Cripto (cripto, EGF-CFC family member) - Rat Genome Database

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Gene: Cripto (cripto, EGF-CFC family member) Rattus norvegicus
Analyze
Symbol: Cripto (Ensembl: Tdgf1)
Name: cripto, EGF-CFC family member (Ensembl:teratocarcinoma-derived growth factor 1)
RGD ID: 1594185
Description: Predicted to enable several functions, including Wnt-protein binding activity; coreceptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; circulatory system development; and regionalization. Predicted to act upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in cell surface and extracellular region. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH trichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog); 2,2',5,5'-tetrachlorobiphenyl (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680246; similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor); Tdgf1; teratocarcinoma-derived growth factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,803,182 - 119,808,714 (-)NCBIGRCr8
mRatBN7.28110,924,774 - 110,938,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,925,024 - 110,930,308 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08119,215,266 - 119,220,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,215,495 - 119,219,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,554,829 - 118,560,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,341,587 - 115,346,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8110,206,645 - 110,212,260 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
anterior/posterior axis specification, embryo  (ISO)
anterior/posterior pattern specification  (IBA)
biological_process  (ND)
blood vessel development  (IBA)
cardiac muscle cell differentiation  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
determination of left/right symmetry  (IBA)
epidermal growth factor receptor signaling pathway  (ISO)
fibroblast proliferation  (ISO)
gastrulation  (ISO)
heart development  (IBA,ISO)
in utero embryonic development  (ISO)
morphogenesis of a branching structure  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nodal signaling pathway  (IBA,ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of fibroblast migration  (ISO)
regulation of signal transduction  (ISO)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Lonardo E, etal., Stem Cells. 2010 Aug;28(8):1326-37. doi: 10.1002/stem.458.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. Wang B, etal., Int J Cardiol. 2011 Jan 21;146(2):225-7. doi: 10.1016/j.ijcard.2009.08.046. Epub 2009 Oct 24.
9. Cripto: a novel target for antibody-based cancer immunotherapy. Xing PX, etal., Cancer Res. 2004 Jun 1;64(11):4018-23.
Additional References at PubMed
PMID:8006041   PMID:8588926   PMID:9013573   PMID:9576836   PMID:9790191   PMID:9876177   PMID:10493495   PMID:10640699   PMID:11133982   PMID:11389842   PMID:11909953   PMID:11992720  
PMID:12052855   PMID:12649175   PMID:12925698   PMID:15797385   PMID:17360443   PMID:17568773   PMID:17720976   PMID:17936261   PMID:17991893   PMID:18241853   PMID:18425773  


Genomics

Comparative Map Data
Cripto
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,803,182 - 119,808,714 (-)NCBIGRCr8
mRatBN7.28110,924,774 - 110,938,545 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,925,024 - 110,930,308 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08119,215,266 - 119,220,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,215,495 - 119,219,232 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,554,829 - 118,560,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,341,587 - 115,346,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8110,206,645 - 110,212,260 (-)NCBICelera
Cytogenetic Map8q32NCBI
CRIPTO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,574,535 - 46,582,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,574,534 - 46,582,457 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,616,025 - 46,623,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,594,217 - 46,598,957 (+)NCBINCBI36Build 36hg18NCBI36
Build 34346,594,216 - 46,598,954NCBI
Celera346,553,783 - 46,561,683 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,658,557 - 46,666,459 (+)NCBIHuRef
CHM1_1346,566,173 - 46,574,073 (+)NCBICHM1_1
T2T-CHM13v2.0346,590,623 - 46,598,545 (+)NCBIT2T-CHM13v2.0
Cripto
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,768,676 - 110,775,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,768,671 - 110,775,226 (-)EnsemblGRCm39 Ensembl
GRCm389110,939,608 - 110,946,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,939,603 - 110,946,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,842,112 - 110,848,662 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,784,418 - 110,790,883 (-)NCBIMGSCv36mm8
Celera9110,664,719 - 110,671,594 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Cripto
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,477,122 - 25,479,969 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,476,975 - 25,479,969 (-)NCBIChiLan1.0ChiLan1.0
CRIPTO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,530,938 - 46,535,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,535,714 - 46,540,728 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,473,282 - 46,478,454 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,577,949 - 47,583,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,577,949 - 47,583,126 (+)Ensemblpanpan1.1panPan2
CRIPTO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,137,939 - 42,140,590 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,053,910 - 42,056,560 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,620,327 - 42,622,979 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,620,327 - 42,623,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,861,683 - 41,864,330 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,262,807 - 42,265,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,543,717 - 42,546,368 (-)NCBIUU_Cfam_GSD_1.0
Cripto
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,900,937 - 200,905,070 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936596451,483 - 453,892 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRIPTO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,540,314 - 29,543,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,537,874 - 29,544,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,774,947 - 32,777,177 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRIPTO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,993,724 - 8,000,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,997,383 - 8,000,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,149,573 - 159,153,094 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cripto
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,547,226 - 74,550,526 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cripto
247 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000040840
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 19 17 17 20 6 13 6 2 58 36 14 8 40 14

Sequence


Ensembl Acc Id: ENSRNOT00000040840   ⟹   ENSRNOP00000047852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,925,024 - 110,930,308 (-)Ensembl
Rnor_6.0 Ensembl8119,215,495 - 119,219,232 (-)Ensembl
RefSeq Acc Id: XM_063266259   ⟹   XP_063122329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,803,182 - 119,808,714 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001417320 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122329 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047852.6
Ensembl Acc Id: ENSRNOP00000047852   ⟸   ENSRNOT00000040840
RefSeq Acc Id: XP_063122329   ⟸   XM_063266259
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M2P2-F1-model_v2 AlphaFold F1M2P2 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696342
Promoter ID:EPDNEW_R6865
Type:single initiation site
Name:AC132539_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6867  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,214,513 - 119,214,573EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594185 AgrOrtholog
BioCyc Gene G2FUF-29041 BioCyc
Ensembl Genes ENSRNOG00000037171 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040840.6 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro Cryptic/Cripto_CFC-dom UniProtKB/TrEMBL
  Dev_Signal_Modulators UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
NCBI Gene 680246 ENTREZGENE
PANTHER EGF-LIKE-DOMAIN, MULTIPLE 7, 8 UniProtKB/TrEMBL
  TERATOCARCINOMA-DERIVED GROWTH FACTOR 1 UniProtKB/TrEMBL
Pfam CFC UniProtKB/TrEMBL
PhenoGen Cripto PhenoGen
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037171 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt F1M2P2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-19 Cripto  cripto, EGF-CFC family member  Tdgf1  teratocarcinoma-derived growth factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tdgf1  teratocarcinoma-derived growth factor 1  LOC680246  similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680246  similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor)  LOC686890  similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor)  Data merged from RGD:1592468 1643240 APPROVED
2006-11-20 LOC680246  similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686890  similar to Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor)      Symbol and Name status set to provisional 70820 PROVISIONAL