Ntan1 (N-terminal asparagine amidase) - Rat Genome Database

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Gene: Ntan1 (N-terminal asparagine amidase) Rattus norvegicus
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Symbol: Ntan1
Name: N-terminal asparagine amidase
RGD ID: 1305160
Description: Predicted to enable protein-N-terminal asparagine amidohydrolase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within adult locomotory behavior and memory. Predicted to be located in cytoplasm and nucleus. Orthologous to human NTAN1 (N-terminal asparagine amidase); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 3',5'-cyclic AMP; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360462; MGC108792; N-terminal Asn amidase; protein N-terminal asparagine amidohydrolase; RGD1305160; similar to N-terminal asparagine amidohydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2102,111,085 - 2,126,123 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx106,807,930 - 6,822,876 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01033,742,965 - 33,757,911 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0102,014,376 - 2,029,330 (-)NCBIRnor_WKY
Rnor_6.0103,218,414 - 3,235,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,218,466 - 3,235,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,095,991 - 2,112,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4101,531,025 - 1,545,977 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1101,531,054 - 1,545,841 (+)NCBI
Celera101,141,452 - 1,156,350 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10805755   PMID:21375249  


Genomics

Comparative Map Data
Ntan1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2102,111,085 - 2,126,123 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx106,807,930 - 6,822,876 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01033,742,965 - 33,757,911 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0102,014,376 - 2,029,330 (-)NCBIRnor_WKY
Rnor_6.0103,218,414 - 3,235,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl103,218,466 - 3,235,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0102,095,991 - 2,112,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4101,531,025 - 1,545,977 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1101,531,054 - 1,545,841 (+)NCBI
Celera101,141,452 - 1,156,350 (-)NCBICelera
Cytogenetic Map10q11NCBI
NTAN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,037,857 - 15,056,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1615,037,854 - 15,056,079 (-)EnsemblGRCh38hg38GRCh38
GRCh371615,131,714 - 15,149,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,039,215 - 15,057,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 341615,039,217 - 15,057,334NCBI
Celera1616,188,840 - 16,208,298 (+)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1614,776,857 - 14,795,255 (-)NCBIHuRef
CHM1_11615,133,826 - 15,152,060 (+)NCBICHM1_1
T2T-CHM13v2.01615,038,909 - 15,057,126 (-)NCBIT2T-CHM13v2.0
Ntan1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,636,629 - 13,653,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,636,709 - 13,653,315 (+)EnsemblGRCm39 Ensembl
GRCm381613,818,834 - 13,835,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,818,845 - 13,835,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,819,370 - 13,835,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,732,855 - 13,749,028 (+)NCBIMGSCv36mm8
Celera1614,423,558 - 14,439,498 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.64NCBI
Ntan1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442169,814 - 186,253 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442169,814 - 186,253 (+)NCBIChiLan1.0ChiLan1.0
NTAN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01613,704,891 - 13,722,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NTAN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,465,028 - 28,478,201 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,465,035 - 28,478,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,828,270 - 29,840,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,627,989 - 28,640,143 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1628,431,110 - 28,443,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,321,233 - 28,333,288 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,726,984 - 28,739,024 (-)NCBIUU_Cfam_GSD_1.0
Ntan1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,841,403 - 114,849,514 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,932,605 - 2,947,374 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365012,939,271 - 2,947,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTAN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,520,774 - 7,535,503 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,520,771 - 7,535,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap3p16-p17NCBI
NTAN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,276,047 - 14,294,126 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,276,093 - 14,293,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606815,752,920 - 15,770,999 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntan1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248248,617,134 - 8,635,138 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248248,617,116 - 8,633,227 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ntan1
272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000004429
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

Markers in Region
RH141284  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2102,111,743 - 2,111,962 (+)MAPPERmRatBN7.2
mRatBN7.2102,111,743 - 2,111,962 (-)MAPPERmRatBN7.2
Rnor_6.0101,682,712 - 1,682,930NCBIRnor6.0
Rnor_6.0103,234,352 - 3,234,570NCBIRnor6.0
Rnor_5.010572,264 - 572,482UniSTSRnor5.0
Rnor_5.0102,111,868 - 2,112,086UniSTSRnor5.0
RGSC_v3.4101,545,100 - 1,545,318UniSTSRGSC3.4
Celera101,142,111 - 1,142,329UniSTS
Cytogenetic Map10q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 4 6 74 35 41 11 4
Low 8 4 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077695   ⟹   ENSRNOP00000069865
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,218,505 - 3,235,093 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088075   ⟹   ENSRNOP00000072473
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,227,160 - 3,235,227 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093197   ⟹   ENSRNOP00000076096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,225,484 - 3,230,577 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093338   ⟹   ENSRNOP00000076257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,218,475 - 3,225,074 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093456   ⟹   ENSRNOP00000076340
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,225,527 - 3,235,160 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093598   ⟹   ENSRNOP00000076329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,225,481 - 3,235,229 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093629   ⟹   ENSRNOP00000076300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,218,466 - 3,234,985 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093663   ⟹   ENSRNOP00000076348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl103,218,474 - 3,218,585 (+)Ensembl
RefSeq Acc Id: NM_001025124   ⟹   NP_001020295
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2102,111,085 - 2,126,123 (-)NCBI
Rnor_6.0103,218,475 - 3,235,229 (+)NCBI
Rnor_5.0102,095,991 - 2,112,745 (+)NCBI
RGSC_v3.4101,531,025 - 1,545,977 (+)RGD
Celera101,141,452 - 1,156,350 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020295 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91175 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001020295   ⟸   NM_001025124
- UniProtKB: Q5BK79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076329   ⟸   ENSRNOT00000093598
RefSeq Acc Id: ENSRNOP00000072473   ⟸   ENSRNOT00000088075
RefSeq Acc Id: ENSRNOP00000076340   ⟸   ENSRNOT00000093456
RefSeq Acc Id: ENSRNOP00000076096   ⟸   ENSRNOT00000093197
RefSeq Acc Id: ENSRNOP00000069865   ⟸   ENSRNOT00000077695
RefSeq Acc Id: ENSRNOP00000076300   ⟸   ENSRNOT00000093629
RefSeq Acc Id: ENSRNOP00000076257   ⟸   ENSRNOT00000093338
RefSeq Acc Id: ENSRNOP00000076348   ⟸   ENSRNOT00000093663

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWG0-F1-model_v2 AlphaFold A0A0G2JWG0 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696930
Promoter ID:EPDNEW_R7453
Type:initiation region
Name:Ntan1_1
Description:Mus musculus N-terminal Asn amidase , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0103,218,456 - 3,218,516EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305160 AgrOrtholog
BioCyc Gene G2FUF-26212 BioCyc
BioCyc Pathway PWY-7799 [Arg/N-end rule pathway (eukaryotic)] BioCyc
Ensembl Genes ENSRNOG00000051382 Ensembl
IMAGE_CLONE IMAGE:7321868 IMAGE-MGC_LOAD
InterPro NTAN1 UniProtKB/TrEMBL
KEGG Report rno:360462 UniProtKB/TrEMBL
MGC_CLONE MGC:108792 IMAGE-MGC_LOAD
NCBI Gene 360462 ENTREZGENE
PANTHER PTHR12498 UniProtKB/TrEMBL
Pfam N_Asn_amidohyd UniProtKB/TrEMBL
PhenoGen Ntan1 PhenoGen
UniProt Q5BK79 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Ntan1  N-terminal asparagine amidase  RGD1305160  similar to N-terminal asparagine amidohydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305160  similar to N-terminal asparagine amidohydrolase  RGD1305160_predicted  similar to N-terminal asparagine amidohydrolase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305160_predicted  similar to N-terminal asparagine amidohydrolase (predicted)  LOC360462_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360462_predicted  similar to N-terminal asparagine amidohydrolase (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL