Galm (galactose mutarotase) - Rat Genome Database

Name: Galm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Galm (galactose mutarotase) Rattus norvegicus

Analyze

Symbol:

Galm

Name:

galactose mutarotase

RGD ID:

1359459

Description:

Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase); PARTICIPATES IN Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

aldose 1-epimerase; galactose mutarotase (aldose 1-epimerase); MGC93738

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GALM (galactose mutarotase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101967759 (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GALM (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Galm (galactose mutarotase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GALM (galactose mutarotase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Galm (galactose mutarotase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	galm (galactose mutarotase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10467	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C01B4.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YHR210C	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG10996	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32444	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32445	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4988	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YNR071C	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	Y19D10A.16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	14,837,540 - 14,889,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,837,548 - 14,889,310 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	15,135,882 - 15,187,744 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,458,146 - 15,509,901 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	14,954,424 - 15,006,178 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	2,808,988 - 2,860,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	2,808,841 - 2,860,744 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	2,785,889 - 2,837,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	3,024,123 - 3,078,720 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	3,024,122 - 3,078,719 (+)	NCBI
Celera	6	14,514,739 - 14,566,190 (-)	NCBI		Celera
Cytogenetic Map	6	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Galactosemia IV (ISO)

RASopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzoates (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fenthion (ISO)

fenvalerate (EXP)

flutamide (EXP,ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen peroxide (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

lithium atom (EXP)

lithium hydride (EXP)

menadione (ISO)

methapyrilene (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thalidomide (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

Triptolide (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (ISO)

galactose catabolic process via UDP-galactose (IBA,ISO)

galactose metabolic process (IEA,ISO)

glucose metabolic process (IBA,ISO)

Cellular Component

cytoplasm (IEA)

Molecular Function

aldose 1-epimerase activity (IBA,ISO)

carbohydrate binding (IEA)

isomerase activity (IEA)

protein homodimerization activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fanconi syndrome pathway (ISO)

fructose-1,6-bisphosphatase deficiency pathway (ISO)

gluconeogenesis pathway (IEA,ISO)

glycogen storage disease type Ia pathway (ISO)

glycogen storage disease type Ib pathway (ISO)

glycogen storage disease type VII pathway (ISO)

glycolysis pathway (IEA,ISO)

glycolysis/gluconeogenesis pathway (IEA)

phosphoenolpyruvate carboxykinase deficiency pathway (ISO)

triosephosphate isomerase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7.	Identification and characterisation of human aldose 1-epimerase.	Timson DJ and Reece RJ, FEBS Lett 2003 May 22;543(1-3):21-4.

Additional References at PubMed

PMID:15489334	PMID:19056867	PMID:23376485

Genomics

Comparative Map Data

Galm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	14,837,540 - 14,889,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,837,548 - 14,889,310 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	15,135,882 - 15,187,744 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	15,458,146 - 15,509,901 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	14,954,424 - 15,006,178 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	2,808,988 - 2,860,742 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	2,808,841 - 2,860,744 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	2,785,889 - 2,837,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	3,024,123 - 3,078,720 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	3,024,122 - 3,078,719 (+)	NCBI
Celera	6	14,514,739 - 14,566,190 (-)	NCBI		Celera
Cytogenetic Map	6	q11	NCBI

GALM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	38,666,114 - 38,734,765 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	38,666,081 - 38,741,237 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	38,893,256 - 38,961,907 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	38,746,743 - 38,815,049 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	38,804,889 - 38,873,176	NCBI
Celera	2	38,734,098 - 38,802,942 (+)	NCBI		Celera
Cytogenetic Map	2	p22.1	NCBI
HuRef	2	38,632,684 - 38,700,744 (+)	NCBI		HuRef
CHM1_1	2	38,823,545 - 38,892,563 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	38,672,993 - 38,743,547 (+)	NCBI		T2T-CHM13v2.0

Galm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	80,434,886 - 80,492,461 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	80,434,900 - 80,492,530 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	80,127,458 - 80,185,032 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	80,127,471 - 80,185,101 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	80,526,811 - 80,584,372 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	80,035,797 - 80,093,358 (+)	NCBI		MGSCv36	mm8
Celera	17	84,443,907 - 84,501,487 (+)	NCBI		Celera
Cytogenetic Map	17	E3	NCBI

Galm
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	6,330,410 - 6,403,219 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	6,330,520 - 6,399,522 (+)	NCBI	ChiLan1.0	ChiLan1.0

GALM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	39,456,786 - 39,527,119 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	39,456,786 - 39,527,116 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	38,697,338 - 38,770,470 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GALM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	30,741,990 - 30,793,456 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	30,742,127 - 30,792,465 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	30,558,189 - 30,609,682 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	31,397,079 - 31,448,378 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	31,397,221 - 31,447,503 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	30,619,873 - 30,671,292 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	30,689,932 - 30,741,032 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	30,902,711 - 30,953,995 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101967759
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	41,066,829 - 41,333,563 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936508	12,495,438 - 12,502,236 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GALM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	101,617,526 - 101,753,125 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	101,617,521 - 101,682,821 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	107,762,128 - 107,827,418 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GALM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	68,647,287 - 68,720,735 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	68,647,297 - 68,720,739 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	43,259,741 - 43,332,630 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Galm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	20,163,901 - 20,235,256 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	20,164,179 - 20,236,151 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Galm
294 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	102
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000009221
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	5074497	19988050	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	9843312	20338915	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	9843312	20338915	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat

Markers in Region

RH129850

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	14,837,767 - 14,837,966 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	2,860,316 - 2,860,514	NCBI	Rnor6.0
Rnor_5.0	6	2,837,209 - 2,837,407	UniSTS	Rnor5.0
RGSC_v3.4	6	3,078,294 - 3,078,492	UniSTS	RGSC3.4
Celera	6	14,514,967 - 14,515,165	UniSTS
Cytogenetic Map	6	q11	UniSTS

AA892666

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	14,838,019 - 14,838,207 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	2,860,075 - 2,860,262	NCBI	Rnor6.0
Rnor_5.0	6	2,836,968 - 2,837,155	UniSTS	Rnor5.0
RGSC_v3.4	6	3,078,053 - 3,078,240	UniSTS	RGSC3.4
Celera	6	14,515,219 - 14,515,406	UniSTS
RH 3.4 Map	6	65.3	UniSTS
Cytogenetic Map	6	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	16	49	37	11	37			23	35	34	11
Low		27	8	4	8	4	8	11	51		7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000009221 ⟹ ENSRNOP00000009221

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	14,837,548 - 14,889,310 (-)	Ensembl
Rnor_6.0 Ensembl	6	2,808,841 - 2,860,744 (+)	Ensembl

RefSeq Acc Id:

NM_001007704 ⟹ NP_001007705

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	14,837,540 - 14,889,283 (-)	NCBI
Rnor_6.0	6	2,808,988 - 2,860,742 (+)	NCBI
Rnor_5.0	6	2,785,889 - 2,837,635 (+)	NCBI
RGSC_v3.4	6	3,024,123 - 3,078,720 (+)	RGD
Celera	6	14,514,739 - 14,566,190 (-)	RGD

Sequence:

show sequence

CCAGGCTAGAGTTTGAACAGCAAGGAGAAGCTGCGCGCCCCGAACTTTCCCAATGGTTTCGGTG
ACCAGAACCGTGTTTGGAGAGCTGCCCTCGGGGGGAGGGGCAGTGGAGAAGTTCCAGCTTCGGT
CAGACCAGCTGAATGTGGACATCATCTCCTGGGGCTGCACGATCACTGCTCTGCAGGTCAAAGA
CAGGCAGGGGAAAGCCTCAGACGTGGTGCTTGGCTTTGCCGAGTTGGAAGGTTACCTCCAGAAG
CAGCCCTACTTCGGAGCAGTGGTTGGGAGGGTAGCCAACCGAATTGCCAAAGGAAGGTTCACAG
TAGATGGGAAGGAGTACCACCTGCCCATTAACAGAGAGCCCAACAGTCTCCATGGAGGATTCAG
AGGATTTGATAAGGTCCTCTGGACTCCTCAGGTGCTGTCCAACGGCGTCCAGTTCTCTCGAGTC
AGTCCAGATGGTGAGGAAGGCTACCCTGGAGAGTTGAAAGTCTGGGTGACATATACCCTGGATG
GCGGAGAGCTTGTAGTCAACTACAGAGCCCAGGCCAGCCAGACCACTCCAGTTAATCTCACCAA
CCATTCTTATTTTAACCTAGCAGGCCAGGGCTCCCCAGATATATATGACCACGAAGTCACCATT
GCCGCAGATGCATACTTGCCTGTGGATGAAACTCTGATTCCAACAGGAGTCATTGCTCCGGTGG
AAGGAACTGCTTTCGACCTGAGAAAGCCAGTGGAGCTCGGGAAACACCTGCAGAGTTACCACAT
CCATGGTTTCGACCATAATTTCTGTCTGAAGGAGTCCAAAGAAAAGAAGTTTTGTGCAAGGGTG
CATCACGCTGCAAGTGGGAGGATCCTGGAAGTGTACACCACCCAACCTGGCGTCCAGTTCTACA
CAGGAAACTTCTTGGATGGTACCCTGAAGGGCAAGAGTGGAGAGGTCTATCCCAAGCACTCTGG
TTTCTGCCTCGAGACCCAGAACTGGCCTGATGCAGTCAACCAGCCCCAGTTCCCTCCGATACTG
CTGAGGCCTGGAGAGGAGTACAACCACACCACCTGGTTCAAGTTCTCCGTTGCTTAAAGAAGAC
AGAAGATGGGACCTGGTTCGAGGCCAGACTGGTTCCCACTCATCTGCCTCGCTTTAAAAGTAAT
CCTGTGTGTTAAGTCATTCAGACGGTAGCTGCCATAACAATCAACTAGAATACCGATACCCTTT
CCCGAGAGCTGGCTGTAGGCTGTGTCTAACGACCAGCTCTGTTCTCTGTCATCACTAAGGTCTG
CTCCTGGTAGAGAAGTGGTCCTCTGGACTCTCCTGACTTCATAGGCTCCACCTCTCCGTCCTGG
CTCCATTGTGTCCGTTTTCTTCAAGCCTTCCTTTCCTTGACAGAACTGTTTTCCTGCCTTCTCT
TTTACCTCAGACTACCCCCGCAGAAGTTTTAACCAGGTCTTGAGCTATGAGAATTCAGGTTCCC
CTTCTGTGCCCCTACCTCAGTCTGCCTAAGCATTCCTAGGGCCACTGAAGGACAAGCAGGGTTT
TGGGCCCTGTCCTGTCAGAGCCTTCTTCTCCGGAGCTGCAGAGATGGCTGAGCAGTGAAGAGCA
GAGGACCAGAGTCCACCCATGCCAGGCTCGAGGGGAGCAAGCACCCTCTTCTAGCCTCCGGGGA
CACCTCCACACGTACACATCCACAACGGTTAAAAACAAACCTTAAAAAAGCAAAAAAAAAAAGG
GGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGGAAGCGCAAGGCCCTGGGTTCGG
TCCCCAGCTCCGAAAAAAAGAAAGAAAAAAAAAATCACTTTAGAAGCATTAGAGTTGACCTATC
TTTTTAGAGATGTTGTGATTTAAATTGTAAGACCCAAAAACCCAGAATAATTTCAATTTTCCTG
CTTTCGTGGTTAACTAGGAGCTTGGCTAAGGTGTAGCAAGATGCACGGGCATAGAAGGCTGGAG
CCTCACATACTTTGCACTAGAAGTAGACGCTCCCCTGAGATGAAGTGGGTGGAGGCTCCTCTTT
TCCTCAAAGGTTACATCATCGCTGATGTGCCTAGGCTGCTGATTTTGAAAAAACGCATATAGTT
TGTGTTATTATCTACTACAGTCAGTTCAAATAAAACCAAAATTTCCATCTTCAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XR_005505502

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	14,841,293 - 14,889,484 (-)	NCBI

RefSeq Acc Id:

XR_005505503

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	14,839,589 - 14,889,484 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007705	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81876	(Get FASTA)	NCBI Sequence Viewer
	EDM02781	(Get FASTA)	NCBI Sequence Viewer
	Q66HG4	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001007705 ⟸ NM_001007704

- UniProtKB:

Q66HG4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MVSVTRTVFGELPSGGGAVEKFQLRSDQLNVDIISWGCTITALQVKDRQGKASDVVLGFAELEG
YLQKQPYFGAVVGRVANRIAKGRFTVDGKEYHLPINREPNSLHGGFRGFDKVLWTPQVLSNGVQ
FSRVSPDGEEGYPGELKVWVTYTLDGGELVVNYRAQASQTTPVNLTNHSYFNLAGQGSPDIYDH
EVTIAADAYLPVDETLIPTGVIAPVEGTAFDLRKPVELGKHLQSYHIHGFDHNFCLKESKEKKF
CARVHHAASGRILEVYTTQPGVQFYTGNFLDGTLKGKSGEVYPKHSGFCLETQNWPDAVNQPQF
PPILLRPGEEYNHTTWFKFSVA

hide sequence

RefSeq Acc Id:

ENSRNOP00000009221 ⟸ ENSRNOT00000009221

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HG4-F1-model_v2	AlphaFold	Q66HG4	1-342	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694363

Promoter ID:

EPDNEW_R4888

Type:

multiple initiation site

Name:

Galm_1

Description:

galactose mutarotase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	2,808,995 - 2,809,055	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359459	AgrOrtholog
BioCyc Gene	G2FUF-38520	BioCyc
Ensembl Genes	ENSRNOG00000007023	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000009221	ENTREZGENE
	ENSRNOP00000009221.5	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009221	ENTREZGENE
	ENSRNOT00000009221.7	UniProtKB/TrEMBL
Gene3D-CATH	2.70.98.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107751	IMAGE-MGC_LOAD
InterPro	Ald1_epimerase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldose_1-epimerase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldose_1/G6P_1-epimerase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gal_mutarotase_sf_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GH-type_carb-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:313843	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93738	IMAGE-MGC_LOAD
NCBI Gene	313843	ENTREZGENE
Pfam	Aldose_epim	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Galm	PhenoGen
PIRSF	GALM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDOSE_1_EPIMERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF74650	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2Q447_RAT	UniProtKB/TrEMBL
	GALM_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-01	Galm	galactose mutarotase	Galm	galactose mutarotase (aldose 1-epimerase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-17	Galm	galactose mutarotase (aldose 1-epimerase)	Galm	galactose mutarotase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Galm	galactose mutarotase			Name updated	1299863	APPROVED
2005-07-29	Galm	galactose mutarotase (aldose 1-epimerase)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_other	human homolog shows a preference for galactose over glucose	1556538

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)