Uqcc5 (ubiquinol-cytochrome c reductase complex assembly factor 5) - Rat Genome Database

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Gene: Uqcc5 (ubiquinol-cytochrome c reductase complex assembly factor 5) Rattus norvegicus
Analyze
Symbol: Uqcc5
Name: ubiquinol-cytochrome c reductase complex assembly factor 5
RGD ID: 1307583
Description: Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex III assembly. Predicted to be active in mitochondrial inner membrane. Orthologous to human UQCC5 (ubiquinol-cytochrome c reductase complex assembly factor 5); INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361111; RGD1307583; small integral membrane protein 4; small nucleolar RNA host gene (non-protein coding) 8; Smim4; Snhg8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,323,071 - 6,326,911 (-)NCBIGRCr8
mRatBN7.2166,316,631 - 6,320,471 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,286,300 - 6,320,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,328,622 - 6,332,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,473,846 - 7,477,683 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,335,579 - 6,339,417 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,206,632 - 7,210,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0167,135,195 - 7,139,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,553,765 - 6,557,642 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,553,762 - 6,559,561 (-)NCBI
Celera168,868,939 - 8,872,824 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:34165173   PMID:34585441  


Genomics

Comparative Map Data
Uqcc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,323,071 - 6,326,911 (-)NCBIGRCr8
mRatBN7.2166,316,631 - 6,320,471 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,286,300 - 6,320,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,328,622 - 6,332,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,473,846 - 7,477,683 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,335,579 - 6,339,417 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,206,632 - 7,210,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0167,135,195 - 7,139,086 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,553,765 - 6,557,642 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,553,762 - 6,559,561 (-)NCBI
Celera168,868,939 - 8,872,824 (+)NCBICelera
Cytogenetic Map16p16NCBI
UQCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,536,605 - 52,541,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,534,013 - 52,579,237 (+)EnsemblGRCh38hg38GRCh38
GRCh37352,570,621 - 52,575,906 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,543,954 - 52,549,863 (+)NCBINCBI36Build 36hg18NCBI36
Celera352,550,126 - 52,554,091 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,633,221 - 52,637,183 (+)NCBIHuRef
CHM1_1352,522,929 - 52,526,891 (+)NCBICHM1_1
T2T-CHM13v2.0352,567,702 - 52,574,786 (+)NCBIT2T-CHM13v2.0
Uqcc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,810,081 - 30,850,894 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,810,089 - 30,850,913 (-)EnsemblGRCm39 Ensembl
GRCm381431,088,127 - 31,128,930 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,088,132 - 31,128,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,937,691 - 31,942,116 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,953,514 - 29,957,933 (-)NCBIMGSCv36mm8
Celera1427,382,925 - 27,387,270 (-)NCBICelera
Cytogenetic Map14BNCBI
Smim4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049563131,988 - 5,240 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049563131,988 - 5,240 (+)NCBIChiLan1.0ChiLan1.0
LOC100991966
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,531,072 - 52,535,345 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,535,908 - 52,540,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,478,192 - 52,482,186 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,704,939 - 53,710,622 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,706,374 - 53,749,398 (+)Ensemblpanpan1.1panPan2
UQCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,234,675 - 37,238,450 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,228,887 - 37,238,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,216,641 - 37,220,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,584,265 - 37,588,036 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12036,948,834 - 36,952,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,357,437 - 37,361,208 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,635,691 - 37,639,458 (-)NCBIUU_Cfam_GSD_1.0
Smim4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,236,382 - 170,240,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,374,966 - 3,378,797 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,374,954 - 3,378,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMIM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,682,294 - 34,686,027 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,679,623 - 34,687,171 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,891,694 - 37,895,304 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMIM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,904,843 - 13,909,062 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,904,852 - 13,910,667 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,991,260 - 152,995,450 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smim4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,669,627 - 4,672,979 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,670,433 - 4,672,997 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uqcc5
11 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000113907   ⟹   ENSRNOP00000096582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,286,300 - 6,320,326 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116930   ⟹   ENSRNOP00000083865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,315,881 - 6,320,642 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119717   ⟹   ENSRNOP00000089813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,316,225 - 6,320,642 (-)Ensembl
RefSeq Acc Id: NM_001399168   ⟹   NP_001386097
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,323,071 - 6,326,911 (-)NCBI
mRatBN7.2166,316,631 - 6,320,471 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386097 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88965 (Get FASTA)   NCBI Sequence Viewer  
  EDL88966 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083865.1
  ENSRNOP00000089813
  ENSRNOP00000089813.1
  ENSRNOP00000096582.1
RefSeq Acc Id: ENSRNOP00000089813   ⟸   ENSRNOT00000119717
RefSeq Acc Id: ENSRNOP00000083865   ⟸   ENSRNOT00000116930
RefSeq Acc Id: ENSRNOP00000096582   ⟸   ENSRNOT00000113907
RefSeq Acc Id: NP_001386097   ⟸   NM_001399168
- UniProtKB: A0A8I6ACI0 (UniProtKB/TrEMBL),   A0A8I5ZY67 (UniProtKB/TrEMBL),   A6KG08 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307583 AgrOrtholog
BioCyc Gene G2FUF-12162 BioCyc
Ensembl Genes ENSRNOG00000068020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000113907.1 UniProtKB/TrEMBL
  ENSRNOT00000116930.1 UniProtKB/TrEMBL
  ENSRNOT00000119717 ENTREZGENE
  ENSRNOT00000119717.1 UniProtKB/TrEMBL
InterPro UPF0640 UniProtKB/TrEMBL
KEGG Report rno:361111 UniProtKB/TrEMBL
NCBI Gene 361111 ENTREZGENE
PANTHER PTHR35250 UniProtKB/TrEMBL
  SMALL INTEGRAL MEMBRANE PROTEIN 4 UniProtKB/TrEMBL
Pfam UPF0640 UniProtKB/TrEMBL
PhenoGen Uqcc5 PhenoGen
RatGTEx ENSRNOG00000068020 RatGTEx
UniProt A0A8I5ZY67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACI0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQ87_RAT UniProtKB/TrEMBL
  A6KG08 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Uqcc5  ubiquinol-cytochrome c reductase complex assembly factor 5  Smim4  small integral membrane protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-06-02 Smim4  small integral membrane protein 4  Smim4  small integral membrane protein 4  Data merged from RGD:149736513 737654 PROVISIONAL
2021-08-09 Smim4  small integral membrane protein 4      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-02 Smim4  small integral membrane protein 4  Snhg8  small nucleolar RNA host gene (non-protein coding) 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Snhg8  small nucleolar RNA host gene (non-protein coding) 8  RGD1307583_predicted  LOC361111 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307583_predicted  LOC361111 (predicted)  LOC361111_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361111_predicted  LOC361111 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL