Bod1 (biorientation of chromosomes in cell division 1) - Rat Genome Database

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Gene: Bod1 (biorientation of chromosomes in cell division 1) Rattus norvegicus
Analyze
Symbol: Bod1
Name: biorientation of chromosomes in cell division 1
RGD ID: 1305622
Description: Predicted to enable protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Predicted to be involved in mitotic sister chromatid biorientation; mitotic sister chromatid cohesion, centromeric; and protein localization to chromosome, centromeric region. Predicted to be located in centrosome; spindle microtubule; and spindle pole. Predicted to be part of Set1C/COMPASS complex and outer kinetochore. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1); INTERACTS WITH (+)-schisandrin B; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: biorientation defective protein 1; biorientation of chromosomes in cell division protein 1; Fam44b; family with sequence similarity 44, member B; hypothetical LOC287173; LOC287173; RGD1305622
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,497,918 - 16,504,259 (+)NCBIGRCr8
mRatBN7.21015,993,454 - 15,999,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,740,896 - 20,747,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,229,826 - 20,236,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,719,433 - 15,725,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,259,728 - 16,266,069 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,152,118 - 16,158,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,255,404 - 16,261,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,256,452 - 16,262,788 (+)NCBI
Celera1015,659,266 - 15,665,607 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:17938248   PMID:24157919  


Genomics

Comparative Map Data
Bod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81016,497,918 - 16,504,259 (+)NCBIGRCr8
mRatBN7.21015,993,454 - 15,999,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,740,896 - 20,747,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01020,229,826 - 20,236,167 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,719,433 - 15,725,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01016,259,728 - 16,266,069 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01016,152,118 - 16,158,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41016,255,404 - 16,261,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11016,256,452 - 16,262,788 (+)NCBI
Celera1015,659,266 - 15,665,607 (+)NCBICelera
Cytogenetic Map10q12NCBI
BOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385173,607,145 - 173,616,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5173,607,145 - 173,616,659 (-)EnsemblGRCh38hg38GRCh38
GRCh375173,034,148 - 173,043,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,967,146 - 172,976,262 (-)NCBINCBI36Build 36hg18NCBI36
Build 345172,967,149 - 172,976,262NCBI
Celera5169,066,406 - 169,075,924 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5168,129,859 - 168,139,374 (-)NCBIHuRef
CHM1_15172,466,671 - 172,476,189 (-)NCBICHM1_1
T2T-CHM13v2.05174,147,207 - 174,156,712 (-)NCBIT2T-CHM13v2.0
Bod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,615,150 - 31,621,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,615,181 - 31,621,885 (-)EnsemblGRCm39 Ensembl
GRCm381131,665,150 - 31,671,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,665,181 - 31,671,885 (-)EnsemblGRCm38mm10GRCm38
MGSCv371131,565,150 - 31,571,862 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361131,565,150 - 31,571,862 (-)NCBIMGSCv36mm8
Celera1134,080,907 - 34,087,599 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.55NCBI
Bod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540826,235,229 - 26,242,576 (-)NCBIChiLan1.0ChiLan1.0
BOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24168,734,263 - 168,743,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15166,873,789 - 166,882,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05168,951,787 - 168,960,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15175,857,814 - 175,866,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5175,857,814 - 175,866,951 (-)Ensemblpanpan1.1panPan2
BOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1438,888,096 - 38,895,539 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha438,834,963 - 38,842,274 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0439,259,503 - 39,266,976 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1439,077,779 - 39,085,242 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0439,266,320 - 39,273,785 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0439,774,971 - 39,782,432 (+)NCBIUU_Cfam_GSD_1.0
Bod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721393,357,695 - 93,425,351 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366092,034,271 - 2,096,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11650,734,510 - 50,743,417 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21654,988,365 - 54,996,776 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12375,761,476 - 75,771,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660342,834,544 - 2,844,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473316,459,383 - 16,469,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bod1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:263
Interacting mature miRNAs:316
Transcripts:ENSRNOT00000028115
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028115   ⟹   ENSRNOP00000028115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,993,454 - 15,999,787 (+)Ensembl
Rnor_6.0 Ensembl1016,259,728 - 16,266,061 (+)Ensembl
RefSeq Acc Id: NM_001013854   ⟹   NP_001013876
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81016,497,918 - 16,504,255 (+)NCBI
mRatBN7.21015,993,454 - 15,999,791 (+)NCBI
Rnor_6.01016,259,728 - 16,266,065 (+)NCBI
Rnor_5.01016,152,118 - 16,158,459 (+)NCBI
RGSC_v3.41016,255,404 - 16,261,741 (+)RGD
Celera1015,659,266 - 15,665,603 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073160
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81016,497,921 - 16,504,259 (+)NCBI
mRatBN7.21015,993,457 - 15,999,795 (+)NCBI
Rnor_6.01016,259,731 - 16,266,069 (+)NCBI
Rnor_5.01016,152,118 - 16,158,459 (+)NCBI
Celera1015,659,269 - 15,665,607 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001013876 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79025 (Get FASTA)   NCBI Sequence Viewer  
  EDM04034 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028115.5
GenBank Protein Q6AYJ2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013876   ⟸   NM_001013854
- UniProtKB: A0A0H2UHS5 (UniProtKB/TrEMBL),   A6HDC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028115   ⟸   ENSRNOT00000028115

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYJ2-F1-model_v2 AlphaFold Q6AYJ2 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697085
Promoter ID:EPDNEW_R7609
Type:initiation region
Name:Bod1_1
Description:biorientation of chromosomes in cell division 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01016,259,809 - 16,259,869EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305622 AgrOrtholog
BioCyc Gene G2FUF-25671 BioCyc
Ensembl Genes ENSRNOG00000020717 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028115.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113945 IMAGE-MGC_LOAD
InterPro Bod1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93951 IMAGE-MGC_LOAD
NCBI Gene 287173 ENTREZGENE
PANTHER BIORIENTATION OF CHROMOSOMES IN CELL DIVISION PROTEIN 1-LIKE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31532 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COMPASS-Shg1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bod1 PhenoGen
RatGTEx ENSRNOG00000020717 RatGTEx
UniProt A0A0H2UHS5 ENTREZGENE, UniProtKB/TrEMBL
  A6HDC9 ENTREZGENE, UniProtKB/TrEMBL
  BOD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-03-24 Bod1  biorientation of chromosomes in cell division 1  Fam44b  family with sequence similarity 44, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fam44b  family with sequence similarity 44, member B  RGD1305622  hypothetical LOC287173  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305622  hypothetical LOC287173  RGD1305622_predicted  hypothetical LOC287173 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305622_predicted  hypothetical LOC287173 (predicted)  LOC287173_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC287173_predicted  hypothetical LOC287173 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL