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Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) Rattus norvegicus
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Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Description: Predicted to have Rac guanyl-nucleotide exchange factor activity and phospholipid binding activity. Involved in positive regulation of cell migration; regulation of actin filament polymerization; and regulation of dendrite development. Localizes to the neuron projection; perinuclear region of cytoplasm; and plasma membrane. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC311647; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; RGD1306534; similar to P-Rex1
Orthologs:
Allele / Splice: Prex1em2Mcwi  
Genetic Models: SS-Prex1em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated
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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Prex1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306534
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.