thalidomide - Ontology Report - Rat Genome Database

thalidomide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	thalidomide	go back to main search page
Accession:	CHEBI:9513	browse the term
Definition:	A racemate comprising equimolar amounts of R- and S-thalidomide.
Synonyms:	exact_synonym:	rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
	related_synonym:	1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline; 2,6-dioxo-3-phthalimidopiperidine; 3-phthalimidoglutarimide; Distaval; Formula=C13H10N2O4; K-17; N-(2,6-dioxo-3-piperidyl)phthalimide; N-Phthalyl-glutaminsaeure-imid; N-phthaloylglutamimide; N-phthalylglutamic acid imide; Sedalis; Softenon; Talimol; alpha-(N-phthalimido)glutarimide; alpha-N-phthalylglutaramide; alpha-phthalimidoglutarimide; talidomida; thalidomidum
	xref:	CAS:50-35-1; DrugBank:DB01041; HMDB:HMDB0015175; KEGG:C07910; KEGG:D00754; LINCS:LSM-1914
	xref_mesh:	MESH:D013792
	xref:	PMID:11349879; PMID:11803357; PMID:12724820; PMID:14689682; PMID:17449064; PMID:18925849; PMID:21207098; PMID:2694291; PMID:8469046; Patent:GB768821; Patent:US2012142734; Patent:WO2013100657; Reaxys:30233; Wikipedia:Thalidomide

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Genes (473)

thalidomide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

decreases expression

Thalidomide results in decreased expression of AADAT mRNA

NCBI chr16:34,520,236...34,566,388
Ensembl chr16:29,509,394...29,544,332

G

ATP binding cassette subfamily A member 1

increases response to substance

ABCA1 gene SNP results in increased susceptibility to Thalidomide

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

decreases expression
decreases activity

Thalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 protein
Thalidomide results in decreased activity of ABCB1 protein

PMID:15920492 PMID:19840843

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression
increases activity

Thalidomide results in increased expression of ABCB1B protein
Thalidomide results in increased activity of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

acid phosphatase 5, tartrate resistant

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 protein

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:20,663,985...20,667,929

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

[Thalidomide co-treated with Dimethylnitrosamine] results in decreased expression of ACTA2 protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Thalidomide results in decreased expression of ACTA2 protein

PMID:16604421 PMID:16943688 PMID:17030452 PMID:17174718

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actinin alpha 2

decreases expression

Thalidomide results in decreased expression of ACTN2 mRNA

PMID:26006729 PMID:26217789

NCBI chr17:62,835,055...62,902,331
Ensembl chr17:58,142,625...58,210,622

G

actin related protein 6

decreases expression

Thalidomide results in decreased expression of ACTR6 mRNA

NCBI chr 7:24,150,250...24,171,057
Ensembl chr 7:24,150,250...24,171,067

G

adenylosuccinate synthase 1

decreases expression

Thalidomide results in decreased expression of ADSS1 mRNA

NCBI chr 6:137,500,549...137,523,087
Ensembl chr 6:131,679,701...131,701,998

G

ALF transcription elongation factor 2

decreases expression

Thalidomide results in decreased expression of AFF2 mRNA

NCBI chr X:152,972,579...153,477,080
Ensembl chr X:147,928,407...148,429,995

G

AKT serine/threonine kinase 1

decreases phosphorylation
increases phosphorylation
decreases activity

Thalidomide analog results in decreased phosphorylation of AKT1 protein
Thalidomide analog results in increased phosphorylation of AKT1 protein
Thalidomide results in decreased activity of AKT1 protein

PMID:15067094 PMID:15858615

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

Thalidomide results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:71,877,850...71,957,107

G

alkaline phosphatase, intestinal

increases expression

Thalidomide results in increased expression of ALPI mRNA

NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:87,773,411...87,776,877

G

alpha-methylacyl-CoA racemase

decreases expression

Thalidomide results in decreased expression of AMACR mRNA

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:59,946,153...59,958,255

G

angiopoietin 2

affects expression

Thalidomide affects the expression of ANGPT2 mRNA

NCBI chr16:77,790,760...77,841,241
Ensembl chr16:71,088,364...71,138,804

G

ankyrin repeat domain 37

decreases expression

Thalidomide results in decreased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:46,268,443...46,271,963

G

annexin A2

decreases expression

Thalidomide results in decreased expression of ANXA2 mRNA; Thalidomide results in decreased expression of ANXA2 protein

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658

G

APAF1 interacting protein

decreases expression

Thalidomide results in decreased expression of APIP mRNA

NCBI chr 3:109,886,919...109,913,295
Ensembl chr 3:89,432,037...89,458,340

G

apelin

decreases expression

Thalidomide results in decreased expression of APLN mRNA

NCBI chr X:132,058,739...132,091,518
Ensembl chr X:127,203,823...127,213,391

G

aquaporin 4

increases expression

Thalidomide results in increased expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 5

increases expression

Thalidomide results in increased expression of AQP5 mRNA

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:130,721,748...130,726,209

G

Rho GDP dissociation inhibitor alpha

increases expression

Thalidomide results in increased expression of ARHGDIA mRNA

NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023

G

actin related protein 2/3 complex, subunit 4

decreases expression

Thalidomide results in decreased expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:146,522,176...146,532,785

G

aristaless related homeobox

increases expression

Thalidomide results in increased expression of ARX mRNA

NCBI chr X:62,010,097...62,022,009
Ensembl chr X:58,016,233...58,028,142

G

adipocyte-related X-chromosome expressed sequence 1

decreases expression

Thalidomide results in decreased expression of ARXES1 mRNA

NCBI chr X:98,950,530...98,952,049
Ensembl chr X:98,950,528...98,952,045

G

ankyrin repeat and SOCS box-containing 12

decreases expression

Thalidomide results in decreased expression of ASB12 mRNA

NCBI chr X:60,328,325...60,478,031
Ensembl chr X:60,328,328...60,415,619

G

activating transcription factor 3

increases expression

Thalidomide analog results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

aurora kinase A

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Thalidomide results in increased expression of BAX mRNA
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]

PMID:18291259 PMID:33015978

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

B-cell receptor-associated protein 29

decreases expression

Thalidomide results in decreased expression of BCAP29 mRNA

NCBI chr 6:53,910,209...53,950,206
Ensembl chr 6:48,182,706...48,222,720

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein
Thalidomide results in decreased expression of BCL2 protein
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]

PMID:15867202 PMID:15982930 PMID:33015978

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Thalidomide results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

bradykinin receptor B1

multiple interactions

Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747

G

beclin 1

multiple interactions

Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

BCL2 interacting protein like

increases expression

Thalidomide results in increased expression of BNIPL mRNA

NCBI chr 2:185,507,591...185,519,415
Ensembl chr 2:182,818,595...182,828,588

G

biorientation of chromosomes in cell division 1

decreases expression

Thalidomide results in decreased expression of BOD1 mRNA

NCBI chr10:16,497,918...16,504,259
Ensembl chr10:15,993,454...15,999,787

G

bone marrow stromal cell antigen 2

decreases expression

Thalidomide results in decreased expression of BST2 mRNA

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,217,407...18,220,979

G

BUB1 mitotic checkpoint serine/threonine kinase B

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

complement C3

decreases expression

Thalidomide results in decreased expression of C3 protein

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429

G

calcium voltage-gated channel subunit alpha1 C

decreases expression

Thalidomide results in decreased expression of CACNA1C mRNA

PMID:26006729 PMID:26217789

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648

G

calcium voltage-gated channel auxiliary subunit beta 4

decreases expression

Thalidomide results in decreased expression of CACNB4 mRNA

NCBI chr 3:57,315,900...57,578,271
Ensembl chr 3:36,910,427...37,168,944

G

calbindin 1

decreases expression

Thalidomide results in decreased expression of CALB1 mRNA

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:29,375,642...29,402,431

G

caspase 3

decreases activity
increases activity
increases expression

Thalidomide results in decreased activity of CASP3 protein
Thalidomide results in increased activity of CASP3 protein
Thalidomide results in increased expression of CASP3 mRNA

PMID:14682394 PMID:15067094 PMID:18291259

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage
decreases expression

Thalidomide analog results in increased cleavage of CASP8 protein
Thalidomide results in decreased expression of CASP8 mRNA

PMID:15858615 PMID:26217789

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases activity

Thalidomide results in decreased activity of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

cytosolic arginine sensor for mTORC1 subunit 1

decreases expression

Thalidomide results in decreased expression of CASTOR1 mRNA

NCBI chr14:83,309,710...83,314,123
Ensembl chr14:79,086,136...79,090,548

G

catalase

multiple interactions

CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

decreases expression

Thalidomide results in decreased expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

coiled-coil domain containing 141

decreases expression

Thalidomide results in decreased expression of CCDC141 mRNA

NCBI chr 3:82,357,046...82,517,199
Ensembl chr 3:61,948,646...62,110,079

G

C-C motif chemokine ligand 2

decreases expression

Thalidomide analog results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases expression

Thalidomide results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

cyclin A2

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

decreases expression

Thalidomide analog results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin O

increases expression

Thalidomide results in increased expression of CCNO mRNA

NCBI chr 2:46,364,074...46,367,113
Ensembl chr 2:44,626,369...44,633,914

G

CD24 molecule

affects expression

Thalidomide affects the expression of CD24A mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662

G

CD274 molecule

decreases expression
multiple interactions

Thalidomide results in decreased expression of CD274 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CD274 protein]

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450

G

cell division cycle 20

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

CDC42 effector protein 5

decreases expression

Thalidomide results in decreased expression of CDC42EP5 mRNA

PMID:26006729 PMID:26217789

NCBI chr 1:79,108,036...79,110,550

G

cadherin 1

increases expression
multiple interactions

Thalidomide results in increased expression of CDH1 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in increased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 10

decreases expression

Thalidomide results in decreased expression of CDH10 mRNA

NCBI chr 2:70,355,521...70,577,880
Ensembl chr 2:68,628,780...68,850,995

G

cadherin 2

decreases expression
multiple interactions

Thalidomide results in decreased expression of CDH2 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CDH2 protein]

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cadherin 6

increases expression

Thalidomide results in increased expression of CDH6 mRNA

NCBI chr 2:63,801,630...63,952,309
Ensembl chr 2:62,079,137...62,225,228

G

cyclin-dependent kinase 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

centromere protein A

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein F

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:101,184,127...101,229,669

G

cerberus 1, DAN family BMP antagonist

decreases expression

Thalidomide results in decreased expression of CER1 mRNA

NCBI chr 5:102,352,364...102,355,720
Ensembl chr 5:97,306,431...97,309,783

G

cripto, FRL-1, cryptic family 1

decreases expression

Thalidomide results in decreased expression of CFC1 mRNA

NCBI chr 9:44,234,997...44,247,846
Ensembl chr 9:36,739,071...36,751,930

G

CASP8 and FADD-like apoptosis regulator

decreases expression

Thalidomide results in decreased expression of CFLAR protein

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065

G

churchill domain containing 1

decreases expression

Thalidomide results in decreased expression of CHURC1 mRNA

NCBI chr 6:101,203,778...101,218,364
Ensembl chr 6:95,470,683...95,619,586

G

claudin 4

increases expression

Thalidomide results in increased expression of CLDN4 mRNA

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436

G

claudin domain containing 1

decreases expression

Thalidomide results in decreased expression of CLDND1 mRNA

NCBI chr11:55,352,321...55,358,779
Ensembl chr11:41,883,134...41,889,354

G

C-type lectin domain containing 9A

decreases expression

Thalidomide results in decreased expression of CLEC9A mRNA

NCBI chr 4:162,859,742...162,875,742
Ensembl chr 4:162,860,308...162,875,352

G

collagen type I alpha 1 chain

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

complexin 3

decreases expression

Thalidomide results in decreased expression of CPLX3 mRNA

NCBI chr 8:66,899,438...66,906,200
Ensembl chr 8:58,003,535...58,010,297

G

cereblon

multiple interactions
affects binding
affects response to substance

Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
Thalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN protein
CRBN gene SNP affects the susceptibility to Thalidomide
Thalidomide binds to [CRBN protein binds to DDB1 protein]

PMID:25043012 PMID:25108355 PMID:27751757 PMID:30067223

NCBI chr 4:141,255,400...141,276,722
Ensembl chr 4:139,701,094...139,719,938

G

cAMP responsive element binding protein 5

decreases expression

Thalidomide results in decreased expression of CREB5 mRNA

NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:82,393,730...82,790,325

G

CREB3 regulatory factor

increases expression

Thalidomide analog results in increased expression of CREBRF mRNA

NCBI chr10:16,903,607...16,967,450
Ensembl chr10:16,404,596...16,461,999

G

cripto, EGF-CFC family member

decreases expression

Thalidomide results in decreased expression of CRIPTO mRNA

PMID:26006729 PMID:26217789

NCBI chr 8:119,803,182...119,808,714
Ensembl chr 8:110,925,024...110,930,308

G

C-reactive protein

decreases expression

Thalidomide results in decreased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 2

decreases activity

Thalidomide results in decreased activity of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

decreases activity

Thalidomide results in decreased activity of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

chondroitin sulfate N-acetylgalactosaminyltransferase 2

decreases expression

Thalidomide results in decreased expression of CSGALNACT2 mRNA

NCBI chr 4:152,944,154...152,981,237
Ensembl chr 4:151,277,645...151,308,839

G

C-X-C motif chemokine ligand 10

increases expression

Thalidomide results in increased expression of CXCL10

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine receptor 1

decreases expression

Thalidomide results in decreased expression of CXCR1 protein

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:75,766,770...75,771,084

G

C-X-C motif chemokine receptor 2

decreases expression

Thalidomide results in decreased expression of CXCR2 protein

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome c, somatic

increases expression

Thalidomide results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Thalidomide results in increased expression of CYP2B6 mRNA

PMID:24460184 PMID:28496040

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases hydroxylation
increases oxidation
multiple interactions

CYP2C19 protein results in increased hydroxylation of Thalidomide
CYP2C19 protein results in increased oxidation of Thalidomide
[CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide

PMID:20443640 PMID:24350712

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases hydroxylation
multiple interactions
increases metabolic processing

Thalidomide results in increased expression of CYP3A4 mRNA; Thalidomide results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Thalidomide
[CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A4 protein results in increased metabolism of Thalidomide

PMID:20443640 PMID:24460184 PMID:28496040 PMID:28745489

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
increases hydroxylation
increases expression
increases metabolic processing

[CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
Thalidomide results in increased expression of CYP3A5 mRNA
CYP3A5 protein results in increased metabolism of Thalidomide

PMID:20443640 PMID:28496040 PMID:28745489

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

cytohesin 3

decreases expression

Thalidomide results in decreased expression of CYTH3 mRNA

NCBI chr12:15,953,781...16,076,584
Ensembl chr12:10,840,157...10,933,812

G

dishevelled associated activator of morphogenesis 2

decreases expression

Thalidomide results in decreased expression of DAAM2 mRNA

NCBI chr 9:18,926,620...19,044,672
Ensembl chr 9:11,428,724...11,545,497

G

dihydrolipoamide branched chain transacylase E2

decreases expression

Thalidomide results in decreased expression of DBT mRNA

NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:204,481,737...204,510,609

G

damage-specific DNA binding protein 1

affects binding

Thalidomide binds to [CRBN protein binds to DDB1 protein]

NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676

G

DNA-damage inducible transcript 3

increases expression

Thalidomide analog results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

defensin alpha 3

increases expression

Thalidomide results in increased expression of DEFA3 mRNA

NCBI chr16:77,235,885...77,238,041
Ensembl chr16:70,533,436...70,535,604

G

defensin beta 15

increases expression

Thalidomide results in increased expression of DEFB15 mRNA

NCBI chr16:76,843,661...76,846,359
Ensembl chr16:70,141,193...70,143,834

G

desmin

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of DES protein]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699

G

Dexi homolog

increases expression

Thalidomide results in increased expression of DEXI mRNA

NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,137,288...5,138,738

G

DLG associated protein 5

decreases expression

Thalidomide results in decreased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:20,633,966...20,664,518

G

delta like non-canonical Notch ligand 1

decreases expression

Thalidomide results in decreased expression of DLK1 mRNA

NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:128,410,316...128,417,522

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Thalidomide analog results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Thalidomide analog results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Thalidomide analog results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Thalidomide results in decreased expression of DNAJC19 mRNA

NCBI chr 2:118,851,497...118,875,813
Ensembl chr 2:116,923,272...116,945,264

G

dihydrouridine synthase 4-like

decreases expression

Thalidomide results in decreased expression of DUS4L mRNA

NCBI chr 6:48,228,111...48,242,553
Ensembl chr 6:48,228,111...48,242,449

G

dual specificity phosphatase 1

increases expression

Thalidomide analog results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

dual specificity phosphatase 10

increases expression

Thalidomide analog results in increased expression of DUSP10 mRNA

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 8

increases expression

Thalidomide analog results in increased expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:197,169,422...197,182,921

G

eukaryotic translation elongation factor 1 epsilon 1

decreases expression

Thalidomide results in decreased expression of EEF1E1 mRNA

NCBI chr17:26,354,247...26,364,953
Ensembl chr17:26,148,633...26,215,720

G

EF-hand calcium binding domain 2

decreases expression

Thalidomide results in decreased expression of EFCAB2 mRNA

NCBI chr13:92,683,182...92,769,939
Ensembl chr13:90,152,185...90,238,218

G

eukaryotic translation initiation factor 1B

decreases expression

Thalidomide results in decreased expression of EIF1B mRNA

NCBI chr 8:129,080,497...129,083,772
Ensembl chr 8:120,203,451...120,206,176
Ensembl chr 5:120,203,451...120,206,176

G

eukaryotic translation initiation factor 4E

decreases expression

Thalidomide results in decreased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683

G

elastase, neutrophil expressed

multiple interactions

Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein]

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100

G

ER membrane protein complex subunit 8

decreases expression

Thalidomide results in decreased expression of EMC8 mRNA

NCBI chr19:65,620,365...65,630,328
Ensembl chr19:48,582,574...48,721,543

G

EPH receptor A10

decreases expression

Thalidomide results in decreased expression of EPHA10 mRNA

NCBI chr 5:142,424,260...142,460,305
Ensembl chr 5:137,140,735...137,174,157

G

Eph receptor B1

decreases expression

Thalidomide results in decreased expression of EPHB1 mRNA

NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:102,507,549...102,944,839

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

[ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

esterase D

decreases expression

Thalidomide results in decreased expression of ESD mRNA

NCBI chr15:56,453,082...56,472,582
Ensembl chr15:50,043,632...50,063,144

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

Thalidomide results in decreased expression of EYA1 mRNA

NCBI chr 5:9,646,599...9,884,609
Ensembl chr 5:4,955,543...5,101,483

G

coagulation factor II (thrombin) receptor

decreases expression

Thalidomide results in decreased expression of F2R mRNA; Thalidomide results in decreased expression of F2R protein

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870

G

fatty acid binding protein 5

decreases expression

Thalidomide results in decreased expression of FABP5 mRNA

NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:91,765,056...91,853,773

G

fatty acid binding protein 7

affects expression

Thalidomide affects the expression of FABP7 mRNA

NCBI chr20:37,667,125...37,673,299
Ensembl chr20:37,123,193...37,126,880

G

family with sequence similarity 174, member B

decreases expression

Thalidomide results in decreased expression of FAM174B mRNA

NCBI chr 1:136,925,162...137,006,082
Ensembl chr 1:127,514,041...127,596,128
Ensembl chr 1:127,514,041...127,596,128

G

Fas cell surface death receptor

decreases expression
increases expression

Thalidomide results in decreased expression of FAS protein
Thalidomide results in increased expression of FAS mRNA

PMID:16531263 PMID:18291259

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions
decreases expression

Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]
Thalidomide results in decreased expression of FASLG protein

PMID:16510725 PMID:16531263

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

flap structure-specific endonuclease 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:206,844,884...206,850,003

G

FYVE, RhoGEF and PH domain containing 3

increases expression

Thalidomide results in increased expression of FGD3 mRNA

NCBI chr17:15,531,237...15,593,678
Ensembl chr17:15,336,837...15,385,712

G

fibroblast growth factor 2

increases response to substance
affects expression
affects secretion
multiple interactions
decreases activity
decreases expression

FGF2 protein results in increased susceptibility to Thalidomide
Thalidomide affects the expression of FGF2 mRNA; Thalidomide affects the expression of FGF2 protein
Thalidomide affects the secretion of FGF2 protein
Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased activity of FGF2 protein
[Temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]
Thalidomide results in decreased expression of FGF2 protein

PMID:11555579 PMID:12644816 PMID:14558594 PMID:15863203 PMID:15939924 More...

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 8

increases expression

Thalidomide results in increased expression of FGF8 mRNA

NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359

G

Fibroblast growth factor receptor 1

affects expression

Thalidomide affects the expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

decreases expression

Thalidomide results in decreased expression of FGFR2 mRNA; Thalidomide results in decreased expression of FGFR2 protein

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

affects expression

Thalidomide affects the expression of FGFR3 mRNA

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Thalidomide analog results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Thalidomide analog results in increased expression of FOSB mRNA

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box C2

decreases expression

Thalidomide results in decreased expression of FOXC2 mRNA

NCBI chr19:66,094,718...66,097,420
Ensembl chr19:49,185,662...49,188,737

G

FAD-dependent oxidoreductase domain containing 1

decreases expression

Thalidomide results in decreased expression of FOXRED1 mRNA

NCBI chr 8:41,789,557...41,818,064
Ensembl chr 8:33,551,013...33,560,192

G

frizzled class receptor 8

decreases expression

Thalidomide results in decreased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:57,314,450...57,320,650

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA]

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046

G

galactose mutarotase

decreases expression

Thalidomide results in decreased expression of GALM mRNA

NCBI chr 6:20,589,775...20,641,516
Ensembl chr 6:14,837,548...14,889,310

G

GATA binding protein 3

increases expression

Thalidomide results in increased expression of GATA3 protein

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391

G

glucosaminyl (N-acetyl) transferase 2

decreases expression

Thalidomide results in decreased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:23,796,859...23,901,611

G

gem (nuclear organelle) associated protein 2

decreases expression

Thalidomide results in decreased expression of GEMIN2 mRNA

NCBI chr 6:76,706,424...76,721,154
Ensembl chr 6:76,707,523...76,721,153

G

GDNF family receptor alpha 2

decreases expression

Thalidomide results in decreased expression of GFRA2 mRNA

NCBI chr15:52,351,499...52,443,369
Ensembl chr15:45,941,828...46,033,714

G

glutamic-oxaloacetic transaminase 1

increases expression

Thalidomide results in increased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633

G

glycoprotein 2

increases expression

Thalidomide results in increased expression of GP2 mRNA

NCBI chr 1:183,228,395...183,243,954
Ensembl chr 1:173,797,057...173,812,619

G

G patch domain containing 4

decreases expression

Thalidomide results in decreased expression of GPATCH4 mRNA

NCBI chr 2:175,797,503...175,816,547
Ensembl chr 2:173,509,897...173,518,684

G

glutathione peroxidase 1

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 8

decreases expression

Thalidomide results in decreased expression of GPX8 mRNA

NCBI chr 2:46,409,646...46,413,401
Ensembl chr 2:44,676,454...44,680,195

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

Thalidomide results in decreased expression of GRIA3 mRNA

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor AMPA type subunit 4

increases expression

Thalidomide results in increased expression of GRIA4 mRNA

NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:1,562,119...2,034,979

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Thalidomide results in decreased expression of GRIN2A mRNA

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Thalidomide results in decreased expression of GRIN2C mRNA

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,488,431...100,506,427

G

general transcription factor IIE subunit 1

decreases expression

Thalidomide results in decreased expression of GTF2E1 mRNA

NCBI chr11:76,687,382...76,720,253
Ensembl chr11:63,182,349...63,213,942

G

GULP PTB domain containing engulfment adaptor 1

decreases expression

Thalidomide results in decreased expression of GULP1 mRNA

NCBI chr 9:54,114,823...54,391,058
Ensembl chr 9:46,622,669...46,899,005

G

H2B clustered histone 12

decreases expression

Thalidomide results in decreased expression of H2BC12 mRNA

NCBI chr17:47,181,477...47,181,940

G

H3 clustered histone 1

decreases expression

Thalidomide results in decreased expression of H3C1 mRNA

NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

decreases expression

Thalidomide results in decreased expression of HCN1 mRNA

NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:49,495,771...49,899,774

G

histone deacetylase 6

multiple interactions

HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]]; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]]; Thalidomide inhibits the reaction [Paraquat results in increased expression of HDAC6 mRNA]

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:14,551,044...14,572,441

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

Thalidomide analog results in increased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,598,417...10,618,424

G

hepatocyte growth factor

affects expression
decreases activity
affects secretion

Thalidomide affects the expression of HGF mRNA; Thalidomide affects the expression of HGF protein
Thalidomide results in decreased activity of HGF protein
Thalidomide affects the secretion of HGF protein

PMID:15939924 PMID:17557286

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409

G

HIRA interacting protein 3

decreases expression

Thalidomide results in decreased expression of HIRIP3 mRNA

NCBI chr 1:190,903,065...190,905,610
Ensembl chr 1:181,472,056...181,475,079

G

histone cluster 1, H2bc

decreases expression

Thalidomide results in decreased expression of H2BC4 mRNA

NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642

G

high mobility group nucleosome binding domain 5

decreases expression

Thalidomide results in decreased expression of HMGN5 mRNA

NCBI chr X:78,161,439...78,170,613
Ensembl chr X:74,085,875...74,094,441
Ensembl chr 1:74,085,875...74,094,441

G

homeo box B7

increases expression

Thalidomide results in increased expression of HOXB7 mRNA

NCBI chr10:81,749,159...81,752,577
Ensembl chr10:81,252,553...81,256,034

G

homeo box B9

increases expression

Thalidomide results in increased expression of HOXB9 mRNA

NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,237,312...81,240,818

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

Thalidomide results in decreased expression of HSD11B2 mRNA

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899

G

heat shock transcription factor 1

decreases expression

Thalidomide results in decreased expression of HSF1 mRNA

PMID:26006729 PMID:26217789

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family B (small) member 1

decreases expression

Thalidomide results in decreased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family H (Hsp110) member 1

increases expression

Thalidomide analog results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:5,390,922...5,410,224

G

intercellular adhesion molecule 1

increases response to substance
decreases expression

ICAM1 gene SNP results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of ICAM1 mRNA; Thalidomide results in decreased expression of ICAM1 protein

PMID:17174718 PMID:21245421

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

Idnk, gluconokinase

decreases expression

Thalidomide results in decreased expression of IDNK mRNA

NCBI chr17:6,489,397...6,496,520
Ensembl chr17:6,483,576...6,490,905

G

interferon gamma

multiple interactions
affects expression
increases expression
decreases expression

[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
Thalidomide affects the expression of IFNG mRNA
Thalidomide results in increased expression of IFNG; Thalidomide results in increased expression of IFNG protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IFNG protein]
Thalidomide results in decreased expression of IFNG protein

PMID:15588918 PMID:16078585 PMID:16454849 PMID:16514283 PMID:16815871 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

intraflagellar transport 27

decreases expression

Thalidomide results in decreased expression of IFT27 mRNA

PMID:26006729 PMID:26217789

NCBI chr 7:111,619,145...111,635,129
Ensembl chr 7:109,738,622...109,754,416

G

intraflagellar transport 70A1

decreases expression

Thalidomide results in decreased expression of IFT70A1 mRNA

NCBI chr 3:81,309,158...81,312,612
Ensembl chr 3:60,901,896...60,905,350

G

intraflagellar transport 74

decreases expression

Thalidomide results in decreased expression of IFT74 mRNA

NCBI chr 5:114,576,106...114,679,581
Ensembl chr 5:109,474,255...109,563,833

G

insulin-like growth factor 1

affects expression

Thalidomide affects the expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

affects expression
decreases expression

Thalidomide affects the expression of IGFBP3 mRNA
Thalidomide results in decreased expression of IGFBP3 mRNA

PMID:15939924 PMID:26217789

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

affects expression
decreases expression

Thalidomide affects the expression of IL10 mRNA
Thalidomide results in decreased expression of IL10 protein

PMID:16454849 PMID:16514283

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

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interleukin 12A

multiple interactions

Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734

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interleukin 12B

multiple interactions

Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]

PMID:11788559 PMID:16510725

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903

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interleukin 18

increases expression

Thalidomide results in increased expression of IL18

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

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interleukin 1 beta

decreases expression
multiple interactions

Thalidomide results in decreased expression of IL1B protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IL1B protein]
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]

PMID:15863203 PMID:16815871 PMID:23510834 PMID:25478868

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor type 1

decreases expression

Thalidomide results in decreased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937

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interleukin 1 receptor antagonist

multiple interactions

Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

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interleukin 2

multiple interactions
decreases expression

[Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
Thalidomide results in decreased expression of IL2 protein
Thalidomide inhibits the reaction [irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [irinotecan results in decreased expression of IL2 protein]

PMID:15588918 PMID:16815871

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

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interleukin 4

increases expression

Thalidomide results in increased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

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interleukin 6

decreases secretion
decreases activity
multiple interactions

Thalidomide analog results in decreased secretion of IL6 protein
Thalidomide results in decreased activity of IL6 protein
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]

PMID:15858615 PMID:16815871 PMID:17557286 PMID:23510834 PMID:25478868 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

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interleukin 6 cytokine family signal transducer

decreases expression

Thalidomide results in decreased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936

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inhibitor of growth family, member 3

increases expression

Thalidomide analog results in increased expression of ING3 mRNA

NCBI chr 4:51,439,218...51,469,502
Ensembl chr 4:50,477,962...50,503,715

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intracisternal A particle-promoted polypeptide

decreases expression

Thalidomide results in decreased expression of IPP mRNA

NCBI chr 5:135,199,198...135,237,912
Ensembl chr 5:129,962,643...130,001,242

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Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Thalidomide analog results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

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kalirin, RhoGEF kinase

decreases expression

Thalidomide results in decreased expression of KALRN mRNA

NCBI chr11:79,703,345...80,309,210
Ensembl chr11:66,198,173...66,797,610

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kinase insert domain receptor

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

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kinesin family member 2C

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:130,637,347...130,662,637

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kelch-like family member 4

decreases expression

Thalidomide results in decreased expression of KLHL4 mRNA

NCBI chr X:83,626,047...83,916,328
Ensembl chr X:79,622,113...79,719,480

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kallikrein 1

decreases expression

Thalidomide results in decreased expression of KLK1 mRNA

NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754

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kallikrein 1-related peptidase C10

decreases expression

Thalidomide results in decreased expression of KLK3 protein

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052

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keratin associated protein 1-1

increases expression

Thalidomide results in increased expression of KRTAP1-4 mRNA

NCBI chr10:85,041,910...85,042,476
Ensembl chr10:84,545,580...84,546,354

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large tumor suppressor kinase 2

increases expression

Thalidomide analog results in increased expression of LATS2 mRNA

NCBI chr15:35,940,632...35,992,225
Ensembl chr15:31,825,092...31,877,220

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leucine rich repeat protein 1

decreases expression

Thalidomide results in decreased expression of LRR1 mRNA

NCBI chr 6:87,643,195...87,651,894
Ensembl chr 6:87,643,217...87,651,894

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lactotransferrin

multiple interactions

Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein]

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795

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lymphocyte antigen 96

decreases expression

Thalidomide results in decreased expression of LY96 mRNA

PMID:26006729 PMID:26217789

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:2,582,254...2,612,386

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LYR motif containing 2

decreases expression

Thalidomide results in decreased expression of LYRM2 mRNA

NCBI chr 5:47,198,192...47,200,470
Ensembl chr 5:47,198,185...47,201,611

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LYR motif containing 4

decreases expression

Thalidomide results in decreased expression of LYRM4 mRNA

NCBI chr17:28,951,912...29,067,300
Ensembl chr17:28,746,469...28,861,750

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microtubule-associated protein 1 light chain 3 beta

multiple interactions

Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

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mitogen activated protein kinase 1

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

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mitogen activated protein kinase 14

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

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mitogen activated protein kinase 3

increases phosphorylation

Thalidomide analog results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

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MCL1 apoptosis regulator, BCL2 family member

decreases expression

Thalidomide analog results in decreased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

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minichromosome maintenance complex component 5

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,483,066...13,504,389

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Meis homeobox 2

multiple interactions

Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]

NCBI chr 3:123,197,066...123,399,002
Ensembl chr 3:102,742,900...102,949,696

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mesenchyme homeobox 1

decreases expression

Thalidomide results in decreased expression of MEOX1 mRNA

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:86,818,478...86,837,660

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mesoderm posterior bHLH transcription factor 2

decreases expression

Thalidomide results in decreased expression of MESP2 mRNA

NCBI chr 1:143,165,914...143,168,520
Ensembl chr 1:133,756,601...133,759,198

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methyltransferase 5, N6-adenosine

decreases expression

Thalidomide results in decreased expression of METTL5 mRNA

NCBI chr 3:75,033,605...75,046,359
Ensembl chr 3:54,625,793...54,638,039

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microRNA 126a

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR126]

NCBI chr 3:29,813,150...29,813,267
Ensembl chr 3:9,415,063...9,415,180

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microRNA 141

multiple interactions

MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of BAX protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of FGF2 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR141]

NCBI chr 4:159,209,525...159,209,618
Ensembl chr 4:157,523,239...157,523,332

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microRNA 206

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR206]

NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:23,094,249...23,094,332

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microRNA 21

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in decreased expression of MIR21]

NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348

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microRNA 221

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR221]

NCBI chr X:6,023,182...6,023,290
Ensembl chr X:3,429,465...3,429,573

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microRNA 222

multiple interactions

Thalidomide inhibits the reaction [Paraquat results in increased expression of MIR222]

NCBI chr X:6,022,621...6,022,723
Ensembl chr X:3,428,904...3,429,006

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microRNA 301b

increases expression

Thalidomide results in increased expression of MIR301B mRNA

NCBI chr11:97,384,033...97,384,110
Ensembl chr11:83,879,816...83,879,893

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microRNA 30e

decreases expression

Thalidomide results in decreased expression of MIR30E mRNA

NCBI chr 5:139,637,450...139,637,541
Ensembl chr 5:134,352,232...134,352,323

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microRNA 449c

increases expression

Thalidomide results in increased expression of MIR449C mRNA

NCBI chr 2:46,402,375...46,402,473
Ensembl chr 2:44,669,179...44,669,277

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Mix paired-like homeobox 1

decreases expression

Thalidomide results in decreased expression of MIXL1 mRNA

NCBI chr13:94,953,907...94,957,938
Ensembl chr13:92,422,031...92,426,065

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marker of proliferation Ki-67

multiple interactions
decreases expression

[Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA
Thalidomide results in decreased expression of MKI67 protein

PMID:18720364 PMID:34520751

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

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myeloid leukemia factor 2

decreases expression

Thalidomide results in decreased expression of MLF2 mRNA

NCBI chr 4:159,425,542...159,430,584
Ensembl chr 4:157,728,756...157,744,317

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membrane metallo-endopeptidase

decreases expression

Thalidomide results in decreased expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792

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matrix metallopeptidase 2

multiple interactions
decreases expression

Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased expression of MMP2 protein

PMID:14558594 PMID:15863203

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

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matrix metallopeptidase 9

decreases expression

Thalidomide results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

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monooxygenase, DBH-like 1

decreases expression

Thalidomide results in decreased expression of MOXD1 mRNA

NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:21,075,122...21,161,779

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myeloperoxidase

multiple interactions

Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:15138204 PMID:25478868

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

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MAGUK p55 scaffold protein 1

decreases expression

Thalidomide results in decreased expression of MPP1 mRNA

G

mitochondrial ribosomal protein L32

decreases expression

Thalidomide results in decreased expression of MRPL32 mRNA

NCBI chr17:55,260,651...55,263,517
Ensembl chr17:50,565,055...50,568,010

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mitochondrial ribosomal protein L34

decreases expression

Thalidomide results in decreased expression of MRPL34 mRNA

NCBI chr16:18,186,447...18,187,182
Ensembl chr16:18,151,342...18,153,208

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mitochondrial ribosomal protein L47

decreases expression

Thalidomide results in decreased expression of MRPL47 mRNA

NCBI chr 2:117,436,199...117,447,790
Ensembl chr 2:115,500,264...115,518,994

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mitochondrial ribosomal protein L52

decreases expression

Thalidomide results in decreased expression of MRPL52 mRNA

NCBI chr15:27,882,777...27,886,131
Ensembl chr15:27,882,829...27,886,799

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mitochondrial ribosomal protein S21

decreases expression

Thalidomide results in decreased expression of MRPS21 mRNA

NCBI chr 2:186,095,729...186,103,351
Ensembl chr 2:183,406,792...183,414,372

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mitochondrial fission regulator 2

decreases expression

Thalidomide results in decreased expression of MTFR2 mRNA

NCBI chr 1:16,942,814...16,958,218
Ensembl chr 1:15,070,894...15,148,832

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MYB proto-oncogene, transcription factor

multiple interactions
decreases activity
decreases phosphorylation

CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]
Thalidomide results in decreased phosphorylation of MYB protein

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:15,939,761...15,973,057

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myosin binding protein C3

decreases expression

Thalidomide results in decreased expression of MYBPC3 mRNA

PMID:26006729 PMID:26217789

NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:77,095,252...77,113,405

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MYD88, innate immune signal transduction adaptor

decreases expression

Thalidomide results in decreased expression of MYD88 mRNA

PMID:26006729 PMID:26217789

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

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myosin heavy chain 6

affects expression

Thalidomide affects the expression of MYH6 mRNA

PMID:26006729 PMID:26217789

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720

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myosin light chain 3

affects expression
decreases expression

Thalidomide affects the expression of MYL3 mRNA
Thalidomide results in decreased expression of MYL3 mRNA

PMID:26006729 PMID:26217789

NCBI chr 8:119,617,077...119,623,215
Ensembl chr 8:110,738,661...110,744,816

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myosin light chain 7

decreases expression

Thalidomide results in decreased expression of MYL7 mRNA

NCBI chr14:84,994,644...84,997,173
Ensembl chr14:80,779,776...80,783,244

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myosin light chain kinase

increases expression

Thalidomide results in increased expression of MYLK mRNA

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261

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myomesin 1

decreases expression

Thalidomide results in decreased expression of MYOM1 mRNA

PMID:26006729 PMID:26217789

NCBI chr 9:118,362,547...118,485,954
Ensembl chr 9:110,915,943...111,039,344

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N(alpha)-acetyltransferase 20, NatB catalytic subunit

decreases expression

Thalidomide results in decreased expression of NAA20 mRNA

NCBI chr 3:153,775,351...153,790,129
Ensembl chr 3:133,322,064...133,337,009

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Nanog homeobox

decreases expression

Thalidomide results in decreased expression of NANOG mRNA

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116

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NAD(P)HX epimerase

decreases expression

Thalidomide results in decreased expression of NAXE mRNA

NCBI chr 2:175,816,824...175,818,903
Ensembl chr 2:173,518,971...173,521,040

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NADH:ubiquinone oxidoreductase subunit B8

decreases expression

Thalidomide results in decreased expression of NDUFB8 mRNA

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817

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nebulette

decreases expression

Thalidomide results in decreased expression of NEBL mRNA

NCBI chr17:85,022,953...85,374,848
Ensembl chr17:80,118,543...80,466,210

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neuronal differentiation 4

increases expression

Thalidomide results in increased expression of NEUROD4 mRNA

NCBI chr 7:7,740,852...7,828,052
Ensembl chr 7:7,090,045...7,102,030

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neurogenin 2

increases expression

Thalidomide results in increased expression of NEUROG2 mRNA

NCBI chr 2:218,767,205...218,769,772
Ensembl chr 2:216,093,363...216,094,154

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NFE2 like bZIP transcription factor 2

multiple interactions

Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

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nuclear factor kappa B subunit 1

multiple interactions
decreases expression

[resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]
Thalidomide results in decreased expression of NFKB1 protein

PMID:16333628 PMID:17164350

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

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NFKB inhibitor alpha

multiple interactions
increases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]; Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
Thalidomide results in increased expression of NFKBIA protein

PMID:15687330 PMID:16288038 PMID:16604421 PMID:16943688 PMID:17174718 More...

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

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nescient helix loop helix 1

increases expression

Thalidomide results in increased expression of NHLH1 mRNA

NCBI chr13:87,049,733...87,054,934
Ensembl chr13:84,517,289...84,525,094

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neuromedin S

increases expression

Thalidomide results in increased expression of NMS mRNA

NCBI chr 9:48,665,398...48,676,461
Ensembl chr 9:41,169,634...41,180,697

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nitric oxide synthase 2

multiple interactions

Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

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natriuretic peptide B

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168

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N-ribosyldihydronicotinamide:quinone dehydrogenase 2

decreases expression

Thalidomide results in decreased expression of NQO2 mRNA

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320

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nuclear receptor subfamily 1, group I, member 2

increases expression

Thalidomide results in increased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658

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nuclear receptor subfamily 4, group A, member 1

increases expression

Thalidomide analog results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

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nuclear receptor subfamily 4, group A, member 2

increases expression

Thalidomide analog results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877

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neuropilin 1

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA]

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633

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neuropilin 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA]

NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:64,123,132...64,237,958

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neurexin 1

decreases expression

Thalidomide results in decreased expression of NRXN1 mRNA

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710

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5'-nucleotidase, cytosolic IIIA

decreases expression

Thalidomide results in decreased expression of NT5C3 mRNA

NCBI chr 4:86,161,642...86,204,656
Ensembl chr 4:86,161,643...86,204,628

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5' nucleotidase, ecto

decreases expression

Thalidomide results in decreased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:89,270,696...89,314,881

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N-terminal asparagine amidase

decreases expression

Thalidomide results in decreased expression of NTAN1 mRNA

NCBI chr10:2,618,239...2,633,185

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nudix hydrolase 14

decreases expression

Thalidomide results in decreased expression of NUDT14 mRNA

NCBI chr 6:137,831,382...137,838,370
Ensembl chr 6:132,010,297...132,017,298

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nudix hydrolase 22

decreases expression

Thalidomide results in decreased expression of NUDT22 mRNA

NCBI chr 1:204,182,797...204,186,421
Ensembl chr 1:204,182,802...204,186,280

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nucleoporin 62 C-terminal like

decreases expression

Thalidomide results in decreased expression of NUP62CL mRNA

NCBI chr X:108,457,043...108,513,525
Ensembl chr X:103,668,455...103,724,081

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nucleolar and spindle associated protein 1

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Thalidomide results in decreased expression of OAS1G mRNA

NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517

G

occludin

multiple interactions

Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

oligodendrocyte transcription factor 2

increases expression

Thalidomide results in increased expression of OLIG2 mRNA

NCBI chr11:43,961,585...43,964,961
Ensembl chr11:30,475,398...30,480,152

G

oligodendrocyte transcription factor 3

increases expression

Thalidomide results in increased expression of OLIG3 mRNA

NCBI chr 1:15,900,881...15,902,953
Ensembl chr 1:14,081,328...14,082,149

G

olfactory receptor family 10 subfamily Q member 1

increases expression

Thalidomide results in increased expression of OR10Q1 mRNA

NCBI chr 1:220,285,910...220,286,866
Ensembl chr 1:210,854,142...210,864,961

G

olfactory receptor family 1 subfamily D member 2

increases expression

Thalidomide results in increased expression of OR1D2 mRNA

NCBI chr10:59,711,377...59,712,312
Ensembl chr10:59,207,257...59,214,085

G

olfactory receptor family 2 subfamily AG member 1

increases expression

Thalidomide results in increased expression of OR2AG1 mRNA

NCBI chr 1:170,095,543...170,096,493
Ensembl chr 1:160,682,533...160,688,018

G

olfactory receptor family 2 subfamily Y member 1I

increases expression

Thalidomide results in increased expression of OR2Y1 mRNA

NCBI chr10:34,238,313...34,239,242
Ensembl chr10:33,732,012...33,738,729

G

olfactory receptor family 51 subfamily Q member 1D

increases expression

Thalidomide results in increased expression of OR51Q1 mRNA

NCBI chr 1:167,838,348...167,839,313
Ensembl chr 1:158,426,462...158,427,427

G

olfactory receptor family 5 subfamily I member 1

increases expression

Thalidomide results in increased expression of OR5I1 mRNA

NCBI chr 3:93,723,884...93,724,828
Ensembl chr 3:73,267,610...73,268,560

G

olfactory receptor family 5 subfamily P member 80

increases expression

Thalidomide results in increased expression of OR5P80 mRNA

NCBI chr 1:162,509,473...162,510,405
Ensembl chr 1:162,509,473...162,510,405

G

olfactory receptor family 8 subfamily A member 1B

decreases expression

Thalidomide results in decreased expression of OR8A1B mRNA

NCBI chr 8:45,623,650...45,624,579
Ensembl chr 8:37,434,551...37,439,746

G

olfactory receptor family 9 subfamily K member 2

increases expression

Thalidomide results in increased expression of OR9K2 mRNA

NCBI chr 7:7,519,060...7,520,019
Ensembl chr 7:6,866,872...6,872,699

G

osteoclast stimulating factor 1

decreases expression

Thalidomide results in decreased expression of OSTF1 mRNA

NCBI chr 1:225,428,661...225,475,851
Ensembl chr 1:216,002,044...216,049,221

G

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

decreases expression

Thalidomide results in decreased expression of PABIR1 mRNA

NCBI chr 1:231,541,411...231,542,717
Ensembl chr 1:222,112,591...222,116,396

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein
Thalidomide analog results in increased cleavage of PARP1 protein

PMID:15858615 PMID:19372569

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

paired box 3

decreases expression

Thalidomide results in decreased expression of PAX3 mRNA

NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:79,568,634...79,664,042

G

paired box 6

increases expression

Thalidomide results in increased expression of PAX6 mRNA

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014

G

programmed cell death 10

decreases expression

Thalidomide results in decreased expression of PDCD10 mRNA

NCBI chr 2:162,602,516...162,644,690
Ensembl chr 2:160,303,449...160,346,018

G

PDZ and LIM domain 3

decreases expression

Thalidomide results in decreased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:46,352,467...46,383,657

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Thalidomide results in decreased expression of PECAM1 protein

PMID:18291259 PMID:34520751

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116

G

prefoldin subunit 6

decreases expression

Thalidomide results in decreased expression of PFDN6 mRNA

NCBI chr20:4,947,844...4,949,318
Ensembl chr20:4,945,959...4,947,433

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

[ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

paired immunoglobin-like type 2 receptor alpha

decreases expression

Thalidomide results in decreased expression of PILRA mRNA

NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases expression

Thalidomide results in decreased expression of PIM1 protein

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,554,921...7,559,174

G

plasminogen activator, urokinase

decreases expression

Thalidomide results in decreased expression of PLAU protein

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

multiple interactions
decreases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]
Thalidomide results in decreased expression of PLAUR protein

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595

G

phospholipid transfer protein

decreases expression

Thalidomide results in decreased expression of PLTP mRNA

NCBI chr 3:173,994,162...174,011,982
Ensembl chr 3:153,574,825...153,592,647

G

RNA polymerase II, I and III subunit K

decreases expression

Thalidomide results in decreased expression of POLR2K mRNA

NCBI chr 7:69,241,233...69,244,579
Ensembl chr 7:67,356,113...67,357,668

G

popeye domain cAMP effector 2

decreases expression

Thalidomide results in decreased expression of POPDC2 mRNA

NCBI chr11:75,850,068...75,897,094
Ensembl chr11:62,374,759...62,390,756

G

peroxisome proliferator-activated receptor delta

increases response to substance

PPARD gene SNP results in increased susceptibility to Thalidomide

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968

G

protein phosphatase 1, regulatory (inhibitor) subunit 11

decreases expression

Thalidomide results in decreased expression of PPP1R11 mRNA

NCBI chr20:1,606,583...1,610,090
Ensembl chr20:1,601,346...1,604,846

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Thalidomide analog results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

decreases expression

Thalidomide results in decreased expression of PPP1R1A mRNA

NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:134,654,579...134,662,230

G

PRELI domain containing 2

decreases expression

Thalidomide results in decreased expression of PRELID2 mRNA

NCBI chr18:34,120,989...34,212,699
Ensembl chr18:33,873,599...33,961,225

G

perforin 1

increases expression

Thalidomide results in increased expression of PRF1

NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,246,202...29,251,701

G

protein kinase C, delta

decreases expression

Thalidomide results in decreased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase cGMP-dependent 1

decreases expression

Thalidomide results in decreased expression of PRKG1 mRNA

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080

G

proline rich 5

decreases expression

Thalidomide results in decreased expression of PRR5 mRNA

NCBI chr 7:117,675,308...117,717,833
Ensembl chr 7:115,813,954...115,834,834

G

peroxiredoxin like 2A

decreases expression

Thalidomide results in decreased expression of PRXL2A mRNA

NCBI chr16:16,900,697...16,920,521
Ensembl chr16:16,866,603...16,886,433

G

proteasome activator subunit 2

increases expression

Thalidomide results in increased expression of PSME2 mRNA

NCBI chr15:33,048,452...33,053,055
Ensembl chr15:29,078,500...29,082,946

G

phosphatase and tensin homolog

increases expression

Thalidomide results in increased expression of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

increases degradation
decreases expression
multiple interactions
decreases stability

Thalidomide results in increased degradation of PTGS2 protein
Thalidomide results in decreased expression of PTGS2 protein
Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Thalidomide results in decreased stability of PTGS2 mRNA

PMID:11705847 PMID:15982930 PMID:17638016

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RAB2B, member RAS oncogene family

decreases expression

Thalidomide results in decreased expression of RAB2B mRNA

PMID:26006729 PMID:26217789

NCBI chr15:27,441,860...27,462,479
Ensembl chr15:24,968,803...24,989,113

G

RAB8A, member RAS oncogene family

decreases expression

Thalidomide results in decreased expression of RAB8A mRNA

NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,654,034...17,675,678

G

RAP1B, member of RAS oncogene family

decreases expression

Thalidomide results in decreased expression of RAP1B mRNA

NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:53,423,130...53,456,370

G

Ras association domain family member 9

decreases expression

Thalidomide results in decreased expression of RASSF9 mRNA

NCBI chr 7:39,486,257...39,518,090
Ensembl chr 7:37,599,720...37,635,245

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

[irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [irinotecan co-treated with Thalidomide] results in increased expression of RELA protein; [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
[Thalidomide co-treated with Dimethylnitrosamine] results in decreased transport of RELA protein; HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]
Thalidomide results in decreased expression of RELA protein
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat affects the localization of RELA protein]

PMID:15687330 PMID:16078585 PMID:16333628 PMID:16604421 PMID:16685529 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

RELB proto-oncogene, NF-kB subunit

increases expression

Thalidomide analog results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507

G

replication factor C subunit 3

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA

NCBI chr12:5,836,546...5,847,331
Ensembl chr12:1,000,994...1,011,778

G

ras homolog family member A

affects expression

Thalidomide affects the expression of RHOA mRNA

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746

G

ribonuclease H2, subunit C

decreases expression

Thalidomide results in decreased expression of RNASEH2C mRNA

NCBI chr 1:212,323,916...212,325,011
Ensembl chr 1:202,894,643...202,897,516

G

ring finger protein 138

decreases expression

Thalidomide results in decreased expression of RNF138 mRNA

NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,291,590...12,315,930

G

ring finger protein 166

multiple interactions

Thalidomide results in increased degradation of and results in decreased expression of RNF166 protein

NCBI chr19:67,437,974...67,447,814
Ensembl chr19:50,529,434...50,539,274

G

ribosomal protein S15

increases expression

Thalidomide results in increased expression of RPS15 mRNA

NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

ribosomal protein S6 kinase A2

decreases expression

Thalidomide results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:52,631,736...52,906,739

G

RAS related

decreases expression

Thalidomide results in decreased expression of RRAS mRNA

PMID:26006729 PMID:26217789

NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:95,500,566...95,504,357

G

ribonucleotide reductase regulatory subunit M2

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

RT1 class Ia, locus A2

affects expression

Thalidomide affects the expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class I, locus CE16

increases expression

Thalidomide results in increased expression of H2-Q1 mRNA

NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563

G

reticulon 2

decreases expression

Thalidomide results in decreased expression of RTN2 mRNA

NCBI chr 1:88,063,124...88,076,082
Ensembl chr 1:78,935,104...78,948,069

G

ryanodine receptor 2

decreases expression

Thalidomide results in decreased expression of RYR2 mRNA

PMID:26006729 PMID:26217789

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142

G

spalt-like transcription factor 4

increases expression
multiple interactions
affects binding

Thalidomide results in increased expression of SALL4 mRNA
Bortezomib inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; pevonedistat inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; TAK-243 inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein
Thalidomide binds to [SALL4 protein binds to CRBN protein]

NCBI chr 3:177,891,705...177,909,743
Ensembl chr 3:157,474,642...157,490,822

G

Sin3A associated protein 30

decreases expression

Thalidomide results in decreased expression of SAP30 mRNA

NCBI chr16:37,758,494...37,763,825
Ensembl chr16:32,747,734...32,753,112

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

Thalidomide results in decreased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813

G

sodium voltage-gated channel alpha subunit 7

decreases expression

Thalidomide results in decreased expression of SCN7A mRNA

NCBI chr 3:71,743,873...71,846,454
Ensembl chr 3:51,335,841...51,438,256

G

succinate dehydrogenase complex assembly factor 1

decreases expression

Thalidomide results in decreased expression of SDHAF1 mRNA

NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366
Ensembl chr 1:85,576,041...85,577,366

G

succinate dehydrogenase complex subunit C

decreases expression

Thalidomide results in decreased expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:83,544,652...83,566,253

G

selenoprotein S

decreases expression

Thalidomide results in decreased expression of SELENOS mRNA

NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:119,659,751...119,669,833

G

selectin L

decreases expression

Thalidomide results in decreased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

serpin family B member 2

increases response to substance

SERPINB2 gene SNP results in increased susceptibility to Thalidomide

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:23,541,400...23,550,408

G

secreted frizzled-related protein 2

increases expression

Thalidomide results in increased expression of SFRP2 mRNA

NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063

G

SH3 domain binding glutamate-rich protein

decreases expression

Thalidomide results in decreased expression of SH3BGR mRNA

NCBI chr11:48,973,033...48,997,328
Ensembl chr11:35,503,725...35,527,853

G

solute carrier family 12, member 6

increases response to substance

SLC12A6 gene SNP results in increased susceptibility to Thalidomide

NCBI chr 3:119,525,521...119,624,655
Ensembl chr 3:99,071,391...99,170,258

G

solute carrier family 13 member 4

decreases expression

Thalidomide results in decreased expression of SLC13A4 mRNA

NCBI chr 4:64,910,505...64,955,986
Ensembl chr 4:63,943,395...63,988,857

G

solute carrier family 22 member 2

multiple interactions

Thalidomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 25 member 20

decreases expression

Thalidomide results in decreased expression of SLC25A20 mRNA

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:109,365,002...109,386,512

G

solute carrier family 25, member 30

decreases expression

Thalidomide results in decreased expression of SLC25A30 mRNA

NCBI chr15:57,486,346...57,508,981
Ensembl chr15:51,077,002...51,099,613

G

solute carrier family 2 member 3

increases expression

Thalidomide results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 44, member 3

decreases expression

Thalidomide results in decreased expression of SLC44A3 mRNA

NCBI chr 2:212,234,425...212,312,886
Ensembl chr 2:209,552,144...209,629,044

G

solute carrier family 8 member A1

decreases expression

Thalidomide results in decreased expression of SLC8A1 mRNA

PMID:26006729 PMID:26217789

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier organic anion transporter family, member 4C1

decreases expression

Thalidomide results in decreased expression of SLCO4C1 mRNA

NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:97,178,861...97,229,715

G

sphingomyelin phosphodiesterase 2

multiple interactions

sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein]

NCBI chr20:46,568,627...46,571,741
Ensembl chr20:44,986,231...44,989,441

G

SET and MYND domain containing 1

decreases expression

Thalidomide results in decreased expression of SMYD1 mRNA

PMID:26006729 PMID:26217789

NCBI chr 4:104,757,281...104,811,307
Ensembl chr 4:103,200,322...103,311,766

G

synaptosome associated protein 25

increases expression

Thalidomide results in increased expression of SNAP25 mRNA; Thalidomide results in increased expression of SNAP25 protein

NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:124,041,898...124,123,760

G

small nucleolar RNA, C/D box 104

increases expression

Thalidomide results in increased expression of SNORD104 mRNA

NCBI chr10:91,435,313...91,435,382
Ensembl chr10:91,435,313...91,435,382

G

small nucleolar RNA, C/D box 111

increases expression

Thalidomide results in increased expression of SNORD111 mRNA

NCBI chr19:38,812,486...38,812,574
Ensembl chr19:38,812,486...38,812,574

G

small nucleolar RNA, C/D box 123

increases expression

Thalidomide results in increased expression of SNORD123 mRNA

NCBI chr 2:83,306,918...83,306,987
Ensembl chr 2:83,306,918...83,306,987

G

small nuclear ribonucleoprotein D1 polypeptide

decreases expression

Thalidomide results in decreased expression of SNRPD1 mRNA

NCBI chr18:1,969,351...1,980,207
Ensembl chr18:1,696,852...1,708,256

G

sorting nexin 16

increases expression

Thalidomide analog results in increased expression of SNX16 mRNA

NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619

G

sorting nexin 24

decreases expression

Thalidomide results in decreased expression of SNX24 mRNA

NCBI chr18:48,869,804...49,024,352
Ensembl chr18:46,671,443...46,826,068

G

superoxide dismutase 1

multiple interactions

Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]

PMID:16510725 PMID:17030452

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 1

decreases expression

Thalidomide results in decreased expression of SOX1 mRNA

NCBI chr16:83,837,689...83,841,703
Ensembl chr16:77,137,584...77,138,762

G

SRY-box transcription factor 17

decreases localization

Thalidomide results in decreased localization of SOX17 protein

NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:15,016,731...15,022,228

G

Sp1 transcription factor

decreases activity

Thalidomide results in decreased activity of SP1 protein

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

Sp5 transcription factor

decreases expression

Thalidomide results in decreased expression of SP5 mRNA

NCBI chr 3:75,682,677...75,685,479
Ensembl chr 3:55,274,931...55,277,733

G

sperm autoantigenic protein 17

decreases expression

Thalidomide results in decreased expression of SPA17 mRNA

NCBI chr 8:45,496,175...45,507,262
Ensembl chr 8:37,307,557...37,318,639

G

sperm associated antigen 5

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA

NCBI chr10:63,693,300...63,714,813
Ensembl chr10:63,198,768...63,216,745

G

SPHK1 interactor, AKAP domain containing

decreases expression

Thalidomide results in decreased expression of SPHKAP mRNA

NCBI chr 9:91,957,497...92,105,834
Ensembl chr 9:84,510,964...84,657,559

G

SRR1 domain containing

decreases expression

Thalidomide results in decreased expression of SRRD mRNA

NCBI chr12:49,955,081...49,960,693
Ensembl chr12:44,294,271...44,300,287

G

signal transducer and activator of transcription 3

decreases phosphorylation
multiple interactions

Thalidomide analog results in decreased phosphorylation of STAT3 protein
[resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; Thalidomide promotes the reaction [Capsaicin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

PMID:15858615 PMID:17164350 PMID:17505005

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

stathmin 2

decreases expression

Thalidomide results in decreased expression of STMN2 mRNA

NCBI chr 2:95,112,017...95,159,642
Ensembl chr 2:93,204,692...93,252,011

G

SWIM-type zinc finger 7 associated protein 1

decreases expression

Thalidomide results in decreased expression of SWSAP1 mRNA

NCBI chr 8:28,762,753...28,765,281
Ensembl chr 8:20,486,678...20,489,211

G

synaptojanin 2 binding protein

decreases expression

Thalidomide results in decreased expression of SYNJ2BP mRNA

NCBI chr 6:106,920,970...106,958,653
Ensembl chr 6:101,189,714...101,227,406

G

synaptotagmin 15

decreases expression

Thalidomide results in decreased expression of SYT15 mRNA

NCBI chr16:9,538,740...9,549,548
Ensembl chr16:9,532,478...9,543,281

G

synaptotagmin 4

increases expression

Thalidomide results in increased expression of SYT4 mRNA

NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332

G

tandem C2 domains, nuclear

decreases expression

Thalidomide results in decreased expression of TC2N mRNA

NCBI chr 6:126,526,006...126,622,163
Ensembl chr 6:120,761,119...120,849,326

G

transcription factor 15

decreases expression

Thalidomide results in decreased expression of TCF15 mRNA

NCBI chr 3:161,099,301...161,105,083
Ensembl chr 3:140,638,984...140,644,766

G

thymine-DNA glycosylase

decreases expression

Thalidomide results in decreased expression of TDG mRNA

NCBI chr 7:22,965,388...22,990,311
Ensembl chr 7:21,077,853...21,097,567

G

transcription elongation factor, mitochondrial

decreases expression

Thalidomide results in decreased expression of TEFM mRNA

NCBI chr10:65,617,547...65,622,042
Ensembl chr10:65,119,659...65,124,486

G

TEK receptor tyrosine kinase

decreases expression

Thalidomide results in decreased expression of TEK mRNA

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804

G

testis expressed gene 16

decreases expression

Thalidomide results in decreased expression of TEX16 mRNA

NCBI chr X:76,948,823...77,316,809
Ensembl chr X:76,952,421...77,246,799

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]
Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
Thalidomide results in decreased expression of TGFB1 mRNA; Thalidomide results in decreased expression of TGFB1 protein

PMID:15464241 PMID:16288038 PMID:16510725 PMID:16549389 PMID:16604421 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

decreases expression

Thalidomide results in decreased expression of TGFBI mRNA

PMID:26006729 PMID:26217789

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,955,603...7,985,240

G

transforming growth factor, beta receptor 1

decreases expression

Thalidomide results in decreased expression of TGFBR1 mRNA; Thalidomide results in decreased expression of TGFBR1 protein

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777

G

TIMP metallopeptidase inhibitor 1

multiple interactions

Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]

PMID:15464241 PMID:17030452

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

tubulointerstitial nephritis antigen-like 1

decreases expression

Thalidomide results in decreased expression of TINAGL1 mRNA

NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:142,513,714...142,523,720

G

tight junction protein 1

multiple interactions

Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

TM2 domain containing 3

decreases expression

Thalidomide results in decreased expression of TM2D3 mRNA

NCBI chr 1:128,677,680...128,687,580
Ensembl chr 1:119,264,576...119,277,099

G

transmembrane protein 138

decreases expression

Thalidomide results in decreased expression of TMEM138 mRNA

NCBI chr 1:216,644,047...216,651,091

G

transmembrane protein 176A

decreases expression

Thalidomide results in decreased expression of TMEM176A mRNA

NCBI chr 4:79,101,946...79,109,499
Ensembl chr 4:77,774,843...77,778,620

G

thymopoietin

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:25,586,725...25,667,727

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression
increases degradation

Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]
Thalidomide results in increased expression of TNF protein
Thalidomide results in decreased expression of TNF mRNA
HDAC6 protein inhibits the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; MIR141 promotes the reaction [Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein]
Thalidomide results in increased expression of TNF mRNA
Thalidomide results in increased degradation of TNF mRNA
Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein

PMID:9068814 PMID:9623511 PMID:10496904 PMID:10720640 PMID:11367517 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

decreases expression

Thalidomide results in decreased expression of TNFRSF10A protein

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 1A

decreases expression

Thalidomide results in decreased expression of TNFRSF1A mRNA; Thalidomide results in decreased expression of TNFRSF1A protein

PMID:15618473 PMID:16344495

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

decreases expression

Thalidomide results in decreased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 10

decreases expression

Thalidomide results in decreased expression of TNFSF10 protein

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

multiple interactions

[Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445

G

troponin C1, slow skeletal and cardiac type

decreases expression

Thalidomide results in decreased expression of TNNC1 mRNA

PMID:26006729 PMID:26217789

NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,402,171...6,405,634

G

DNA topoisomerase II alpha

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression

Thalidomide analog results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

translocation associated membrane protein 1-like 1

decreases expression

Thalidomide results in decreased expression of TRAM1L1 mRNA

NCBI chr 2:212,511,130...212,513,311

G

trafficking protein particle complex subunit 2L

decreases expression

Thalidomide results in decreased expression of TRAPPC2L mRNA

NCBI chr19:67,570,954...67,574,722
Ensembl chr19:50,662,507...50,666,192

G

tribbles pseudokinase 3

increases expression

Thalidomide analog results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 55

decreases expression

Thalidomide results in decreased expression of TRIM55 mRNA

NCBI chr 2:104,016,361...104,058,302
Ensembl chr 2:102,088,443...102,142,168

G

tetraspanin 33

decreases expression

Thalidomide results in decreased expression of TSPAN33 mRNA

NCBI chr 4:59,270,713...59,294,249
Ensembl chr 4:58,305,437...58,328,940

G

tetratricopeptide repeat domain 32

decreases expression

Thalidomide results in decreased expression of TTC32 mRNA

NCBI chr 6:31,834,428...31,841,027
Ensembl chr 6:31,834,428...31,842,621

G

Ttk protein kinase

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651

G

titin

decreases expression

Thalidomide results in decreased expression of TTN mRNA

PMID:26006729 PMID:26217789

NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741

G

ubiquitin-conjugating enzyme E2C

multiple interactions

[Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

UBX domain protein 1

decreases expression

Thalidomide results in decreased expression of UBXN1 mRNA

NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:205,745,120...205,816,520

G

ubiquitin C-terminal hydrolase L3

decreases expression

Thalidomide results in decreased expression of UCHL3 mRNA

NCBI chr15:84,888,847...84,942,095
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355

G

UNC homeobox

decreases expression

Thalidomide results in decreased expression of UNCX mRNA

NCBI chr12:20,206,604...20,211,125
Ensembl chr12:15,092,784...15,097,300

G

uridine phosphorylase 1

decreases expression

Thalidomide results in decreased expression of UPP1 mRNA

NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462

G

ubiquinol-cytochrome c reductase complex assembly factor 5

decreases expression

Thalidomide results in decreased expression of UQCC5 mRNA

NCBI chr16:6,323,071...6,326,911
Ensembl chr16:6,286,300...6,320,642

G

vascular cell adhesion molecule 1

decreases expression

Thalidomide results in decreased expression of VCAM1 mRNA; Thalidomide results in decreased expression of VCAM1 protein

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

affects expression
affects secretion
decreases secretion
decreases activity
decreases expression
increases expression
multiple interactions

Thalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA protein
Thalidomide affects the secretion of VEGFA protein
Thalidomide analog results in decreased secretion of VEGFA protein
Thalidomide results in decreased activity of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in increased expression of VEGFA protein
[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNA
[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein]; Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein

PMID:15858615 PMID:15863203 PMID:15939924 PMID:15982930 PMID:16313753 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFB mRNA
Thalidomide results in decreased expression of VEGFB mRNA

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:204,172,225...204,177,944

G

vascular endothelial growth factor C

affects expression

Thalidomide affects the expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

vascular endothelial growth factor D

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFD mRNA
Thalidomide results in decreased expression of VEGFD mRNA

NCBI chr X:33,704,582...33,740,305
Ensembl chr X:30,074,163...30,108,295

G

vitronectin

decreases expression

Thalidomide results in decreased expression of VTN mRNA

NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810

G

Wnt family member 5B

decreases expression

Thalidomide results in decreased expression of WNT5B mRNA

NCBI chr 4:154,281,852...154,406,081
Ensembl chr 4:152,609,569...152,733,407

G

Wnt family member 8A

decreases expression

Thalidomide results in decreased expression of WNT8A mRNA

NCBI chr18:26,411,833...26,417,426
Ensembl chr18:26,137,690...26,143,283

G

X-linked inhibitor of apoptosis

decreases expression

Thalidomide analog results in decreased expression of XIAP protein

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

YJU2 splicing factor homolog B

decreases expression

Thalidomide results in decreased expression of YJU2B mRNA

NCBI chr19:40,799,392...40,810,885
Ensembl chr19:23,894,649...23,906,077

G

zinc finger CCHC-type containing 17

increases expression

Thalidomide results in increased expression of ZCCHC17 mRNA

NCBI chr 5:147,942,789...147,984,596
Ensembl chr 5:142,658,589...142,700,426

G

zinc finger E-box binding homeobox 1

multiple interactions
decreases expression

FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of ZEB1 protein]

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214

G

zinc finger protein 692

multiple interactions

Thalidomide results in increased degradation of and results in decreased expression of ZNF692 protein

NCBI chr10:42,988,946...42,997,009
Ensembl chr10:42,488,588...42,496,018

G

zinc finger protein 758

decreases expression

Thalidomide results in decreased expression of ZFP758 mRNA

NCBI chr 1:70,614,167...70,662,261
Ensembl chr 1:61,942,116...61,989,490

G

zinc finger protein-like 1

decreases expression

Thalidomide results in decreased expression of ZFPL1 mRNA

NCBI chr 1:212,803,790...212,807,803
Ensembl chr 1:203,374,504...203,378,487

G

zinc finger with KRAB and SCAN domains 5

decreases expression

Thalidomide results in decreased expression of ZKSCAN5 mRNA

NCBI chr12:14,498,342...14,519,537
Ensembl chr12:9,384,571...9,405,881

G

zinc finger, matrin type 5

decreases expression

Thalidomide results in decreased expression of ZMAT5 mRNA

NCBI chr14:83,791,005...83,823,095
Ensembl chr14:79,568,758...79,599,594

G

zinc finger protein 780B

decreases expression

Thalidomide results in decreased expression of ZFP780B mRNA

NCBI chr 1:92,136,761...92,159,076
Ensembl chr 1:83,009,189...83,082,107

G

zinc ribbon domain containing 2

decreases expression

Thalidomide results in decreased expression of ZNRD2 mRNA

NCBI chr 1:212,447,010...212,448,793
Ensembl chr 1:203,017,682...203,019,465

G

zinc finger and SCAN domain containing 12

decreases expression

Thalidomide results in decreased expression of ZSCAN12 mRNA

NCBI chr17:47,942,976...47,948,930
Ensembl chr17:43,247,095...43,253,264

pomalidomide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bromodomain containing 4

multiple interactions

pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539

G

caspase 3

multiple interactions

[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine ligand 2

increases secretion

pomalidomide results in increased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

CCAAT/enhancer binding protein alpha

increases expression

pomalidomide results in increased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein delta

increases expression

pomalidomide results in increased expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:84,764,565...84,765,829

G

CCAAT/enhancer binding protein epsilon

increases expression

pomalidomide results in increased expression of CEBPE mRNA

NCBI chr15:32,139,716...32,141,476
Ensembl chr15:28,169,704...28,171,814

G

cereblon

multiple interactions
affects binding
increases response to substance

[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide

PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223

NCBI chr 4:141,255,400...141,276,722
Ensembl chr 4:139,701,094...139,719,938

G

colony stimulating factor 2

decreases secretion

pomalidomide results in decreased secretion of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases secretion

pomalidomide results in increased secretion of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases oxidation

CYP2C19 protein results in increased oxidation of pomalidomide

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily j, polypeptide 4

increases oxidation

CYP2J2 protein results in increased oxidation of pomalidomide

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases oxidation

CYP3A4 protein results in increased oxidation of pomalidomide

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

DTW domain containing 1

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein

NCBI chr 3:133,845,768...133,859,965
Ensembl chr 3:113,392,457...113,408,105

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

family with sequence similarity 83, member F

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein

NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:112,211,164...112,240,452

G

Fibroblast growth factor receptor 1

decreases expression

pomalidomide results in decreased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 3

affects expression

pomalidomide affects the expression of FGFR3 mRNA

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341

G

forkhead box O1

multiple interactions

[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein]

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

GATA binding protein 1

decreases expression

pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein

NCBI chr X:17,193,291...17,209,462
Ensembl chr X:14,529,702...14,537,530

G

GATA binding protein 2

decreases expression

pomalidomide results in decreased expression of GATA2 mRNA

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:120,658,986...120,667,761

G

growth factor independent 1 transcriptional repressor

increases expression

pomalidomide results in increased expression of GFI1 mRNA

NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,042,434...2,051,814

G

growth factor independent 1B transcriptional repressor

decreases expression

pomalidomide results in decreased expression of GFI1B mRNA

NCBI chr 3:32,338,213...32,350,963
Ensembl chr 3:11,940,233...11,952,942

G

inhibitor of DNA binding 1

increases expression

pomalidomide results in increased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

increases expression

pomalidomide results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

IKAROS family zinc finger 1

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein]

NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416

G

IKAROS family zinc finger 3

multiple interactions

[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein]

NCBI chr10:83,956,850...84,049,861
Ensembl chr10:83,465,745...83,553,591

G

interleukin 10

increases secretion

pomalidomide results in increased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

decreases secretion

pomalidomide results in decreased secretion of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 2

multiple interactions

Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 5

decreases secretion

pomalidomide results in decreased secretion of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213

G

interferon regulatory factor 4

multiple interactions

[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression

pomalidomide results in decreased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799

G

KLF transcription factor 1

decreases expression

pomalidomide results in decreased expression of KLF1 mRNA

NCBI chr19:40,155,476...40,158,651
Ensembl chr19:23,250,631...23,253,758

G

LIM domain only 2

decreases expression

pomalidomide results in decreased expression of LMO2 mRNA

NCBI chr 3:110,810,162...110,832,895
Ensembl chr 3:90,365,883...90,377,953

G

Meis homeobox 2

multiple interactions

pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]

NCBI chr 3:123,197,066...123,399,002
Ensembl chr 3:102,742,900...102,949,696

G

nuclear factor, erythroid 2

decreases expression

pomalidomide results in decreased expression of NFE2 mRNA

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:134,382,761...134,390,108

G

protein kinase C, theta

multiple interactions

pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]

NCBI chr17:72,156,215...72,288,508
Ensembl chr17:67,246,394...67,378,704

G

RAB28, member RAS oncogene family

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein

NCBI chr14:73,458,386...73,535,367
Ensembl chr14:69,245,854...69,322,967

G

spalt-like transcription factor 4

affects binding
multiple interactions

pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein

NCBI chr 3:177,891,705...177,909,743
Ensembl chr 3:157,474,642...157,490,822

G

Spi-1 proto-oncogene

increases expression
decreases expression

pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein

PMID:15292067 PMID:16373662

NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393

G

WIZ zinc finger

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of WIZ protein

NCBI chr 7:12,017,374...12,045,812
Ensembl chr 7:11,367,035...11,395,490

G

zinc finger and BTB domain containing 39

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein

NCBI chr 7:63,576,998...63,584,549
Ensembl chr 7:63,576,917...63,589,210

G

zinc finger protein 653

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein

NCBI chr 8:28,862,618...28,881,439
Ensembl chr 8:20,586,563...20,604,864

G

zinc finger protein 91

multiple interactions

pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein

NCBI chr 1:219,316,002...219,353,654
Ensembl chr 1:209,891,344...209,927,762

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
application	19697
anti-inflammatory agent	16678
anti-inflammatory drug	14962
thalidomide	473
5-(2,2-diferuloylethen-1-yl)thalidomide	0
5-[2-(feruloyl)ethen-1-yl]thalidomide	0
pomalidomide	45
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
p-block element atom	19824
carbon group element atom	19763
carbon atom	19760
organic molecular entity	19760
organic molecule	19713
organic cyclic compound	19505
organic heterocyclic compound	18875
organic heteropolycyclic compound	18302
organic heterobicyclic compound	17242
benzopyrrole	9750
isoindoles	1151
phthalimides	1013
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione	473
(R)-thalidomide	473
thalidomide	473
5-(2,2-diferuloylethen-1-yl)thalidomide	0
5-[2-(feruloyl)ethen-1-yl]thalidomide	0
pomalidomide	45

paths to the root