Ror2 (receptor tyrosine kinase-like orphan receptor 2) - Rat Genome Database
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Gene: Ror2 (receptor tyrosine kinase-like orphan receptor 2) Rattus norvegicus
Analyze
Symbol: Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
RGD ID: 1305275
Description: Predicted to have several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and positive regulation of protein serine/threonine kinase activity. Localizes to several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC306782; tyrosine-protein kinase transmembrane receptor ROR2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21711,972,830 - 12,148,152 (+)NCBI
Rnor_6.0 Ensembl1711,953,552 - 12,134,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01711,953,552 - 12,134,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01714,049,344 - 14,228,982 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41717,735,999 - 17,917,032 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11717,736,906 - 17,919,811 (-)NCBI
Celera1711,736,765 - 11,913,446 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte development  (IDA)
BMP signaling pathway  (ISO)
bone mineralization  (IEP)
cartilage condensation  (ISO)
cell differentiation  (ISO)
cell fate commitment  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic genitalia morphogenesis  (ISO)
inner ear morphogenesis  (ISO)
JNK cascade  (ISO)
macrophage migration  (IMP)
male genitalia development  (IEP)
multicellular organism development  (IBA)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of JUN kinase activity  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of macrophage differentiation  (IMP)
positive regulation of MAPK cascade  (IBA)
positive regulation of neuron projection development  (IBA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA)
positive regulation of protein kinase C activity  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transcription, DNA-templated  (ISO)
regulation of canonical Wnt signaling pathway  (ISO)
skeletal system development  (ISO)
SMAD protein signal transduction  (ISO)
smoothened signaling pathway  (ISO)
somitogenesis  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
Wnt signaling pathway, calcium modulating pathway  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Cerpa W, etal., Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4797-802. doi: 10.1073/pnas.1417053112. Epub 2015 Mar 30.
2. Dong S, etal., Ann Clin Lab Sci. 2015 Winter;45(1):94-9.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Habib R, etal., Clin Dysmorphol. 2013 Apr;22(2):47-50. doi: 10.1097/MCD.0b013e32835c6c8c.
6. Harisis GN, etal., J Pediatr Surg. 2013 Jul;48(7):1573-7. doi: 10.1016/j.jpedsurg.2012.08.038.
7. Huang D, etal., Gene. 2014 Aug 15;547(1):106-10. doi: 10.1016/j.gene.2014.06.035. Epub 2014 Jun 19.
8. Li CM, etal., Yi Chuan. 2011 Feb;33(2):147-52.
9. Lv D, etal., J Hum Genet. 2009 Jul;54(7):422-5. doi: 10.1038/jhg.2009.48. Epub 2009 May 22.
10. MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline
12. Paganoni S, etal., Glia. 2004 May;46(4):456-66.
13. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Raz R, etal., Development. 2008 May;135(9):1713-23. doi: 10.1242/dev.015149. Epub 2008 Mar 19.
15. RGD automated data pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. RGD comprehensive gene curation
19. Schwabe GC, etal., Dev Dyn. 2004 Feb;229(2):400-10.
20. Tamhankar PM, etal., J Clin Res Pediatr Endocrinol. 2014;6(2):79-83. doi: 10.4274/Jcrpe.1233.
21. Wang H, etal., Chin Med J (Engl). 2012 Feb;125(3):476-80.
22. Xin H, etal., Int J Mol Med. 2013 Mar;31(3):583-8. doi: 10.3892/ijmm.2013.1242. Epub 2013 Jan 15.
23. Yang T, etal., J Dent Res. 2015 Jun;94(6):803-12. doi: 10.1177/0022034515576051. Epub 2015 Mar 6.
Additional References at PubMed
PMID:10700181   PMID:12839624   PMID:15702250   PMID:16602827   PMID:18215320   PMID:18606138   PMID:18762249   PMID:19486338   PMID:20660756   PMID:22609204   PMID:26003414  


Genomics

Comparative Map Data
Ror2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21711,972,830 - 12,148,152 (+)NCBI
Rnor_6.0 Ensembl1711,953,552 - 12,134,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01711,953,552 - 12,134,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01714,049,344 - 14,228,982 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41717,735,999 - 17,917,032 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11717,736,906 - 17,919,811 (-)NCBI
Celera1711,736,765 - 11,913,446 (+)NCBICelera
Cytogenetic Map17p14NCBI
ROR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl991,563,091 - 91,950,228 (-)EnsemblGRCh38hg38GRCh38
GRCh38991,722,598 - 91,950,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37994,484,883 - 94,712,510 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37994,484,878 - 94,712,444 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36993,524,705 - 93,752,265 (-)NCBINCBI36hg18NCBI36
Build 34991,564,438 - 91,791,999NCBI
Celera964,921,783 - 65,148,752 (-)NCBI
Cytogenetic Map9q22.31NCBI
HuRef964,163,034 - 64,390,111 (-)NCBIHuRef
CHM1_1994,631,872 - 94,858,883 (-)NCBICHM1_1
Ror2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391353,263,353 - 53,440,160 (-)NCBIGRCm39mm39
GRCm381353,109,317 - 53,286,124 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1353,109,312 - 53,286,124 (-)EnsemblGRCm38mm10GRCm38
MGSCv371353,204,686 - 53,381,478 (-)NCBIGRCm37mm9NCBIm37
MGSCv361353,121,749 - 53,293,643 (-)NCBImm8
Celera1354,186,098 - 54,362,690 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1327.68NCBI
Ror2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955515313,604 - 553,774 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955515313,612 - 554,751 (+)NCBIChiLan1.0ChiLan1.0
ROR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1990,879,826 - 90,939,834 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl990,851,983 - 90,965,084 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0962,782,183 - 63,005,626 (-)NCBIMhudiblu_PPA_v0panPan3
ROR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl195,088,745 - 95,280,151 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1195,209,122 - 95,280,956 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ror2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936796630,307 - 675,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,804,061 - 3,035,241 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,803,840 - 3,035,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2143,602,862 - 3,834,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112102,172,288 - 102,397,297 (-)NCBI
Ror2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624868479,303 - 732,723 (+)NCBI

Position Markers
D17Got13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01712,081,372 - 12,081,504NCBIRnor6.0
Rnor_5.01714,175,968 - 14,176,100UniSTSRnor5.0
RGSC_v3.41717,788,879 - 17,789,012RGDRGSC3.4
RGSC_v3.41717,788,880 - 17,789,012UniSTSRGSC3.4
RGSC_v3.11717,788,880 - 17,789,012RGD
Celera1711,860,445 - 11,860,585UniSTS
RH 3.4 Map17114.1RGD
RH 3.4 Map17114.1UniSTS
RH 2.0 Map1784.7RGD
Cytogenetic Map17p14UniSTS
BF389188  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01712,080,047 - 12,080,217NCBIRnor6.0
Rnor_5.01714,174,643 - 14,174,813UniSTSRnor5.0
RGSC_v3.41717,790,167 - 17,790,337UniSTSRGSC3.4
Celera1711,859,120 - 11,859,290UniSTS
RH 3.4 Map17112.7UniSTS
Cytogenetic Map17p14UniSTS
BF416265  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01712,133,997 - 12,134,192NCBIRnor6.0
Rnor_5.01714,228,593 - 14,228,788UniSTSRnor5.0
RGSC_v3.41717,736,193 - 17,736,388UniSTSRGSC3.4
Celera1711,913,057 - 11,913,252UniSTS
RH 3.4 Map17113.8UniSTS
Cytogenetic Map17p14UniSTS
AU048412  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01712,061,034 - 12,061,248NCBIRnor6.0
Rnor_5.01714,155,630 - 14,155,844UniSTSRnor5.0
RGSC_v3.41717,808,957 - 17,809,171UniSTSRGSC3.4
Cytogenetic Map17p14UniSTS
Ror2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01712,133,146 - 12,134,095NCBIRnor6.0
Rnor_5.01714,227,742 - 14,228,691UniSTSRnor5.0
Celera1711,912,206 - 11,913,155UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17333697224030841Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17333697224030841Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17341403928073589Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17471606727691136Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17471606727691136Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17519104750191047Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17519104750191047Rat
1581553Pur14Proteinuria QTL 145.30.0001total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17842446716620067Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17973026321491085Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17973026321491085Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17973026321491085Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17973026321491085Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17982730454827304Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)171052970942542027Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:578
Count of miRNA genes:290
Interacting mature miRNAs:357
Transcripts:ENSRNOT00000015504
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 2 2 2 12 18 27
Low 3 6 35 25 13 25 2 3 60 17 13 11 2
Below cutoff 10 19 13 6 13 6 8 2 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090782   ⟹   ENSRNOP00000069636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1711,953,552 - 12,134,386 (+)Ensembl
RefSeq Acc Id: NM_001107339   ⟹   NP_001100809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21711,972,830 - 12,148,152 (+)NCBI
Rnor_6.01711,953,552 - 12,134,386 (+)NCBI
Rnor_5.01714,049,344 - 14,228,982 (+)NCBI
RGSC_v3.41717,735,999 - 17,917,032 (-)RGD
Celera1711,736,765 - 11,913,446 (+)RGD
Sequence:
RefSeq Acc Id: XM_017600508   ⟹   XP_017455997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21712,037,411 - 12,148,151 (+)NCBI
Rnor_6.01712,022,295 - 12,134,385 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100809 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98062 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100809   ⟸   NM_001107339
- Peptide Label: precursor
- UniProtKB: D3ZNY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455997   ⟸   XM_017600508
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000069636   ⟸   ENSRNOT00000090782
Protein Domains
FZ   Ig-like   Kringle   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700332
Promoter ID:EPDNEW_R10856
Type:initiation region
Name:Ror2_1
Description:receptor tyrosine kinase-like orphan receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01711,953,527 - 11,953,587EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 12132873 12132874 C T snv ACI/N (MCW), WN/N (MCW), MR/N (MCW), F344/NRrrc (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305275 AgrOrtholog
Ensembl Genes ENSRNOG00000053232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069636 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090782 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Frizzled-like_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Tyr_kinase_rcpt_ROR_subgr UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:306782 UniProtKB/TrEMBL
NCBI Gene 306782 ENTREZGENE
Pfam I-set UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Ror2 PhenoGen
PIRSF TyrPK_TMrec_ROR UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt D3ZNY8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ror2  receptor tyrosine kinase-like orphan receptor 2   Ror2_predicted  receptor tyrosine kinase-like orphan receptor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ror2_predicted  receptor tyrosine kinase-like orphan receptor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED