Serpina5 (serpin family A member 5) - Rat Genome Database

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Gene: Serpina5 (serpin family A member 5) Rattus norvegicus
Analyze
Symbol: Serpina5
Name: serpin family A member 5
RGD ID: 619817
Description: Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis and seminal vesicle development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular exosome; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Orthologous to human SERPINA5 (serpin family A member 5); PARTICIPATES IN fibrinolysis pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93420; Pci; plasma serine protease inhibitor; protein C inhibitor; serine (or cysteine) peptidase inhibitor, clade A, member 5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serpin peptidase inhibitor, clade A, member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Serpina5m1Mcwi  
Genetic Models: SS-Serpina5m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,774,006 - 128,793,187 (+)NCBIGRCr8
mRatBN7.26123,009,224 - 123,028,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,023,306 - 123,028,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,164,246 - 123,169,377 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,459,540 - 123,464,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,796,353 - 122,801,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,753,152 - 127,772,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,766,470 - 127,772,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,972,583 - 136,990,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,156,901 - 128,161,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,160,647 - 128,165,080 (+)NCBI
Celera6120,503,068 - 120,508,038 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
genistein  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
kojic acid  (ISO)
levonorgestrel  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein C inhibitor expression by adult rat Sertoli cells: effects of testosterone withdrawal and replacement. Anway MD, etal., J Androl. 2005 Sep-Oct;26(5):578-85.
2. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
5. Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis. Meijers JC, etal., Br J Haematol. 2002 Aug;118(2):604-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Molecular cloning, tissue distribution and androgen regulation of rat protein C inhibitor. Wakita T, etal., FEBS Lett 1998 Jun 16;429(3):263-8.
Additional References at PubMed
PMID:1725227   PMID:2844223   PMID:3501295   PMID:6323392   PMID:7521127   PMID:8536714   PMID:8665956   PMID:9510955   PMID:9556620   PMID:10340997   PMID:11120760   PMID:11722589  
PMID:14696115   PMID:15328353   PMID:15853774   PMID:19056867   PMID:21557262   PMID:23376485   PMID:23533145   PMID:34964303   PMID:38136662  


Genomics

Comparative Map Data
Serpina5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,774,006 - 128,793,187 (+)NCBIGRCr8
mRatBN7.26123,009,224 - 123,028,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,023,306 - 123,028,407 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,164,246 - 123,169,377 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,459,540 - 123,464,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,796,353 - 122,801,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,753,152 - 127,772,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,766,470 - 127,772,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,972,583 - 136,990,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,156,901 - 128,161,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,160,647 - 128,165,080 (+)NCBI
Celera6120,503,068 - 120,508,038 (+)NCBICelera
Cytogenetic Map6q32NCBI
SERPINA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,581,426 - 94,593,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,561,442 - 94,593,118 (+)EnsemblGRCh38hg38GRCh38
GRCh371495,047,763 - 95,059,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,117,564 - 94,129,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 341494,117,563 - 94,129,204NCBI
Celera1475,103,903 - 75,115,619 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,228,133 - 75,239,873 (+)NCBIHuRef
CHM1_11494,985,498 - 94,997,214 (+)NCBICHM1_1
T2T-CHM13v2.01488,811,397 - 88,823,118 (+)NCBIT2T-CHM13v2.0
Serpina5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,065,572 - 104,072,397 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,067,372 - 104,072,396 (+)EnsemblGRCm39 Ensembl
GRCm3812104,099,313 - 104,106,138 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,101,113 - 104,106,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,339,323 - 105,344,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,502,163 - 104,507,187 (+)NCBIMGSCv36mm8
Celera12105,318,382 - 105,323,416 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.3NCBI
Serpina5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,787,399 - 17,796,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,787,398 - 17,796,013 (-)NCBIChiLan1.0ChiLan1.0
SERPINA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,729,564 - 95,742,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,946,069 - 94,958,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,205,446 - 75,217,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,537,115 - 94,548,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,537,115 - 94,548,803 (+)Ensemblpanpan1.1panPan2
SERPINA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,567,060 - 63,577,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,566,356 - 63,576,308 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,143,801 - 63,153,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,834,133 - 63,844,074 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,833,699 - 63,843,370 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,509,369 - 63,519,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,561,712 - 63,571,667 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,892,389 - 63,902,350 (+)NCBIUU_Cfam_GSD_1.0
LOC101958459
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864010,883,273 - 10,897,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936846146,116 - 150,438 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936846141,334 - 150,381 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,802,150 - 115,810,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,799,414 - 115,810,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,916,002 - 122,927,421 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,369,082 - 72,388,439 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,381,119 - 72,384,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,588,553 - 59,602,023 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpina5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,236,833 - 7,244,752 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,236,833 - 7,245,579 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpina5
115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000013138
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat

Markers in Region
BE121264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,028,174 - 123,028,325 (+)MAPPERmRatBN7.2
Rnor_6.06127,772,166 - 127,772,316NCBIRnor6.0
Rnor_5.06136,990,575 - 136,990,725UniSTSRnor5.0
RGSC_v3.46128,161,097 - 128,161,247UniSTSRGSC3.4
Celera6120,507,801 - 120,507,951UniSTS
RH 3.4 Map6818.8UniSTS
Cytogenetic Map6q32UniSTS
BI280884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26123,028,102 - 123,028,309 (+)MAPPERmRatBN7.2
Rnor_6.06127,772,094 - 127,772,300NCBIRnor6.0
Rnor_5.06136,990,503 - 136,990,709UniSTSRnor5.0
RGSC_v3.46128,161,025 - 128,161,231UniSTSRGSC3.4
Celera6120,507,729 - 120,507,935UniSTS
RH 3.4 Map6818.8UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Serpina5 is modified in the following models/strains:
SS-Serpina5m1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 9
Low 41 41 41 1 1 1 10 1
Below cutoff 1 1 7 8 3 3 1 8 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013138   ⟹   ENSRNOP00000013138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6123,023,306 - 123,028,407 (+)Ensembl
Rnor_6.0 Ensembl6127,766,470 - 127,772,420 (+)Ensembl
RefSeq Acc Id: NM_001244739   ⟹   NP_001231668
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,788,081 - 128,793,187 (+)NCBI
mRatBN7.26123,023,306 - 123,028,412 (+)NCBI
Rnor_6.06127,767,268 - 127,772,403 (+)NCBI
Rnor_5.06136,972,583 - 136,990,812 (+)NCBI
Celera6120,503,068 - 120,508,038 (+)NCBI
Sequence:
RefSeq Acc Id: NM_022957   ⟹   NP_075246
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,788,081 - 128,793,187 (+)NCBI
mRatBN7.26123,023,306 - 123,028,412 (+)NCBI
Rnor_6.06127,767,268 - 127,772,403 (+)NCBI
Rnor_5.06136,972,583 - 136,990,812 (+)NCBI
RGSC_v3.46128,156,901 - 128,161,334 (+)RGD
Celera6120,503,068 - 120,508,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240494   ⟹   XP_006240556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,774,006 - 128,793,187 (+)NCBI
mRatBN7.26123,009,224 - 123,028,411 (+)NCBI
Rnor_6.06127,753,152 - 127,772,403 (+)NCBI
Rnor_5.06136,972,583 - 136,990,812 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594349   ⟹   XP_017449838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,788,039 - 128,793,187 (+)NCBI
mRatBN7.26123,023,267 - 123,027,792 (+)NCBI
Rnor_6.06127,753,152 - 127,772,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112916   ⟹   XP_038968844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,788,051 - 128,793,187 (+)NCBI
mRatBN7.26123,023,277 - 123,027,792 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_075246   ⟸   NM_022957
- Peptide Label: isoform 2 precursor
- UniProtKB: Q66HL5 (UniProtKB/TrEMBL),   F7EMJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231668   ⟸   NM_001244739
- Peptide Label: isoform 1
- UniProtKB: Q66HL5 (UniProtKB/TrEMBL),   A6JEQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240556   ⟸   XM_006240494
- Peptide Label: isoform X1
- UniProtKB: F7EMJ6 (UniProtKB/TrEMBL),   Q66HL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449838   ⟸   XM_017594349
- Peptide Label: isoform X1
- UniProtKB: F7EMJ6 (UniProtKB/TrEMBL),   Q66HL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013138   ⟸   ENSRNOT00000013138
RefSeq Acc Id: XP_038968844   ⟸   XM_039112916
- Peptide Label: isoform X1
- UniProtKB: F7EMJ6 (UniProtKB/TrEMBL),   Q66HL5 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EMJ6-F1-model_v2 AlphaFold F7EMJ6 1-442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619817 AgrOrtholog
BioCyc Gene G2FUF-36393 BioCyc
Ensembl Genes ENSRNOG00000009855 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013138 ENTREZGENE
  ENSRNOT00000013138.7 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112069 IMAGE-MGC_LOAD
  IMAGE:7453034 IMAGE-MGC_LOAD
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:65051 UniProtKB/TrEMBL
MGC_CLONE MGC:114315 IMAGE-MGC_LOAD
  MGC:93420 IMAGE-MGC_LOAD
NCBI Gene 65051 ENTREZGENE
PANTHER PLASMA SERINE PROTEASE INHIBITOR UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina5 PhenoGen
RatGTEx ENSRNOG00000009855 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6JEQ3 ENTREZGENE, UniProtKB/TrEMBL
  F7EMJ6 ENTREZGENE, UniProtKB/TrEMBL
  Q66HL5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpina5  serpin family A member 5  Serpina5  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpina5  serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5  Serpina5  serpin peptidase inhibitor, clade A, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpina5  serpin peptidase inhibitor, clade A, member 5  Serpina5  serine (or cysteine) peptidase inhibitor, clade A, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Serpina5  serine (or cysteine) peptidase inhibitor, clade A, member 5  Pci  protein C inhibitor  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pci  protein C inhibitor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is androgen dependent 633526