Tmem255b (transmembrane protein 255B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tmem255b (transmembrane protein 255B) Rattus norvegicus
Analyze
Symbol: Tmem255b
Name: transmembrane protein 255B
RGD ID: 1566042
Description: Predicted to be located in membrane. Orthologous to human TMEM255B (transmembrane protein 255B); INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam70b; family with sequence similarity 70, member B; LOC290877; RGD1566042; similar to hypothetical protein MGC20579
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,759,236 - 82,810,450 (-)NCBIGRCr8
mRatBN7.21676,079,840 - 76,108,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,079,845 - 76,106,795 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,360,430 - 81,387,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,813,400 - 84,840,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,062,183 - 80,089,171 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,181,095 - 81,209,429 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,189,073 - 81,209,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,669,678 - 80,697,629 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,934,869 - 80,939,527 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1673,887,215 - 73,891,873 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Tmem255b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,759,236 - 82,810,450 (-)NCBIGRCr8
mRatBN7.21676,079,840 - 76,108,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,079,845 - 76,106,795 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,360,430 - 81,387,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,813,400 - 84,840,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,062,183 - 80,089,171 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,181,095 - 81,209,429 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,189,073 - 81,209,429 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,669,678 - 80,697,629 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,934,869 - 80,939,527 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1673,887,215 - 73,891,873 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
TMEM255B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,759,226 - 113,816,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,759,226 - 113,816,995 (+)EnsemblGRCh38hg38GRCh38
GRCh3713114,462,199 - 114,519,968 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,599,044 - 113,651,873 (-)NCBINCBI36Build 36hg18NCBI36
Celera1395,189,821 - 95,224,279 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,916,943 - 94,969,537 (-)NCBIHuRef
CHM1_113114,430,544 - 114,482,979 (+)NCBICHM1_1
T2T-CHM13v2.013112,968,205 - 113,025,166 (+)NCBIT2T-CHM13v2.0
Tmem255b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,485,118 - 13,543,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,485,189 - 13,518,473 (+)EnsemblGRCm39 Ensembl
GRCm38813,435,113 - 13,493,434 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,435,189 - 13,468,473 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,435,459 - 13,461,452 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,435,436 - 13,461,430 (+)NCBIMGSCv36mm8
Celera813,603,619 - 13,629,613 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.0NCBI
Tmem255b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404308,791 - 331,385 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404309,132 - 331,371 (-)NCBIChiLan1.0ChiLan1.0
TMEM255B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,224,137 - 115,277,730 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,917,149 - 113,972,882 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,860,657 - 94,907,680 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,913,998 - 113,953,391 (+)NCBIpanpan1.1PanPan1.1panPan2
TMEM255B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,936,662 - 60,967,505 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,936,631 - 60,978,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,646,480 - 60,678,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,620,434 - 61,653,827 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,619,339 - 61,663,565 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,058,834 - 61,091,738 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,060,783 - 61,092,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,091,987 - 61,125,180 (+)NCBIUU_Cfam_GSD_1.0
Tmem255b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,819,081 - 195,883,875 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647267,295 - 133,080 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647267,741 - 133,058 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM255B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,816,867 - 78,837,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,816,794 - 78,837,685 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,550,160 - 86,574,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM255B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,674,347 - 91,714,130 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604648,762,624 - 48,828,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem255b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793421,981 - 441,615 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793420,887 - 441,647 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem255b
186 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000042465
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 78 77 46 25 46 6 203 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000042465   ⟹   ENSRNOP00000044310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,204,766 - 81,209,424 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076516   ⟹   ENSRNOP00000068423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,079,845 - 76,106,795 (-)Ensembl
Rnor_6.0 Ensembl1681,189,073 - 81,209,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076982   ⟹   ENSRNOP00000067899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,079,845 - 76,106,795 (-)Ensembl
Rnor_6.0 Ensembl1681,189,073 - 81,209,429 (+)Ensembl
RefSeq Acc Id: NM_001106094   ⟹   NP_001099564
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,782,025 - 82,808,929 (-)NCBI
mRatBN7.21676,079,840 - 76,106,747 (-)NCBI
Rnor_6.01681,204,766 - 81,209,424 (+)NCBI
Rnor_5.01680,669,678 - 80,697,629 (+)NCBI
RGSC_v3.41680,934,869 - 80,939,527 (-)RGD
Celera1673,887,215 - 73,891,873 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600045   ⟹   XP_017455534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,782,025 - 82,810,450 (-)NCBI
mRatBN7.21676,079,840 - 76,108,152 (-)NCBI
Rnor_6.01681,181,097 - 81,209,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094418   ⟹   XP_038950346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,786,558 - 82,810,450 (-)NCBI
mRatBN7.21676,084,374 - 76,108,168 (-)NCBI
RefSeq Acc Id: XM_039094419   ⟹   XP_038950347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,786,558 - 82,810,450 (-)NCBI
mRatBN7.21676,084,374 - 76,108,167 (-)NCBI
RefSeq Acc Id: XM_063275257   ⟹   XP_063131327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,782,025 - 82,810,450 (-)NCBI
RefSeq Acc Id: XM_063275259   ⟹   XP_063131329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,759,236 - 82,810,450 (-)NCBI
RefSeq Acc Id: XM_063275260   ⟹   XP_063131330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,782,025 - 82,808,956 (-)NCBI
RefSeq Acc Id: NP_001099564   ⟸   NM_001106094
- UniProtKB: A0A096MK90 (UniProtKB/TrEMBL),   A6IWH3 (UniProtKB/TrEMBL),   A0A096MIW1 (UniProtKB/TrEMBL),   A6IWH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455534   ⟸   XM_017600045
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000044310   ⟸   ENSRNOT00000042465
Ensembl Acc Id: ENSRNOP00000067899   ⟸   ENSRNOT00000076982
Ensembl Acc Id: ENSRNOP00000068423   ⟸   ENSRNOT00000076516
RefSeq Acc Id: XP_038950346   ⟸   XM_039094418
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038950347   ⟸   XM_039094419
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063131329   ⟸   XM_063275259
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131327   ⟸   XM_063275257
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131330   ⟸   XM_063275260
- Peptide Label: isoform X4
- UniProtKB: A0A096MIW1 (UniProtKB/TrEMBL),   A6IWH2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFM9-F1-model_v2 AlphaFold B5DFM9 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566042 AgrOrtholog
BioCyc Gene G2FUF-10723 BioCyc
Ensembl Genes ENSRNOG00000026336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076516 ENTREZGENE
  ENSRNOT00000076516.3 UniProtKB/TrEMBL
  ENSRNOT00000076982.3 UniProtKB/TrEMBL
InterPro FAM70 UniProtKB/TrEMBL
KEGG Report rno:290877 UniProtKB/TrEMBL
NCBI Gene 290877 ENTREZGENE
PANTHER PTHR33721 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 255B UniProtKB/TrEMBL
Pfam FAM70 UniProtKB/TrEMBL
PhenoGen Tmem255b PhenoGen
RatGTEx ENSRNOG00000026336 RatGTEx
UniProt A0A096MIW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MK90 ENTREZGENE, UniProtKB/TrEMBL
  A6IWH2 ENTREZGENE, UniProtKB/TrEMBL
  A6IWH3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFM9_RAT UniProtKB/TrEMBL
UniProt Secondary F1LQW1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Tmem255b  transmembrane protein 255B  Fam70b  family with sequence similarity 70, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam70b  family with sequence similarity 70, member B  RGD1566042_predicted  similar to hypothetical protein MGC20579 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566042_predicted  similar to hypothetical protein MGC20579 (predicted)  LOC290877  similar to hypothetical protein MGC20579  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290877  similar to hypothetical protein MGC20579      Symbol and Name status set to provisional 70820 PROVISIONAL