Adamts6 (ADAM metallopeptidase with thrombospondin type 1 motif, 6) - Rat Genome Database

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Gene: Adamts6 (ADAM metallopeptidase with thrombospondin type 1 motif, 6) Rattus norvegicus
Analyze
Symbol: Adamts6
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 6
RGD ID: 1307678
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within circulatory system development and kidney development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 6; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; LOC361886
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2235,421,483 - 35,633,305 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl235,421,510 - 35,633,298 (+)Ensembl
Rnor_6.0234,374,142 - 34,589,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,374,158 - 34,586,755 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0253,495,958 - 53,716,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4235,213,712 - 35,434,336 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1235,133,406 - 35,352,203 (+)NCBI
Celera231,397,794 - 31,599,803 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:25807483   PMID:30361391  


Genomics

Comparative Map Data
Adamts6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2235,421,483 - 35,633,305 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl235,421,510 - 35,633,298 (+)Ensembl
Rnor_6.0234,374,142 - 34,589,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,374,158 - 34,586,755 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0253,495,958 - 53,716,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4235,213,712 - 35,434,336 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1235,133,406 - 35,352,203 (+)NCBI
Celera231,397,794 - 31,599,803 (+)NCBICelera
Cytogenetic Map2q12NCBI
ADAMTS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38565,148,738 - 65,481,920 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl565,148,738 - 65,481,920 (-)EnsemblGRCh38hg38GRCh38
GRCh37564,444,565 - 64,777,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36564,480,319 - 64,813,460 (-)NCBINCBI36hg18NCBI36
Build 34564,480,321 - 64,530,348NCBI
Celera561,441,460 - 61,776,222 (-)NCBI
Cytogenetic Map5q12.3NCBI
HuRef561,399,229 - 61,733,640 (-)NCBIHuRef
CHM1_1564,444,425 - 64,777,370 (-)NCBICHM1_1
T2T-CHM13v2.0565,968,856 - 66,303,685 (-)NCBI
Adamts6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913104,423,026 - 104,633,203 (+)NCBIGRCm39mm39
GRCm39 Ensembl13104,424,343 - 104,633,203 (+)Ensembl
GRCm3813104,286,518 - 104,496,695 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13104,287,835 - 104,496,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713105,077,953 - 105,284,843 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613105,408,255 - 105,615,145 (+)NCBImm8
Celera13108,683,304 - 108,890,181 (+)NCBICelera
Cytogenetic Map13D1NCBI
Adamts6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554463,620,795 - 3,902,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554463,620,795 - 3,902,829 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1550,173,296 - 50,505,528 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl550,181,529 - 50,502,433 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0548,517,814 - 48,854,545 (+)NCBIMhudiblu_PPA_v0panPan3
ADAMTS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1250,955,180 - 51,249,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl250,955,481 - 51,236,421 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha247,908,675 - 48,192,053 (-)NCBI
ROS_Cfam_1.0251,443,822 - 51,727,266 (-)NCBI
ROS_Cfam_1.0 Ensembl251,443,823 - 51,735,601 (-)Ensembl
UMICH_Zoey_3.1248,498,253 - 48,787,512 (-)NCBI
UNSW_CanFamBas_1.0249,293,388 - 49,576,663 (-)NCBI
UU_Cfam_GSD_1.0250,181,510 - 50,468,796 (-)NCBI
Adamts6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213194,739,311 - 195,028,741 (+)NCBI
SpeTri2.0NW_0049364803,798,044 - 3,965,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1643,663,002 - 44,080,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11643,702,519 - 44,010,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21646,987,181 - 47,283,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1461,339,444 - 61,673,366 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660499,980,945 - 10,314,741 (-)NCBIVero_WHO_p1.0
Adamts6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248154,427,371 - 4,725,031 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248154,427,297 - 4,727,991 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,630,982 - 35,631,116 (+)MAPPERmRatBN7.2
Rnor_6.0234,587,358 - 34,587,491NCBIRnor6.0
Rnor_5.0253,714,116 - 53,714,249UniSTSRnor5.0
RGSC_v3.4235,432,437 - 35,432,570UniSTSRGSC3.4
Celera231,597,907 - 31,598,040UniSTS
RH 3.4 Map2155.7UniSTS
Cytogenetic Map2q13UniSTS
RH143095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,509,264 - 35,509,559 (+)MAPPERmRatBN7.2
Rnor_6.0234,463,514 - 34,463,808NCBIRnor6.0
Rnor_5.0253,591,654 - 53,591,948UniSTSRnor5.0
RGSC_v3.4235,309,304 - 35,309,598UniSTSRGSC3.4
Celera231,475,974 - 31,476,268UniSTS
RH 3.4 Map2150.6UniSTS
Cytogenetic Map2q13UniSTS
BI301712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,562,185 - 35,562,378 (+)MAPPERmRatBN7.2
Rnor_6.0234,518,552 - 34,518,744NCBIRnor6.0
Rnor_5.0253,645,227 - 53,645,419UniSTSRnor5.0
RGSC_v3.4235,363,101 - 35,363,293UniSTSRGSC3.4
Celera231,529,256 - 31,529,448UniSTS
RH 3.4 Map2155.5UniSTS
Cytogenetic Map2q13UniSTS
BM392312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,622,363 - 35,622,528 (+)MAPPERmRatBN7.2
Rnor_6.0234,578,739 - 34,578,903NCBIRnor6.0
Rnor_5.0253,705,497 - 53,705,661UniSTSRnor5.0
RGSC_v3.4235,423,818 - 35,423,982UniSTSRGSC3.4
Celera231,589,288 - 31,589,452UniSTS
RH 3.4 Map2155.7UniSTS
Cytogenetic Map2q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:54
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000016997, ENSRNOT00000072577
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 1 10 3
Low 2 34 46 31 19 31 8 10 74 35 31 8 8
Below cutoff 1 1 10 10 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN542748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016997   ⟹   ENSRNOP00000016997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl235,421,510 - 35,633,298 (+)Ensembl
Rnor_6.0 Ensembl234,374,158 - 34,586,755 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072577   ⟹   ENSRNOP00000064275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl234,546,988 - 34,586,755 (+)Ensembl
RefSeq Acc Id: NM_001108544   ⟹   NP_001102014
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,421,510 - 35,633,301 (+)NCBI
RefSeq Acc Id: XM_017591186   ⟹   XP_017446675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,449,909 - 35,633,305 (+)NCBI
Rnor_6.0234,403,071 - 34,589,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591187   ⟹   XP_017446676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,508,204 - 35,633,305 (+)NCBI
Rnor_6.0234,463,886 - 34,589,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591188   ⟹   XP_017446677
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,521,282 - 35,633,305 (+)NCBI
Rnor_6.0234,476,116 - 34,589,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102547   ⟹   XP_038958475
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,421,483 - 35,611,875 (+)NCBI
RefSeq Acc Id: XM_039102548   ⟹   XP_038958476
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,421,483 - 35,590,609 (+)NCBI
RefSeq Acc Id: XM_039102549   ⟹   XP_038958477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,449,909 - 35,633,305 (+)NCBI
RefSeq Acc Id: XM_039102550   ⟹   XP_038958478
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,449,982 - 35,633,305 (+)NCBI
RefSeq Acc Id: XM_039102551   ⟹   XP_038958479
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,449,909 - 35,633,305 (+)NCBI
RefSeq Acc Id: XM_039102552   ⟹   XP_038958480
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,508,209 - 35,633,305 (+)NCBI
RefSeq Acc Id: XM_039102553   ⟹   XP_038958481
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,421,483 - 35,575,064 (+)NCBI
RefSeq Acc Id: XR_005500311
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2235,421,483 - 35,602,936 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_017446675   ⟸   XM_017591186
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017446676   ⟸   XM_017591187
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017446677   ⟸   XM_017591188
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000064275   ⟸   ENSRNOT00000072577
RefSeq Acc Id: ENSRNOP00000016997   ⟸   ENSRNOT00000016997
RefSeq Acc Id: XP_038958475   ⟸   XM_039102547
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038958476   ⟸   XM_039102548
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038958481   ⟸   XM_039102553
- Peptide Label: isoform X8
RefSeq Acc Id: NP_001102014   ⟸   NM_001108544
RefSeq Acc Id: XP_038958477   ⟸   XM_039102549
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958479   ⟸   XM_039102551
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038958478   ⟸   XM_039102550
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038958480   ⟸   XM_039102552
- Peptide Label: isoform X7
Protein Domains
Peptidase M12B   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A065-F1-model_v2 AlphaFold D4A065 1-1117 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307678 AgrOrtholog
BioCyc Gene G2FUF-54551 BioCyc
Ensembl Genes ENSRNOG00000012655 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016997 ENTREZGENE
  ENSRNOP00000016997.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016997 ENTREZGENE
  ENSRNOT00000016997.8 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene 361886 ENTREZGENE
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts6 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP TSP1 UniProtKB/TrEMBL
UniProt D4A065_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts6  ADAM metallopeptidase with thrombospondin type 1 motif, 6  Adamts6  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Adamts6  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6  Adamts6  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Adamts6  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6  Adamts6_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Adamts6_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED