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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Capn8 | Rat | celiac disease | | ISO | CAPN8 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:30097691 | |
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Capn8 | Rat | celiac disease | | ISO | CAPN8 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:30097691 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
3. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
4. | GOA pipeline | RGD automated data pipeline |
5. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
7. | A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain. | Sorimachi H, etal., J Biol Chem 1993 Sep 15;268(26):19476-82. |
Capn8 (Rattus norvegicus - Norway rat) |
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CAPN8 (Homo sapiens - human) |
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Capn8 (Mus musculus - house mouse) |
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Capn8 (Chinchilla lanigera - long-tailed chinchilla) |
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CAPN8 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CAPN8 (Canis lupus familiaris - dog) |
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Capn8 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CAPN8 (Sus scrofa - pig) |
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CAPN8 (Chlorocebus sabaeus - green monkey) |
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Capn8 (Heterocephalus glaber - naked mole-rat) |
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Variants in Capn8
632 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 5 | 41 | 111 | 62 | 61 | 31 | 24 | 31 | 6 | 169 | 85 | 91 | 39 | 59 | 30 |
RefSeq Transcripts | NM_133309 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006250363 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017598654 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271979 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271980 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271981 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271982 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063271983 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AF514419 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473985 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D14478 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D14479 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D14480 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000013 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000004649 ⟹ ENSRNOP00000004649 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000067005 ⟹ ENSRNOP00000062898 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000096500 ⟹ ENSRNOP00000097093 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_133309 ⟹ NP_579843 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006250363 ⟹ XP_006250425 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_063271979 ⟹ XP_063128049 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063271980 ⟹ XP_063128050 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063271981 ⟹ XP_063128051 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063271982 ⟹ XP_063128052 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063271983 ⟹ XP_063128053 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_579843 | (Get FASTA) | NCBI Sequence Viewer |
XP_006250425 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128049 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128050 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128051 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128052 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063128053 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAM94284 | (Get FASTA) | NCBI Sequence Viewer |
BAA03369 | (Get FASTA) | NCBI Sequence Viewer | |
BAA03370 | (Get FASTA) | NCBI Sequence Viewer | |
BAA03371 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94877 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94878 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94879 | (Get FASTA) | NCBI Sequence Viewer | |
EDL94880 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000004649.6 | ||
ENSRNOP00000062898.3 | |||
ENSRNOP00000097093.1 | |||
GenBank Protein | Q78EJ9 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_579843 ⟸ NM_133309 |
- UniProtKB: | Q78EJ9 (UniProtKB/Swiss-Prot), Q78EJ8 (UniProtKB/Swiss-Prot), Q64698 (UniProtKB/Swiss-Prot), Q8K407 (UniProtKB/Swiss-Prot), A6JGM1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006250425 ⟸ XM_006250363 |
- Peptide Label: | isoform X5 |
- UniProtKB: | A6JGM3 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000062898 ⟸ ENSRNOT00000067005 |
Ensembl Acc Id: | ENSRNOP00000004649 ⟸ ENSRNOT00000004649 |
Ensembl Acc Id: | ENSRNOP00000097093 ⟸ ENSRNOT00000096500 |
RefSeq Acc Id: | XP_063128053 ⟸ XM_063271983 |
- Peptide Label: | isoform X6 |
- UniProtKB: | A6JGM1 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063128049 ⟸ XM_063271979 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063128052 ⟸ XM_063271982 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063128051 ⟸ XM_063271981 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_063128050 ⟸ XM_063271980 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q78EJ9-F1-model_v2 | AlphaFold | Q78EJ9 | 1-703 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13699079 | ||||||||
Promoter ID: | EPDNEW_R9604 | ||||||||
Type: | single initiation site | ||||||||
Name: | Capn8_1 | ||||||||
Description: | calpain 8 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:620085 | AgrOrtholog |
BioCyc Gene | G2FUF-17062 | BioCyc |
Ensembl Genes | ENSRNOG00000003468 | Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000004649.7 | UniProtKB/Swiss-Prot |
ENSRNOT00000067005.5 | UniProtKB/Swiss-Prot | |
ENSRNOT00000096500.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.120.380 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cysteine proteinases | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EF-hand | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | C2_III | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Calpain_cysteine_protease | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Calpain_domain_III | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Calpain_III | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Calpain_III_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EF-hand-dom_pair | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EF_hand_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Papain-like_cys_pep_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pept_cys_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_C2_calpain_cat | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:170808 | UniProtKB/Swiss-Prot |
NCBI Gene | 170808 | ENTREZGENE |
PANTHER | CALPAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CALPAIN, SMALL SUBUNIT 1 A-RELATED | UniProtKB/TrEMBL | |
CALPAIN, SMALL SUBUNIT 1 A-RELATED | UniProtKB/TrEMBL | |
PTHR10183:SF374 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Calpain_III | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EF-hand_8 | UniProtKB/TrEMBL | |
Peptidase_C2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Capn8 | PhenoGen |
PRINTS | CALPAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | CALPAIN_CAT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
EF_HAND_1 | UniProtKB/Swiss-Prot | |
EF_HAND_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
THIOL_PROTEASE_CYS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000003468 | RatGTEx |
ENSRNOG00055012655 | RatGTEx | |
ENSRNOG00060007746 | RatGTEx | |
ENSRNOG00065017838 | RatGTEx | |
SMART | calpain_III | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CysPc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
EFh | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF47473 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF49758 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF54001 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I6ASA4_RAT | UniProtKB/TrEMBL |
A6JGM1 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JGM2_RAT | UniProtKB/TrEMBL | |
A6JGM3 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JGM4_RAT | UniProtKB/TrEMBL | |
CAN8_RAT | UniProtKB/Swiss-Prot | |
Q64698 | ENTREZGENE | |
Q78EJ8 | ENTREZGENE | |
Q78EJ9 | ENTREZGENE | |
Q8K407 | ENTREZGENE | |
UniProt Secondary | Q64698 | UniProtKB/Swiss-Prot |
Q78EJ8 | UniProtKB/Swiss-Prot | |
Q8K407 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2004-02-26 | Capn8 | calpain 8 | Symbol and Name status set to approved | 625702 | APPROVED | ||
2002-08-07 | Capn8 | calpain 8 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_transcript | alternative splice variants nCL-2 and nCL-2' both contain cysteine protease domains, however, variant nCL-2' does not contain the calcium binding domain | 632482 |