Myom1 (myomesin 1) - Rat Genome Database

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Gene: Myom1 (myomesin 1) Rattus norvegicus
Analyze
Symbol: Myom1
Name: myomesin 1
RGD ID: 631436
Description: Predicted to enable kinase binding activity and protein homodimerization activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM1 (myomesin 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myomesin 1 (skelemin) 185kDa; myomesin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29110,916,156 - 111,039,344 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9110,915,943 - 111,039,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9119,308,091 - 119,433,086 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,437,676 - 124,562,686 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09122,774,056 - 122,899,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,353,840 - 119,469,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,353,840 - 119,468,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09118,808,061 - 118,922,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,218,668 - 110,341,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,492,862 - 110,499,352 (+)NCBI
Celera9108,050,734 - 108,169,433 (+)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
M band  (IDA,ISO)
sarcomere  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, etal., J Exp Biol 2003 Sep 1;206(Pt 17):3101-3112.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. Vinkemeier U, etal., J Cell Sci. 1993 Sep;106 ( Pt 1):319-30.
Additional References at PubMed
PMID:8618961   PMID:12651156   PMID:12972258   PMID:16702235   PMID:18059477   PMID:18177667   PMID:18310078   PMID:18521710   PMID:19182904   PMID:20215401   PMID:20368620   PMID:22347812  
PMID:22562206   PMID:25152160  


Genomics

Comparative Map Data
Myom1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29110,916,156 - 111,039,344 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9110,915,943 - 111,039,344 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9119,308,091 - 119,433,086 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,437,676 - 124,562,686 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09122,774,056 - 122,899,053 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,353,840 - 119,469,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,353,840 - 119,468,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09118,808,061 - 118,922,531 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,218,668 - 110,341,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,492,862 - 110,499,352 (+)NCBI
Celera9108,050,734 - 108,169,433 (+)NCBICelera
Cytogenetic Map9q38NCBI
MYOM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38183,066,807 - 3,247,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl183,066,807 - 3,219,968 (-)EnsemblGRCh38hg38GRCh38
GRCh37183,066,805 - 3,219,966 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36183,056,805 - 3,210,106 (-)NCBINCBI36Build 36hg18NCBI36
Build 34183,056,805 - 3,210,106NCBI
Celera182,942,458 - 3,099,594 (-)NCBICelera
Cytogenetic Map18p11.31NCBI
HuRef183,028,045 - 3,184,538 (-)NCBIHuRef
CHM1_1183,066,174 - 3,219,476 (-)NCBICHM1_1
T2T-CHM13v2.0183,222,339 - 3,405,523 (-)NCBIT2T-CHM13v2.0
Myom1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391771,326,455 - 71,433,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1771,309,628 - 71,433,851 (+)EnsemblGRCm39 Ensembl
GRCm381771,003,332 - 71,126,856 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1771,002,633 - 71,126,856 (+)EnsemblGRCm38mm10GRCm38
MGSCv371771,368,897 - 71,476,196 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361770,924,378 - 71,031,712 (+)NCBIMGSCv36mm8
Celera1775,288,990 - 75,395,041 (+)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1741.87NCBI
Myom1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554027,297,502 - 7,417,583 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554027,293,415 - 7,418,226 (+)NCBIChiLan1.0ChiLan1.0
MYOM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11820,887,583 - 21,071,649 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01811,057,733 - 11,215,998 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11813,368,052 - 13,523,834 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1813,368,052 - 13,523,834 (+)Ensemblpanpan1.1panPan2
MYOM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,703,057 - 69,837,987 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl769,703,540 - 69,857,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha769,158,406 - 69,293,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0769,764,740 - 69,899,505 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,764,752 - 69,899,495 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1769,447,603 - 69,582,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0769,467,081 - 69,602,041 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,765,301 - 69,900,453 (-)NCBIUU_Cfam_GSD_1.0
Myom1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494466,059,985 - 66,191,003 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366721,351,002 - 1,482,124 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366721,351,053 - 1,481,954 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6103,451,343 - 103,597,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16103,451,206 - 103,593,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2696,478,318 - 96,620,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYOM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11862,321,086 - 62,474,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1862,320,793 - 62,465,485 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605037,178,674 - 37,338,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myom1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477013,239,723 - 13,355,954 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477013,239,572 - 13,356,041 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myom1
605 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:78
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000029583
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

Markers in Region
D9Got126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29110,940,957 - 110,941,239 (+)MAPPERmRatBN7.2
Rnor_6.09119,374,278 - 119,374,559NCBIRnor6.0
Rnor_5.09118,828,425 - 118,828,706UniSTSRnor5.0
RGSC_v3.49110,239,452 - 110,239,731RGDRGSC3.4
RGSC_v3.49110,239,451 - 110,239,732UniSTSRGSC3.4
RGSC_v3.19110,448,932 - 110,449,211RGD
Celera9108,071,174 - 108,071,455UniSTS
RH 3.4 Map9853.8UniSTS
RH 3.4 Map9853.8RGD
RH 2.0 Map91031.4RGD
Cytogenetic Map9q38UniSTS
RH128912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29111,039,095 - 111,039,275 (+)MAPPERmRatBN7.2
Rnor_6.09119,468,948 - 119,469,127NCBIRnor6.0
Rnor_5.09118,922,283 - 118,922,462UniSTSRnor5.0
RGSC_v3.49110,340,781 - 110,340,960UniSTSRGSC3.4
Celera9108,169,185 - 108,169,364UniSTS
RH 3.4 Map16440.11UniSTS
Cytogenetic Map9q38UniSTS
AI171311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29111,000,576 - 111,000,755 (+)MAPPERmRatBN7.2
Rnor_6.09119,430,702 - 119,430,881NCBIRnor6.0
Rnor_5.09118,884,328 - 118,884,507UniSTSRnor5.0
RGSC_v3.49110,299,907 - 110,300,087UniSTSRGSC3.4
Celera9108,130,553 - 108,130,732UniSTS
RH 3.4 Map9869.3UniSTS
Cytogenetic Map9q38UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 8 11 5 7 8
Low 3 47 31 17 31 49 35 34 4
Below cutoff 10 10 2 10 25 2

Sequence


RefSeq Acc Id: ENSRNOT00000085362   ⟹   ENSRNOP00000073506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9110,915,943 - 111,038,863 (+)Ensembl
Rnor_6.0 Ensembl9119,353,840 - 119,468,715 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095102   ⟹   ENSRNOP00000087945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9110,915,943 - 111,039,344 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112958   ⟹   ENSRNOP00000085118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9110,915,943 - 111,039,344 (+)Ensembl
RefSeq Acc Id: NM_001191584   ⟹   NP_001178513
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,920,526 - 111,039,344 (+)NCBI
Rnor_6.09119,353,840 - 119,469,196 (+)NCBI
Rnor_5.09118,808,061 - 118,922,531 (+)NCBI
Celera9108,050,734 - 108,169,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083797   ⟹   XP_038939725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,916,156 - 111,039,344 (+)NCBI
RefSeq Acc Id: XM_039083798   ⟹   XP_038939726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,916,644 - 111,039,344 (+)NCBI
RefSeq Acc Id: XM_039083799   ⟹   XP_038939727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29110,916,156 - 111,039,344 (+)NCBI
RefSeq Acc Id: NP_001178513   ⟸   NM_001191584
- UniProtKB: A0A8I6GBP8 (UniProtKB/TrEMBL),   A0A0G2K5P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073506   ⟸   ENSRNOT00000085362
RefSeq Acc Id: XP_038939727   ⟸   XM_039083799
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GBP8 (UniProtKB/TrEMBL),   A0A0G2K5P5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939725   ⟸   XM_039083797
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFM8 (UniProtKB/TrEMBL),   A0A0G2K5P5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939726   ⟸   XM_039083798
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFM8 (UniProtKB/TrEMBL),   A0A0G2K5P5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085118   ⟸   ENSRNOT00000112958
RefSeq Acc Id: ENSRNOP00000087945   ⟸   ENSRNOT00000095102
Protein Domains
Fibronectin type-III   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5P5-F1-model_v2 AlphaFold A0A0G2K5P5 1-1688 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631436 AgrOrtholog
BioCyc Gene G2FUF-26340 BioCyc
Ensembl Genes ENSRNOG00000057701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085362.2 UniProtKB/TrEMBL
  ENSRNOT00000095102 ENTREZGENE
  ENSRNOT00000095102.1 UniProtKB/TrEMBL
  ENSRNOT00000112958 ENTREZGENE
  ENSRNOT00000112958.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
KEGG Report rno:316740 UniProtKB/TrEMBL
NCBI Gene 316740 ENTREZGENE
PANTHER IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1-RELATED UniProtKB/TrEMBL
  MYOMESIN-1 UniProtKB/TrEMBL
  TITIN UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
PhenoGen Myom1 PhenoGen
PRINTS FNTYPEIII UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057701 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K5P5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFM8 ENTREZGENE, UniProtKB/TrEMBL
  A6KF96_RAT UniProtKB/TrEMBL
  Q80UL1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Myom1  myomesin 1  Myom1  myomesin 1 (skelemin) 185kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Myom1  myomesin 1 (skelemin) 185kDa    myomesin 1  Name updated 1299863 APPROVED
2004-02-11 Myom1  myomesin 1      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is postnatally downregulated 633368