Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pomalidomide
go back to main search page
Accession:CHEBI:72690 term browser browse the term
Definition:An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Synonyms:exact_synonym: 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
 related_synonym: 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide;   4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;   4-Aminothalidomide;   CC-4047;   Formula=C13H11N3O4;   InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18);   InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N;   Pomalyst;   SMILES=Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
 alt_id: MESH:C467566
 xref: CAS:19171-19-8;   Drug_Central:4746;   KEGG:D08976
 xref_mesh: MESH:C467566
 xref: PMID:22081489;   PMID:22278747;   PMID:22493299;   PMID:22507780;   PMID:22507794;   PMID:22507799;   PMID:22552008;   PMID:22580766;   PMID:22668122;   PMID:22718823;   PMID:22875080;   PMID:22904257;   PMID:22966948;   PMID:23178378;   PMID:23203815;   PMID:23210501;   PMID:23243282;   PMID:23265189;   PMID:23319574;   PMID:23370364;   PMID:23373782;   PMID:23374145;   Patent:US2007004920;   Patent:US2007048327;   Patent:US2007155791;   Reaxys:8340987;   Wikipedia:Pomalidomide


show annotations for term's descendants           Sort by:
 
pomalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 multiple interactions ISO pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein CTD PMID:29928335 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO pomalidomide results in increased secretion of CCL2 protein CTD PMID:15292067 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO pomalidomide results in increased expression of CEBPA mRNA CTD PMID:15292067 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO pomalidomide results in increased expression of CEBPD mRNA CTD PMID:15292067 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon increases expression ISO pomalidomide results in increased expression of CEBPE mRNA CTD PMID:15292067 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Crbn cereblon multiple interactions
affects binding
increases response to substance
ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide
CTD PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
JBrowse link
G Csf2 colony stimulating factor 2 decreases secretion ISO pomalidomide results in decreased secretion of CSF2 protein CTD PMID:15292067 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO pomalidomide results in increased secretion of CSF3 protein CTD PMID:15292067 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation ISO CYP2C19 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases oxidation ISO CYP2J2 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation ISO CYP3A4 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dtwd1 DTW domain containing 1 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein CTD PMID:30067223 NCBI chr 3:113,392,402...113,409,322
Ensembl chr 3:113,392,457...113,408,105
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:29928335 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO pomalidomide results in decreased expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO pomalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein] CTD PMID:29928335 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gata1 GATA binding protein 1 decreases expression ISO pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 decreases expression ISO pomalidomide results in decreased expression of GATA2 mRNA CTD PMID:15292067 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor increases expression ISO pomalidomide results in increased expression of GFI1 mRNA CTD PMID:15292067 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814
JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor decreases expression ISO pomalidomide results in decreased expression of GFI1B mRNA CTD PMID:15292067 NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO pomalidomide results in increased expression of ID1 mRNA CTD PMID:15292067 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO pomalidomide results in increased expression of ID2 mRNA CTD PMID:15292067 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein] CTD PMID:29928335 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein] CTD PMID:29928335 NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591
JBrowse link
G Il10 interleukin 10 increases secretion ISO pomalidomide results in increased secretion of IL10 protein CTD PMID:15292067 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases secretion ISO pomalidomide results in decreased secretion of IL13 protein CTD PMID:15292067 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il5 interleukin 5 decreases secretion ISO pomalidomide results in decreased secretion of IL5 protein CTD PMID:15292067 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein CTD PMID:29928335 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO pomalidomide results in decreased expression of JUND mRNA CTD PMID:15292067 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Klf1 Kruppel like factor 1 decreases expression ISO pomalidomide results in decreased expression of KLF1 mRNA CTD PMID:15292067 NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758
JBrowse link
G Lmo2 LIM domain only 2 decreases expression ISO pomalidomide results in decreased expression of LMO2 mRNA CTD PMID:15292067 NCBI chr 3:90,355,234...90,377,970
Ensembl chr 3:90,365,883...90,377,953
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Nfe2 nuclear factor, erythroid 2 decreases expression ISO pomalidomide results in decreased expression of NFE2 mRNA CTD PMID:15292067 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Prkcq protein kinase C, theta multiple interactions ISO pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein] CTD PMID:16241859 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Spi1 Spi-1 proto-oncogene increases expression
decreases expression
ISO pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein
CTD PMID:15292067 PMID:16373662 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Wiz WIZ zinc finger multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of WIZ protein CTD PMID:30067223 NCBI chr 7:11,366,837...11,395,279
Ensembl chr 7:11,367,035...11,395,490
JBrowse link
G Zbtb39 zinc finger and BTB domain containing 39 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein CTD PMID:30067223 NCBI chr 7:63,577,030...63,584,527
Ensembl chr 7:63,576,917...63,589,210
JBrowse link
G Zfp653 zinc finger protein 653 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein CTD PMID:30067223 NCBI chr 8:20,586,563...20,605,439
Ensembl chr 8:20,586,563...20,604,864
JBrowse link
G Zfp91 zinc finger protein 91 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein CTD PMID:30067223 NCBI chr 1:209,891,344...209,928,890
Ensembl chr 1:209,891,344...209,927,762
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        immunomodulator 14893
          pomalidomide 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      benzopyrrole 9559
                                        isoindoles 1127
                                          phthalimides 998
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 450
                                              (R)-thalidomide 450
                                                thalidomide 450
                                                  pomalidomide 45
paths to the root