Gfi1 (growth factor independent 1 transcriptional repressor) - Rat Genome Database
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Gene: Gfi1 (growth factor independent 1 transcriptional repressor) Rattus norvegicus
Analyze
Symbol: Gfi1
Name: growth factor independent 1 transcriptional repressor
RGD ID: 2680
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including inner ear development; regulation of cell fate specification; and regulation of cellular biosynthetic process. Predicted to localize to nuclear body; nuclear matrix; and transcription repressor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent protein 1; Growth factor independent-1; zinc finger protein Gfi-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2142,040,576 - 2,056,874 (+)NCBI
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0143,058,035 - 3,073,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0143,060,287 - 3,069,973 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,597,303 - 2,606,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,597,302 - 2,606,681 (+)NCBI
Celera142,061,330 - 2,070,708 (+)NCBICelera
RH 3.4 Map1437.2RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Basu S, etal., Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1433-8. doi: 10.1073/pnas.0804863106. Epub 2009 Jan 22.
2. Duan Z, etal., Mol Cell Biol. 2005 Dec;25(23):10338-51.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gilks CB, etal., Mol Cell Biol 1993 Mar;13(3):1759-68.
5. GOA data from the GO Consortium
6. Huang M, etal., Acta Haematol. 2010;123(1):1-5. doi: 10.1159/000253856. Epub 2009 Nov 2.
7. Huh HJ, etal., Int J Lab Hematol. 2009 Jun;31(3):344-51. doi: 10.1111/j.1751-553X.2008.01056.x. Epub 2008 Mar 25.
8. Karsunky H, etal., Nat Genet. 2002 Mar;30(3):295-300. Epub 2002 Jan 28.
9. Khandanpour C, etal., Blood. 2010 Mar 25;115(12):2462-72. doi: 10.1182/blood-2009-08-239822. Epub 2010 Jan 14.
10. Khandanpour C, etal., Blood. 2012 Nov 8;120(19):4006-17. doi: 10.1182/blood-2011-02-334722. Epub 2012 Aug 28.
11. Khandanpour C, etal., Stem Cells. 2011 Feb;29(2):376-85. doi: 10.1002/stem.575.
12. Kok CH, etal., Leukemia. 2013 Jun;27(6):1427-30. doi: 10.1038/leu.2013.47. Epub 2013 Feb 15.
13. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline
17. Online Mendelian Inheritance in Man, OMIM (TM).
18. Ordonez-Rueda D, etal., Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589.
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. RGD comprehensive gene curation
23. Shin MS, etal., Cancer Res. 2004 Jul 1;64(13):4419-27.
24. Wang TT, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Aug;18(4):834-7.
Additional References at PubMed
PMID:11060035   PMID:12441305   PMID:12721361   PMID:12874834   PMID:15131254   PMID:15947108   PMID:16230531   PMID:19026687   PMID:19506020   PMID:20153336   PMID:20190815   PMID:20547752  


Genomics

Comparative Map Data
Gfi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2142,040,576 - 2,056,874 (+)NCBI
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0143,058,035 - 3,073,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0143,060,287 - 3,069,973 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,597,303 - 2,606,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1142,597,302 - 2,606,681 (+)NCBI
Celera142,061,330 - 2,070,708 (+)NCBICelera
RH 3.4 Map1437.2RGD
Cytogenetic Map14p22NCBI
GFI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl192,473,043 - 92,486,925 (-)EnsemblGRCh38hg38GRCh38
GRCh38192,473,043 - 92,486,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37192,938,600 - 92,952,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,712,909 - 92,725,021 (-)NCBINCBI36hg18NCBI36
Build 34192,652,341 - 92,664,451NCBI
Celera191,193,179 - 91,205,211 (-)NCBI
Cytogenetic Map1p22.1NCBI
HuRef191,061,525 - 91,073,603 (-)NCBIHuRef
CHM1_1193,055,130 - 93,067,261 (-)NCBICHM1_1
Gfi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,864,521 - 107,873,671 (-)NCBIGRCm39mm39
GRCm39 Ensembl5107,864,523 - 107,873,902 (-)Ensembl
GRCm385107,716,655 - 107,725,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,716,657 - 107,726,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375108,145,674 - 108,153,363 (-)NCBIGRCm37mm9NCBIm37
MGSCv365107,956,961 - 107,964,646 (-)NCBImm8
Celera5104,829,261 - 104,836,969 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map552.23NCBI
Gfi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,022,417 - 2,033,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554232,024,084 - 2,032,530 (+)NCBIChiLan1.0ChiLan1.0
GFI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,875,880 - 93,883,558 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,876,245 - 93,883,528 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0195,139,171 - 95,151,054 (-)NCBIMhudiblu_PPA_v0panPan3
GFI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl656,256,305 - 56,484,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1656,473,032 - 56,484,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gfi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365376,610,565 - 6,618,509 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4124,621,258 - 124,629,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14124,619,887 - 124,629,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GFI1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12040,771,238 - 40,786,008 (+)NCBI
ChlSab1.1 Ensembl2040,776,816 - 40,783,717 (+)Ensembl
Gfi1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247425,260,651 - 5,271,908 (+)NCBI

Position Markers
RH94680  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0143,067,812 - 3,067,914NCBIRnor6.0
Rnor_5.0143,069,262 - 3,069,364UniSTSRnor5.0
RGSC_v3.4142,606,122 - 2,606,224UniSTSRGSC3.4
Celera142,070,149 - 2,070,251UniSTS
RH 3.4 Map1437.2UniSTS
Cytogenetic Map14p22UniSTS
D1S3707E  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0143,063,643 - 3,063,761NCBIRnor6.0
Rnor_5.0143,065,094 - 3,065,212UniSTSRnor5.0
RGSC_v3.4142,601,953 - 2,602,071UniSTSRGSC3.4
Celera142,065,980 - 2,066,098UniSTS
Cytogenetic Map14p22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14222782512680613Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14222782519230541Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:224
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000002807
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 7
Low 3 19 18 12 18 1 5 10
Below cutoff 22 24 18 18 6 6 4 22 36 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002807   ⟹   ENSRNOP00000002807
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)Ensembl
RefSeq Acc Id: NM_012566   ⟹   NP_036698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,042,434 - 2,051,814 (+)NCBI
Rnor_6.0143,058,993 - 3,068,371 (+)NCBI
Rnor_5.0143,060,287 - 3,069,973 (+)NCBI
RGSC_v3.4142,597,303 - 2,606,681 (+)RGD
Celera142,061,330 - 2,070,708 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769917   ⟹   XP_008768139
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,040,576 - 2,051,821 (+)NCBI
Rnor_6.0143,058,035 - 3,068,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769918   ⟹   XP_008768140
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,042,941 - 2,051,821 (+)NCBI
Rnor_6.0143,059,499 - 3,068,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769919   ⟹   XP_008768141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,058,035 - 3,066,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769920   ⟹   XP_008768142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,042,302 - 2,056,874 (+)NCBI
Rnor_6.0143,058,035 - 3,073,332 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599074   ⟹   XP_017454563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,059,499 - 3,068,375 (+)NCBI
Sequence:
RefSeq Acc Id: XR_359278
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2142,042,302 - 2,051,821 (+)NCBI
Rnor_6.0143,058,035 - 3,068,375 (+)NCBI
Rnor_5.0143,060,287 - 3,069,973 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036698   ⟸   NM_012566
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008768142   ⟸   XM_008769920
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768139   ⟸   XM_008769917
- Peptide Label: isoform X1
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008768141   ⟸   XM_008769919
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768140   ⟸   XM_008769918
- Peptide Label: isoform X1
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454563   ⟸   XM_017599074
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002807   ⟸   ENSRNOT00000002807

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699156
Promoter ID:EPDNEW_R9681
Type:single initiation site
Name:Gfi1_1
Description:growth factor independent 1 transcriptional repressor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,058,940 - 3,059,000EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2680 AgrOrtholog
Ensembl Genes ENSRNOG00000002042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000002807 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002807 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GFI1/1B UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:24388 UniProtKB/Swiss-Prot
NCBI Gene 24388 ENTREZGENE
PANTHER PTHR24404:SF46 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Gfi1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt GFI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Gfi1  growth factor independent 1 transcriptional repressor  Gfi1  growth factor independent 1 transcription repressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Gfi1  growth factor independent 1 transcription repressor  Gfi1  growth factor independent 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gfi1  Growth factor independent-1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in thymus, spleen and testis in adult animals 728614