpina5
serpin family A member 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINA5 mRNA
CTD
PMID:36139627
NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407
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Serpinb8
serpin family B member 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINB8 mRNA
CTD
PMID:36139627
NCBI chr13:23,626,936...23,650,277
Ensembl chr13:23,626,945...23,650,835
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Serpine1
serpin family E member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINE1 mRNA
CTD
PMID:36139627
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpine2
serpin family E member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SERPINE2 mRNA
CTD
PMID:36139627
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Serpini1
serpin family I member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SERPINI1 mRNA
CTD
PMID:36139627
NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
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Sfn
stratifin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SFN mRNA
CTD
PMID:36139627
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Sfxn2
sideroflexin 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SFXN2 mRNA
CTD
PMID:36139627
NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411 Ensembl chr 1:245,447,015...245,468,411
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Sfxn3
sideroflexin 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SFXN3 mRNA
CTD
PMID:36139627
NCBI chr 1:243,907,958...243,917,065
Ensembl chr 1:243,907,751...243,917,073
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Sh2d5
SH2 domain containing 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH2D5 mRNA
CTD
PMID:36139627
NCBI chr 5:150,469,738...150,480,615
Ensembl chr 5:150,467,728...150,479,955
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Sh3d21
SH3 domain containing 21
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH3D21 mRNA
CTD
PMID:36139627
NCBI chr 5:138,429,180...138,444,540
Ensembl chr 5:138,429,180...138,444,407
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Sh3tc2
SH3 domain and tetratricopeptide repeats 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SH3TC2 mRNA
CTD
PMID:36139627
NCBI chr18:55,416,383...55,477,419
Ensembl chr18:55,416,413...55,483,083
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Shf
Src homology 2 domain containing F
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SHF mRNA
CTD
PMID:36139627
NCBI chr 3:109,296,517...109,316,315
Ensembl chr 3:109,296,784...109,316,328
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Siglec15
sialic acid binding Ig-like lectin 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SIGLEC15 mRNA
CTD
PMID:36139627
NCBI chr18:71,506,416...71,521,894
Ensembl chr18:71,505,399...71,521,881
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Slc10a5
solute carrier family 10, member 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC10A5 mRNA
CTD
PMID:36139627
NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651
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Slc17a7
solute carrier family 17 member 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC17A7 mRNA
CTD
PMID:36139627
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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Slc2a3
solute carrier family 2 member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC2A3 mRNA
CTD
PMID:36139627
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC47A2 mRNA
CTD
PMID:36139627
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc4a11
solute carrier family 4 member 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC4A11 mRNA
CTD
PMID:36139627
NCBI chr 3:117,900,223...117,912,787
Ensembl chr 3:117,900,223...117,912,674
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Slc4a7
solute carrier family 4 member 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC4A7 mRNA
CTD
PMID:36139627
NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781
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Slc5a1
solute carrier family 5 member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC5A1 mRNA
CTD
PMID:36139627
NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
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Slc6a9
solute carrier family 6 member 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLC6A9 mRNA
CTD
PMID:36139627
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slc9a3
solute carrier family 9 member A3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SLC9A3 mRNA
CTD
PMID:36139627
NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
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Slitrk3
SLIT and NTRK-like family, member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SLITRK3 mRNA
CTD
PMID:36139627
NCBI chr 2:157,680,067...157,697,404
Ensembl chr 2:157,687,535...157,696,709
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Smim5
small integral membrane protein 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SMIM5 mRNA
CTD
PMID:36139627
NCBI chr10:101,134,033...101,139,814
Ensembl chr10:101,134,033...101,139,813
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Smoc2
SPARC related modular calcium binding 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SMOC2 mRNA
CTD
PMID:36139627
NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
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Smpd3
sphingomyelin phosphodiesterase 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SMPD3 mRNA
CTD
PMID:36139627
NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
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Snai2
snail family transcriptional repressor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SNAI2 mRNA
CTD
PMID:36139627
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Snai3
snail family transcriptional repressor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SNAI3 mRNA
CTD
PMID:36139627
NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486
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Socs2
suppressor of cytokine signaling 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SOCS2 mRNA
CTD
PMID:36139627
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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Spata18
spermatogenesis associated 18
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SPATA18 mRNA
CTD
PMID:36139627
NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687
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Spats2l
spermatogenesis associated, serine-rich 2-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPATS2L mRNA
CTD
PMID:36139627
NCBI chr 9:59,319,949...59,493,864
Ensembl chr 9:59,320,276...59,493,967
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Spns3
sphingolipid transporter 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPNS3 mRNA
CTD
PMID:36139627
NCBI chr10:57,114,247...57,169,056
Ensembl chr10:57,114,266...57,168,951
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Spocd1
SPOC domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPOCD1 mRNA
CTD
PMID:36139627
NCBI chr 5:142,288,822...142,297,113
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Spon1
spondin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPON1 mRNA
CTD
PMID:36139627
NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
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Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SPSB1 mRNA
CTD
PMID:36139627
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Sptb
spectrin, beta, erythrocytic
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPTB mRNA
CTD
PMID:36139627
NCBI chr 6:95,310,342...95,437,221
Ensembl chr 6:95,310,326...95,437,118
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Sptbn4
spectrin, beta, non-erythrocytic 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SPTBN4 mRNA
CTD
PMID:36139627
NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228
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Srxn1
sulfiredoxin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SRXN1 mRNA
CTD
PMID:36139627
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ST3GAL1 mRNA
CTD
PMID:36139627
NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236
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Stambpl1
STAM binding protein-like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STAMBPL1 mRNA
CTD
PMID:36139627
NCBI chr 1:231,699,620...231,745,034
Ensembl chr 1:231,699,995...231,745,032
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Stc1
stanniocalcin 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STC1 mRNA
CTD
PMID:36139627
NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
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Stn1
STN1 subunit of CST complex
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STN1 mRNA
CTD
PMID:36139627
NCBI chr 1:246,391,311...246,429,844
Ensembl chr 1:246,395,613...246,429,531
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Stom
stomatin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of STOM mRNA
CTD
PMID:36139627
NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354
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Sulf2
sulfatase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SULF2 mRNA
CTD
PMID:36139627
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Sult2b1
sulfotransferase family 2B member 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SULT2B1 mRNA
CTD
PMID:36139627
NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295
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Sycp2
synaptonemal complex protein 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYCP2 mRNA
CTD
PMID:36139627
NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789
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Sync
syncoilin, intermediate filament protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SYNC mRNA
CTD
PMID:36139627
NCBI chr 5:141,631,837...141,656,184
Ensembl chr 5:141,632,367...141,688,659
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Syne3
spectrin repeat containing, nuclear envelope family member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYNE3 mRNA
CTD
PMID:36139627
NCBI chr 6:123,872,895...123,964,773
Ensembl chr 6:123,873,174...123,953,409
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Syt12
synaptotagmin 12
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYT12 mRNA
CTD
PMID:36139627
NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609
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Syt5
synaptotagmin 5
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYT5 mRNA
CTD
PMID:36139627
NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
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Sytl2
synaptotagmin-like 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of SYTL2 mRNA
CTD
PMID:36139627
NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222
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Tac3
tachykinin precursor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAC3 mRNA
CTD
PMID:36139627
NCBI chr 7:63,562,552...63,569,170
Ensembl chr 7:63,562,552...63,569,170
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Tafa2
TAFA chemokine like family member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAFA2 mRNA
CTD
PMID:36139627
NCBI chr 7:58,942,598...59,418,640
Ensembl chr 7:58,942,610...59,417,299
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Tapbpl
TAP binding protein-like
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TAPBPL mRNA
CTD
PMID:36139627
NCBI chr 4:158,021,454...158,028,905
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Tbx4
T-box transcription factor 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TBX4 mRNA
CTD
PMID:36139627
NCBI chr10:70,730,686...70,760,829
Ensembl chr10:70,731,163...70,760,825
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Tcaf2
TRPM8 channel-associated factor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TCAF2 mRNA
CTD
PMID:36139627
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Tchh
trichohyalin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TCHH mRNA
CTD
PMID:36139627
NCBI chr 2:179,103,660...179,112,014
Ensembl chr 2:179,109,609...179,110,985 Ensembl chr 2:179,109,609...179,110,985
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Tex9
testis expressed 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TEX9 mRNA
CTD
PMID:36139627
NCBI chr 8:73,168,519...73,213,935
Ensembl chr 8:73,177,810...73,214,261
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Tfpi2
tissue factor pathway inhibitor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TFPI2 mRNA
CTD
PMID:36139627
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tfr2
transferrin receptor 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TFR2 mRNA
CTD
PMID:36139627
NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
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Tjp3
tight junction protein 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TJP3 mRNA
CTD
PMID:36139627
NCBI chr 7:8,427,650...8,446,279
Ensembl chr 7:8,432,811...8,446,279
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Tlcd1
TLC domain containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TLCD1 mRNA
CTD
PMID:36139627
NCBI chr10:63,074,469...63,076,502
Ensembl chr10:63,074,469...63,076,501
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Tle6
TLE family member 6, subcortical maternal complex member
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLE6 mRNA
CTD
PMID:36139627
NCBI chr 7:8,107,050...8,118,639
Ensembl chr 7:8,107,207...8,118,639
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Tlr1
toll-like receptor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLR1 mRNA
CTD
PMID:36139627
NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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Tlr3
toll-like receptor 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TLR3 mRNA
CTD
PMID:36139627
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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Tlr6
toll-like receptor 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TLR6 mRNA
CTD
PMID:36139627
NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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Tm4sf19
transmembrane 4 L six family member 19
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TM4SF19 mRNA
CTD
PMID:36139627
NCBI chr11:68,372,945...68,386,192
Ensembl chr11:68,371,647...68,384,591
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Tmc8
transmembrane channel-like 8
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMC8 mRNA
CTD
PMID:36139627
NCBI chr10:103,000,038...103,010,601
Ensembl chr10:102,998,402...103,010,590
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Tmem117
transmembrane protein 117
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM117 mRNA
CTD
PMID:36139627
NCBI chr 7:125,757,591...126,219,692
Ensembl chr 7:125,757,591...126,219,690
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Tmem144
transmembrane protein 144
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM144 mRNA
CTD
PMID:36139627
NCBI chr 2:164,960,649...164,993,562
Ensembl chr 2:164,961,247...164,992,368
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Tmem156
transmembrane protein 156
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM156 mRNA
CTD
PMID:36139627
NCBI chr14:43,221,464...43,252,453
Ensembl chr14:43,223,381...43,252,449
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Tmem158
transmembrane protein 158
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM158 mRNA
CTD
PMID:36139627
NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
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Tmem236
transmembrane protein 236
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM236 mRNA
CTD
PMID:36139627
NCBI chr17:77,180,919...77,241,258
Ensembl chr17:77,188,163...77,238,671
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Tmem25
transmembrane protein 25
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM25 mRNA
CTD
PMID:36139627
NCBI chr 8:45,107,116...45,112,657
Ensembl chr 8:45,107,121...45,116,389
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Tmem255b
transmembrane protein 255B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM255B mRNA
CTD
PMID:36139627
NCBI chr16:76,079,840...76,108,179
Ensembl chr16:76,079,845...76,106,795
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Tmem269
transmembrane protein 269
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM269 mRNA
CTD
PMID:36139627
NCBI chr 5:132,817,324...132,836,360
Ensembl chr 5:132,817,324...132,829,977
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Tmem270
transmembrane protein 270
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM270 mRNA
CTD
PMID:36139627
NCBI chr12:21,793,631...21,798,723
Ensembl chr12:21,794,130...21,798,731
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Tmem45a
transmembrane protein 45A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM45A mRNA
CTD
PMID:36139627
NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
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Tmem92
transmembrane protein 92
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TMEM92 mRNA
CTD
PMID:36139627
NCBI chr10:79,749,242...79,760,807
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Tnfsf15
TNF superfamily member 15
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TNFSF15 mRNA
CTD
PMID:36139627
NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
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Tnxb
tenascin XB
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TNXB mRNA
CTD
PMID:36139627
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Tp53i3
tumor protein p53 inducible protein 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TP53I3 mRNA
CTD
PMID:36139627
NCBI chr 6:27,818,327...27,825,753
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Tph1
tryptophan hydroxylase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TPH1 mRNA
CTD
PMID:36139627
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRANK1 mRNA
CTD
PMID:36139627
NCBI chr 8:111,275,973...111,355,491
Ensembl chr 8:111,276,354...111,355,092
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Trib1
tribbles pseudokinase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIB1 mRNA
CTD
PMID:36139627
NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
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Trib2
tribbles pseudokinase 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIB2 mRNA
CTD
PMID:36139627
NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
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Trim29
tripartite motif-containing 29
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRIM29 mRNA
CTD
PMID:36139627
NCBI chr 8:43,682,221...43,706,992
Ensembl chr 8:43,682,221...43,706,992
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Trim63
tripartite motif containing 63
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIM63 mRNA
CTD
PMID:36139627
NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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Trim9
tripartite motif-containing 9
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRIM9 mRNA
CTD
PMID:36139627
NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:88,757,303...88,856,542
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Trmt9b
tRNA methyltransferase 9B (putative)
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TRMT9B mRNA
CTD
PMID:36139627
NCBI chr16:55,740,551...55,792,198
Ensembl chr16:55,743,018...55,792,144
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Trpv2
transient receptor potential cation channel, subfamily V, member 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TRPV2 mRNA
CTD
PMID:36139627
NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
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Tsc22d3
TSC22 domain family, member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TSC22D3 mRNA
CTD
PMID:36139627
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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Tsnaxip1
translin-associated factor X interacting protein 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TSNAXIP1 mRNA
CTD
PMID:36139627
NCBI chr19:33,716,834...33,734,824
Ensembl chr19:33,716,785...33,734,824
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Ttc39a
tetratricopeptide repeat domain 39A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TTC39A mRNA
CTD
PMID:36139627
NCBI chr 5:124,165,102...124,204,740
Ensembl chr 5:124,151,760...124,204,973
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Ttpa
alpha tocopherol transfer protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TTPA mRNA
CTD
PMID:36139627
NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
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Tuba1a
tubulin, alpha 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TUBA1A mRNA
CTD
PMID:36139627
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
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Txk
TXK tyrosine kinase
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of TXK mRNA
CTD
PMID:36139627
NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448
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Uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UAP1L1 mRNA
CTD
PMID:36139627
NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
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Uba7
ubiquitin-like modifier activating enzyme 7
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UBA7 mRNA
CTD
PMID:36139627
NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099
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Ufsp1
UFM1-specific peptidase 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UFSP1 mRNA
CTD
PMID:36139627
NCBI chr12:19,406,133...19,407,147
Ensembl chr12:19,406,142...19,407,195
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Uhrf2
ubiquitin like with PHD and ring finger domains 2
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UHRF2 mRNA
CTD
PMID:36139627
NCBI chr 1:227,814,639...227,877,907
Ensembl chr 1:227,814,963...227,877,904
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Upk1a
uroplakin 1A
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UPK1A mRNA
CTD
PMID:36139627
NCBI chr 1:85,859,672...85,870,147
Ensembl chr 1:85,859,671...85,870,354
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Upk3b
uroplakin 3B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of UPK3B mRNA
CTD
PMID:36139627
NCBI chr12:20,630,231...20,637,634
Ensembl chr12:20,631,525...20,637,724
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Ush1g
USH1 protein network component sans
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of USH1G mRNA
CTD
PMID:36139627
NCBI chr10:100,559,721...100,563,590
Ensembl chr10:100,557,629...100,563,590
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Vdr
vitamin D receptor
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VDR mRNA
CTD
PMID:36139627
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Veph1
ventricular zone expressed PH domain-containing 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VEPH1 mRNA
CTD
PMID:36139627
NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266
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Vgf
VGF nerve growth factor inducible
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of VGF mRNA
CTD
PMID:36139627
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vtn
vitronectin
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of VTN mRNA
CTD
PMID:36139627
NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
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Wasf3
WASP family member 3
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WASF3 mRNA
CTD
PMID:36139627
NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751
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Wnt10b
Wnt family member 10B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT10B mRNA
CTD
PMID:36139627
NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892
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Wnt11
Wnt family member 11
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT11 mRNA
CTD
PMID:36139627
NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
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Wnt2b
Wnt family member 2B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT2B mRNA
CTD
PMID:36139627
NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308
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Wnt4
Wnt family member 4
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of WNT4 mRNA
CTD
PMID:36139627
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
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Wnt7b
Wnt family member 7B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of WNT7B mRNA
CTD
PMID:36139627
NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581
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Wnt8b
Wnt family member 8B
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of WNT8B mRNA
CTD
PMID:36139627
NCBI chr 1:243,354,145...243,376,000
Ensembl chr 1:243,354,086...243,374,286
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Xaf1
XIAP associated factor 1
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of XAF1 mRNA
CTD
PMID:36139627
NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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Zc3h6
zinc finger CCCH type containing 6
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZC3H6 mRNA
CTD
PMID:36139627
NCBI chr 3:116,203,466...116,254,186
Ensembl chr 3:116,204,197...116,253,282
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Zfp608
zinc finger protein 608
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZNF608 mRNA
CTD
PMID:36139627
NCBI chr18:48,304,873...48,412,846
Ensembl chr18:48,304,880...48,410,465
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Zwint
ZW10 interacting kinetochore protein
multiple interactions
ISO
[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ZWINT mRNA
CTD
PMID:36139627
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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