Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) - Rat Genome Database

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Gene: Prex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1) Rattus norvegicus
Analyze
Symbol: Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
RGD ID: 1306534
Description: Predicted to enable GTPase activator activity; guanyl-nucleotide exchange factor activity; and phospholipid binding activity. Involved in positive regulation of cell migration; regulation of actin filament polymerization; and regulation of dendrite development. Located in dendritic shaft; growth cone; and perinuclear region of cytoplasm. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311647; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; RGD1306534; similar to P-Rex1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Prex1em2Mcwi  
Genetic Models: SS-Prex1em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,724,939 - 175,875,764 (-)NCBIGRCr8
mRatBN7.23155,306,950 - 155,456,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,108,046 - 159,257,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,607,015 - 167,756,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,348,709 - 165,498,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cerium trichloride  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
nickel atom  (ISO)
nitrogen dioxide  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Qin J, etal., Oncogene. 2009 Apr 23;28(16):1853-63. Epub 2009 Mar 23.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
8. P-Rex1 - a multidomain protein that regulates neurite differentiation. Waters JE, etal., J Cell Sci. 2008 Sep 1;121(Pt 17):2892-903. Epub 2008 Aug 12.
9. Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration. Yoshizawa M, etal., J Neurosci. 2005 Apr 27;25(17):4406-19.
Additional References at PubMed
PMID:11955434   PMID:21178006   PMID:21179475   PMID:26514267   PMID:33347743  


Genomics

Comparative Map Data
Prex1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83175,724,939 - 175,875,764 (-)NCBIGRCr8
mRatBN7.23155,306,950 - 155,456,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,108,046 - 159,257,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03167,607,015 - 167,756,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,348,709 - 165,498,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,329,580 - 163,477,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03169,494,331 - 169,575,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43157,693,897 - 157,863,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13157,599,463 - 157,770,600 (-)NCBI
Celera3153,891,483 - 154,040,542 (-)NCBICelera
Cytogenetic Map3q42NCBI
PREX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382048,624,252 - 48,888,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2048,624,252 - 48,827,999 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,240,790 - 47,444,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362046,674,200 - 46,877,827 (-)NCBINCBI36Build 36hg18NCBI36
Celera2043,945,979 - 44,149,646 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2043,990,060 - 44,195,320 (-)NCBIHuRef
CHM1_12047,145,458 - 47,349,091 (-)NCBICHM1_1
T2T-CHM13v2.02050,394,065 - 50,597,825 (-)NCBIT2T-CHM13v2.0
Prex1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,408,265 - 166,555,752 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,408,262 - 166,555,752 (-)EnsemblGRCm39 Ensembl
GRCm382166,566,345 - 166,713,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2166,566,342 - 166,713,832 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,391,845 - 166,539,332 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,256,959 - 166,405,037 (-)NCBIMGSCv36mm8
Celera2172,502,260 - 172,653,067 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.09NCBI
Prex1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554459,229,793 - 9,398,662 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554459,229,775 - 9,401,277 (+)NCBIChiLan1.0ChiLan1.0
PREX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,369,425 - 54,573,462 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12054,362,530 - 54,566,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02044,965,850 - 45,169,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,034,724 - 46,157,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,033,937 - 46,226,500 (-)Ensemblpanpan1.1panPan2
PREX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12435,403,078 - 35,503,428 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2435,404,564 - 35,582,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2434,646,334 - 34,825,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,111,037 - 36,287,341 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,112,187 - 36,287,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,349,797 - 35,528,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02435,484,549 - 35,662,320 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,026,106 - 36,205,507 (-)NCBIUU_Cfam_GSD_1.0
Prex1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,903,846 - 189,990,356 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365145,368,629 - 5,444,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365145,291,473 - 5,443,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1750,354,775 - 50,550,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11750,352,273 - 50,550,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PREX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1215,152,001 - 15,354,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl215,152,096 - 15,354,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605063,656,144 - 63,859,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prex1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247906,453,066 - 6,637,597 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247906,453,085 - 6,622,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prex1
743 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:67
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000009517
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
D3Got151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,414,056 - 155,414,238 (+)MAPPERmRatBN7.2
Rnor_6.03163,435,007 - 163,435,188NCBIRnor6.0
Rnor_5.03169,599,540 - 169,599,721UniSTSRnor5.0
RGSC_v3.43157,820,472 - 157,820,654RGDRGSC3.4
RGSC_v3.43157,820,473 - 157,820,654UniSTSRGSC3.4
RGSC_v3.13157,726,509 - 157,726,690RGD
Celera3153,998,020 - 153,998,201UniSTS
RH 3.4 Map31464.6UniSTS
RH 3.4 Map31464.6RGD
RH 2.0 Map31004.9RGD
Cytogenetic Map3q42UniSTS
D3Cebr5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,367,549 - 155,367,700 (+)MAPPERmRatBN7.2
Rnor_6.03163,388,554 - 163,388,704NCBIRnor6.0
Rnor_5.03169,553,087 - 169,553,237UniSTSRnor5.0
RGSC_v3.43157,773,968 - 157,774,118UniSTSRGSC3.4
Celera3153,951,467 - 153,951,617UniSTS
Cytogenetic Map3q42UniSTS
BB045044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,425,628 - 155,425,707 (+)MAPPERmRatBN7.2
Rnor_6.03163,446,579 - 163,446,657NCBIRnor6.0
Rnor_5.03169,611,112 - 169,611,190UniSTSRnor5.0
RGSC_v3.43157,832,426 - 157,832,504UniSTSRGSC3.4
Celera3154,009,618 - 154,009,696UniSTS
Cytogenetic Map3q42UniSTS
AU049770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,434,203 - 155,434,379 (+)MAPPERmRatBN7.2
Rnor_6.03163,455,154 - 163,455,329NCBIRnor6.0
Rnor_6.03163,051,700 - 163,051,875NCBIRnor6.0
Rnor_5.03169,221,539 - 169,221,714UniSTSRnor5.0
Rnor_5.03169,619,687 - 169,619,862UniSTSRnor5.0
RGSC_v3.43157,841,001 - 157,841,176UniSTSRGSC3.4
Celera3154,018,189 - 154,018,364UniSTS
Cytogenetic Map3q42UniSTS
STS-Z39767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,337,564 - 155,338,153 (+)MAPPERmRatBN7.2
Rnor_6.03163,359,583 - 163,360,171NCBIRnor6.0
Rnor_5.03169,524,116 - 169,524,704UniSTSRnor5.0
RGSC_v3.43157,724,858 - 157,725,446UniSTSRGSC3.4
Celera3153,922,123 - 153,922,711UniSTS
Cytogenetic Map3q42UniSTS


Genetic Models
This gene Prex1 is modified in the following models/strains:
SS-Prex1em2Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 10 2 19 2 74 23 26 11
Low 1 17 47 39 39 8 11 12 15 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009517   ⟹   ENSRNOP00000009517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,308,495 - 155,456,688 (-)Ensembl
Rnor_6.0 Ensembl3163,329,975 - 163,477,715 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108011   ⟹   ENSRNOP00000096783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,306,950 - 155,456,688 (-)Ensembl
RefSeq Acc Id: NM_001135718   ⟹   NP_001129190
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,726,012 - 175,875,764 (-)NCBI
mRatBN7.23155,306,950 - 155,456,688 (-)NCBI
Rnor_6.03163,329,580 - 163,477,822 (-)NCBI
Rnor_5.03169,494,331 - 169,575,981 (-)NCBI
RGSC_v3.43157,693,897 - 157,863,943 (-)RGD
Celera3153,891,483 - 154,040,542 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105138   ⟹   XP_038961066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83175,724,939 - 175,751,749 (-)NCBI
mRatBN7.23155,306,954 - 155,332,712 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001129190 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96434 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009517.8
  ENSRNOP00000096783
  ENSRNOP00000096783.1
Reference Protein Sequences
RefSeq Acc Id: NP_001129190   ⟸   NM_001135718
- UniProtKB: A0A8I6GLR6 (UniProtKB/TrEMBL),   D3ZS72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009517   ⟸   ENSRNOT00000009517
RefSeq Acc Id: XP_038961066   ⟸   XM_039105138
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000096783   ⟸   ENSRNOT00000108011
Protein Domains
DEP   DH   PDZ   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS72-F1-model_v2 AlphaFold D3ZS72 1-1643 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692684
Promoter ID:EPDNEW_R3209
Type:initiation region
Name:Prex1_1
Description:phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchangefactor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03163,477,800 - 163,477,860EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306534 AgrOrtholog
BioCyc Gene G2FUF-46766 BioCyc
Ensembl Genes ENSRNOG00000006952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009517.8 UniProtKB/TrEMBL
  ENSRNOT00000108011 ENTREZGENE
  ENSRNOT00000108011.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DEP_dom UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:311647 UniProtKB/TrEMBL
NCBI Gene 311647 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Prex1 PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006952 RatGTEx
SMART DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8I6GLR6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS72 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-01 Prex1  phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1  RGD1306534  similar to P-Rex1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306534  similar to P-Rex1   RGD1306534_predicted  similar to P-Rex1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306534_predicted  similar to P-Rex1 (predicted)  LOC311647_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311647_predicted  similar to P-Rex1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL