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Gene: Cplx3 (complexin 3) Rattus norvegicus

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Symbol:

Cplx3

Name:

complexin 3

RGD ID:

1560104

Description:

Predicted to enable SNARE binding activity and neurotransmitter transmembrane transporter activity. Predicted to be involved in modulation of chemical synaptic transmission; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and signal release. Predicted to act upstream of or within regulation of neurotransmitter secretion. Predicted to be located in cytosol; plasma membrane; and synapse. Predicted to be part of SNARE complex. Predicted to be active in several cellular components, including photoreceptor ribbon synapse; presynaptic active zone membrane; and synaptic vesicle membrane. Orthologous to human CPLX3 (complexin 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

complexin-3; LOC501005; RGD1560104; similar to Complexin III

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CPLX3 (complexin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cplx3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cplx3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CPLX3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CPLX3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cplx3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CPLX3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CPLX3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cplx3 (complexin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CPLX3 (complexin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cplx3 (complexin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cplx3a (complexin 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cplx3a (complexin 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	cplx3b (complexin 3b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	cpx	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lman1l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	66,899,438 - 66,906,200 (-)	NCBI		GRCr8
GRCr8 Ensembl	8	66,899,438 - 66,906,200 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	8	58,003,535 - 58,010,297 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	58,003,535 - 58,010,297 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	63,536,334 - 63,543,094 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	61,813,911 - 61,820,671 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	59,678,458 - 59,685,218 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	62,379,502 - 62,386,264 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	62,379,502 - 62,386,264 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	62,157,074 - 62,163,836 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	61,354,177 - 61,360,939 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	57,469,456 - 57,476,217 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome (ISO)

Bloom syndrome (ISO)

Brugada syndrome 8 (ISO)

colorectal cancer (ISO)

PAPA syndrome (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

copper atom (EXP)

copper(0) (EXP)

diazinon (EXP)

diiodine (ISO)

disodium selenite (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

folic acid (ISO)

glyphosate (EXP)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (ISO)

Ptaquiloside (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thalidomide (ISO)

Theaflavin 3,3'-digallate (ISO)

tributylstannane (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

exocytosis (IEA)

insulin secretion (IEA,ISO)

modulation of chemical synaptic transmission (IBA)

neurotransmitter transport (IEA)

regulation of neurotransmitter secretion (IEA,ISO)

regulation of synaptic vesicle fusion to presynaptic active zone membrane (IBA,IEA,ISO)

synaptic vesicle exocytosis (IBA,IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

membrane (IEA,ISO)

nucleus (ISO)

photoreceptor ribbon synapse (IEA,ISO)

plasma membrane (IEA,ISO)

presynaptic active zone membrane (IEA,ISO)

SNARE complex (IBA)

synapse (IEA,ISO)

synaptic vesicle membrane (IEA,ISO)

terminal bouton (IBA)

Molecular Function

neurotransmitter transmembrane transporter activity (IEA,ISO)

SNARE binding (IBA,IEA,ISO)

syntaxin binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15911881	PMID:27239031

Genomics

Comparative Map Data

Cplx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	66,899,438 - 66,906,200 (-)	NCBI		GRCr8
GRCr8 Ensembl	8	66,899,438 - 66,906,200 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	8	58,003,535 - 58,010,297 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	58,003,535 - 58,010,297 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	63,536,334 - 63,543,094 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	61,813,911 - 61,820,671 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	59,678,458 - 59,685,218 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	62,379,502 - 62,386,264 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	62,379,502 - 62,386,264 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	62,157,074 - 62,163,836 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	61,354,177 - 61,360,939 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	57,469,456 - 57,476,217 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

CPLX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	74,826,627 - 74,831,802 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	74,826,627 - 74,831,802 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	75,118,968 - 75,124,143 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	72,906,004 - 72,911,189 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	52,068,980 - 52,074,165 (+)	NCBI		Celera
Cytogenetic Map	15	q24.1	NCBI
HuRef	15	51,915,985 - 51,921,170 (+)	NCBI		HuRef
CHM1_1	15	75,237,636 - 75,242,821 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	72,696,523 - 72,701,698 (+)	NCBI		T2T-CHM13v2.0

Cplx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	57,507,275 - 57,513,564 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	57,507,275 - 57,513,564 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	57,599,992 - 57,606,281 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	57,599,992 - 57,606,281 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	57,447,799 - 57,454,088 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	57,398,129 - 57,404,369 (-)	NCBI		MGSCv36	mm8
Celera	9	54,835,800 - 54,842,101 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	31.11	NCBI

Cplx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	3,105,203 - 3,110,374 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	3,105,364 - 3,110,246 (-)	NCBI	ChiLan1.0	ChiLan1.0

CPLX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	64,054,330 - 64,058,989 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	68,217,996 - 68,222,660 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	53,769,138 - 53,774,330 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	73,386,826 - 73,391,991 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	73,386,826 - 73,391,991 (+)	Ensembl	panpan1.1		panPan2

CPLX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	37,888,770 - 37,893,168 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	37,888,076 - 37,893,182 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	37,820,094 - 37,825,164 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	38,092,804 - 38,097,575 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	38,093,160 - 38,097,571 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	38,045,283 - 38,050,349 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	38,091,612 - 38,096,684 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	38,327,114 - 38,332,184 (+)	NCBI		UU_Cfam_GSD_1.0

Cplx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	115,950,458 - 115,954,982 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	33,798,635 - 33,802,176 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	33,798,523 - 33,803,045 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CPLX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	58,712,744 - 58,716,997 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	58,712,743 - 58,717,028 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	63,401,337 - 63,405,623 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CPLX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	8,640,661 - 8,649,510 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	8,641,551 - 8,645,155 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	132,986,105 - 132,991,288 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cplx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624894	45,093 - 49,923 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624894	42,204 - 49,875 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cplx3
25 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	513
Count of miRNA genes:	257
Interacting mature miRNAs:	327
Transcripts:	ENSRNOT00000026165
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat

Markers in Region

RH134227

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	58,005,341 - 58,005,522 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	62,381,309 - 62,381,489	NCBI	Rnor6.0
Rnor_5.0	8	62,158,881 - 62,159,061	UniSTS	Rnor5.0
RGSC_v3.4	8	61,355,984 - 61,356,164	UniSTS	RGSC3.4
Celera	8	57,471,262 - 57,471,442	UniSTS
RH 3.4 Map	8	668.2	UniSTS
Cytogenetic Map	8	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	39	113	59	58	27	25	27	6	160	87	93	29	48	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026165 ⟹ ENSRNOP00000026165

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	66,899,438 - 66,906,200 (-)	Ensembl
mRatBN7.2 Ensembl	8	58,003,535 - 58,010,297 (-)	Ensembl
Rnor_6.0 Ensembl	8	62,379,502 - 62,386,264 (-)	Ensembl

RefSeq Acc Id:

NM_001109295 ⟹ NP_001102765

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	66,899,438 - 66,906,200 (-)	NCBI
mRatBN7.2	8	58,003,535 - 58,010,297 (-)	NCBI
Rnor_6.0	8	62,379,502 - 62,386,264 (-)	NCBI
Rnor_5.0	8	62,157,074 - 62,163,836 (-)	NCBI
RGSC_v3.4	8	61,354,177 - 61,360,939 (-)	RGD
Celera	8	57,469,456 - 57,476,217 (-)	RGD

Sequence:

show sequence

AAGCCGAAGTCCTGGTTTCGGATGACCCAGGAGAAGAGGACATTGGAGGGTAGGAAGCGGAAAT
CAAGGCACACTTCAGCGCAGCCCCTTCTCCCAGGGCAGCGACCCCACCACCGCGATCCCTAATC
AGTTGTCAGCAGTAGCCAGCAGAGCTTTGCTGGCGCTAAAGAAGGCACGTGGGAAAGGCGGGAG
TGAGGAGCAGGCACGTGGTCCAGGCTTCTCAGCCCCGTGCATGCCCCCCGCCCCCCGTGAGGAG
GGTTTTGGGAAGGTAGGGACCAGTGCTCAAAGCTTGGGGCGCGAGCTCGCAACCGGAGCTGTCC
CCGGGACTTAGTGCTGAAGTAGTCGCTGACGAACCAGGCGCCTGGTGCGGTGGCCAGAGAAGAC
CATGGCGTTCATGGTGAAGTCCATGGTGGGTGGCCAGCTGAAGAACCTCACCGGTAGCCTGGGG
GGCGGCGAGGACAAGGGGGACGGAGACAAGTCTGCAGCCGAAGCACAGGGCATGAGCCGAGAAG
AGTATGAGGAGTATCAGAAGCAACTGGTGGAGGAGAAGATGGAGCGAGACGCACAGTTCACACA
GAGGAAGGCAGAACGGGCCACGCTACGGAGTCACTTCAGGGACAAATACCGTCTGCCCAAGAAT
GAGACGGATGAAAGCCAGATCCAGCTGGCAGGCGGAGATGTGGAACTGCCTCGGGAGCTAGCCA
AGATGATCGAGGAGGACACGGAGGAAGAGGAAGATAAGGCCTCTGTGCTTGGGCAGCTGGCCAG
CCTCCCTGGCTTGGACCTCAGCTCACTCAAGGACAAGGCCCAGACTACGCTAGGGGACCTCAAG
CAATCAGCTGAGAAGTGCCATATCATGTGACCGCTTCCCCTGGGTTTGCCTCTAGGATGGCCAG
AGGGTCGGTCCCATGTGAGGGCTAAGAGAGTGAGTGTCTCAACTTCCAGATACCTCCAGTCCAT
TTGGGCTCTGTTTTCCCTGCCCCAGCCTAGCCTCAGAGCCTTCTCATCCATGTCCAGCTGTCCA
GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTAGCAAAGTTCCTA
TTCTTCCCTCTCTCCCTCTGCTGCCTGGAAAGTTTCCCAAGTTGATAGAATTAGCCCAACCCTC
TCTGGGTACAGCCCCCTGTTCTTCACACAAGAGCACTCACAGAAAGACACAGAAGCCCCGGCTC
GTTTGCCACAGATGCATCCTGGCACACACAGACACACATCCCTTGGATTCCCAGCCCCTCCAGA
TACCAGCACTCAGATGCTTAGGCGAGCCTCTGGGCACACAGAAGACCTGTTCTTATCCCTCCCT
CCCTTCGTAATCCTAGAAGCTTTTGCTCTTTCCGAGTTTTATCTTATCATCTGTAAAATGGGAA
TGGACTGAGTGATTTCCAAAATTCTGTCCCGATTGGCATTCCTGGCCACTCAGGACAGAGCCCA
CATCCCTTCTTGGGCAGGGCAGCAGCTGCAGTCACAGCATCACACAGCTGCCACTGTGGGTTCT
GGGAACTGAGCAATGCTGTGTGAGGGGCAGAGTGCCAGGTATGGAACTGGCACTGAACAGTAGC
TCCAGACCTCCTCTGGGCCCAGGGCTGAGCCAAATTTTGTTCTGTTCCTGTAGAAGTCTCTGTA
GTCCATAGTTGGAATTTCCTCTTCTTGTTCAGCAAAAAATAAAAATTCCAAATGACGTGGCTAT
CTTCCCACTTCCTGCTGACCTGGGGTTCACAGGCCCCAGGCCTGCCCTTTGAGGGGTATCATCT
GCCTCTTCACCTGCAGCTTCAGGGGGTCCTAGGTGAAGAACGGGGGCTTCTGTGGGGCTCTCTA
GTGACAGCCCTTGTAAGAGTGCCTCTCAGGGTGGCAGGTGAAGGGGGTCTCACTGAGGGAGCAG
ATGCCCTTTGGGCTGGATGAAGTTCAGTCTGAGCACCAAGAGTGAGGAGGATGTGGCAGGAGGC
AGCTGAATGGAGAGGTATACGGGAAGATGGAGCCTTAGGGTGTTTCCTGAGATCAGAGAAGGGG
CTGTCTCTAACACTGGTCCTGTACTTTCCCCTCACCTCAGAGATGGAGCGTGAAACAGAGAAGA
AAGGGTGATTGTGCCCCAGCCTGGCTCTGTGTGTGTACTTCAGTAGGTCCCTGAGCCTGCGTTC
CTCTTGGTAAAATGAACAGTTCTCTTCCCCAAGAATAATAACATGTATTTCAAAGAGTGGCCAT
TTGTCCCTGCCCCCTCCTCCTCCTGGCAGTGCTGGGGACTCAGGGCCTCACACACTGCATACTA
AGGCAAGTGGTCTGCCACTCAGCCTCACCCACGGCCCCTGAGAATGACGCTTATCAGCTGTGGT
AACACATTCTTTAAAGTAACAGAGGCGGAGGCACCAGCAGTCATGCTACACTGAGTGAGACCTG
CTGGTGAAGACAGTGTTAGTCCCACCTCGCAGGGAGGTGGCCTGAGGTGGTAAGCTGGTGCCCT
CAAAGTTTGTGTTTGTGTTTATGCAGTGAATTAGTTTCAGTCAGATTTCTTCTCTTTGTGTCCC
TCCCTCCCTCCTTCCTTCTCACCTCCCTTCCTCCTTCTCTCCATCTCTCTCTCTGTGTTAGTTG
GTATTATTGTCATTTTGTTTTCTTCCAGACAGAATCTTGTGTAGCTCAGGCTAGCCTCAAACTC
CTAGGTAGGCAGGGATGATCTTGGACTTCTTTTTTTTTTTTTTCGGAGCTGGGGACCGAACCCA
GGGCCTTGCGCTTCCTAGGTAAGCGCTCTACCACTGAGCTAAATCCCCAGCCCCGATCTTGGAC
TTCTAACCATCTTGCCTCAACTTCCCAGGTACTCTGATTACAGGAACGGATCATCACACCTAGT
TTCAGCTGTGCTTGAAACCTAGCCAAGAGCTTTGTGCGTGTTAGGCACCAACTGGCTGCATTCT
CACCTGTGTTTGGTGGGGTTTTAAATTTAATTTTATTATTTTATGTATATGAATGTTTGCCTGC
ACACTGTTATGTATTTGCACATGTGTGCCTGGTGACCAAGGAGGTCAGAAGAGGGGGTCAGATA
TCCCTGTGCCTGGAGTTACAGACGGTTTTGAGTTGCCATGTGGGTGCTGGGAATTGAATTTGTG
TCTGGAAAAGCACTGAGCATTCTCTCCAGCCCCTTTGTGTTAGAAATGGGATCTCACTACATAG
CCCAAGCTAGCCTCCCAAGGGCTAGGATTACAGATGTACAACAGCACTACATGTGACTTTAATG
AGGAATAAAAGGAAAAAAATGTTTTTTTTTCTTTTTTTCGGAGCTGGGGACCAAACCCAGGGCC
TTGCGCTTACTAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAACCCAAAATGTTTTTTCCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102765	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95641	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026165
	ENSRNOP00000026165.3

RefSeq Acc Id:	NP_001102765 ⟸ NM_001109295
- UniProtKB:	D4ABY0 (UniProtKB/TrEMBL), A6J4W9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFMVKSMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQ RKAERATLRSHFRDKYRLPKNETDESQIQLAGGDVELPRELAKMIEEDTEEEEDKASVLGQLAS LPGLDLSSLKDKAQTTLGDLKQSAEKCHIM hide sequence

Ensembl Acc Id:

ENSRNOP00000026165 ⟸ ENSRNOT00000026165

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ABY0-F1-model_v2	AlphaFold	D4ABY0	1-158	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560104	AgrOrtholog
BioCyc Gene	G2FUF-30302	BioCyc
Ensembl Genes	ENSRNOG00000019317	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026165	ENTREZGENE
	ENSRNOT00000026165.5	UniProtKB/TrEMBL
Gene3D-CATH	Single Helix bin	UniProtKB/TrEMBL
InterPro	Synaphin	UniProtKB/TrEMBL
KEGG Report	rno:501005	UniProtKB/TrEMBL
NCBI Gene	501005	ENTREZGENE
PANTHER	COMPLEXIN-3	UniProtKB/TrEMBL
	Synaphin	UniProtKB/TrEMBL
Pfam	Synaphin	UniProtKB/TrEMBL
PhenoGen	Cplx3	PhenoGen
RatGTEx	ENSRNOG00000019317	RatGTEx
UniProt	A6J4W9	ENTREZGENE, UniProtKB/TrEMBL
	D4ABY0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-28	Cplx3	complexin 3	RGD1560104_predicted	similar to Complexin III (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1560104_predicted	similar to Complexin III (predicted)	LOC501005	similar to Complexin III	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501005	similar to Complexin III			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar