Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PKD1L2 mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pkd1l2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PKD1L2 gene | CTD | PMID:21212295 | 2-palmitoylglycerol | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of PKD1L2 mRNA | CTD | PMID:37199045 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PKD1L2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1L2 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Pkd1l2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PKD1L2 gene | CTD | PMID:31683443 | 5-aza-2'-deoxycytidine | affects expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Decitabine affects the expression of PKD1L2 mRNA | CTD | PMID:23300844 | acrylamide | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of PKD1L2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PKD1L2 exon | CTD | PMID:30157460 | aflatoxin B1 | affects methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of PKD1L2 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PKD1L2 intron | CTD | PMID:30157460 | aldrin | decreases expression | ISO | Pkd1l2 (Mus musculus) | 6480464 | Aldrin results in decreased expression of PKD1L2 mRNA | CTD | PMID:18579281 | antirheumatic drug | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PKD1L2 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | affects methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PKD1L2 intron and Benzo(a)pyrene affects the methylation of PKD1L2 promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PKD1L2 mRNA | CTD | PMID:32234424 | benzo[e]pyrene | affects methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | benzo(e)pyrene affects the methylation of PKD1L2 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Pkd1l2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PKD1L2 mRNA | CTD | PMID:26063408 | bisphenol A | decreases methylation | ISO | Pkd1l2 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of PKD1L2 promoter | CTD | PMID:27312807 | bisphenol A | increases methylation | ISO | Pkd1l2 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of PKD1L2 promoter | CTD | PMID:27312807 | bisphenol A | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PKD1L2 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PKD1L2 mRNA | CTD | PMID:28628672 and PMID:31601247 | bisphenol A | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PKD1L2 mRNA | CTD | PMID:27685785 | bisphenol F | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1L2 mRNA | CTD | PMID:28628672 | butanal | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PKD1L2 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PKD1L2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PKD1L2 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PKD1L2 gene] | CTD | PMID:28238834 | chloroethene | decreases expression | ISO | Pkd1l2 (Mus musculus) | 6480464 | Vinyl Chloride results in decreased expression of PKD1L2 mRNA | CTD | PMID:18579281 | cisplatin | affects expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of PKD1L2 mRNA | CTD | PMID:23300844 | cisplatin | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of PKD1L2 mRNA | CTD | PMID:27392435 | dexamethasone | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PKD1L2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1L2 mRNA | CTD | PMID:28628672 | dicrotophos | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PKD1L2 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethyl methanesulfonate | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of PKD1L2 mRNA | CTD | PMID:23649840 | formaldehyde | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PKD1L2 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PKD1L2 gene | CTD | PMID:31601247 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PKD1L2 mRNA | CTD | PMID:33387578 | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of PKD1L2 gene | CTD | PMID:31011160 | indometacin | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PKD1L2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1L2 mRNA | CTD | PMID:28628672 | lipopolysaccharide | multiple interactions | ISO | Pkd1l2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of PKD1L2 gene | CTD | PMID:21212295 | mercury dibromide | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of PKD1L2 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKD1L2 mRNA | CTD | PMID:27188386 | methapyrilene | affects methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | Methapyrilene affects the methylation of PKD1L2 intron | CTD | PMID:30157460 | methyl methanesulfonate | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PKD1L2 mRNA | CTD | PMID:23649840 | O-methyleugenol | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of PKD1L2 mRNA | CTD | PMID:32234424 | ozone | increases expression | ISO | Pkd1l2 (Mus musculus) | 6480464 | Ozone results in increased expression of PKD1L2 mRNA | CTD | PMID:31626304 | ozone | multiple interactions | ISO | Pkd1l2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PKD1L2 mRNA | CTD | PMID:27106289 | p-chloromercuribenzoic acid | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of PKD1L2 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKD1L2 mRNA | CTD | PMID:27188386 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PKD1L2 mRNA | CTD | PMID:33387578 | pentanal | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | pentanal results in decreased expression of PKD1L2 mRNA | CTD | PMID:26079696 | phenylmercury acetate | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKD1L2 mRNA | CTD | PMID:27188386 | SB 431542 | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PKD1L2 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PKD1L2 mRNA | CTD | PMID:34032870 | sotorasib | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PKD1L2 mRNA | CTD | PMID:36139627 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PKD1L2 mRNA | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PKD1L2 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Pkd1l2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PKD1L2 mRNA | CTD | PMID:29264374 | trametinib | multiple interactions | ISO | PKD1L2 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PKD1L2 mRNA | CTD | PMID:36139627 | urethane | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Urethane results in decreased expression of PKD1L2 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | PKD1L2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PKD1L2 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | PKD1L2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PKD1L2 mRNA | CTD | PMID:24383497 | |