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ONTOLOGY REPORT - ANNOTATIONS


Term:pomalidomide
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Accession:CHEBI:72690 term browser browse the term
Definition:An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Synonyms:exact_synonym: 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
 related_synonym: 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide;   4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;   4-Aminothalidomide;   CC-4047;   Formula=C13H11N3O4;   InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18);   InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N;   Pomalyst;   SMILES=Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
 alt_id: MESH:C467566
 xref: CAS:19171-19-8 "ChemIDplus";   CAS:19171-19-8 "KEGG DRUG";   Drug_Central:4746 "DrugCentral";   KEGG:D08976
 xref_mesh: MESH:C467566
 xref: PMID:22081489 "Europe PMC";   PMID:22278747 "Europe PMC";   PMID:22493299 "Europe PMC";   PMID:22507780 "Europe PMC";   PMID:22507794 "Europe PMC";   PMID:22507799 "Europe PMC";   PMID:22552008 "Europe PMC";   PMID:22580766 "Europe PMC";   PMID:22668122 "Europe PMC";   PMID:22718823 "Europe PMC";   PMID:22875080 "Europe PMC";   PMID:22904257 "Europe PMC";   PMID:22966948 "Europe PMC";   PMID:23178378 "Europe PMC";   PMID:23203815 "Europe PMC";   PMID:23210501 "Europe PMC";   PMID:23243282 "Europe PMC";   PMID:23265189 "Europe PMC";   PMID:23319574 "Europe PMC";   PMID:23370364 "Europe PMC";   PMID:23373782 "Europe PMC";   PMID:23374145 "Europe PMC";   Patent:US2007004920;   Patent:US2007048327;   Patent:US2007155791;   Reaxys:8340987 "Reaxys";   Wikipedia:Pomalidomide


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pomalidomide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:6480464
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6480464
G Cebpe CCAAT/enhancer binding protein epsilon JBrowse link 15 33,356,119 33,357,517 RGD:6480464
G Crbn cereblon JBrowse link 4 138,864,910 138,885,786 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Dtwd1 DTW domain containing 1 JBrowse link 3 118,427,790 118,443,003 RGD:6480464
G Fam83f family with sequence similarity 83, member F JBrowse link 7 121,889,157 121,918,772 RGD:6480464
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6480464
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6480464
G Gata1 GATA binding protein 1 JBrowse link X 15,273,937 15,281,759 RGD:6480464
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:6480464
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:6480464
G Gfi1b growth factor independent 1B transcriptional repressor JBrowse link 3 7,190,721 7,203,444 RGD:6480464
G Id1 inhibitor of DNA binding 1, HLH protein JBrowse link 3 148,214,623 148,216,715 RGD:6480464
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:6480464
G Klf1 Kruppel like factor 1 JBrowse link 19 26,016,289 26,019,557 RGD:6480464
G Lmo2 LIM domain only 2 JBrowse link 3 93,909,156 93,931,888 RGD:6480464
G Meis2 Meis homeobox 2 JBrowse link 3 107,560,172 107,762,732 RGD:6480464
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:6480464
G Prkcq protein kinase C, theta JBrowse link 17 70,971,915 71,105,286 RGD:6480464
G Rab28 RAB28, member RAS oncogene family JBrowse link 14 73,888,968 73,963,209 RGD:6480464
G Sall4 spalt-like transcription factor 4 JBrowse link 3 165,520,155 165,538,176 RGD:6480464
G Spi1 Spi-1 proto-oncogene JBrowse link 3 79,918,127 79,937,708 RGD:6480464
G Wiz WIZ zinc finger JBrowse link 7 14,374,358 14,402,647 RGD:6480464
G Zbtb39 zinc finger and BTB domain containing 39 JBrowse link 7 71,036,581 71,044,057 RGD:6480464
G Zfp653 zinc finger protein 653 JBrowse link 8 23,066,576 23,085,502 RGD:6480464
G Zfp91 zinc finger protein 91 JBrowse link 1 229,602,499 229,640,906 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        immunomodulator 12650
          pomalidomide 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      benzopyrrole 5747
                                        isoindoles 504
                                          phthalimides 442
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 428
                                              (R)-thalidomide 428
                                                thalidomide 428
                                                  pomalidomide 37
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.