Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Adamts6 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of ADAMTS6 mRNA | CTD | PMID:28960355 | 17beta-estradiol | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of ADAMTS6 mRNA | CTD | PMID:30165855 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS6 mRNA | CTD | PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS6 mRNA | CTD | PMID:32741896 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Adamts6 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ADAMTS6 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ADAMTS6 mRNA | CTD | PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Adamts6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ADAMTS6 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | increases expression | ISO | Adamts6 (Mus musculus) | 6480464 | bisphenol S results in increased expression of ADAMTS6 mRNA | CTD | PMID:33297965 | 8-Br-cAMP | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ADAMTS6 mRNA | CTD | PMID:20147733 and PMID:22079614 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of ADAMTS6 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ADAMTS6 gene | CTD | PMID:27153756 | aflatoxin B1 | increases methylation | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ADAMTS6 gene | CTD | PMID:31555880 | aflatoxin B1 | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ADAMTS6 mRNA | CTD | PMID:31555880 and PMID:32234424 | all-trans-retinoic acid | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ADAMTS6 mRNA | CTD | PMID:21934132 | antirheumatic drug | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of ADAMTS6 mRNA | CTD | PMID:24449571 | arsenite(3-) | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to ADAMTS6 mRNA] | CTD | PMID:32406909 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of ADAMTS6 gene | CTD | PMID:28931070 and PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ADAMTS6 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases methylation | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ADAMTS6 gene | CTD | PMID:31555880 | bisphenol A | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ADAMTS6 mRNA | CTD | PMID:29275510 | bisphenol A | decreases expression | ISO | Adamts6 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of ADAMTS6 mRNA | CTD | PMID:32156529 | bisphenol A | increases expression | ISO | Adamts6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ADAMTS6 mRNA | CTD | PMID:30245210 | bisphenol F | increases methylation | ISO | ADAMTS6 (Homo sapiens) | 6480464 | bisphenol F results in increased methylation of ADAMTS6 gene | CTD | PMID:31601247 | buta-1,3-diene | decreases expression | ISO | Adamts6 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of ADAMTS6 mRNA | CTD | PMID:29038090 | CGP 52608 | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ADAMTS6 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Adamts6 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ADAMTS6 mRNA | CTD | PMID:37019170 | cisplatin | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of ADAMTS6 mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ADAMTS6 mRNA | CTD | PMID:27392435 | copper(II) sulfate | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of ADAMTS6 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ADAMTS6 mRNA | CTD | PMID:25562108 | dexamethasone | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of ADAMTS6 mRNA | CTD | PMID:25047013 | dimethylarsinic acid | multiple interactions | ISO | Adamts6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ADAMTS6 mRNA | CTD | PMID:34876320 | dimethylarsinous acid | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | dimethylarsinous acid results in increased expression of ADAMTS6 mRNA | CTD | PMID:23487506 | dorsomorphin | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS6 mRNA | CTD | PMID:27188386 | epoxiconazole | increases expression | ISO | Adamts6 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of ADAMTS6 mRNA | CTD | PMID:35436446 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ADAMTS6 mRNA | CTD | PMID:33387578 | malathion | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Malathion results in increased expression of ADAMTS6 mRNA | CTD | PMID:37047231 | methylarsonic acid | multiple interactions | ISO | Adamts6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ADAMTS6 mRNA | CTD | PMID:34876320 | O-methyleugenol | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of ADAMTS6 mRNA | CTD | PMID:32234424 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of ADAMTS6 mRNA | CTD | PMID:32680482 | PD 0325901 | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [(+)-JQ1 compound co-treated with mirdametinib] results in decreased expression of ADAMTS6 mRNA | CTD | PMID:25119042 | pentanal | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | pentanal results in increased expression of ADAMTS6 mRNA | CTD | PMID:26079696 | propanal | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of ADAMTS6 mRNA | CTD | PMID:26079696 | SB 431542 | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS6 mRNA | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | Adamts6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ADAMTS6 mRNA | CTD | PMID:34876320 | sodium arsenite | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of ADAMTS6 mRNA | CTD | PMID:22714537 and PMID:34032870 | sodium arsenite | multiple interactions | ISO | Adamts6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ADAMTS6 mRNA | CTD | PMID:34876320 | sodium arsenite | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of ADAMTS6 mRNA | CTD | PMID:29301061 | sotorasib | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADAMTS6 mRNA | CTD | PMID:36139627 | sulforaphane | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of ADAMTS6 mRNA | CTD | PMID:31838189 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ADAMTS6 mRNA | CTD | PMID:32741896 | tetrachloroethene | increases expression | ISO | Adamts6 (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of ADAMTS6 mRNA | CTD | PMID:28973375 | trametinib | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of ADAMTS6 mRNA | CTD | PMID:36139627 | trichostatin A | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ADAMTS6 mRNA | CTD | PMID:24935251 and PMID:27188386 | urethane | decreases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of ADAMTS6 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ADAMTS6 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | ADAMTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS6 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ADAMTS6 mRNA | CTD | PMID:23179753 more ... | vorinostat | increases expression | ISO | ADAMTS6 (Homo sapiens) | 6480464 | vorinostat results in increased expression of ADAMTS6 mRNA | CTD | PMID:27188386 | |