CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pomalidomide
Accession: CHEBI:72690
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Definition: An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Synonyms: exact_synonym: 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
related_synonym: 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-Aminothalidomide; CC-4047; Formula=C13H11N3O4; InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18); InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N; Pomalyst; SMILES=Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
alt_id: MESH:C467566
xref: CAS:19171-19-8; Drug_Central:4746; KEGG:D08976
xref_mesh: MESH:C467566
xref: PMID:22081489; PMID:22278747; PMID:22493299; PMID:22507780; PMID:22507794; PMID:22507799; PMID:22552008; PMID:22580766; PMID:22668122; PMID:22718823; PMID:22875080; PMID:22904257; PMID:22966948; PMID:23178378; PMID:23203815; PMID:23210501; PMID:23243282; PMID:23265189; PMID:23319574; PMID:23370364; PMID:23373782; PMID:23374145; Patent:US2007004920; Patent:US2007048327; Patent:US2007155791; Reaxys:8340987; Wikipedia:Pomalidomide
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Brd4
bromodomain containing 4
multiple interactions
ISO
pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]
CTD
PMID:26051217
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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Casp3
caspase 3
multiple interactions
ISO
[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein
CTD
PMID:29928335
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
multiple interactions
ISO
[afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein
CTD
PMID:29928335
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Ccl2
C-C motif chemokine ligand 2
increases secretion
ISO
pomalidomide results in increased secretion of CCL2 protein
CTD
PMID:15292067
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cebpa
CCAAT/enhancer binding protein alpha
increases expression
ISO
pomalidomide results in increased expression of CEBPA mRNA
CTD
PMID:15292067
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cebpd
CCAAT/enhancer binding protein delta
increases expression
ISO
pomalidomide results in increased expression of CEBPD mRNA
CTD
PMID:15292067
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Cebpe
CCAAT/enhancer binding protein epsilon
increases expression
ISO
pomalidomide results in increased expression of CEBPE mRNA
CTD
PMID:15292067
NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
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Crbn
cereblon
multiple interactions increases response to substance affects binding
ISO
[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CRBN results in increased susceptibility to pomalidomide pomalidomide binds to [SALL4 protein binds to CRBN protein]
CTD
PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223
NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
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Csf2
colony stimulating factor 2
decreases secretion
ISO
pomalidomide results in decreased secretion of CSF2 protein
CTD
PMID:15292067
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
increases secretion
ISO
pomalidomide results in increased secretion of CSF3 protein
CTD
PMID:15292067
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases oxidation
ISO
CYP2C19 protein results in increased oxidation of pomalidomide
CTD
PMID:24350712
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases oxidation
ISO
CYP2J2 protein results in increased oxidation of pomalidomide
CTD
PMID:24350712
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases oxidation
ISO
CYP3A4 protein results in increased oxidation of pomalidomide
CTD
PMID:24350712
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Dtwd1
DTW domain containing 1
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein
CTD
PMID:30067223
NCBI chr 3:113,392,402...113,409,322
Ensembl chr 3:113,392,457...113,408,105
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein]
CTD
PMID:29928335
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Fam83f
family with sequence similarity 83, member F
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein
CTD
PMID:30067223
NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
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Fgfr1
Fibroblast growth factor receptor 1
decreases expression
ISO
pomalidomide results in decreased expression of FGFR1 mRNA
CTD
PMID:30834740
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Fgfr3
fibroblast growth factor receptor 3
affects expression
ISO
pomalidomide affects the expression of FGFR3 mRNA
CTD
PMID:30834740
NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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Foxo1
forkhead box O1
multiple interactions
ISO
[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein]
CTD
PMID:29928335
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Gata1
GATA binding protein 1
decreases expression
ISO
pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein
CTD
PMID:15292067
NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530
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Gata2
GATA binding protein 2
decreases expression
ISO
pomalidomide results in decreased expression of GATA2 mRNA
CTD
PMID:15292067
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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Gfi1
growth factor independent 1 transcriptional repressor
increases expression
ISO
pomalidomide results in increased expression of GFI1 mRNA
CTD
PMID:15292067
NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814
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Gfi1b
growth factor independent 1B transcriptional repressor
decreases expression
ISO
pomalidomide results in decreased expression of GFI1B mRNA
CTD
PMID:15292067
NCBI chr 3:11,940,232...11,952,989
Ensembl chr 3:11,940,233...11,952,942
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Id1
inhibitor of DNA binding 1
increases expression
ISO
pomalidomide results in increased expression of ID1 mRNA
CTD
PMID:15292067
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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Id2
inhibitor of DNA binding 2
increases expression
ISO
pomalidomide results in increased expression of ID2 mRNA
CTD
PMID:15292067
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Ikzf1
IKAROS family zinc finger 1
multiple interactions
ISO
[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein]
CTD
PMID:29928335
NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
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Ikzf3
IKAROS family zinc finger 3
multiple interactions
ISO
[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein]
CTD
PMID:29928335
NCBI chr10:83,460,564...83,553,591
Ensembl chr10:83,465,745...83,553,591
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Il10
interleukin 10
increases secretion
ISO
pomalidomide results in increased secretion of IL10 protein
CTD
PMID:15292067
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il13
interleukin 13
decreases secretion
ISO
pomalidomide results in decreased secretion of IL13 protein
CTD
PMID:15292067
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il2
interleukin 2
multiple interactions
ISO
Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]
CTD
PMID:16241859
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il5
interleukin 5
decreases secretion
ISO
pomalidomide results in decreased secretion of IL5 protein
CTD
PMID:15292067
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Irf4
interferon regulatory factor 4
multiple interactions
ISO
[pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein
CTD
PMID:29928335
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
pomalidomide results in decreased expression of JUND mRNA
CTD
PMID:15292067
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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Klf1
KLF transcription factor 1
decreases expression
ISO
pomalidomide results in decreased expression of KLF1 mRNA
CTD
PMID:15292067
NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758
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Lmo2
LIM domain only 2
decreases expression
ISO
pomalidomide results in decreased expression of LMO2 mRNA
CTD
PMID:15292067
NCBI chr 3:90,355,234...90,377,970
Ensembl chr 3:90,365,883...90,377,953
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Meis2
Meis homeobox 2
multiple interactions
ISO
pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
CTD
PMID:25043012
NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696
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Nfe2
nuclear factor, erythroid 2
decreases expression
ISO
pomalidomide results in decreased expression of NFE2 mRNA
CTD
PMID:15292067
NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
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Prkcq
protein kinase C, theta
multiple interactions
ISO
pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]
CTD
PMID:16241859
NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
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Rab28
RAB28, member RAS oncogene family
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein
CTD
PMID:30067223
NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
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Sall4
spalt-like transcription factor 4
affects binding multiple interactions
ISO
pomalidomide binds to [SALL4 protein binds to CRBN protein] pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD
PMID:30067223
NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
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Spi1
Spi-1 proto-oncogene
increases expression decreases expression
ISO
pomalidomide results in increased expression of SPI1 mRNA pomalidomide results in decreased expression of SPI1 protein
CTD
PMID:15292067 PMID:16373662
NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
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Wiz
WIZ zinc finger
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of WIZ protein
CTD
PMID:30067223
NCBI chr 7:11,366,837...11,395,279
Ensembl chr 7:11,367,035...11,395,490
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Zbtb39
zinc finger and BTB domain containing 39
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein
CTD
PMID:30067223
NCBI chr 7:63,576,998...63,584,549
Ensembl chr 7:63,576,917...63,589,210
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Zfp653
zinc finger protein 653
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein
CTD
PMID:30067223
NCBI chr 8:20,586,607...20,605,439
Ensembl chr 8:20,586,563...20,604,864
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Zfp91
zinc finger protein 91
multiple interactions
ISO
pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein
CTD
PMID:30067223
NCBI chr 1:209,891,344...209,928,890
Ensembl chr 1:209,891,344...209,927,762
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