Obscn (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF)

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Gene: Obscn (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) Rattus norvegicus

Analyze

Symbol:

Obscn

Name:

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

RGD ID:

631335

Description:

Predicted to enable several functions, including cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase signaling and protein autophosphorylation. Located in M band and Z disc. Orthologous to human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hypothetical LOC287353; LOC108352087; LOC287353; Obscnl; obscurin; obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF-like; obscurin-like; RGD1305774

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	43,774,113 - 43,919,718 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	43,789,293 - 43,919,723 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	45,353,185 - 45,483,570 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	45,338,009 - 45,481,008 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,094,419 - 45,240,049 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	45,286,791 - 45,432,832 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	43,040,464 - 43,184,409 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

dilated cardiomyopathy (ISO)

Dwarfism (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

multiple mitochondrial dysfunctions syndrome 3 (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

calcitriol (ISO)

cocaine (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP,ISO)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

ethanol (ISO)

fulvestrant (ISO)

glucose (ISO)

glyphosate (EXP)

hydralazine (ISO)

ivermectin (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

phenobarbital (ISO)

pioglitazone (ISO)

silicon dioxide (ISO)

sotorasib (ISO)

sulforaphane (ISO)

tebuconazole (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of phosphatidylinositol 3-kinase signaling (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

Cellular Component

cytosol (ISO)

extracellular space (ISO)

intercalated disc (ISO)

M band (IDA,ISO)

nuclear body (ISO)

plasma membrane (ISO)

sarcolemma (ISO)

sarcomere (IDA)

Z disc (IDA,ISO)

Molecular Function

ankyrin binding (ISO)

ATP binding (IEA)

cadherin binding (ISO)

guanyl-nucleotide exchange factor activity (NAS)

phosphatidylinositol bisphosphate binding (ISO)

phosphatidylinositol-3,4,5-trisphosphate binding (ISO)

phosphatidylinositol-3,4-bisphosphate binding (ISO)

phosphatidylinositol-3-phosphate binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

phosphatidylinositol-4-phosphate binding (ISO)

phosphatidylinositol-5-phosphate binding (ISO)

protein binding (IPI,ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IEA)

titin binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Obscurin: a multitasking muscle giant.	Kontrogianni-Konstantopoulos A and Bloch RJ, J Muscle Res Cell Motil. 2005;26(6-8):419-26.
3.	Obscurin is a ligand for small ankyrin 1 in skeletal muscle.	Kontrogianni-Konstantopoulos A, etal., Mol Biol Cell 2003 Mar;14(3):1138-48.
4.	Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts.	Makarenko I, etal., Circ Res. 2004 Oct 1;95(7):708-16. Epub 2004 Sep 2.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11717165	PMID:15013951	PMID:15314079	PMID:16205939	PMID:17012262	PMID:18219491	PMID:18477606	PMID:18782775	PMID:19002483	PMID:19403693	PMID:19605563	PMID:22416964
PMID:23392350	PMID:24516603	PMID:28826662

Genomics

Comparative Map Data

Obscn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	43,774,113 - 43,919,718 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	43,789,293 - 43,919,723 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	45,353,185 - 45,483,570 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	45,338,009 - 45,481,008 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,094,419 - 45,240,049 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	45,286,791 - 45,432,832 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	43,040,464 - 43,184,409 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

OBSCN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	228,208,044 - 228,378,876 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	228,208,044 - 228,378,876 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	228,395,745 - 228,566,577 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	226,462,484 - 226,633,198 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	224,702,595 - 224,855,685	NCBI
Celera	1	201,585,880 - 201,756,652 (+)	NCBI		Celera
Cytogenetic Map	1	q42.13	NCBI
HuRef	1	198,910,669 - 199,081,449 (+)	NCBI		HuRef
CHM1_1	1	229,668,122 - 229,838,939 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	227,396,836 - 227,567,714 (+)	NCBI		T2T-CHM13v2.0

Obscn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	58,885,082 - 59,027,201 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	58,885,082 - 59,029,996 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	58,994,256 - 59,136,375 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	58,994,256 - 59,139,170 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	58,807,758 - 58,949,877 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	58,810,527 - 58,824,805 (-)	NCBI		MGSCv36	mm8
Celera	11	63,760,680 - 63,901,312 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI

Obscn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955581	148,571 - 265,062 (-)	NCBI	ChiLan1.0	ChiLan1.0

OBSCN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	208,821,882 - 208,992,327 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	208,825,607 - 208,992,246 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	203,605,558 - 203,781,491 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

OBSCN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	664,404 - 782,376 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	368,668 - 495,174 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	380,493 - 503,404 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	566,842 - 694,225 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	327,479 - 475,088 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	337,710 - 460,914 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101962737
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	87,601,725 - 87,686,594 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936864	619 - 33,574 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OBSCN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	51,285,488 - 51,534,236 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	51,317,538 - 51,534,246 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	53,786,998 - 53,794,594 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OBSCN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	1,356,567 - 1,520,517 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	1,366,179 - 1,514,668 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	1,236,221 - 1,403,869 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Obscn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624937	926,090 - 1,060,233 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Obscn
991 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	345
Count of miRNA genes:	199
Interacting mature miRNAs:	233
Transcripts:	ENSRNOT00000033222, ENSRNOT00000058419
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat

Markers in Region

RH127871

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,789,403 - 43,789,605 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,353,296 - 45,353,497	NCBI	Rnor6.0
Rnor_5.0	10	45,109,710 - 45,109,911	UniSTS	Rnor5.0
RGSC_v3.4	10	45,302,220 - 45,302,421	UniSTS	RGSC3.4
Celera	10	43,055,755 - 43,055,956	UniSTS
RH 3.4 Map	10	501.6	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH134278

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,773,999 - 43,774,199 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,337,892 - 45,338,091	NCBI	Rnor6.0
Rnor_5.0	10	45,094,306 - 45,094,505	UniSTS	Rnor5.0
RGSC_v3.4	10	45,286,816 - 45,287,015	UniSTS	RGSC3.4
Celera	10	43,040,351 - 43,040,550	UniSTS
RH 3.4 Map	10	489.3	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH140532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,790,935 - 43,791,040 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,354,828 - 45,354,932	NCBI	Rnor6.0
Rnor_5.0	10	45,111,242 - 45,111,346	UniSTS	Rnor5.0
RGSC_v3.4	10	45,303,752 - 45,303,856	UniSTS	RGSC3.4
Celera	10	43,057,287 - 43,057,391	UniSTS
RH 3.4 Map	10	502.6	UniSTS
Cytogenetic Map	10	q22	UniSTS

AA800048

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	43,791,878 - 43,792,014 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	45,355,771 - 45,355,906	NCBI	Rnor6.0
Rnor_5.0	10	45,112,185 - 45,112,320	UniSTS	Rnor5.0
RGSC_v3.4	10	45,304,695 - 45,304,830	UniSTS	RGSC3.4
Celera	10	43,058,230 - 43,058,365	UniSTS
RH 3.4 Map	10	501.59	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		43					8	11				2	8
Low			11	9	7	9			31		13	8
Below cutoff	2		44	30	12	30			39	29	28	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_017597640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005490247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY167411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000078353 ⟹ ENSRNOP00000074671

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	45,338,062 - 45,480,999 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000084697 ⟹ ENSRNOP00000069172

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	43,789,293 - 43,919,723 (-)	Ensembl
Rnor_6.0 Ensembl	10	45,353,714 - 45,480,999 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087926 ⟹ ENSRNOP00000072721

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	45,338,009 - 45,481,008 (-)	Ensembl

RefSeq Acc Id:

XM_039087219 ⟹ XP_038943147

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087220 ⟹ XP_038943148

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087221 ⟹ XP_038943149

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087222 ⟹ XP_038943150

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087223 ⟹ XP_038943151

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087224 ⟹ XP_038943152

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087225 ⟹ XP_038943153

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087226 ⟹ XP_038943154

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087227 ⟹ XP_038943155

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087228 ⟹ XP_038943156

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087229 ⟹ XP_038943157

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087230 ⟹ XP_038943158

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087231 ⟹ XP_038943159

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087232 ⟹ XP_038943160

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087234 ⟹ XP_038943162

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087235 ⟹ XP_038943163

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087236 ⟹ XP_038943164

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087237 ⟹ XP_038943165

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087238 ⟹ XP_038943166

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087239 ⟹ XP_038943167

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087240 ⟹ XP_038943168

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087241 ⟹ XP_038943169

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087242 ⟹ XP_038943170

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087243 ⟹ XP_038943171

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087245 ⟹ XP_038943173

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087246 ⟹ XP_038943174

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087247 ⟹ XP_038943175

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087248 ⟹ XP_038943176

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087249 ⟹ XP_038943177

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087250 ⟹ XP_038943178

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XM_039087251 ⟹ XP_038943179

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,789,293 - 43,919,717 (-)	NCBI

RefSeq Acc Id:

XM_039087252 ⟹ XP_038943180

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,789,293 - 43,919,717 (-)	NCBI

RefSeq Acc Id:

XM_039087253 ⟹ XP_038943181

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,838,934 (-)	NCBI

RefSeq Acc Id:

XM_039087254 ⟹ XP_038943182

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,840,706 (-)	NCBI

RefSeq Acc Id:

XM_039087256 ⟹ XP_038943184

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,838,934 (-)	NCBI

RefSeq Acc Id:

XM_039087257 ⟹ XP_038943185

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,774,113 - 43,838,934 (-)	NCBI

RefSeq Acc Id:

XM_039087258 ⟹ XP_038943186

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,789,293 - 43,919,716 (-)	NCBI

RefSeq Acc Id:

XR_005490245

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,837,698 - 43,919,718 (-)	NCBI

RefSeq Acc Id:

XR_005490246

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,833,087 - 43,919,718 (-)	NCBI

RefSeq Acc Id:

XR_005490247

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	43,832,527 - 43,919,718 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038943147	(Get FASTA)	NCBI Sequence Viewer
	XP_038943148	(Get FASTA)	NCBI Sequence Viewer
	XP_038943149	(Get FASTA)	NCBI Sequence Viewer
	XP_038943150	(Get FASTA)	NCBI Sequence Viewer
	XP_038943151	(Get FASTA)	NCBI Sequence Viewer
	XP_038943152	(Get FASTA)	NCBI Sequence Viewer
	XP_038943153	(Get FASTA)	NCBI Sequence Viewer
	XP_038943154	(Get FASTA)	NCBI Sequence Viewer
	XP_038943155	(Get FASTA)	NCBI Sequence Viewer
	XP_038943156	(Get FASTA)	NCBI Sequence Viewer
	XP_038943157	(Get FASTA)	NCBI Sequence Viewer
	XP_038943158	(Get FASTA)	NCBI Sequence Viewer
	XP_038943159	(Get FASTA)	NCBI Sequence Viewer
	XP_038943160	(Get FASTA)	NCBI Sequence Viewer
	XP_038943162	(Get FASTA)	NCBI Sequence Viewer
	XP_038943163	(Get FASTA)	NCBI Sequence Viewer
	XP_038943164	(Get FASTA)	NCBI Sequence Viewer
	XP_038943165	(Get FASTA)	NCBI Sequence Viewer
	XP_038943166	(Get FASTA)	NCBI Sequence Viewer
	XP_038943167	(Get FASTA)	NCBI Sequence Viewer
	XP_038943168	(Get FASTA)	NCBI Sequence Viewer
	XP_038943169	(Get FASTA)	NCBI Sequence Viewer
	XP_038943170	(Get FASTA)	NCBI Sequence Viewer
	XP_038943171	(Get FASTA)	NCBI Sequence Viewer
	XP_038943173	(Get FASTA)	NCBI Sequence Viewer
	XP_038943174	(Get FASTA)	NCBI Sequence Viewer
	XP_038943175	(Get FASTA)	NCBI Sequence Viewer
	XP_038943176	(Get FASTA)	NCBI Sequence Viewer
	XP_038943177	(Get FASTA)	NCBI Sequence Viewer
	XP_038943178	(Get FASTA)	NCBI Sequence Viewer
	XP_038943179	(Get FASTA)	NCBI Sequence Viewer
	XP_038943180	(Get FASTA)	NCBI Sequence Viewer
	XP_038943181	(Get FASTA)	NCBI Sequence Viewer
	XP_038943182	(Get FASTA)	NCBI Sequence Viewer
	XP_038943184	(Get FASTA)	NCBI Sequence Viewer
	XP_038943185	(Get FASTA)	NCBI Sequence Viewer
	XP_038943186	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO34127	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000069172 ⟸ ENSRNOT00000084697

RefSeq Acc Id:

ENSRNOP00000072721 ⟸ ENSRNOT00000087926

RefSeq Acc Id:

ENSRNOP00000074671 ⟸ ENSRNOT00000078353

RefSeq Acc Id:	XP_038943158 ⟸ XM_039087230
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038943166 ⟸ XM_039087238
- Peptide Label:	isoform X19

RefSeq Acc Id:	XP_038943156 ⟸ XM_039087228
- Peptide Label:	isoform X10

RefSeq Acc Id:	XP_038943153 ⟸ XM_039087225
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038943165 ⟸ XM_039087237
- Peptide Label:	isoform X18

RefSeq Acc Id:	XP_038943154 ⟸ XM_039087226
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_038943155 ⟸ XM_039087227
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038943157 ⟸ XM_039087229
- Peptide Label:	isoform X11

RefSeq Acc Id:	XP_038943178 ⟸ XM_039087250
- Peptide Label:	isoform X30

RefSeq Acc Id:	XP_038943174 ⟸ XM_039087246
- Peptide Label:	isoform X26

RefSeq Acc Id:	XP_038943177 ⟸ XM_039087249
- Peptide Label:	isoform X29

RefSeq Acc Id:	XP_038943173 ⟸ XM_039087245
- Peptide Label:	isoform X25

RefSeq Acc Id:	XP_038943176 ⟸ XM_039087248
- Peptide Label:	isoform X28

RefSeq Acc Id:	XP_038943175 ⟸ XM_039087247
- Peptide Label:	isoform X27

RefSeq Acc Id:	XP_038943171 ⟸ XM_039087243
- Peptide Label:	isoform X24

RefSeq Acc Id:	XP_038943149 ⟸ XM_039087221
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038943170 ⟸ XM_039087242
- Peptide Label:	isoform X23

RefSeq Acc Id:	XP_038943168 ⟸ XM_039087240
- Peptide Label:	isoform X21

RefSeq Acc Id:	XP_038943163 ⟸ XM_039087235
- Peptide Label:	isoform X16

RefSeq Acc Id:	XP_038943162 ⟸ XM_039087234
- Peptide Label:	isoform X15

RefSeq Acc Id:	XP_038943152 ⟸ XM_039087224
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038943169 ⟸ XM_039087241
- Peptide Label:	isoform X22

RefSeq Acc Id:	XP_038943167 ⟸ XM_039087239
- Peptide Label:	isoform X20

RefSeq Acc Id:	XP_038943159 ⟸ XM_039087231
- Peptide Label:	isoform X13

RefSeq Acc Id:	XP_038943148 ⟸ XM_039087220
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038943160 ⟸ XM_039087232
- Peptide Label:	isoform X14

RefSeq Acc Id:	XP_038943151 ⟸ XM_039087223
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038943150 ⟸ XM_039087222
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038943164 ⟸ XM_039087236
- Peptide Label:	isoform X17

RefSeq Acc Id:	XP_038943147 ⟸ XM_039087219
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038943182 ⟸ XM_039087254
- Peptide Label:	isoform X32

RefSeq Acc Id:	XP_038943185 ⟸ XM_039087257
- Peptide Label:	isoform X34

RefSeq Acc Id:	XP_038943184 ⟸ XM_039087256
- Peptide Label:	isoform X33

RefSeq Acc Id:	XP_038943181 ⟸ XM_039087253
- Peptide Label:	isoform X32

RefSeq Acc Id:	XP_038943180 ⟸ XM_039087252
- Peptide Label:	isoform X31

RefSeq Acc Id:	XP_038943179 ⟸ XM_039087251
- Peptide Label:	isoform X31

RefSeq Acc Id:	XP_038943186 ⟸ XM_039087258
- Peptide Label:	isoform X35

Protein Domains

DH Fibronectin type-III Ig-like PH SH3

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631335	AgrOrtholog
BioCyc Gene	G2FUF-24915	BioCyc
Ensembl Genes	ENSRNOG00000058068	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069172	ENTREZGENE
	ENSRNOP00000069172.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000084697	ENTREZGENE
	ENSRNOT00000084697.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	Fibronectin_type3	UniProtKB/TrEMBL
	FN3_sf	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
	Obscurin_SH3	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
NCBI Gene	338458	ENTREZGENE
Pfam	fn3	UniProtKB/TrEMBL
	I-set	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
PhenoGen	Obscn	PhenoGen
PROSITE	DH_2	UniProtKB/TrEMBL
	FN3	UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	FN3	UniProtKB/TrEMBL
	IGc2	UniProtKB/TrEMBL
	IGv	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	DH-domain	UniProtKB/TrEMBL
	SSF48726	UniProtKB/TrEMBL
	SSF49265	UniProtKB/TrEMBL
	SSF50044	UniProtKB/TrEMBL
UniProt	A0A0G2JUP3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	LOC108352087	obscurin-like	Data Merged	737654	PROVISIONAL
2016-08-02	LOC108352087	obscurin-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2015-11-06	Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Obscnl	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF-like	Data Merged	737654	APPROVED
2008-03-18	Obscnl	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF-like	RGD1305774_predicted	hypothetical LOC287353 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305774_predicted	hypothetical LOC287353 (predicted)	LOC287353_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC287353_predicted	hypothetical LOC287353 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL
2004-02-11	Obscn	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF			Symbol and Name status set to approved	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar