Cyth3 (cytohesin 3) - Rat Genome Database

Name: Cyth3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Cyth3 (cytohesin 3) Rattus norvegicus

Analyze

Symbol:

Cyth3

Name:

cytohesin 3

RGD ID:

620399

Description:

Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in Golgi vesicle transport. Predicted to act upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Predicted to be located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Orthologous to human CYTH3 (cytohesin 3); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cytohesin-3; MGC124579; PH, SEC7 and coiled-coil domain-containing protein 3; pleckstrin homology, Sec7 and coiled-coil domains 3; pleckstrin homology, Sec7 and coiled/coil domains 3; Pscd3; rSec7-3; Sec7; SEC7 homolog C; Sec7C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYTH3 (cytohesin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Cyth3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cyth3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CYTH3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYTH3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cyth3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYTH3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYTH3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cyth3 (cytohesin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CYTH1 (cytohesin 1)	HGNC	OrthoDB
Homo sapiens (human):	CYTH2 (cytohesin 2)	HGNC	OrthoDB
Homo sapiens (human):	CYTH4 (cytohesin 4)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CYTH3 (cytohesin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cyth3 (cytohesin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyth3b (cytohesin 3b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	cyth3a (cytohesin 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	grp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	step	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SYT1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cyth3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,953,781 - 16,076,584 (-)	NCBI		GRCr8
mRatBN7.2	12	10,840,137 - 10,933,792 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,840,157 - 10,933,812 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	11,647,392 - 11,740,819 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,270,686 - 12,364,108 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,294,673 - 11,388,443 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,877,559 - 12,907,771 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,877,559 - 12,945,192 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	14,921,905 - 14,953,442 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	11,169,420 - 11,198,144 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	11,201,327 - 11,228,073 (-)	NCBI
Celera	12	12,636,946 - 12,730,083 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dorsomorphin (ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

glyphosate (EXP)

kojic acid (ISO)

mercury dibromide (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

temozolomide (ISO)

thalidomide (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

tremolite asbestos (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of epithelial cell polarity (IEA,ISO)

Golgi vesicle transport (IEA,ISO,ISS)

positive regulation of cell adhesion (IEA,ISO)

regulation of ARF protein signal transduction (IEA)

Cellular Component

adherens junction (IEA,ISO)

bicellular tight junction (IEA,ISO)

cytoplasm (ISO)

cytosol (IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

plasma membrane (IEA,ISO,ISS)

ruffle (IEA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (IEA,ISO,ISS)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA,ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Rat homologues of yeast sec7p.	Telemenakis I, etal., Eur J Cell Biol. 1997 Oct;74(2):143-9.

Additional References at PubMed

PMID:9072969	PMID:9707577	PMID:9742223	PMID:10605025	PMID:11001876	PMID:11445584	PMID:12477932	PMID:17398095	PMID:20080746	PMID:23940353

Genomics

Comparative Map Data

Cyth3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,953,781 - 16,076,584 (-)	NCBI		GRCr8
mRatBN7.2	12	10,840,137 - 10,933,792 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,840,157 - 10,933,812 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	11,647,392 - 11,740,819 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,270,686 - 12,364,108 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,294,673 - 11,388,443 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,877,559 - 12,907,771 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,877,559 - 12,945,192 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	14,921,905 - 14,953,442 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	11,169,420 - 11,198,144 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	11,201,327 - 11,228,073 (-)	NCBI
Celera	12	12,636,946 - 12,730,083 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

CYTH3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	6,161,779 - 6,272,624 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	6,161,779 - 6,272,644 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	6,201,410 - 6,312,255 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	6,167,935 - 6,278,767 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	5,974,652 - 6,085,482	NCBI
Celera	7	6,422,869 - 6,533,702 (+)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	6,073,515 - 6,102,268 (-)	NCBI		HuRef
CHM1_1	7	6,201,010 - 6,311,828 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	6,281,155 - 6,392,015 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	6,247,766 - 6,358,597 (-)	NCBI

Cyth3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	143,608,202 - 143,696,005 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	143,608,202 - 143,696,005 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	143,622,447 - 143,710,250 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	143,622,447 - 143,710,250 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	144,383,316 - 144,471,119 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	143,878,153 - 143,965,865 (+)	NCBI		MGSCv36	mm8
Celera	5	140,664,821 - 140,752,813 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	82.36	NCBI

Cyth3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955460	13,439,634 - 13,492,767 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYTH3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	11,398,092 - 11,511,949 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	59,722,808 - 59,836,661 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	7,170,064 - 7,283,000 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	6,357,978 - 6,386,725 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	6,357,978 - 6,386,756 (-)	Ensembl	panpan1.1		panPan2

CYTH3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	11,554,922 - 11,653,201 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	11,556,511 - 11,645,086 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	13,180,741 - 13,285,865 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	11,555,477 - 11,660,618 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	11,555,477 - 11,645,797 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	11,431,973 - 11,537,027 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	11,411,206 - 11,516,184 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	11,637,860 - 11,743,271 (-)	NCBI		UU_Cfam_GSD_1.0

Cyth3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	139,636,669 - 139,727,627 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936750	283,583 - 308,604 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936750	283,994 - 308,591 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYTH3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	4,900,570 - 5,002,194 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	4,900,575 - 5,002,201 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CYTH3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	15,366,238 - 15,479,781 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	15,369,402 - 15,479,540 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666102	604,064 - 717,566 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cyth3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	31,071,193 - 31,191,264 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	31,071,169 - 31,191,318 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cyth3
449 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	244
Count of miRNA genes:	164
Interacting mature miRNAs:	197
Transcripts:	ENSRNOT00000001412
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	9318216	12829686	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	6833190	17870186	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat

Markers in Region

D12Got20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,912,410 - 10,912,644 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,952,147 - 12,952,380	NCBI	Rnor6.0
Rnor_5.0	12	14,997,656 - 14,997,889	UniSTS	Rnor5.0
RGSC_v3.4	12	11,243,844 - 11,244,078	RGD	RGSC3.4
RGSC_v3.4	12	11,243,845 - 11,244,078	UniSTS	RGSC3.4
RGSC_v3.1	12	11,273,773 - 11,274,006	RGD
Celera	12	12,708,694 - 12,708,923	UniSTS
RH 3.4 Map	12	145.92	UniSTS
RH 3.4 Map	12	145.92	RGD
RH 2.0 Map	12	129.6	RGD
Cytogenetic Map	12	p11	UniSTS

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U83897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001412 ⟹ ENSRNOP00000001412

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	10,840,157 - 10,933,812 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,877,559 - 12,907,771 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082529 ⟹ ENSRNOP00000075144

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	12,879,668 - 12,945,192 (-)	Ensembl

RefSeq Acc Id:

NM_053912 ⟹ NP_446364

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,953,781 - 16,047,428 (-)	NCBI
mRatBN7.2	12	10,840,137 - 10,933,792 (-)	NCBI
Rnor_6.0	12	12,877,559 - 12,907,771 (-)	NCBI
Rnor_5.0	12	14,921,905 - 14,953,442 (-)	NCBI
RGSC_v3.4	12	11,169,420 - 11,198,144 (-)	RGD
Celera	12	12,636,946 - 12,730,083 (-)	RGD

Sequence:

show sequence

CGGGCCGCGCACGCTGAGGAGCTCCTCCGTTCTCCCCGCGACCACTTCTCCTAGTCCCGGCTTT
CAGCCCAGTCGCTCCCGCCGGCTCCGGGCTCGCCGGCTGGCTGGGAGTGGCCTCAAGATGGACG
AAGGCGGTGGCGGTGAGGGCGGCAGCGTGCCTGAAGACCTGTCATTAGAAGAGCGAGAAGAGCT
TTTGGACATCCGTAGAAGGAAAAAGGAACTTATTGATGACATTGAGAGGCTGAAATATGAAATT
GCAGAAGTGATGACGGAAATTGACAACCTGACTTCAGTGGAGGAGAGCAAAACGACACAGAGGA
ACAAGCAAATAGCCATGGGAAGAAAGAAATTCAACATGGATCCCAAAAAGGGCATTCAGTTCCT
GATTGAGAACGACCTGCTGCAGAGCTCCCCAGAGGATGTCGCCCAGTTTCTGTACAAAGGAGAG
GGCCTGAACAAGACCGTCATCGGAGACTACCTGGGTGAGAGAGATGATTTTAACATCAAAGTTC
TTCAGGCTTTTGTTGAGCTGCACGAGTTTGCTGATCTCAACCTTGTCCAGGCCTTAAGGCAGTT
CCTGTGGAGCTTCAGACTTCCTGGAGAGGCGCAGAAGATCGACCGCATGATGGAGGCCTTTGCG
TCCCGATACTGCCTGTGCAACCCTGGGGTCTTCCAGTCCACAGACACTTGCTACGTGCTGTCTT
TTGCCATCATCATGCTCAACACCAGCTTGCACAACCACAATGTGCGGGACAAGCCCACTGCTGA
GCGCTTCATCACCATGAACCGAGGCATCAACGAAGGTGGGGACCTTCCCGAGGAGCTGCTGAGG
AACTTGTATGAAAGTATCAAGAATGAGCCGTTCAAGATCCCAGAGGACGATGGGAATGATCTGA
CCCACACCTTCTTCAATCCAGACCGAGAAGGCTGGCTGCTGAAGCTGGGGGGCCGTGTGAAGAC
CTGGAAGCGGCGCTGGTTCATCCTCACAGACAACTGCCTCTACTACTTTGAGTACACCACGGAC
AAGGAGCCCAGGGGGATCATCCCCCTGGAGAACCTGAGCATCAGGGAGGTGGAGGACCCTCGGA
AGCCGAACTGCTTTGAGCTTTATAACCCCAGTCACAAAGGGCAAGTCATTAAAGCCTGCAAGAC
GGAGGCAGATGGCCGTGTGGTGGAGGGGAACCATGTTGTATACCGGATCTCTGCCCCCAGCCCT
GAGGAGAAGGAGGAGTGGATGAAGTCCATCAAAGCGAGCATCAGTAGGGACCCGTTCTATGACA
TGCTGGCCACAAGGAAGAGGAGGATTGCCAATAAGAAATAGGGAAAAGTCAAGATCCAGACTCC
AGCGGATACACTGGCCTCACAAGCCGCAGGACTGGGGACAGTGTGGACCCCATGGGTCCTCCAG
AAGAGCCAGCCAAGGCCGGAGCCCTCCAGCCTGTGCTCTGGGACATTGGCCAGCTGTGAGCGTC
TCTTTCCTGCCACCGTCCTAGTATTGACCTTTGGGGACCCTTGTCCACAACAGCACCTGGTGAT
GACAGCCTCCAGACCTGCACAGCCCACGTGGGACTCCTGTTCCGGAGCCAGAGCCTCAGCCACA
CCAAGCCACACCTGCTCTCTGGGGCAGCACTACATGTTCTAGAAGTCGCTGTTTTATATCAAAA
TGGGAAAGGAAAACTACCACTTTTTTATTCAGAATTTTTCTCAGATATATAGGATTATAGCTTT
TATATGCCTTTTTATATTCTGAAAATTATAATGAAAGATACTTAATTTCTAACAGTAGTATTTT
TAGAATGGCAGCTATAAACTTAACTCCTGGACACAAGTACACGCTGTGCACTGGAAACACTGTA
TATGCAGCCCCCAGGCACTTGGGACTCAGGCAGCCACTCCGGGTGAAGAGGCACTGGGGTGACC
ATGAGGACCAGTGTGCTTTGGAGACTCAGGCGTGACTGCCACTCCCCCACACATGCTTCTCTAA
CGTGAATCAGTAAGATCAGGCTATGGTTTGGGGCATTGATCCTGTCAGCACCAAGGCCTAGAGA
TGGAATTCTCTGGAACAGGCCACTTCTGTGGAGAACCACATTAAACTGCCCTTCGTGGAGGACA
GCTCTGTGGTCTGACTGCACGTGGCTCGTGGCTTTGGTACATTGGTTGCTTGCTGTTTCACACT
TTGGTTAAGTGCTGACATATTTTGATGTAGTGAGTAGGCAGCCAGAAGCAGCCAGAAATAATTG
ATCTGTCCTCTGGTAATGCCAGGTTTTCCAACATTTGACATCCCGTTGAGGAGGGGAAAGGCTG
AAGATGGCACTGGGGGACACCTGTGGCATCTAGACCCCATGTATACCGGCGTATGACTTTAGGG
CACATGTGCTTGGGCGGAGACGTGGTAGGCGACAGGACCCATTCATCTGAGAGAACCCTCTGGA
GGTTGCATGTGCTTCCTGAGAAATGGCTTTCCCCTGCACATTTGCTTCGCCACTCTGCACCCAC
ACATCTGGAGCCTGTGTTCTGAGGGCCCTTGAAACTGCCATCCAAATGCCCTCACACAAGATGT
TCAGTGAGTGGCCTTGAGGCTTTTTGCCTCTGACCTTGGTGGTAGCTGTCATCTAGGCTGACAC
GGGGATGTGGAGGCCAAAGCTCCCTCATGCACCAAACTCATCACTTTTTGGTTTATTCAAGCTT
CTAGGCTCTTACTATACCTCAAATCTGAAACCCTTGCATTTGAGCTGCCTGGCTGGTGTGTATG
CAGCCTGGCTTCCAGTCTTCCATGATCCCTACCCGTTCCCCACCTCAGACCTGAACTTCCTGCT
GGCAGGGCCCCCGTTGAGAGGTGGGAGCGGGCATTCCTTCAGTCAGGACCCAGGTGTCGCCCTG
GGCAACAGAGCTCTCTGTTGGACATTGAGGACGGGACATTAAGCATGAGGCTTCCTAATGTTGT
CTTTAATGCCATAGTCATCTGTGAGGGGACCTTACCTTATGGCTGTTGGTTTGCCTGATGGCTG
TTGGTGCTAAGAATCCTAAGTTACTGGCTCTTGGAGTATCCGCAAGGAGTCACTTAACTCAGGT
TACGTTGTGACAGTATTAAACCCCAAGGGCATCTGGCCACGCCCAGAGCTTGTAAAGGCTGGGC
ACTCATGCCCTTCACCCTTTGTCTGCACTCATCAGTGAAGCATTGAGCCCTACTCTGGCCAAAG
AGCGTTTCCTGTCCTGCTGGGCTTCAGAACACGTGGTGGGACAGCGGTGTAACTGGGAACCCTT
TGGAGATGCAGCCGCCTACTGTGTGCGCTTCGTGTCATACTGACTTCAGAGCTAAGGTGTGCTT
TGCTGACAAGTTAGGTCGTTACAGACCACAAACCATAGGTTGTGATTTCTCCTTTTTATCTTAG
AAAACATTTCTATTTACAATAAATAGTTACTATGTAAATAGTGTAAATATGTATTAATTTCTTC
CATGTTATACAATGTACATACTCCCTACAACCTGCATGAAGAGAGATCCTATTAATGTCCACAT
CAGAATTTCTGGCTATTGCAAACAGCTAGTGAAATGGAGGGCCTTACAGCTGTCAGAACTATTG
CAAATACCGTTTTCCGTAAATAAAAACATACCGCTAAAAACAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039089024 ⟹ XP_038944952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,953,781 - 16,033,195 (-)	NCBI
mRatBN7.2	12	10,840,137 - 10,905,299 (-)	NCBI

RefSeq Acc Id:

XM_039089028 ⟹ XP_038944956

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,953,781 - 16,034,957 (-)	NCBI
mRatBN7.2	12	10,840,137 - 10,921,269 (-)	NCBI

RefSeq Acc Id:

XM_063271012 ⟹ XP_063127082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,953,781 - 16,047,493 (-)	NCBI

RefSeq Acc Id:

XM_063271013 ⟹ XP_063127083

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,953,781 - 16,076,584 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446364	(Get FASTA)	NCBI Sequence Viewer
	XP_038944952	(Get FASTA)	NCBI Sequence Viewer
	XP_038944956	(Get FASTA)	NCBI Sequence Viewer
	XP_063127082	(Get FASTA)	NCBI Sequence Viewer
	XP_063127083	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB41445	(Get FASTA)	NCBI Sequence Viewer
	AAI01885	(Get FASTA)	NCBI Sequence Viewer
	EDL89656	(Get FASTA)	NCBI Sequence Viewer
	EDL89657	(Get FASTA)	NCBI Sequence Viewer
	EDL89658	(Get FASTA)	NCBI Sequence Viewer
	EDL89659	(Get FASTA)	NCBI Sequence Viewer
	EDL89660	(Get FASTA)	NCBI Sequence Viewer
	EDL89661	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001412.8
GenBank Protein	P97696	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446364 ⟸ NM_053912

- UniProtKB:

P97696 (UniProtKB/Swiss-Prot), Q3T1J6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDEGGGGEGGSVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTT
QRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDDFNI
KVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYV
LSFAIIMLNTSLHNHNVRDKPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGN
DLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED
PRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPF
YDMLATRKRRIANKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000075144 ⟸ ENSRNOT00000082529

Ensembl Acc Id:

ENSRNOP00000001412 ⟸ ENSRNOT00000001412

RefSeq Acc Id:	XP_038944956 ⟸ XM_039089028
- Peptide Label:	isoform X3
- UniProtKB:	P97696 (UniProtKB/Swiss-Prot), A6K1K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944952 ⟸ XM_039089024
- Peptide Label:	isoform X1
- UniProtKB:	P97696 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063127083 ⟸ XM_063271013
- Peptide Label:	isoform X3
- UniProtKB:	P97696 (UniProtKB/Swiss-Prot), A6K1K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127082 ⟸ XM_063271012
- Peptide Label:	isoform X2
- UniProtKB:	P97696 (UniProtKB/Swiss-Prot)

Protein Domains

PH SEC7

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97696-F1-model_v2	AlphaFold	P97696	1-400	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620399	AgrOrtholog
BioCyc Gene	G2FUF-20010	BioCyc
Ensembl Genes	ENSRNOG00000001065	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001412.8	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1000.11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.10.220.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7929513	IMAGE-MGC_LOAD
InterPro	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sec7_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sec7_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sec7_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116693	UniProtKB/TrEMBL
MGC_CLONE	MGC:124579	IMAGE-MGC_LOAD
NCBI Gene	116693	ENTREZGENE
PANTHER	CYTOHESIN-3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sec7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cyth3	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SEC7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001065	RatGTEx
SMART	Sec7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00233	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48425	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6K1K3	ENTREZGENE, UniProtKB/TrEMBL
	CYH3_RAT	UniProtKB/Swiss-Prot
	F1LQP0_RAT	UniProtKB/TrEMBL
	P97696	ENTREZGENE
	Q3T1J6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-04	Cyth3	cytohesin 3	Pscd3	pleckstrin homology, Sec7 and coiled-coil domains 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Pscd3	pleckstrin homology, Sec7 and coiled-coil domains 3	Pscd3	pleckstrin homology, Sec7 and coiled/coil domains 3	Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_homology	has homology to S. cerevisiae sec7p	729512

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Annotations - PID (archival)